Clinical trials: Medicine
Cardiac Affections
Comparison of Cardiotoxicity Induced by Selective Estrogen REceptor Modulators and aNti-Aromatase
Selective estrogen receptor modulators and aromatase inhibitors for the treatment of breast cancer seems to have an impact on the cardio-vascular system.
- Trial name
- SERENA (NCT03259711)
- Testing
- Hormonal therapies L02 in the ATC classification
- Where
- France
- Volunteers
- 20,000 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Obesity
Effect and Safety of TCM-FMD in Phlegm-Dampness Type Overweight/Obesity Patients(EASTAR)
The primary aim of this study is to is to determine if a diet (TCM-FMD) which combine fasting-mimicking diet (FMD) with "dispelling dampness" meal replacement (a meal replacement made up of traditional Chinese medicine) is the…
- Trial name
- NCT04029571
- Testing
- TCM-FMD, FMD
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Adherence, Medication, Heart Failure
Medication Adherence in Heart Failure After Hospitalisation
To explore medication adherence in patients who were hospitalised due to heart failure.
- Trial name
- NCT05233644
- Where
- Switzerland
- Volunteers
- 72 people
- Sponsor
- University of Zurich
HIV Infection
Engaging Care for HIV-infected Adolescent Females.
The proposed multi-site, longitudinal study will examine the correlation of substance use, mental health disorders, and social networks to engagement in care for HIV-infected adolescent females, aged 13 years, 0 months - 23…
- Trial name
- NCT00489034
- Testing
- Quantitative Interview, Ethnographic Interview, Gender Interview
- Where
- 5 sites in United States
- Volunteers
- 178 people
- Sponsor
- University of North Carolina, Chapel Hill
Gout
Food Effect Study of Febuxostat XR in Healthy Participants
The purpose of this study is to assess the effect of food on the bioavailability of febuxostat after a single oral dose of 80 mg febuxostat XR and to evaluate the pharmacokinetics (PK) of febuxostat after single oral doses of 40…
- Trial name
- NCT02374164
- Testing
- Febuxostat XR
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Takeda
IgA Nephropathy, Kidney Transplant Recipients
MYTP01 for Immune-Mediated Diseases
The goal of this study is to evaluate whether MYTP01, a traditional Chinese herbal formula developed by clinical experts with the assistance of artificial intelligence (AI), is effective and safe as an additional treatment for…
- Conditions
- IgA Nephropathy, Kidney Transplant Recipients, Lupus Nephritis, Primary Membranous Nephropathy
- Trial name
- NCT07901764
- Testing
- MYTP01
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Zhejiang Provincial People's Hospital
Rheumatoid Arthritis (RA
Efficacy and Safety of Dapagliflozin as an Adjunct to Conventional Disease-Modifying Antirheumatic Drugs in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a long-standing autoimmune inflammatory disease marked by continuous synovial inflammation, which contributes to progressive cartilage and bone damage, eventually resulting in joint destruction.
- Trial name
- NCT07901309
- Testing
- Dapagliflozin (10mg Tab)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Use; Tobacco, Harmful, Alcohol Abuse
Dental and Medical Office iMET to Reduce Teen Tobacco, Alcohol, and Drug Use
The purpose of the project is to improve adolescent behavioral counseling services in healthcare settings with a new Internet/Intranet-based Motivational Enhancement Therapy (iMET) intervention that targets the use of tobacco…
- Conditions
- Use; Tobacco, Harmful, Alcohol Abuse, Drug Abuse
- Trial name
- NCT00907309
- Testing
- iMET, iMET/TE
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Boston Children's Hospital
Chronic Neck Pain
Qigong and Exercise for Neck Pain in Adults (QENA)
The purpose of this study is to assess the effectiveness of qigong for the treatment of chronic neck pain compared to exercise therapy and waiting list group.
- Trial name
- QENA (NCT00615732)
- Testing
- Qigong, exercise therapy
- Where
- Germany
- Volunteers
- 123 people
- Sponsor
- Charite University, Berlin, Germany
Asthma
Inhaled Corticosteroid Replacement Study - Efficacy and Safety of Ro 27-2441 (Test Drug) in Moderate Persistent Asthma
The primary objective of the study is to evaluate the anti-inflammatory action and safety of Ro 27-2441 (study drug) in asthmatic patients currently taking inhaled corticosteroids.
- Trial name
- NCT00048022
- Testing
- Dual Integrin Antagonist
- Where
- 60 sites in United States, Puerto Rico
- Sponsor
- Hoffmann-La Roche
Brugada Syndrome (BrS), Ventricular Arrhythmia
Prospective Multicentre Observational Registry of Peri-procedural Anaesthesia, Sedation and Related Medication Exposure in Patients With Brugada Syndrome
The goal of this observational study is to evaluate the perioperative risk of malignant ventricular arrhythmias in adult patients diagnosed with Brugada Syndrome undergoing anaesthetic procedures.
- Conditions
- Brugada Syndrome (BrS), Ventricular Arrhythmia, Anesthesia, Sedation
- Trial name
- PROSP_BRUGANAE (NCT07655102)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Clinic of Barcelona
Spatial Neglect, Hemispatial Neglect
A Model to Identify Specific Predictors of Spatial Neglect Recovery
This study examines methods to better predict improvement of a hidden disability of functional vision, spatial neglect, following stroke.
- Conditions
- Spatial Neglect, Hemispatial Neglect, Hemineglect, Unilateral Neglect
- Trial name
- NCT00990353
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Kessler Foundation
Deep Venous Thrombosis, Pulmonary Embolism
Drug Interaction Between Paracetamol and Warfarin
The objective of this study is to investigate whether paracetamol, given at therapeutic doses (2g/day and 3 g/day), may potentiate the anticoagulant effect of warfarin.
- Conditions
- Deep Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation, Stroke
- Trial name
- INPAWA2 (NCT01104337)
- Testing
- paracetamol
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Hopital Lariboisière
Ocular Hypertension, Open-Angle Glaucoma
Comparison of Istalol™ 0.5% QD (Timolol Maleate/Sorbitol Complex, ISTA Pharmaceutical) to Brimonidine Tartrate 0.1% BID as Adjunctive Therapy to Latanoprost 0.005% in Adults With Ocular Hypertension (OHT) or Open-Angle Glaucoma (OAG)
To assess the additional benefit of common adjunctive classes on the diurnal IOP curve in patients assessed as needing additional treatment to reach target intraocular pressure (IOP).
- Trial name
- NCT00698945
- Testing
- Istalol and Optive, Alphagan
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bp Consulting, Inc
Overactive Bladder Syndrome
Efficacy, Tolerability and Impact on Quality of Life of Propiverine in Patients With Overactive Bladder Syndrome
The purposes of this study were to assess Quality of Life (QoL) and urination urge, incontinence, and micturition frequency including nocturia after 4 and 12 weeks treatment with propiverine.
- Trial name
- NCT02024945
- Testing
- Propiverine
- Volunteers
- 437 people
- Sponsor
- Takeda
HIV Infections, Hepatitis C
Behavioral Intervention for HIV and HCV-Uninfected Injection Drug Users
The purpose of this study is to test whether a six-session behavioral intervention for HIV and HCV seronegative injection drug users is effective in reducing sexual and injection risk behaviors that could lead to primary HIV and…
- Trial name
- NCT00164372
- Testing
- Peer Education Intervention
- Where
- 5 sites in United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Diabetes Mellitus, Fasting
Effectiveness of Education, Medication Adjustment and Telemonitoring in Reducing Diabetes Complications During Ramadan
Introduction Diabetes is a global emergency with detrimental clinical and financial consequences. Poorly managed diabetes leads to a myriad of serious complications, especially cardiovascular and infectious complications, with…
- Conditions
- Diabetes Mellitus, Fasting, Diabetes Complications
- Trial name
- NCT06033872
- Testing
- Focused education, medication adjustment and telemonitoring
- Where
- Singapore
- Volunteers
- 79 people
- Sponsor
- Sengkang General Hospital
Apnea, Sleep Disorders
A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Do Not Use a Breathing Machine (PAP) (VESPER-OSA 2)
This study is being done to learn about the safety and effects of a study medicine called berobenatide (bear-oh-BEN-uh-tide). The study will see if berobenatide can help adults with breathing problems during sleep (obstructive…
- Conditions
- Apnea, Sleep Disorders, Overweight and/or Obesity
- Trial name
- VESPER-OSA 2 (NCT07881757)
- Testing
- Berobenatide
- Where
- 2 sites in United States
- Volunteers
- 258 people
- Sponsor
- Pfizer
Tuberculosis
Salivary Therapeutic Drug Monitoring of Anti-Tuberculosis Drugs
In tuberculosis patients, salivary concentrations will be compared to plasma/serum concentrations of several anti-tuberculosis drugs.
- Trial name
- NCT03080012
- Testing
- Saliva sampling, Plasma/serum sampling
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- University Medical Center Groningen
Shortness of Breath, Acute Respiratory Failure
Enhanced FoCUS in Patients With Shortness of Breath
Retrospective observational study performed in a internal medicine ward of a French university hospital. Included patients were hospitalized for acute shortness of breath who have benefited from a eFOCUS which was defined as a…
- Trial name
- eFOCUS (NCT05403619)
- Testing
- Diagnostic test
- Where
- France
- Volunteers
- 119 people
- Sponsor
- Nantes University Hospital
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