Clinical trials: Medicine
Drug Hypersensitivity
Establishment of a Registry for Immediate Drug Allergy
Immediate drug hypersensitivity reactions are acute adverse reactions that occur within one hour of drug administration and can result in life-threatening symptoms such as urticaria, angioedema, and anaphylaxis.
- Trial name
- NCT07390370
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Opiate Addiction, Borderline Personality Disorder
Evaluation of DBT Compared to Drug Counseling for Opiate Addicts
The purpose of this study is to compare a one year treatment program of Dialectical Behavior Therapy (DBT) + suboxone for opiate addicted individuals meeting criteria for borderline personality disorder (BPD) to a one year…
- Trial name
- NCT00117741
- Testing
- Dialectical Behavior Therapy, Drug Counseling
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Washington
Genotype-related Drug Metabolism
Open Label Study for the Functional Characterization of Drug Metabolism and Transport
Aim of this study is to comprehensively assess in healthy volunteers the metabolic processes and factors that define drug response.
- Trial name
- IKP243 (NCT01788254)
- Testing
- Codeine, Midazolam, pravastatin
- Where
- 2 sites in Germany
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Matthias Schwab
Breast Cancer
Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04]
This study will compare DS-8201a to physician choice standard treatment. Participants must have HER2-low breast cancer that has been treated before.
- Trial name
- NCT03734029
- Testing
- Trastuzumab deruxtecan (DS-8201a), Capecitabine, Eribulin
- Where
- 208 sites in United States, Austria and 18 more
- Volunteers
- 557 people
- Sponsor
- Daiichi Sankyo
COPD
Optimizing Maintenance Therapy in COPD Patients
Background: Effectiveness of maintenance therapy for COPD with Dry Powder Inhalers (DPIs) requires an optimal Peak Inspiratory Flow Rate (PIFR), a proper inhalation technique and adequate medication adherence from patients.
- Trial name
- PIFOTAL (NCT04532853)
- Where
- 6 sites in Australia, Greece and 4 more
- Volunteers
- 1,434 people
- Sponsor
- General Practitioners Research Institute
Ovarian Cancer
Characterization of Ovarian Cancer Stem Cell
Specific aims: Identification and characterization of cancer stem cell-like population (cancer stem cells or cancer initiating cells) from primary tumor tissue, primary ascites and peripheral blood of ovarian cancer patients and…
- Trial name
- NCT01367353
- Testing
- surgery or debulking surgery
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Diabetes, Diabetes Mellitus
Computer-Assisted Cancer Risk Behavior Counseling
To test whether or not giving patients information before their doctor visits changes the care they receive and what type of information is best to give before the doctor visit.
- Conditions
- Diabetes, Diabetes Mellitus, Hypertension
- Trial name
- NCT00242645
- Testing
- Health Information, Preventive Services, Computer tailored information
- Volunteers
- 200 people
- Sponsor
- Thomas Jefferson University
Glaucoma, Ocular Surface Disease
Treatment of Ocular Discomfort in Glaucoma Patients Using Multiple Topical Medications
To evaluate glaucoma patients' response to treatment with Xiidra, an FDA-approved drug for ocular surface discomfort, which will be prescribed as standard of care treatment.
- Trial name
- NCT04354545
- Testing
- Xiidra (Lifitegrast ophthalmic solution) 5%
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Healthy
Drug-Drug Interaction Study of AG120 in Healthy Subjects
An Open-Label, 2-Period, Fixed Sequence Study to Determine the Effect of Multiple Oral Doses of Itraconazole on the Single Dose Pharmacokinetics of AG 120 in Healthy Adult Subjects.
- Trial name
- NCT02831972
- Testing
- AG120, Itraconazole
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Agios Pharmaceuticals, Inc.
Nausea and Vomiting, Chemotherapy-Induced
The Pharmacokinetic Interaction Between Oral Casopitant and Oral Dolasetron, Granisetron or Rosiglitazone in Subjects
This A Three-Part Drug-Drug Interaction Study To Evaluate Effects of Casopitant On Dolasetron, Granisetron or Rosiglitazone When Co-Administered in Healthy Adults
- Trial name
- NCT00511823
- Testing
- casopitant, dolasetron, granisetron
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Metastatic Solid Tumor, Recurrent Solid Tumor
A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors
The purpose of this study is to find out whether the study drug, LY4101174, is safe, tolerable and effective in participants with select advanced or metastatic solid tumors.
- Conditions
- Metastatic Solid Tumor, Recurrent Solid Tumor, Advanced Solid Tumor, Urinary Bladder Neoplasm
- Trial name
- EXCEED (NCT06238479)
- Testing
- LY4101174
- Where
- 28 sites in United States, Australia and 5 more
- Volunteers
- 490 people
- Sponsor
- Eli Lilly and Company
Heart Failure With Reduced Ejection Fraction
Bisoprolol Plasma Residual Concentrations in Chronic Heart Failure
This study evaluate the dosage of bisoprolol plasma residual concentrations in chronic heart failure with mild to reduced ejection fraction adult patients by dose and renal function.
- Trial name
- PREVALENT (NCT03644446)
- Testing
- Bisoprolol plasma residual concentration dosage
- Where
- France
- Volunteers
- 81 people
- Sponsor
- University Hospital, Caen
Substance Abuse
A Comparison of How Likely it is That Different Tablets of Oxycodone Will be Broken up and Snorted by Adults Who Sometimes Take Drugs for Pleasure
The trial comprises an Enrollment Visit, a Qualification Phase, a Treatment Phase (including 3 treatment periods), a Final Examination, and a Follow-up Phone Call.
- Trial name
- NCT03765346
- Testing
- Oxycodone IR ADF, Oxycodone API powder
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Advanced Malignancies
A Study of MLN8237, a Novel Aurora A Kinase Inhibitor, in Participants With Advanced Solid Tumors
To determine the dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) of MLN8237 when given by mouth (PO) for a minimum of 7 and a maximum of 21 consecutive days, followed by a 14-day recovery period.
- Trial name
- NCT00500903
- Testing
- Alisertib
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Healthy
A Study in Healthy Men to Test Whether Zongertinib Affects How 3 Other Medicines (Midazolam, Omeprazole, and Repaglinide) Are Taken up and Processed by the Body
The main objective of this trial is to assess the effect of multiple oral doses of zongertinib on the pharmacokinetics of midazolam, omeprazole and repaglinide.
- Trial name
- NCT06494761
- Testing
- zongertinib, midazolam, omeprazole
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Graves' Disease in Remission (Disorder)
Heart Rate Monitoring by Wearable Devices in Graves' Disease
A multi center randomized controlled study including 3 arms (wearable device group, control group 1, control group 2). This study is to investigate clinical feasibility of heart rate monitoring using wearable devices to detect…
- Trial name
- NCT04333342
- Testing
- heart rate monitoring using wearable devices
- Where
- 6 sites in South Korea
- Volunteers
- 180 people
- Sponsor
- Seoul National University Bundang Hospital
Alexithymia, Empathy Skills
Film-Based Medical Education and Social Justice Course: Effects on Alexithymia and Empathy in Medical Students
This study will examine whether a 14-week elective course that uses films and guided discussion on social justice in health care can improve medical students' empathy skills and reduce alexithymia (difficulty recognizing and…
- Conditions
- Alexithymia, Empathy Skills, Education, Medical, Social Justice Advocacy
- Trial name
- NCT07399366
- Testing
- Film-Based Medical Education and Social Justice Elective
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
COVID-19 Infection, Hematopoietic and Lymphoid Cell Neoplasm
Patient Perceptions of the Relational Empathy of Healthcare Practitioners From the Department of Emergency Medicine During the COVID-19 Pandemic
This study investigates patients' perceptions of their doctor's or nurse's empathy during an in-person interaction with the doctor or nurse wearing personal protective equipment (PPE) compared to during a video interaction with…
- Conditions
- COVID-19 Infection, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT05102656
- Testing
- Best Practice, Discussion, Questionnaire Administration
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- M.D. Anderson Cancer Center
Granulomatous Colitis, Crohn's Disease
An Investigational Study of Experimental Medication BMS-986165 in Participants With Moderate to Severe Crohn's Disease
The purpose of this study is to assess the safety and effectiveness of BMS-986165 compared to placebo in participants with moderately to severely active Crohn's Disease.
- Conditions
- Granulomatous Colitis, Crohn's Disease, Crohn's Enteritis, Granulomatous Enteritis
- Trial name
- NCT03599622
- Testing
- BMS-986165
- Where
- 259 sites in United States, Australia and 24 more
- Volunteers
- 239 people
- Sponsor
- Bristol-Myers Squibb
Polypharmacy
A Digital Tool to Help Doctors and Pharmacists Prescribe Medicines More Safely for Older Adults in Oman
This is a prospective, multi-phase interventional study evaluating the clinical utility and efficacy of POLYMED-a bilingual (Arabic/English) web-based, explainable-AI medication risk calculator-on optimizing geriatric medication…
- Trial name
- POLYMED (NCT07840222)
- Testing
- OPIP Score Calculator (Oman Potentially Inappropriate Prescribing Risk Score)
- Volunteers
- 400 people
- Sponsor
- Oman Ministry of Health
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