Clinical trials: Medium-chain Triglyceride
Alzheimer's Disease
Effects of Triglycerides on Age-Related Cognitive Function Decline in Older Subjects
This is a single centre, 2 part study in older subjects. Part 1 (Pharmacokinetic [PK] Assessment) is a double blind, randomized, placebo-controlled 4-period crossover study investigating the PK profile of four different doses of…
- Trial name
- NCT01702480
- Testing
- GSK2981710
- Where
- United Kingdom
- Volunteers
- 116 people
- Sponsor
- GlaxoSmithKline
Parkinson Disease, Alzheimer Disease
Effect of Exercise, Endocannabinoids and Ketones on Cerebral Metabolism in a Cognitive Disorders Population
A two months intervention in which two groups of cognitive disorders, Parkinson and Alzheimer's disease, will receive 50g/day of a commercial MCT supplement combined with supervised aerobic exercise 3 times/week.
- Trial name
- PARKA (NCT04322461)
- Testing
- Betaquik MCT supplement
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Université de Sherbrooke
Malnutrition
A Study of an Oral Nutritional Supplement in a Malnourished Population With GI Tolerance Impairment
The purpose is to observe the compliance to a high-calorie, high protein peptide-based nutritional supplement after 3 months in a malnourished population with impaired gastrointestinal tolerance living in nursing homes and as…
- Trial name
- NCT02698540
- Testing
- Nutritional Supplement
- Where
- 23 sites in Spain
- Volunteers
- 95 people
- Sponsor
- Abbott Nutrition
Healthy
Effect of MCT Emulsification on Ketogenesis in Human Adults
Lower brain glucose uptake is present before the onset of cognitive deterioration and may increase the risk of cognitive decline in Alzheimer's disease. Ketones are the brain's main alternative energy substrates.
- Trial name
- NCT02409927
- Testing
- MCT oil 10g, MCT homogenate 10g, Control
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Hyperlipidemias, Triglycerides High
Effects of MCDG Oil on Postprandial Lipid Metabolism
It is well known that medium chain triglycerides (MCTs) and diacylglycerols (DGs) have effects on lowering circulating triglycerides (TGs).
- Trial name
- NCT03415568
- Testing
- LCT oil, MCDG oil
- Where
- South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Ketone Body, Lipid Metabolism
Acute Effects of MCT Formulations on Beta-Hydroxybutyrate Response, Lipid Profile, and Glucose Levels in Healthy Adults
The goal of this clinical trial is to evaluate the effects of medium-chain triglycerides (MCTs), delivered in different formulations, on beta-hydroxybutyrate response (as a marker of ketone body production), lipid metabolism, and…
- Conditions
- Ketone Body, Lipid Metabolism, Glucose Response
- Trial name
- NCT07718048
- Testing
- MCT Beverage, LCT Beverage, Synthetic MCT Powder
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Milan
Epilepsy, Epilepsy Intractable
Betaquik as an Adjunct to Dietary Management of Epilepsy in Adults on the Modified Atkins Diet
The purpose of this pilot study is to measure adherence and quality of life in adults with intractable epilepsy following the Modified Atkins Diet (MAD) with Betaquik, a ready-to-use medium chain triglyceride (MCT) emulsion, as…
- Conditions
- Epilepsy, Epilepsy Intractable, Seizures, Seizure Disorder
- Trial name
- NCT03790436
- Testing
- Betaquik
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Alzheimer's Disease
Retrospective Cohort Study Of The Efficacy Of Axona® (Medium Chain Triglycerides) In Patients With Alzheimer's Disease
This evaluation of the efficacy and safety of AXONA will be a chart review carried out at 16 practices in which AXONA has been prescribed for the treatment of patients with mild-to-moderate AD.
- Trial name
- ACT (NCT01538212)
- Volunteers
- 55 people
- Sponsor
- Cerecin
MELAS Syndrome, Mitochondrial Diseases
Ketones & Mitochondrial Heteroplasmy
The current study is a prospective evaluation of the ability of ketosis to shift mitochondrial DNA (mtDNA) heteroplasmy in subjects harboring a known mutation in their mtDNA at position 3243 (A>G).
- Trial name
- NCT01252979
- Testing
- Medium-Chain Triglycerides
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- The University of Texas Health Science Center, Houston
Injuries, Acute Brain, Severe Trauma Brain Injury (sTBI)
Bioavailability of Medium Chain Triglycerides (MCTs) in Comatose Patients With Acute Brain Injury (ABI)
This study will be targeting patients suffering from acute brain injury (ABI), including those with severe trauma brain injury (sTBI) and those with aneurysmal sub arachnoid hemorrhage (aSAH).
- Conditions
- Injuries, Acute Brain, Severe Trauma Brain Injury (sTBI), Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- MCTs and ABI (NCT02716532)
- Testing
- Peptamen AF
- Where
- Switzerland
- Volunteers
- 17 people
- Sponsor
- Société des Produits Nestlé (SPN)
End Stage Renal Disease, Chronic Hemolysis
Development of an Innovative Hemodialysis Method to Improve Dialytic Clearance of Protein-bound Uremic Toxins
Current hemodialysis techniques fail to efficiently remove protein-bound uremic toxins (such as p-cresyl sulfate (p-CS) or indoxyl sulfate (IS)) due to their strong binding to serum albumin.
- Trial name
- CLEARTOX (NCT06595680)
- Testing
- Medialipide 20% perfusion, NaCl 0,9%, Blood sample
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Hospices Civils de Lyon
Insulin Resistance
Evaluation of Medium Chain Triglycerides in a Mixed Racial Population of Patients: a Feasibility Study
The study team will investigate the racial differences in the metabolic and clinical responses to Medium chain triglycerides (MCT) between African American and Caucasian American subjects.
- Trial name
- NCT02783703
- Testing
- Medium chain triglycerides (MCT)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Boston Medical Center
Mild Cognitive Impairment (MCI)
Evaluation of the Impact of Medium-chain Fatty Acids in the Evolution of Newly Diagnosed Mild Cognitive Impairment
Mild cognitive impairment (MCI) is considered the intermediate stage between the changes observed in physiological aging and dementia.
- Trial name
- MCI-MCT (NCT06951932)
- Testing
- Mediterranean-type diet with MCT supplementation, Mediterranean-type food regimen using extra virgin olive oil
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Metabolic Syndrome
Effect of a Mixed Macronutritional Meal With Medium Chain Triglycerides on the Oxidation of Postprandial Macronutrients
The main aim of this study is to determine the effect of the addition of medium chain triglycerides to a mixed macro nutritional meal on postprandial macronutrients oxidation (i.e.
- Trial name
- NCT04321018
- Testing
- Mixed meal with medium chain triglycerides, Mixed meal with the replacement of medium chain triglycerides with unsaturated tryglicerides
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Hyperlipidemia
Effect of Butter & MCT Oil on Lipoproteins - A RCT
Determine the effects on lipoprotein profiles of high dose concentrated dietary SFA (saturated fatty acids) (from MCT (medium-chain triglyceride) oil + butter) in combination added to coffee.
- Trial name
- NCT02611102
- Testing
- MCT oil + Butter in Coffee
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Obesity
Effect of Medium Chain Triglyceride Consumption on Appetite
The purpose of this study is to test the effects of medium chain triglyceride consumption, relative to long chain triglycerides, on hormones involved in appetite regulation and food intake in overweight men.
- Trial name
- MCT (NCT01952977)
- Testing
- Test breakfast
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Long-chain Fatty Acid Oxidation Disorders (LC-FAOD)
A Study to Determine the Effect of Triheptanoin Compared With Even-Chain MCT on MCEs in Pediatric Patients With LC-FAOD
The main goal of this study is to evaluate the effects of triheptanoin versus Medium-chain Triglycerides (MCT) on frequency of Major Clinical Events (MCEs).
- Trial name
- NCT05933200
- Testing
- Triheptanoin, MCT Oil
- Where
- 15 sites in Czechia, Germany and 5 more
- Volunteers
- 69 people
- Sponsor
- Ultragenyx Pharmaceutical Inc
Healthy
MiCrobiome dieT Study
The human gut microbiome is the community of bacteria that reside within the human intestine. These microbes are constantly exposed to the end-products and partial break-down-products of digestion from the foods consumed each…
- Trial name
- MCTs (NCT03610477)
- Testing
- Medium chain triglycerides, Long chain triglycerides
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Preterm Infants, MCT Oil Massage
Medium-chain Triglyceride Oil Massage on Growth in Preterm
Aim: To explore the effect of medium-chain triglyceride (MCT) oil massage on growth in preterm infants. Methods: This randomized controlled trial was conducted in the newborn center of a regional hospital in Taiwan.
- Conditions
- Preterm Infants, MCT Oil Massage, Growth
- Trial name
- NCT04281563
- Testing
- massage with MCT oil (group 1)
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Chiayi Christian Hospital
Mild Cognitive Impairment
Effect of Medium Chain Triglyceride Oil Supplementation in Mild Cognitive Impairment
The primary aim of this study is to assess whether daily dosing with medium chain triglycerides in subjects with mild cognitive impairment (MCI) will improve cognitive performance.
- Trial name
- NCT01669200
- Testing
- Medium Chain Triglyceride Oil
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Pennington Biomedical Research Center