Clinical trials: Medicine
Epilepsy, Drug Resistant Epilepsy
Evaluation of the Efficacy of Neurofeedback Technique Based on EEG Desynchronization in Epileptic Patients
A large proportion of patients (approximately 30%) with drug-resistant epilepsy are not eligible for surgical treatment. The alternatives that can be offered to reduce the frequency of seizures are neuromodulation (vagus nerve…
- Trial name
- EPIFEED (NCT07356661)
- Testing
- Neurofeedback
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Mental Disorders, Severe
Testing a Novel Community-based Occupational Therapy Model
This study will perform a needs assessment within an outpatient mental health unit, deliver an occupational therapy model of care, track patient and organizational outcomes, and provide training to staff to implement the model.
- Trial name
- NCT03855761
- Testing
- Occupational Therapy, Case management; psychological services
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Indiana University
Antibiotic Drug Concentration in Sweat
DetectAB - Detecting Antibiotics
The secretion of different kinds of antibiotic drugs in sweat is investigated. The concentration and pharmacodynamics of antibiotic drugs in sweat and blood will be compared.
- Trial name
- DetectAB (NCT03678142)
- Testing
- analysis of last resort antibiotic drug (Flucloxacillin, Imipenem, Vancomycin or Cefepim) in sweat and blood
- Where
- Switzerland
- Volunteers
- 17 people
- Sponsor
- University Hospital, Basel, Switzerland
Healthy
Bioequivalence Study of Fenofibrate Capsules, 130 mg Under Fasting Conditions
The study was conducted as an open label, balanced, randomized, two-treatment, two-period, two-sequence, crossover bioequivalence study comparing a single oral dose of fenofibrate capsules, USP 130 mg, of Ohm Laboratories Inc.
- Trial name
- NCT02306889
- Testing
- Fenofibrate, ANTARA® (fenofibrate)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Kidney Transplantation
A Study to Assess the Pharmacokinetics of a Modified-release Tacrolimus Based Immunosuppression Regimen in Stable Kidney Transplant Patients
A study to assess the pharmacokinetics, safety and effectiveness of tacrolimus in stable kidney transplant patients converted from a Prograf® based immunosuppression regimen to a modified release tacrolimus based…
- Trial name
- NCT00282568
- Testing
- Tacrolimus Modified Release (MR), tacrolimus
- Where
- 9 sites in United States, Canada
- Volunteers
- 70 people
- Sponsor
- Astellas Pharma Inc
Medication Errors, Patient Safety
Impact of Computerized Physician Order Entry on Medication Prescription Errors in the Intensive Care Unit: a Controlled Cross-Sectional Trial.
Device: computerized physician order entry. We wanted to investigate if the introduction of a computerized intensive care unit system reduced the incidence and severity of medication prescription errors (MPEs).
- Trial name
- NCT00287274
- Testing
- computerized physician order entry
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- University Hospital, Ghent
Rheumatoid Arthritis
Drug Outcome Survey for Biological Treatments in Rheumatoid Arthritis: an Observational Study (Dose)
The primary purpose of this observational study is to describe and define the current daily practice of management of anti-TNF-agents in Rheumatoid Arthritis (RA) patients.
- Trial name
- DOSE (NCT00794118)
- Testing
- As per clinical practice
- Where
- Italy
- Volunteers
- 299 people
- Sponsor
- Pfizer
Amyotrophic Lateral Sclerosis
HEALEY ALS Platform Trial - Regimen A Zilucoplan
The HEALEY ALS Platform Trial is a perpetual multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of ALS.
- Trial name
- NCT04436497
- Testing
- Zilucoplan
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Merit E. Cudkowicz, MD
Autism Spectrum Disorder
Translating Neuroprediction Into Precision Medicine Via Brain Priming
The present study examines the impact of oxytocin (OXT) and Pivotal Response Treatment (PRT) on the development of language, social, and play skills in young children with Autism Spectrum Disorder (ASD).
- Trial name
- NCT03370510
- Testing
- Oxytocin, Pivotal Response Treatment
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Desmoplastic Small Round Cell Tumor, Peritoneal Cancer
A Study of the Drug I131-Omburtamab in People With Desmoplastic Small Round Cell Tumors and Other Solid Tumors in the Peritoneum
The purpose of this study is to test any good and bad effects of the study drug 131I-omburtamab. 131I-omburtamab could prevent the cancer from returning, or delay the cancer from getting worse, but it could also cause side…
- Conditions
- Desmoplastic Small Round Cell Tumor, Peritoneal Cancer, Peritoneal Carcinoma
- Trial name
- NCT04022213
- Testing
- 131 I-omburtamab, WAP-IMRT
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pneumonia, Sepsis
Therapeutic Drug Monitoring - Targeting IMproved Effectiveness
Severe infections can be caused by various organisms, such as bacteria or viruses, and lead to otherwise healthy people getting very unwell, sometimes needing treatment in hospital or even intensive care.
- Conditions
- Pneumonia, Sepsis, Infection, Bacterial
- Trial name
- TDM-TIME (NCT05971979)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Manchester University NHS Foundation Trust
Hypertension, Renovascular
Drug-eluting Balloon for Treatment of Non-atherosclerotic Renal Artery Stenosis
Efficacy of drug eluting balloon(DEB) for non-atherosclerotic renal artery stenosis will be tested in this study. The intervention group will be treated with paclitaxel eluting balloon.
- Trial name
- NCT04366596
- Testing
- Angioplasty with paclitaxel eluting balloon, Angioplasty with plain old balloon
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Peking Union Medical College Hospital
Atherosclerosis
Women's Isoflavone Soy Health (WISH) Trial
The purpose of this study is to determine whether soy supplementation can reduce hardening of the arteries and cognitive decline in postmenopausal women.
- Trial name
- NCT00118846
- Testing
- 25 gm soy protein supplement
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Gastric Cancer, Organoids
A Clinical Study Aims to Assess the Consistency of Clinical Efficacy in Gastric Cancer Treatment and Drug Susceptibility Outcomes Using a Novel Drug Susceptibility Testing Method
The study is a real-world observational clinical study. Patients diagnosed as gastric cancer through histopathology were screened and enrolled.
- Trial name
- NCT06100003
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Funan Liu
CMT1A
Ulipristal Acetate In Disease Charcot-Marie-Tooth Type of 1A
The disease Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy, for which no treatment has proved its effectiveness.
- Trial name
- UPACOMT (NCT02600286)
- Testing
- EllaOne
- Where
- 5 sites in France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Strasbourg, France
Attention Deficit Hyperactivity Disorder
Neuropsychology, Neuroimage and Neurophysiology in Adults With ADHD
We anticipate that drug-naïve ADHD probands, particularly those with DAT1 or SLC6A2 gene variants may have higher level of altered microstructural integrity of frontostriatal (FS), frontoparietal (FP), other hypothesized fiber…
- Trial name
- NCT02642068
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Cardiotoxicity
Remote Ischaemic Preconditioning in Childhood Cancer
Survival rates of children with cancers have improved significantly in the recent few decades. Nonetheless, the side effect of this class of drugs on heart function remains to be an issue of concern.
- Trial name
- NCT03166813
- Testing
- Remote Ischaemic Preconditioning, Control
- Where
- Hong Kong
- Volunteers
- 68 people
- Sponsor
- The University of Hong Kong
COVID-19, SARS-CoV-2 Infection
Novel Experimental COVID-19 Therapies Affecting Host Response
The overarching goal of the Master Protocol is to find effective strategies for inpatient management of patients with COVID-19. Therapeutic goals for patients hospitalized for COVID-19 include hastening recovery and preventing…
- Conditions
- COVID-19, SARS-CoV-2 Infection, Coronavirus Infection
- Trial name
- NECTAR (NCT04924660)
- Testing
- TXA127, TRV027, Fostamatinib
- Where
- 51 sites in United States
- Volunteers
- 1,060 people
- Sponsor
- Sean Collins
Functional Dyspepsia(FD) Was Studied
To Observe the Clinical Efficacy of Traditional Chinese Medicine Compound(Weipi Formula ) in the Treatment of Epigastric Stuffiness Syndrome
The purpose of this clinical trial is to evaluate the efficacy of the herbal drug Weipi formula in treating functional dyspepsia (FD) in adults. It will also assess the safety of Weipi formula.
- Trial name
- NCT06985524
- Testing
- Weipi Formula（Wu SiSi Formula）
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Unintentional Ingestion of Prescriptions Within Vials and Blisters
Visual Distraction as a Means of Enhancing Child Resistance
Unintentional poisonings of children continues to be a major issue in the US. According to a study conducted by Cincinnati Children's Hospital Medical Centers, during the period from 2001-2008, emergency room visits for children…
- Trial name
- VDCR (NCT01859780)
- Testing
- Visual distractor
- Where
- 3 sites in United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Michigan State University
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