Clinical trials: Medication-Related Osteonecrosis of Jaw
Osteonecrosis of the Jaw, Bisphosphonate Induced, Osteonecrosis of the Jaw, Bisphosphonate Related
Initial Management of MRONJ Stages I and II, a Clinical Trial With Detection of Salivary Biomarkers
Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication in patients receiving antiresorptive therapies, such as Bisphosphonates and Denosumab.
- Trial name
- NCT04584840
- Testing
- Surgical treatment
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Healing Surgical Wounds, Infection
Surgical Management of Medication Related Osteonecrosis of the Jaws With Concentrated Growth Factor
The purpose of this present study was to evaluate the efficiency of the growth factors delivered by concentrated growth factor (CGF) on the healing process of osteoporotic patients with medication-related osteonecrosis of the…
- Trial name
- NCT04531800
- Testing
- Concentrated growth factor, Non-concentrated growth factor
- Volunteers
- 28 people
- Sponsor
- Ege University
MEDICATION RELATED OSTEONECROSIS OF THE JAW
OZONE_EXO: Comparative Analysis of Protocols for Dental Exactions in Patients at Risk of MRONJ: Case-control Study
Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction of antiresorptive and antiangiogenic agents; it is also a potentially painful and debilitating condition.
- Trial name
- OZONE_EXO (NCT06072404)
- Testing
- OxigenOzone_Insufflation
- Where
- Italy
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Bisphosphonate-Associated Osteonecrosis of the Jaw, Osteonecrosis of the Jaw
Piezoeletric Surgery vs Conventional Surgery for Treatment of MRONJ
To date, surgical therapy of MRONJ remains the therapy of choice while still in association with a medical approach. Surgical intervention aims to stop the progression of the pathology through the removal of the tissue…
- Conditions
- Bisphosphonate-Associated Osteonecrosis of the Jaw, Osteonecrosis of the Jaw, Osteonecrosis Due to Drug
- Trial name
- PIEZOPZ-1 (NCT06622421)
- Testing
- Piezoelectric surgery, Conventional surgery
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Osteonecrosis of the Jaw
Leukocyte- and Platelet-Rich Fibrin in the Surgical Treatment of Medication-related Osteonecrosis of the Jaw
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious side-effect of antiresorptive therapies used in the management of bone diseases, such as osteoporosis or bone metastases.
- Trial name
- PeRFOrMand (NCT06419010)
- Testing
- Surgery with the use of L-PRF, Standard surgery
- Where
- 7 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Toulouse
Medication-related Osteonecrosis of the Jaw
Autologous Platelet Concentrates on the Healing of Extraction Sockets
This study will evaluate the effect of A-PRF, a second-generation APC, on early wound healing in high-risk MRONJ patients following dental extractions, utilising advanced non-invasive methods to assess and associate molecular and…
- Trial name
- NCT07673848
- Testing
- Application of A-PRF into extraction socket
- Volunteers
- 44 people
- Sponsor
- Queen Mary University of London
Medication-related Osteonecrosis of the Jaw (MRONJ)
The PENTO Protocol in Medication-related Osteonecrosis of the Jaw
Medication-related osteonecrosis of the jaw (MRONJ) occurs after taking bisphosphonates or targeted therapies. It leads to a significant decrease in quality of life with pain, eating and chewing disorders, and malnutrition.
- Trial name
- PENTO (NCT05795647)
- Testing
- Pentoxifylline+Tocopherol
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Limoges
Medication Related Osteonecrosis of the Jaw
Use of Platelet-Rich Fibrin (PRF) in the Management of Medication-Related Osteonecrosis of the Jaw (MRONJ)
Medication-Related Osteonecrosis of the Jaw (MRONJ) is a severe and increasingly prevalent clinical condition, defined as the presence of exposed mandibular or maxillary bone in the oral cavity persisting for at least eight…
- Trial name
- NCT07464678
- Testing
- Surgical Application of Platelet-Rich Fibrin (PRF)
- Where
- Poland
- Volunteers
- 22 people
- Sponsor
- Poznan University of Medical Sciences
Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ), Oxygen
Topical Oxygen Therapy for BRONJ
A randomized clinical trial comparing Blue®m oral gel and autologous PRF membrane as adjuncts to surgical debridement in BRONJ/MRONJ patients.
- Conditions
- Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ), Oxygen, Topical Administration, Wound Healing
- Trial name
- OXY-BRONJ Tria (NCT07725107)
- Testing
- Topical Blue®m application, PRF membrane placement
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Mansoura University
Medication-related Osteonecrosis of the Jaw, Bisphosphonate-Associated Osteonecrosis of the Jaw
Medication-related Osteonecrosis of the Jaw (MRONJ) Registry
Approximately 500 patients will be included in this patient registry. Data collection includes demographics, clinical data of underlying disease and use of bisphosphonates, denosumab and antiangiogenic drugs , degree and…
- Trial name
- MRONJ (NCT02932501)
- Testing
- Conservative treatment, Surgical treatment, Adjuvant non-surgical treatment
- Where
- 14 sites in United States, Finland and 8 more
- Volunteers
- 518 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Osteonecrosis Due to Drugs, Jaw, Osteonecrosis of the Jaw, Bisphosphonate Related
Medical and Surgical Treatment of MRONJ (Medication-related Osteonecrosis of the Jaw Bones)
MRONJ is an acronym used to describe medication-related osteonecrosis of the jaw bones. It has been reported by the AAOMS that bisphosphonates or denosumab can cause this condition.
- Conditions
- Osteonecrosis Due to Drugs, Jaw, Osteonecrosis of the Jaw, Bisphosphonate Related, Osteonecrosis of the Jaw, Bisphosphonate Induced
- Trial name
- NCT06917846
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Akdeniz University
Medication-related Osteonecrosis of the Jaw (MRONJ)
Early Warning and Risk Prediction of Medication-Related Osteonecrosis of the Jaw
This prospective observational cohort study aims to develop and evaluate an early warning and risk prediction model for medication-related osteonecrosis of the jaw (MRONJ) based on multimodal data fusion.
- Trial name
- NCT07691892
- Volunteers
- 310 people
- Sponsor
- Hospital of Stomatology, Wuhan University
Osteomyelitis of Jaw
Management of Medication Related Osteonecrosis of the Jaws With Double Periosteal Flap Closure
20 patients with MRONJ underwent surgical debridement using piezosurgery then closure using double periosteal flap
- Trial name
- NCT07177378
- Testing
- management of medication related osteonecrosis of the jaw
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tanta University
Medication-Related Osteonecrosis of Jaw
Immunological Parameters Between MRONJ Stages
This study aims to conduct a detailed analysis of the immunological response profiles that emerge at different clinical stages of medication-related osteonecrosis of the jaw (MRONJ).
- Trial name
- NCT06420284
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Marmara University
Oral Squamous Cell Carcinoma, Medication Related Osteonecrosis of the Jaw
The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw
Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the head and neck, and its incidence has increased in recent years.
- Conditions
- Oral Squamous Cell Carcinoma, Medication Related Osteonecrosis of the Jaw, Oral Epithelial Dysplasia
- Trial name
- NCT03418454
- Testing
- Buccal mucosa samples for Extraction of BACTERIAL DNA
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Barzilai Medical Center
Medication-Related Osteonecrosis of Jaw
Assessment of Er:YAG Laser-Assisted Surgical Treatment in Medication-Related Osteonecrosis of the Jaw (MRONJ): A Clinical Trial
The aim of this study is assessing the effectiveness of the Er:YAG laser in relation to the use of conventional surgery in the treatment of drug-induced osteonecrosis of the jaws (MRONJ).
- Trial name
- NCT07029815
- Testing
- irradiation with Er:YAG laser, Tissue preparation
- Where
- Poland
- Volunteers
- 65 people
- Sponsor
- Wroclaw Medical University
Medication Related Osteonecrosis of the Jaw
Comparing Implant Retention Versus Removal for MRONJ at Implant Sites
Medication-related osteonecrosis of the jaw (MRONJ) is a condition that can occur in patients who take medications such as antiresorptive drugs for osteoporosis and other bone-related systemic diseases.
- Trial name
- NCT07435259
- Testing
- Implant Retention Surgery, Implant Removal Sugery
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Kyunghee University Dental Hospital
MEDICATION RELATED OSTEONECROSIS OF THE JAW
Infiltration of Medical Ozone for the Treatment of Medication-Related Osteonecrosis of the Jaws (MRONJ)
Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction of antiresorptive and antiangiogenic agents; it is also a potentially painful and debilitating condition.
- Trial name
- OZOPROMAF (NCT05036837)
- Testing
- OZOPROMAF_SEQ1
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Osteonecrosis Due to Drugs, Jaw
Use of Topical Phenytoin in Bisphosphonate-related Osteonecrosis of the Mandible
Patients who had bisphosphonate-related osteonecrosis of the jaw in stage II were allocated in two groups randomly : In group1, 10 patients underwent debridement and primary closer of the area,in group 2 , patients received…
- Trial name
- NCT03269214
- Testing
- Topical Phenytoin 5%
- Volunteers
- 20 people
- Sponsor
- Shiraz University of Medical Sciences
Osteoradionecrosis of the Jaw, Medicine Related Osteonecrosis of the Jaw
L-PRF in Prevention of ORN and MRONJ Following Tooth Extractions;v3.0
Osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) are debilitating complications following dental extractions in patients who have received head and neck radiotherapy or antiresorptive therapy.
- Trial name
- NCT07585123
- Testing
- L-PRF, Standard Extraction
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Swansea Bay University Health Board