Clinical trials: Medication-Related Osteonecrosis of Jaw, open to volunteers
Medication-related Osteonecrosis of the Jaw (MRONJ)
The PENTO Protocol in Medication-related Osteonecrosis of the Jaw
Medication-related osteonecrosis of the jaw (MRONJ) occurs after taking bisphosphonates or targeted therapies. It leads to a significant decrease in quality of life with pain, eating and chewing disorders, and malnutrition.
- Trial name
- PENTO (NCT05795647)
- Testing
- Pentoxifylline+Tocopherol
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Limoges
Osteoradionecrosis of the Jaw, Medicine Related Osteonecrosis of the Jaw
L-PRF in Prevention of ORN and MRONJ Following Tooth Extractions;v3.0
Osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) are debilitating complications following dental extractions in patients who have received head and neck radiotherapy or antiresorptive therapy.
- Trial name
- NCT07585123
- Testing
- L-PRF, Standard Extraction
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Swansea Bay University Health Board
Medication-Related Osteonecrosis of Jaw
Therapeutic Exposures and Risk Factors in MRONJ
This study focuses on patients who have developed a condition called medication-related osteonecrosis of the jaw (MRONJ), which can occur after using certain medications.
- Trial name
- NCT06430762
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Marmara University
Osteomyelitis of Jaw
Management of Medication Related Osteonecrosis of the Jaws With Double Periosteal Flap Closure
20 patients with MRONJ underwent surgical debridement using piezosurgery then closure using double periosteal flap
- Trial name
- NCT07177378
- Testing
- management of medication related osteonecrosis of the jaw
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tanta University
Medication-related Osteonecrosis of the Jaw
Autologous Platelet Concentrates on the Healing of Extraction Sockets
This study will evaluate the effect of A-PRF, a second-generation APC, on early wound healing in high-risk MRONJ patients following dental extractions, utilising advanced non-invasive methods to assess and associate molecular and…
- Trial name
- NCT07673848
- Testing
- Application of A-PRF into extraction socket
- Volunteers
- 44 people
- Sponsor
- Queen Mary University of London
Osteonecrosis of the Jaw
Leukocyte- and Platelet-Rich Fibrin in the Surgical Treatment of Medication-related Osteonecrosis of the Jaw
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious side-effect of antiresorptive therapies used in the management of bone diseases, such as osteoporosis or bone metastases.
- Trial name
- PeRFOrMand (NCT06419010)
- Testing
- Surgery with the use of L-PRF, Standard surgery
- Where
- 7 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Toulouse
Medication-related Osteonecrosis of the Jaw, Osteonecrosis of the Jaw
Bone Quality Evolution in Medication-Related Osteonecrosis of the Jaw Assessed by CBCT (B-ONJ EVOL)
Medication-related osteonecrosis of the jaw (MRONJ) is a known complication of antiresorptive therapies such as bisphosphonates and denosumab.
- Trial name
- B-ONJ EVOL (NCT07588269)
- Testing
- Cone Beam Computed Tomography Imaging
- Volunteers
- 25 people
- Sponsor
- Nantes University Hospital
Bisphosphonate-Associated Osteonecrosis of the Jaw, Osteonecrosis of the Jaw
Piezoeletric Surgery vs Conventional Surgery for Treatment of MRONJ
To date, surgical therapy of MRONJ remains the therapy of choice while still in association with a medical approach. Surgical intervention aims to stop the progression of the pathology through the removal of the tissue…
- Conditions
- Bisphosphonate-Associated Osteonecrosis of the Jaw, Osteonecrosis of the Jaw, Osteonecrosis Due to Drug
- Trial name
- PIEZOPZ-1 (NCT06622421)
- Testing
- Piezoelectric surgery, Conventional surgery
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Osteonecrosis of the Jaw, Osteonecrosis Due to Drugs, Jaw
Medication Related Osteonecrosis of the Jaws (MRONJ) in a Cohort of Patients Treated by Antiresorptive Drugs
The objective of this prospective observational study is to investigate the incidence of Medication Related Osteonecrosis of the Jaws (MRONJ) in patients receiving antiresorptive drugs for oncohematologic reasons during a 5-year…
- Conditions
- Osteonecrosis of the Jaw, Osteonecrosis Due to Drugs, Jaw, Osteonecrosis Due to Drug, Bisphosphonate-Associated Osteonecrosis
- Trial name
- NCT06457776
- Testing
- Dental management
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- Catholic University of the Sacred Heart
Medication-related Osteonecrosis of the Jaw (MRONJ)
Early Warning and Risk Prediction of Medication-Related Osteonecrosis of the Jaw
This prospective observational cohort study aims to develop and evaluate an early warning and risk prediction model for medication-related osteonecrosis of the jaw (MRONJ) based on multimodal data fusion.
- Trial name
- NCT07691892
- Volunteers
- 310 people
- Sponsor
- Hospital of Stomatology, Wuhan University
Medication Related Osteonecrosis of the Jaw
Comparing Implant Retention Versus Removal for MRONJ at Implant Sites
Medication-related osteonecrosis of the jaw (MRONJ) is a condition that can occur in patients who take medications such as antiresorptive drugs for osteoporosis and other bone-related systemic diseases.
- Trial name
- NCT07435259
- Testing
- Implant Retention Surgery, Implant Removal Sugery
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Kyunghee University Dental Hospital
Medication Related Osteonecrosis of the Jaw
MRONJ and Polynucleotides-Hyaluronic Acid Hydrogel (Regenfast®)
Several circumstances or conditions, such as wound extension or disease, can affect the hard and soft tissue healing after surgical treatment of MRONJ. Supportive therapies are therefore needed to help tissues wound healing.
- Trial name
- REG-MRONJ-1 (NCT06984107)
- Testing
- MRONJ resection plus PN+HA
- Volunteers
- 10 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS