Clinical trials: Medicine
COVID-19
Safety, Tolerability and PK of Ensovibep (MP0420 - a New Candidate With Potential for Treatment of COVID-19)
This study will investigate how ensovibep is distributed throughout the body, the safety and the tolerability of ensovibep in healthy volunteers
- Trial name
- NCT04870164
- Testing
- Ensovibep
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Molecular Partners AG
Atopic Dermatitis
A Study To Learn About Two Study Medicines (PF-07275315 And PF-07264660) In People Who Have Moderate To Severe Atopic Dermatitis
The purpose of this study is to learn about the safety and effects of 2 study medicines (PF-07275315 and PF-07264660) for the treatment of atopic dermatitis (AD). AD is a long- lasting itchy red rash, caused by a skin reaction.
- Trial name
- NCT05995964
- Testing
- PF-07275315, PF-07264660
- Where
- 96 sites in United States, Australia and 5 more
- Volunteers
- 507 people
- Sponsor
- Pfizer
Beta-Thalassemia
Testing SIROLIMUS in Beta-thalassemia Transfusion Dependent Patients
Beta-thalassemias are hereditary blood disorders caused by reduced or absent synthesis of hemoglobin beta chains, with variable outcomes ranging from severe anemia to clinically asymptomatic individuals.
- Trial name
- SIRTHALACLIN (NCT03877809)
- Testing
- Sirolimus 0.5 mg
- Where
- 2 sites in Italy
- Volunteers
- 26 people
- Sponsor
- Rare Partners srl Impresa Sociale
Cardiac Arrest, Out-Of-Hospital, Cardiac Arrest Due to Underlying Cardiac Condition
AID-OMIE - Artificial Intelligence in Detection of Occlusive Myocardial Infarction in Emergency Medicine
Study Objective and Hypothesis The study hypothesizes that artificial intelligence (AI)-assisted interpretation of the 12-lead electrocardiogram (ECG) can improve the care of patients resuscitated after out-of-hospital cardiac…
- Trial name
- AID-OMIE (NCT06767709)
- Volunteers
- 200 people
- Sponsor
- Institute of Mountain Emergency Medicine
Cancer, Advanced Solid Tumor
StrataPATH™ (Precision Indications for Approved Therapies)
StrataPATH™ is a non-randomized, open-label trial designed to explore efficacy and safety of multiple FDA-approved and commercially available cancer therapies in new, biomarker-guided patient populations.
- Trial name
- StrataPATH (NCT05097599)
- Testing
- lorlatinib, encorafenib + binimetinib, talazoparib
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- Strata Oncology
Glaucoma; Drugs
CATS Tonometer IOP Reduction Latanoprost Verses Timolol
Topical Prostaglandin Analog vs Betablocker - Corneal Biomechanical Evaluation using CATS Tonometer Prism
- Trial name
- NCT04178863
- Testing
- CATS Tonometer, Latanoprost
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Intuor Technologies, Inc.
Meditation, Fear of Labor
Meditation for Preparation for Birth and Motherhood Given with Thetahealing Meditation Method
Fear of childbirth If left untreated, it negatively affects women's birth process and preferences. Determining the level of fear experienced by women during pregnancy and helping them cope with this fear will help reduce the…
- Conditions
- Meditation, Fear of Labor, Thetahealing Meditation
- Trial name
- NCT06678087
- Testing
- motherhood preparation meditation training prepared with the thetahealing meditation method, pregnancy school,
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Peripheral Vascular Disease, Critical Limb Ischemia
Drug Eluting Stents In The Critically Ischemic Lower Leg
The Destiny trial compares the use of bare metal stent systems with drug eluting stent systems in the treatment of infrapopliteal lesions in patients with Critical Limb Ischemia.
- Trial name
- DESTINY (NCT00510393)
- Testing
- XIENCE V everolimus eluting coronary stent system, MULTILINK VISION coronary stent system
- Where
- 5 sites in Belgium, France and 1 more
- Volunteers
- 140 people
- Sponsor
- Flanders Medical Research Program
Irritable Bowel Syndrome
Traditional Chinese Medicine for Treatment of Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a prevalent condition that adversely affects patient's quality of life and represents a large health care burden globally.
- Trial name
- NCT03135821
- Testing
- TCM
- Where
- Singapore
- Volunteers
- 104 people
- Sponsor
- Singapore General Hospital
Chronic Musculoskeletal Pain
Assessing Pain, Patient Reported Outcomes and Complementary and Integrative Health
The APPROACH Study (Assessing Pain, Patient-Reported Outcomes and Complementary and Integrative Health) assesses the effects of use of practitioner-delivered CIH therapies alone compared to the combination of self-care and…
- Trial name
- APPROACH (NCT05097521)
- Testing
- Practitioner-delivered CIH therapies, Combination of practitioner-delivered and self-care CIH therapies, Self-care CIH therapies
- Where
- 2 sites in United States
- Volunteers
- 3,603 people
- Sponsor
- VA Office of Research and Development
Ovary Cancer, Cervix Cancer
Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors
The purpose of the trial is to establish the tolerability of tisotumab vedotin (HuMax-TF-ADC) dosed three times every four weeks (3q4wk) in a mixed population of patients with specified solid tumors.
- Conditions
- Ovary Cancer, Cervix Cancer, Endometrium Cancer, Bladder Cancer
- Trial name
- NCT02552121
- Testing
- Tisotumab vedotin (HuMax-TF-ADC)
- Where
- 16 sites in United States, Belgium and 3 more
- Volunteers
- 33 people
- Sponsor
- Seagen Inc.
Spinal Cord Injuries
Foundational Ingredients of Robotic Gait Training for People With Spinal Cord Injury During Inpatient Therapy
The FIRST project compares the dose of robotic gait training (RGT) with usual care gait training for patients with spinal cord injury (SCI) undergoing rehabilitation at Baylor Scott \& White Institute for Rehabilitation (BSWIR).
- Trial name
- FIRST (NCT04781621)
- Testing
- Robotic Gait Training, Usual Care Gait Training
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Baylor Research Institute
Gram-negative Bacterial Infection
Safety, Pharmacokinetics (PK) and Tolerability Study of a Novel Drug for Treatment of Bacterial Infections
The purpose of this study is to evaluate the safety, tolerability and pharmacokinetic profile of an antibacterial compound for treatment of hospital acquired Gram negative infection.
- Trial name
- NCT01015014
- Testing
- AN3365
- Where
- Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Pfizer
Alzheimer Disease, Huntington Disease
Dimebon (PF-01913539)-Digoxin Drug-Drug Interaction Study In Healthy Subjects
This study has been designed to confirm, in healthy subjects, the lack of a clinically important pharmacokinetic interaction between Dimebon, at the proposed maximum commercial dose of 20 mg TID (administered every 8 hours), and…
- Trial name
- NCT00831506
- Testing
- digoxin, dimebon
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Subarachnoid Hemorrhage
Antiepileptic Drugs and Vascular Risk Markers
The purpose of this study is to determine if certain seizure medications raise levels of cholesterol and other blood components which could increase the risk of heart attacks and strokes.
- Trial name
- NCT00774306
- Testing
- phenytoin, valproate, levetiracetam
- Volunteers
- 52 people
- Sponsor
- Thomas Jefferson University
Coronary Artery Disease
Adhesiveness of Coronary Drug-Eluting Stents to the Delivery Balloon-Catheter: A Randomized Comparison
This study will evaluate the 3 drug-eluting stents presently marketed for intervention in the coronary artery with respect to the complications that may occur in case it becomes necessary to retract the stent during the…
- Trial name
- NCT00279006
- Testing
- Percutaneous coronary intervention
- Volunteers
- 150 people
- Sponsor
- Foundation for Cardiovascular Research, Zurich
Prevention, Family Function
Familias Unidas: Preventing Substance Abuse in Hispanic Youth
The focus of this study will be to test the Familias Unidas Intervention program among Hispanic 8th graders in the Miami-Dade County Public School System.
- Conditions
- Prevention, Family Function, Substance Use, Sexual Behavior
- Trial name
- NCT01038206
- Testing
- Familias Unidas
- Where
- United States
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- University of Miami
Adherence, Medication, Adolescent Behavior
Youth-focused Strategies to Promote Adherence to Pre-exposure Prophylaxis Among Youth At-risk for HIV in Thailand
A randomized controlled clinical trial looking at the effect of use of a mobile phone application in addition to standard care compared to standard care alone at a youth-friendly clinic in young men who have sex with men and…
- Conditions
- Adherence, Medication, Adolescent Behavior, HIV Prevention, Sexual Health
- Trial name
- YouthPrEP (NCT03778892)
- Testing
- 'Project Raincoat' Mobile Phone Application
- Where
- Thailand
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Symptomatic Irreversible Pulpitis, Postoperative Endodontic Pain Following Emergency Root Canal Treatment
Tobradex as Intracanal Medicament
The goal of this prospective clinical study was to evaluate and compare the short-term effects of two intracanal medicaments-calcium hydroxide and a tobramycin-dexamethasone combination (Tobradex)-on postoperative pain following…
- Trial name
- NCT07332936
- Testing
- Calcium Hydroxide (Ca(OH)2), Tobramycin + Dexamethasone
- Where
- Saudi Arabia
- Volunteers
- 43 people
- Sponsor
- Umm Al-Qura University
Obesity
Study Examining The Effect Of Renal Impairment On Safety, Toleration And How The Body Processes An Experimental Drug
CP-945,598 is eliminated following extensive metabolism. For some drugs, decreased renal (kidney) function can affect their elimination from the body via metabolism.
- Trial name
- NCT00472836
- Testing
- CP-945,598
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Pfizer
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