Clinical trials: Melancholic Depression
Bipolar Disorder, Depression
A Trial of SAMe for Treatment-Resistant Bipolar Depression
S-adenosyl-L-methionine (SAMe) is a dietary supplement with antidepressant properties. SAMe's mechanism of action remains unclear, but it appears to be distinct from that of conventional antidepressants.
- Conditions
- Bipolar Disorder, Depression, Bipolar Depression
- Trial name
- NCT00762268
- Testing
- SAMe
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Mclean Hospital
Aging, Dementia Alzheimers
Localized Analysis of Normalized Distance From Scalp to Cortex and Personalized Evaluation (LANDSCAPE)
Scalp to cortex distance (SCD), as a key technological parameter of brain stimulation, has been highlighted in the guidelines of non-invasive brain stimulation.
- Conditions
- Aging, Dementia Alzheimers, Parkinson Disease, Dementia Frontotemporal
- Trial name
- NCT05967390
- Testing
- Transcranial Magnetic Stimulation
- Where
- Hong Kong
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Depression, Postpartum
The Northern Babies Longitudinal Study
Postpartum depression (PPD) is a prevalent disorder. Studying the factors related to PPD will help to identify families at risk and provide preventive interventions.
- Trial name
- NCT02538497
- Testing
- The Newborn Behavioral Observation (NBO), Routine care
- Where
- Norway
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Tromso
Depression, Anxiety
Monoamine Oxidase A PET/CT in Various MAO-A-Related Disease
To evaluate the potential usefulness of 18F-AIPF-1026 positron emission tomography/ computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various MAO-A-related disease patients.
- Conditions
- Depression, Anxiety, Heart Injuries
- Trial name
- NCT07685860
- Testing
- Diagnostic Test: 18F-AIPFA-1026
- Where
- 3 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Post COVID -19 Depression
Post-Acute COVID-19, Inflammation, and Depression
Single site, double blind, placebo-controlled, longitudinal study of depression in Subjects with COVID- 19 long haulers syndrome using a 1:1 ratio randomization for a single IV infusion of 6 million cells/kg allogeneic marrow…
- Trial name
- COVID Long (NCT05346120)
- Testing
- allogeneic marrow stromal cells (MSCs)
- Sponsor
- Sean Savitz
Depression
Comparing Effect and Change Processes in Cognitive Behavioral Therapy and Emotion-Focused Therapy for Depression
Depression is a common mental illness which is costly for both society and for those affected. There is a need for effective treatments of depression and there is a need to make sure that the treatments that are given are based…
- Trial name
- NCT04690946
- Testing
- Cognitive Behavioral Therapy, Emotion-Focused Therapy
- Where
- Norway
- Volunteers
- 112 people
- Sponsor
- Institutt for Psykologisk Radgivning
Stress, Emotional, Stress-related Mental Disorders
School-Based Intervention to Enhance Resilience and Stress Coping in Rural Chinese Adolescents
This study aims to evaluate the effectiveness of school-based psychological interventions in improving stress resilience and coping skills among adolescents in rural China.
- Trial name
- EASY (NCT07115186)
- Testing
- Psychoeducation, guided written therapy, wait-list condition
- Where
- China
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Peking University
Depression, Myalgia
IV Ibuprofen for Post-Electroconvulsive Therapy Myalgia
Post-procedure myalgia (muscle ache) is a well-known and common complication of Electro-convulsive Treatment (ECT). Myalgias are a serious concern of patients and occur in approximately 50% of these cases.
- Trial name
- NCT01200069
- Testing
- ibuprofen intravenous
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Rutgers, The State University of New Jersey
Postoperative Pain, Cesarean Section Surgery
Analysis of the Incidence and Risk Factors of Chronic Pain After Cesarean Section
Persistent postoperative pain is a globally recognized issue that deserves attention. Cesarean section is one of the surgeries that may cause persistent postoperative pain.
- Trial name
- NCT06704490
- Testing
- Cesarean section
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Huazhong University of Science and Technology
Bipolar Depression
Behavioural Activation for Bipolar Depression: A Case Series
Bipolar Disorders affect around 2% of the population. Most people with Bipolar experience depression; these periods can cause difficulties with relationships, work and daily life.
- Trial name
- BA-BD (NCT03658824)
- Testing
- Behavioural Activation (BA)
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Exeter
Sleep Initiation and Maintenance Disorders, Depression
Improving Sleep and Psychological Functioning in People With Depression and Insomnia
This study will evaluate the safety and effectiveness of treatment with both a sleeping pill and antidepressant medication in improving sleep and psychological functioning in people with depression and insomnia.
- Trial name
- NCT00247624
- Testing
- Eszopiclone, Fluoxetine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Wake Forest University Health Sciences
Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD)
Impact of Anxiety and Depression on Implicit and Explicit Memory Performance
This study examines the effect of anxiety and depression on memory processes, focusing on implicit and explicit memory. Implicit memory involves unconscious recall, such as recognizing familiar words without effort, while…
- Conditions
- Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), Memory Bias, Implicit Memory
- Trial name
- ADEM (NCT06663423)
- Where
- Iran
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Major Depressive Disorder
Fluoxetine vs. Brief Psychotherapy for Major Depression
In this study we compare two treatments for major depression - fluoxetine and brief psychodynamic psychotherapy. In addition to more traditional outcome measures, we also measure the densities of 5HT-1A and D-2 receptors before…
- Trial name
- NCT00714779
- Testing
- Fluoxetine, Short-term psychodynamic psychotherapy
- Volunteers
- 85 people
- Sponsor
- University of Turku
Major Depressive Disorder
Study of Escitalopram in Adult Patients With Major Depressive Disorder
Escitalopram is the S-enantiomer of citalopram. Both escitalopram and citalopram are selective serotonin reuptake inhibitors (SSRIs) and are used to treat depression in adults.
- Trial name
- NCT00108979
- Testing
- Escitalopram
- Where
- 9 sites in United States
- Volunteers
- 240 people
- Sponsor
- Forest Laboratories
Contraception, Mood Change
Stress Hormones and IUDs
Determine what kind of side effects women experience in the first year after they start using an intrauterine device.
- Trial name
- NCT03499379
- Testing
- Mirena, Paraguard
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Respiratory Insufficiency, Clinical Deterioration
Wearable Wireless Respiratory Monitoring System That Detects and Predicts Opioid Induced Respiratory Depression
An observational study will be conducted in approximately 14 participants to evaluate the ability of a wearable, wireless acoustic Respiratory Monitoring System (RMS) to accurately measure a participant's respiratory rate, tidal…
- Trial name
- NCT06442488
- Testing
- Respiratory Monitoring System
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Jeffrey Joseph
Quality of Life, Cognitive Decline
Health and Energy Through Active Living Every Day After Cancer Intervention for Cancer Survivors
The purpose of the Health and Energy through Active Living Every Day (HEALED) intervention, is to examine the effect of a web-based intervention on changes in device-measured physical activity (light and moderate-to-vigorous…
- Conditions
- Quality of Life, Cognitive Decline, Fatigue, Sleep
- Trial name
- HEALED (NCT05356988)
- Testing
- Physical activity experiment, Balance and flexibility control
- Where
- United States
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- American Cancer Society, Inc.
Depression
Bioequivalency Study of Sertraline Under Fed Conditions
The objective of this study was the bioequivalence of a Roxane Laboratories' Sertraline Tablets, 100 mg, to Zoloft® Tablets, 100 mg (Pfizer) under fed conditions using a single-dose, 2-treatment, 2-period, crossover design.
- Trial name
- NCT00601588
- Testing
- Sertraline
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Menopause
The Effect of Music Therapy on Sleep Quality and Depression in Menopausal Women
About one-third of women experience no or mild symptoms during their menopausal life, while another third experience moderate symptoms, while the remaining one-third may experience severe symptoms.
- Trial name
- NCT05545761
- Testing
- music therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Meryem Vural Şahin
Depressive Disorder
Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive Therapy
Ketamine has been used successfully as the sole medication for anesthesia in the setting of electroconvulsive therapy (ECT), and has more recently been studied as an adjunct agent in combination with propofol (the most commonly…
- Trial name
- NCT02579642
- Testing
- Ketamine
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- University of Alberta