Clinical trials: Medicine
Malaria, Malaria, Falciparum
Mass Drug Administration With Dihydroartemisinin + Piperaquine for Reducing Malaria in Southern Zambia
To quantify the relative effectiveness, cost, and cost-effectiveness of fMDA and MDA with DHAp against no mass treatment for reducing P.
- Trial name
- NCT02329301
- Testing
- MDA with DHAp (Eurartesim), Focal MDA with DHAp (Eurartesim)
- Where
- Zambia
- Volunteers
- 2,430 people, healthy volunteers welcome
- Sponsor
- PATH
Medication Administered in Error, Adverse Drug Events
Ambulatory Medication Reconciliation Following Hospital Discharge
Adverse drug events (ADEs) after hospital discharge are common. The purpose of this research study is see if we can design an electronic tool given to your primary care provider (PCP) that will reduce adverse drug events…
- Trial name
- NCT00740675
- Testing
- Outpatient Medication Reconciliation
- Where
- 2 sites in United States
- Volunteers
- 912 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Diabetes Mellitus, Kidney Disease
Impact of Antiglycemic & Immunosuppressive Therapies on NETosis in Diabetes & Kidney Disease (NETs - Neutrophil Traps)
This study aims to investigate whether new glucose-lowering medications, such as SGLT2 inhibitors (e.g., Forxiga/Jardiance) and GLP-1 receptor agonists (e.g., Ozempic), can reduce NETosis in diabetic patients, thereby mitigating…
- Trial name
- NETs (NCT06821919)
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Urologic Injuries, Kidney Disease
The Clinical Research of Traditional Chinese Medicine Formula
This study examines the efficacy and safety of Bushen Huoxue Simiao formula for tonifying the kidneys and promoting blood circulation in treating postoperative complications of upper urinary tract stones, thereby providing…
- Trial name
- NCT07746219
- Testing
- Bushen Huoxue Simiao Formula, control group
- Volunteers
- 80 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Pain
Oxycodone User Registry (OUR)
The purpose of this study is to describe clinical and demographic characteristics of patients receiving prescription medications containing oxycodone immediate release (OXYRX), to characterize patient and prescriber perceptions…
- Trial name
- NCT00978328
- Testing
- oxycodone immediate release (OXYRX)
- Volunteers
- 827 people
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Drug Use, Alcohol Use
Specialized Community Disease Management to Reduce Substance Use and Hospital Readmissions
This study will assess Specialized Community Disease Management (SCDM), an intervention which employs various evidence-based strategies to engage substance using co-morbid patients while in the hospital and follow them into the…
- Conditions
- Drug Use, Alcohol Use, Congestive Heart Failure, Pneumonia
- Trial name
- NCT02059005
- Testing
- Specialized Community Disease Management, Treatment As Usual
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Treatment Research Institute
Open-angle Glaucoma
Open-angle Glaucoma Subjects on One Ocular Hypotensive Medication Randomized to Treatment With Two Trabecular Micro-bypass Stents or Selective Laser Trabeculoplasty
Evaluation of intraocular pressure (IOP) lowering effect of two iStent stents versus a SLT procedure in subjects with open-angle glaucoma on one ocular hypotensive medication.
- Trial name
- NCT01444105
- Testing
- iStent, SLT
- Where
- Armenia
- Volunteers
- 80 people
- Sponsor
- Glaukos Corporation
Schizophrenia
Observational Study of Long Acting Injectable Medications (LAIs) in Schizophrenia (OASIS)
The objectives of this study are to describe characteristics, treatment patterns, and outcomes of patients with schizophrenia newly initiated on 1 of 4 FDA-approved atypical Long Acting Injectable (LAI) antipsychotics (ABILIFY…
- Trial name
- NCT03919994
- Where
- 57 sites in United States
- Volunteers
- 338 people
- Sponsor
- Alkermes, Inc.
Depression
Tai Chi Intervention for Chinese Americans With Depression
The purpose of this study is to conduct a pilot randomized controlled trial (RCT) that provides the feasibility, safety, and preliminary efficacy data required to design a large scale trial evaluating Tai Chi for Chinese…
- Trial name
- NCT01619631
- Testing
- 12-week Tai Chi intervention, Education control group
- Where
- 2 sites in United States
- Volunteers
- 94 people
- Sponsor
- Massachusetts General Hospital
Neuroendocrine Tumors, Carcinoid Syndrome
Prospective Assessment of Patients With Neuroendocrine Tumors and Current or Prior History of Carcinoid Syndrome or Diarrhea Undergoing Peptide Receptor Radionuclide Therapy With or Without Telotristat Ethyl
The NET-PACS trial is a Prospective Assessment of patients with neuroendocrine tumors and current or prior history of Carcinoid Syndrome or diarrhea undergoing peptide receptor radionuclide therapy with or without telotristat…
- Conditions
- Neuroendocrine Tumors, Carcinoid Syndrome, Diarrhea
- Trial name
- NET-PACS (NCT04713202)
- Testing
- Telotristat ethyl, Peptide Receptor Radionuclide Therapy
- Where
- United States
- Sponsor
- Chandrikha Chandrasekhara
Brain Activity Related to Opioid Administration, Brain Activity Related to Drug Liking
Characterizing the EEG Signature of Fentanyl and Its Association With Drug Liking
The goal of this study is to characterize an electroencephalogram (EEG) biomarker for fentanyl and understand where this signal is coming from in the brain.
- Trial name
- NCT06699953
- Testing
- Observational study in patients receiving fentanyl for surgery
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Uterine Fibroids
A Phase 3 Study to Evaluate the Efficacy and Safety of Relugolix (TAK-385) 40 mg Compared With Leuprorelin in the Treatment of Uterine Fibroids
The purpose of this study is to evaluate the efficacy of Relugolix (TAK-385) 40 mg administered orally once daily for 12 weeks, compared with leuprorelin injection (once every 4 weeks, 1.88 mg or 3.75 mg subcutaneously [SC]/time)…
- Trial name
- NCT02655237
- Testing
- Relugolix, Leuprorelin
- Where
- 25 sites in Japan
- Volunteers
- 281 people
- Sponsor
- Takeda
Periodontal Diseases, Oral Health Literacy
Oral Health Literacy and Periodontal Status Among Turkish Adults
This observational cross-sectional study aimed to investigate the association between oral health literacy (OHL) and periodontal status among adult individuals attending Biruni University Faculty of Dentistry, Istanbul, Türkiye.
- Conditions
- Periodontal Diseases, Oral Health Literacy, Periodontitis, Health Behaviour
- Trial name
- NCT07341945
- Testing
- Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Biruni University
Bruxism, Temporomandibular Disorders (TMD)
Short-Term Symptom Changes in Adults With Teeth Clenching or Grinding and Jaw Symptoms Receiving Splint, Botulinum Toxin, or Medication Plus Splint Care
This prospective observational study evaluated short-term patient-reported symptom changes in adults with bruxism-related and temporomandibular disorder symptoms who received one of three clinically selected management…
- Conditions
- Bruxism, Temporomandibular Disorders (TMD), Myofascial Pain
- Trial name
- NCT07586072
- Testing
- Occlusal splint, Botulinum Toxin Type A (Dysport®), Thiocolchicoside
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Recep Tayyip Erdogan University
HIV Infections, HCV
The Ganchero Intervention for Migrant People Who Inject Drugs From Puerto Rico in New York City
The goal of this pilot clinical trial is to learn if an intervention that trains Gancheros (people who provide injection services in exchange for drugs or money) to conduct risk-reduction outreach could help lower risk for human…
- Conditions
- HIV Infections, HCV, Overdose
- Trial name
- NCT06316739
- Testing
- Ganchero intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- North Jersey AIDS Alliance dba North Jersey Community Research Initiative (NJCRI)
Chronic Kidney Disease
OPTIMISE-CKD Drug Utilization
This is a multi-national, observational study program using secondary data sources to address research questions related to 1) real-world dapagliflozin utilisation in CKD and potential for further utilisation, 2), the current CKD…
- Trial name
- OPTIMISE-CKD (NCT05932901)
- Where
- 5 sites in United States, Japan and 1 more
- Volunteers
- 2,682,052 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
Post-marketing Surveillance of Atrovent® in Chronic Obstructive Pulmonary Disease
Study to obtain further information on the tolerability and efficacy of Atrovent® inhalets in the treatment of Chronic Obstructive Pulmonary Disease under conditions of daily practice
- Trial name
- NCT02233881
- Testing
- Atrovent® - inhalets
- Volunteers
- 4,222 people
- Sponsor
- Boehringer Ingelheim
Septic Shock
Hypotension in the Weaning From Vasopressor Drugs
Although there is consensus in the literature on hemodynamic management of septic shock in the resuscitation phase, the best way to conduct the weaning of vasopressor drugs in the stabilization phase remains open.
- Trial name
- RENOVA (NCT05506319)
- Testing
- Norepinephrine, Vasopressin
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Lumbar Radiculopathy, Lesion of Sciatic Nerve, Left Lower Limb
Cost Effectiveness of OMT for Chronic Low Back Pain
The specific aim of this study is to conduct a prospective, multicenter cohort study over four months to compare the cost of standard of allopathic care (control group, N=90) versus standard of care plus osteopathic manipulative…
- Conditions
- Lumbar Radiculopathy, Lesion of Sciatic Nerve, Left Lower Limb, Lesion of Sciatic Nerve, Right Lower Limb, Lumbar Spinal Stenosis
- Trial name
- NCT03532230
- Testing
- Osteopathic Manipulative Treatment (OMT)
- Where
- 3 sites in United States
- Volunteers
- 146 people
- Sponsor
- Rowan University
Neck Pain, Nurse-Patient Relations
Integrating Chiropractic Care and Mind-Body Training for the Treatment of Nonspecific Chronic Neck Pain
Chronic neck pain is particularly prevalent among nurses. Nurses experiencing neck pain frequently report its impacts including decreased job satisfaction and reduced productivity.
- Trial name
- NCT06523036
- Testing
- Combined chiropractic care and Tai Chi
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Brigham and Women's Hospital
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