Clinical trials: Melasma
Melasma
Randomized Study Using SM-030 Gel for Adults With Melasma
Brief Summary This is a phase 2b, observer-blinded, randomized study that will evaluate the safety and efficacy of topically applied SM-030 gel 0.64% and SM-030 gel 0.08% compared against placebo gel in healthy adult male and…
- Trial name
- NCT06454747
- Testing
- SM-030 gel 0.64%, SM-030 gel 0.08%
- Where
- 2 sites in El Salvador
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- DermBiont, Inc.
Melasma, Post-acne Hyperpigmentation
Efficacy and Safety of a Combined Serum Containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES
The goal of this clinical trial is to evaluate the efficacy and safety of a combination serum containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES when used as a moisturizer after QS-Nd:YAG 1064 nm low-fluence laser…
- Trial name
- NCT07121439
- Testing
- a combination serum containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES, 2% hydroquinone cream
- Where
- Indonesia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Dr.dr.Irma Bernadette, SpKK (K)
Hyperpigmentation
Efficacy and Tolerability of Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06253468
- Testing
- tested product
- Where
- Singapore
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Hyperpigmentation, Melasma
Annurca Apple Peel Oleolite for the Treatment of Skin Hyperpigmentation
The aim of this cosmetic clinical trial is to learn if an oleolite derived from Annurca Apple peel (AAO) works to enhance skin tone and luminosity, by counteracting the visibility of skin hyperpigmentation and dark spots in adult…
- Conditions
- Hyperpigmentation, Melasma, Skin Spots, Photodamaged Skin
- Trial name
- EAAO22G01 (NCT07040345)
- Testing
- Annurca apple oleolite
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ritamaria Di Lorenzo
Melasma
Efficacy and Tolerability of Test Product Versus Cysteamine 5% in Treatment of Facial Epidermal Melasma
This interventional, randomized, investigator blinded, controlled study conducted in one centre consists in a 4-month evaluation period within the same season avoiding sunny season on 140 subjects with facial epidermal melasma.
- Trial name
- NCT06278948
- Testing
- Group TP, Group CYS
- Where
- India
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Melasma
Effectiveness and Safety of Pigment Solution Program (PSP) as Adjuvant Therapy in Melasma
This research is a clinical study with a single-blind randomized clinical trial design (randomized controlled trial) in multicenters at two Dermatology and Venereology Education centers in Indonesia.
- Trial name
- NCT06174545
- Testing
- Pigment Solution Program
- Where
- Indonesia
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Dr.dr.Irma Bernadette, SpKK (K)
Melasma
Comparison of Intradermal Microinjections of Tanexamic Acid and Oral Tranexamic Acid in the Management of Melasma.
In this study we compared the effect of intradermal microinjections of tranexamic acid vs oral tranexamic acid in treatment of melasma.
- Trial name
- NCT07280234
- Testing
- Intradermal microinjections of tranexamic acid, Oral tranexamic acid
- Where
- Pakistan
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Hayat Abad Medical Complex, Peshawar
Melasma
Opsin Receptors in Melasma
Melasma is a hyperpigmentation disorder that is probably exacerbated by visible light. Opsin receptors (OPN 1, 2, 3, 4 y 5) were described in the skin, being capable of activating melanogenesis induced by visible light.
- Trial name
- NCT04417348
- Testing
- Retinoic acid
- Where
- Mexico
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Melasma
Oral Tranexamic Acid and Laser for Treatment of Melasma
Tranexamic acid and 1927 diode laser non-ablative fractionated laser for the treatment of Melasma.
- Trial name
- NCT03686787
- Testing
- Tranexamic Acid
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Laser and Skin Surgery Center of New York
Melasma
Efficacy of Melanostop Peeling for Improvement of Melasma
Participants with face melasma will receive 4 Melanostop peel treatments containing 20% azelaic acid, 10% resorcinol and 6% phytic acid. Peels will be performed at 2-week interval.
- Trial name
- VIMEL (NCT03826277)
- Testing
- Melanostop peel
- Where
- Slovenia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- VIST - Faculty of Applied Sciences
Hyperpigmentation, Melasma
A 4-week Study Investigating Two Targeted Brightening Serum (A and B) Versus 4% Hydroquinone in Women With Mild to Severe Full-face Hyperpigmentation
This a short four-week pilot study to measure the efficacy and tolerance of two brightening serums (cosmetics) versus 4% hydroquinone. The study was conducted in two sites across the USA, one in PA and in one in CA.
- Conditions
- Hyperpigmentation, Melasma, Dark Spots
- Trial name
- NCT07644871
- Testing
- Facial Cleanser, Facial Moisturizer, Sunscreen SPF 55
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Melasma
Polypodium Leucotomos Extract for the Treatment of Melasma
We will assess whether oral supplementation with Polypodium leucotomos, a commercially marketed fern extract, improves facial melasma in Hispanic women with moderate to severe melasma.
- Trial name
- NCT01092884
- Testing
- Polypodium leucotomos extract
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Melasma
Sylfirm X Radiofrequency Microneedling for the Treatment of Melasma
Microneedling radiofrequency technology has been shown in clinical studies to improve skin quality, tone, pigment, and to treat various skin conditions related to aging.
- Trial name
- NCT06415435
- Testing
- Radiofrequency Microneedling
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Benev Company, Inc.
Hyperpigmentation
Efficacy and Tolerability of the Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06268496
- Testing
- serum formula 2039125 03
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Melasma
Efficacy of Radiofrequency Micro Needling for the Treatment of Melasma in Skin of Color.
The objective of this study is to test the effectiveness of radiofrequency microneedling (RFMN) as a treatment for melasma. The Investigator hypothesize that RFMN will be an effective treatment for melasma in skin of color…
- Trial name
- SylfirmX (NCT06616311)
- Testing
- Radiofrequency microneedling
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Melasma
DNA Methylation in Malar Melasma and Its Change by Sunscreen, Retinoic Acid and Niacinamide.
BACKGROUND: Malar melasma has a chronic and recurrent character that may be related with epigenetic changes.
- Trial name
- NCT03392623
- Testing
- Retinoic acid, colorimetry measurement, sunscreen
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Melasma
EFFICACY and TOLERABILITY of TESTED FORMULA VS. HYDROQUINONE 4% in the TREATMENT of FACIAL MELASMA
This study aims at assessing the non-inferiority of tested formula facial serum (2039125 03) versus hydroquinone 4% over 3 months for treatment and then 3 months for maintenance ofwomen subjects presenting facial melasma.
- Trial name
- NCT06787846
- Testing
- Experimental: Group TP, Active Comparator: Group HQ: Hydroquinone 4%
- Where
- Brazil
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Melasma
Study Evaluating the Efficacy of DOSE Formulations in Treating Melasma and Cutaneous Signs of Aging
The primary objective is to evaluate the efficacy, of D.O.S.E formulations in the treatment of melasma and cutaneous signs of aging.
- Trial name
- NCT04137263
- Testing
- DOSE formulation
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Goldman, Butterwick, Fitzpatrick and Groff
Chloasma
Efficacy and Safety Trial of Using Ultra-Pulsed Shockwaves to Deliver Tranexamic Acid for the Treatment of Melasma
Melasma is a prevalent chronic facial pigmentation condition affecting Asian women of childbearing age, attributed to genetic predisposition, sunlight exposure, and hormonal changes.
- Trial name
- NCT06418568
- Testing
- Ultra-pulsed Shockwave Therapy Device by Shenzhen Lifotronic Technology Co., Ltd.
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Melasma, Hyperpigmentation
Evaluation of an Herbal-Based De-Pigmenting System
The purpose of this study is to evaluate the effectiveness and tolerability of an herbal de-pigmenting regimen applied to one side of the face compared with hydroquinone applied to the other side of the face in treating mottled…
- Trial name
- NCT02138539
- Testing
- Herbal depigmenting agent (Epionce), Hydroquinone
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Sadick Research Group