Clinical trials: Melasma
Melasma
Comparison of Effectiveness and Safety of Triple Combination Cream of Fucinolone Acetonide 0.01%, Hydroquinone 4%, Tretinoin 0.05% with Mometasone Furoate 0.1%, Hydroquinone 4%, Tretinoin 0.05% in the Treatment of Melasma
This Research is a clinical study with a single-blind randomized controlled trial of evaluators. Clinical trial Randomized Controlled Trial (RCT) design that compares the use of a triple combination cream of flucinolone acetonide…
- Trial name
- NCT06780644
- Testing
- Triple combination cream
- Where
- Indonesia
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Melasma
Comparison of Azelaic Acid 20 % Cream Versus Hydroquinone 4% Cream as an Adjuvant to Oral Tranexamic Acid in Melasma
Methodology: Fifty female patients presented with melasma (symmetrically distributed hyperpigmented macules and patches on the face) diagnosed by consultant dermatologist on clinical presentation were included in this study.
- Trial name
- NCT05887219
- Testing
- Group A 4 % Hydroquinone Cream Topically and Oral Tranexamic Acid, Group B Azelaic Acid 20 % Cream for 6 months
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Combined Military Hospital Abbottabad
Hyperpigmentation, Melasma
Combined Q-switched Nd:YAG Laser and Platelet Rich Plasma Versus Q- Switched Nd:YAG Laser Alone in Melasma
Melasma is a common, acquired, esthetically disfiguring hypermelanosis of the face. Melasma is considered a disappointing challenge when treatment options are addressed.
- Conditions
- Hyperpigmentation, Melasma, PRP, Lasers
- Trial name
- NCT04765930
- Testing
- Q-switched nd:YAG laser toning
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Melasma
Efficacy of Eflornithine Hydrochloride Cream in the Treatment of Melasma: A Randomized, Double-blinded, Split-face Controlled Study
The goal of this clinical trial is to learn if Eflornithine hydrochloride cream works to treat melasma in adults, in comparison to Hydroquinone cream. It will also learn about the safety of Eflornithine hydrochloride cream.
- Trial name
- NCT06957834
- Testing
- Eflornithine hydrochloride cream, Hydroquinone cream
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- National Skin Centre
Melanosis
Azelaic Acid Versus Hydroquinone in Melasma
The purpose of this study is to compare the safety and effectiveness of Azelaic Acid Gel to Hydroquinone Cream in the treatment of melasma.
- Trial name
- NCT00927771
- Testing
- azelaic acid gel, hydroquinone cream
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Callender Center for Clinical Research
Melasma, Rosacea
Microfocused Ultrasound for Facial Pigmentary Diseases and Rosacea
This clinical study will evaluate the efficacy and safety of microfocused ultrasound treatment in patients with facial pigmentary diseases and rosacea.
- Conditions
- Melasma, Rosacea, Periorbital Hyperpigmentation, Melanosis
- Trial name
- NCT07667972
- Testing
- Microfocused Ultrasound Treatment
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University
Melasma, Lichen Planus Pigmentosus
Efficacy of Red Light in the Treatment of Pigmentary Disorders
Pigmentary disorders such as melasma, lichen planus pigmentosus and vitiligo can significantly affect patients' quality of life. Treatment responses are usually slow and typically have limited efficacy.
- Conditions
- Melasma, Lichen Planus Pigmentosus, Vitiligo
- Trial name
- NCT04308421
- Testing
- Red light
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- University of British Columbia
Melasma
Development of Products Based on Secretom From Stem Cell Conditioned Medium for Melasma Therapy
This research is a clinical study with a single-blind randomized clinical trial design (randomized controlled trial) in RSCM-FKUI This study aims to Assess the effectiveness and safety of intradermal concentrated secretome…
- Trial name
- NCT06516419
- Testing
- Concentrated secretome Injection 2mL, Tranexamic acid injection, Triple Combination Cream
- Where
- 2 sites in Indonesia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dr.dr.Irma Bernadette, SpKK (K)
Melasma
Combination Alexandrite Laser and Topical Therapy vs Topical Therapy Alone for Treatment of Melasma
The purpose of this study is to evaluate the efficacy and safety of a combination of non-hydroquinone topical therapy and a 755nm Alexandrite compared to topical therapy alone for the treatment of facial melasma.
- Trial name
- NCT02095756
- Testing
- 755nm Alexandrite Laser and Lytera Skin Brightening System (Non-Hydroquinone Topical Therapy), Lytera Skin Brightening System (Non-hydroquinone topical therapy)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cynosure, Inc.
Skin Aging, Hyperpigmentation
Homocysteic Acid Biostimulator for Photoaged Facial Skin
This study evaluated whether a chemical skin biostimulator containing ammonium trichloroacetate, homocysteic acid, phytic acid and citric acid can improve signs of photoaged skin in women with mature skin.
- Trial name
- NCT07722351
- Testing
- Chemical skin biostimulation with ammonium trichloroacetate and homocysteic acid
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Medical University of Silesia
Refractory Mixed Type Melasma
Study of Laser Treatment of Melasma
The purpose of this study is to evaluate the RevLite laser in the treatment of refractory mixed type melasma.
- Trial name
- NCT01335581
- Testing
- Q-Switched Nd:YAG Laser (RevLite), Retin-A and microdermabrasion
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- ConBio, a Cynosure Company
Melasma
The Efficacy in Treatment of Facial Melasma Combined With Thulium 1927-nm Fractional Laser and Topical H2R Antagonist
Melasma is a hyperpigmentary disorder of the skin especially of the face. Compared with normal skin, histologic features of melasma include the enhanced activity of melanocytes, higher solar elastosis in upper dermis, basement…
- Trial name
- NCT06313307
- Testing
- topical H2R antagonist, Thulium 1927-nm Fractional Laser
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Rosacea, Acne
Clinical Evaluation and Study of the Efficacy of a Centella Asiatica-Infused Facial Mask on Discosmetic Dermatosis
The purpose of this study was to investigate the efficacy and safety of repairing facial mask containing Asiaticum asiatica in treating disjunctive skin diseases.
- Conditions
- Rosacea, Acne, Centella, Melasma
- Trial name
- NCT06763367
- Testing
- Face mask containing Centella sinensis
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Melasma
Efficacy of Radiofrequency Micro Needling for the Treatment of Melasma in Skin of Color.
The objective of this study is to test the effectiveness of radiofrequency microneedling (RFMN) as a treatment for melasma. The Investigator hypothesize that RFMN will be an effective treatment for melasma in skin of color…
- Trial name
- SylfirmX (NCT06616311)
- Testing
- Radiofrequency microneedling
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Melasma
Randomized Study Using SM-030 Gel for Adults With Melasma
Brief Summary This is a phase 2b, observer-blinded, randomized study that will evaluate the safety and efficacy of topically applied SM-030 gel 0.64% and SM-030 gel 0.08% compared against placebo gel in healthy adult male and…
- Trial name
- NCT06454747
- Testing
- SM-030 gel 0.64%, SM-030 gel 0.08%
- Where
- 2 sites in El Salvador
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- DermBiont, Inc.
Melasma
Study Evaluating the Efficacy of DOSE Formulations in Treating Melasma and Cutaneous Signs of Aging
The primary objective is to evaluate the efficacy, of D.O.S.E formulations in the treatment of melasma and cutaneous signs of aging.
- Trial name
- NCT04137263
- Testing
- DOSE formulation
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Goldman, Butterwick, Fitzpatrick and Groff
Healthy, Melasma (Facial Melasma)
COMPARISON OF A COSMETIC SERUM AND 4% HYDROQUINONE FOR TREATING MELASMA OVER 84 DAYS
The goal of this clinical trial is to compare the dermatological tolerance and skin-lightening efficacy of a cosmetic depigmenting serum to a 4% hydroquinone-based product in adult male and female subjects aged 18-65 years with…
- Conditions
- Healthy, Melasma (Facial Melasma), Epidermal Melasma
- Trial name
- NCT07071363
- Testing
- Depigmenting Cosmetic Serum (Applied Morning and Evening)
- Where
- Mauritius
- Volunteers
- 40 people
- Sponsor
- Laboratoire Dermatologique ACM
Melasma
Microneedle and Trichloroaceticacid in Treatment of Melasma
Melasma is an acquired disorder of hyperpigmentation characterised by blotchy, light-to-dark brown macules distributed symmetrically on the sun-exposed parts of the body.
- Trial name
- NCT03472235
- Testing
- Microneedle
- Volunteers
- 40 people
- Sponsor
- Assiut University
Melasma, Melasma (Facial Melasma)
Azelaic Acid 20% vs Hydroquinone 4% in Epidermal Melasma
Melasma is a common skin condition that causes dark patches on the face and can significantly affect quality of life. This study compared two commonly used topical treatments, 20% azelaic acid and 4% hydroquinone, in adults with…
- Trial name
- NCT07327983
- Testing
- Topical Azelaic Acid 20% Cream, Topical 4% hydroquinone cream
- Where
- Pakistan
- Volunteers
- 146 people
- Sponsor
- Gujranwala medical college District Headquarters Hospital, Gujranwala
Melanosis
A Pilot Study Testing Salicylic Acid Peels Versus Glycolic Acid Peels for the Treatment of Melasma
The purpose of this study is to find out the safety and effectiveness of Glycolic Acid Chemical Peels compared to Salicylic Acid Chemical Peels for the treatment of melasma.
- Trial name
- NCT01976286
- Testing
- Salicylic Acid Peels, Glycolic Acid Peels
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Northwestern University