Clinical trials: Melasma, open to volunteers
Melasma, Post-acne Hyperpigmentation
Efficacy and Safety of a Combined Serum Containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES
The goal of this clinical trial is to evaluate the efficacy and safety of a combination serum containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES when used as a moisturizer after QS-Nd:YAG 1064 nm low-fluence laser…
- Trial name
- NCT07121439
- Testing
- a combination serum containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES, 2% hydroquinone cream
- Where
- Indonesia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Dr.dr.Irma Bernadette, SpKK (K)
Melasma
Comparative Efficacy of Intralesional Tranexamic Acid Versus Mandelic Acid Peel in the Treatment of Melasma
Melasma is a chronic acquired disorder of facial hyperpigmentation that significantly affects quality of life. Both intralesional tranexamic acid and mandelic acid chemical peels are effective treatment options with favorable…
- Trial name
- NCT07604844
- Testing
- Mandelic Acid Peel, Intralesional Tranexamic Acid
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Combined Military Hospital Abbottabad
Rosacea, Acne
Clinical Evaluation and Study of the Efficacy of a Centella Asiatica-Infused Facial Mask on Discosmetic Dermatosis
The purpose of this study was to investigate the efficacy and safety of repairing facial mask containing Asiaticum asiatica in treating disjunctive skin diseases.
- Conditions
- Rosacea, Acne, Centella, Melasma
- Trial name
- NCT06763367
- Testing
- Face mask containing Centella sinensis
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Melasma
COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMA
Melasma is a common acquired hyperpigmentation disorder that significantly affects quality of life. Various topical agents are used in its treatment, including Vitamin C and Niacinamide, both of which possess depigmenting…
- Trial name
- NCT07890571
- Testing
- Ascorbic acid, niacinamide
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Pak Emirates Military Hospital
Melasma
Comparative Efficacy of Resveratrol 1 % Gel and Trichloroacetic Acid 20% in Treatment of Melasma: A Split-face Study
1. To evaluate the efficacy and safety of topical resveratrol 1 % gel in treatment of melasma. 2. To compare between the efficacy of topical resveratrol 1 %gel versrs chemical peeling with TCA 20% in melasma.
- Trial name
- NCT07060157
- Testing
- resveratrol 1 % gel, TCA20%
- Where
- Egypt
- Volunteers
- 41 people
- Sponsor
- Assiut University
Melasma
Baseline Dermoscopic Vascular Score and Response to Oral Tranexamic Acid in Facial Melasma
Melasma is a common, long-lasting pigmentation disorder of the face. Some patients improve well with treatment and others improve little, and there is no simple way to predict this at the first visit.
- Trial name
- NCT07881328
- Testing
- Tranexamic acid, Standardised sunscreen and emollient
- Where
- Pakistan
- Volunteers
- 128 people
- Sponsor
- Allied Hospital Faisalabad
Melasma
Comparison of Effectiveness and Safety of Triple Combination Cream of Fucinolone Acetonide 0.01%, Hydroquinone 4%, Tretinoin 0.05% with Mometasone Furoate 0.1%, Hydroquinone 4%, Tretinoin 0.05% in the Treatment of Melasma
This Research is a clinical study with a single-blind randomized controlled trial of evaluators. Clinical trial Randomized Controlled Trial (RCT) design that compares the use of a triple combination cream of flucinolone acetonide…
- Trial name
- NCT06780644
- Testing
- Triple combination cream
- Where
- Indonesia
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Melasma, Melasma (Facial Melasma)
Expert Consensus on the Clinical Management of Melasma: A Delphi Method Study
This study aims to gather expert opinions on the best ways to treat and manage melasma, a common skin condition characterized by dark patches on the face.
- Trial name
- NCT07296549
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Venus Research Center
Post-inflammatory Hyperpigmentation, Melasma
A Clinical Study to Evaluate the Efficacy in Improving Dark Spots After 8 Weeks of Use of Facial Sunscreens in Adult Participants
The study aims to evaluate the efficacy of a facial sunscreen under two experimental conditions-untinted and tinted-in improving facial spots (melasma and solar lentigines/post-inflammatory hyperpigmentation) after 8 weeks of…
- Conditions
- Post-inflammatory Hyperpigmentation, Melasma, Solar Lentigo
- Trial name
- El Porto Ex-US (NCT07679945)
- Testing
- Sunscreen untinted, Sunscreen tinted
- Where
- Brazil
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Kenvue Brands LLC
Healthy, Melasma (Facial Melasma)
COMPARISON OF A COSMETIC SERUM AND 4% HYDROQUINONE FOR TREATING MELASMA OVER 84 DAYS
The goal of this clinical trial is to compare the dermatological tolerance and skin-lightening efficacy of a cosmetic depigmenting serum to a 4% hydroquinone-based product in adult male and female subjects aged 18-65 years with…
- Conditions
- Healthy, Melasma (Facial Melasma), Epidermal Melasma
- Trial name
- NCT07071363
- Testing
- Depigmenting Cosmetic Serum (Applied Morning and Evening)
- Where
- Mauritius
- Volunteers
- 40 people
- Sponsor
- Laboratoire Dermatologique ACM
Melasma (Facial Melasma)
Ultrasound-Enhanced Delivery of Compound TXA Solution in Melasma
Melasma is a localized, acquired hyperpigmentary skin disorder characterized by well-defined, light to dark brown patches. Based on clinical practice and extensive literature reports, tranexamic acid and reduced Glutathione (GSH)…
- Trial name
- NCT07202156
- Testing
- 10%TXA+2%Reduced Glutathione applied via ultrasound at 5W/cm² in10min, 10%TXA+2%Reduced Glutathione applied via ultrasound at 0W/cm² 10min
- Where
- China
- Volunteers
- 35 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Hyperpigmentation, Melasma
Evaluation of Efficacy and Tolerabilty of MelaB3 Serum in Combination of 35% Glycolic Acid Peeling Compared to 35% Glycolic Acid Peeling Alone in Various Hyperpigmentation Conditions
Randomized clinical trial to assess the effectiveness and tolerability of Mela B3 serum in combination with 35% glycolic acid peel vs.
- Conditions
- Hyperpigmentation, Melasma, Solar Lentigo, Peeling
- Trial name
- NCT07429786
- Testing
- Glycolic acid peel alone, MelaB3 serum
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Melasma, Melasma (Facial Melasma)
Oral Tranexamic Acid Plus Triple Combination vs Triple Combination Alone in Melasma
The data will be collected after the permission of the ethical committee of hospital. Following the enrollment, patients will be selected by lottery in the two equal groups.
- Trial name
- NCT07732192
- Testing
- Oral tranexamic acid + triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin), Triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin) alone
- Volunteers
- 128 people
- Sponsor
- Combined Military Hospital Abbottabad
Melasma
Comparative Evaluation of Topical Metformin and Topical Tranexamic Acid in Melasma
This randomised controlled trial aims to compare the efficacy of topical metformin (30%) and topical tranexamic acid (3%) in the treatment of melasma using reduction in the Melasma Area and Severity Index (MASI) score over 12…
- Trial name
- Melasma (NCT07495748)
- Testing
- topical 3% tranexamic acid solution, Topical 30% metformin cream
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Foundation University Islamabad
Melasma, Facial Melasma
Injectable Platelet-Rich Fibrin Versus Intradermal Tranexamic Acid for Melasma
Melasma is a chronic acquired hyperpigmentation disorder that commonly affects the face and has a significant impact on quality of life.
- Trial name
- NCT07540702
- Testing
- Injectable Platelet-Rich Fibrin, Tranexamic acid 100 mg/mL (Kapron)
- Where
- Egypt
- Volunteers
- 21 people
- Sponsor
- Kasr El Aini Hospital
Melasma
Randomized Study Using SM-030 Gel for Adults With Melasma
Brief Summary This is a phase 2b, observer-blinded, randomized study that will evaluate the safety and efficacy of topically applied SM-030 gel 0.64% and SM-030 gel 0.08% compared against placebo gel in healthy adult male and…
- Trial name
- NCT06454747
- Testing
- SM-030 gel 0.64%, SM-030 gel 0.08%
- Where
- 2 sites in El Salvador
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- DermBiont, Inc.
Hyperpigmentation, Melasma (Facial Melasma)
Efficacy Evaluation of a Cosmetic Product for Facial Hyperpigmentation
This is a single-center, single-blind clinical study designed to evaluate the efficacy of a depigmenting gel cream through clinical, subjective, and instrumental assessments.
- Trial name
- HYPERPIG (NCT07769268)
- Testing
- Blancy Pro
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Melasma (Facial Melasma)
Oral Melatonin Versus Oral Tranexamic Acid in the Management of Melasma
This study will compare the efficacy of oral melatonin and oral tranexamic acid in treating melasma, with the aim of determining whether melatonin is more effective than tranexamic acid, as measured by MASI scores.
- Trial name
- Melasma (NCT07169383)
- Testing
- Melatonin tablet, Tranexamic Acid (TXA)
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- Hina Malik
Melasma (Facial Melasma), Melasma
Comparative Evaluation of Topical 30% Metformin and Kligman's Regimen in Women With Melasma
It's a prospective, randomised, assessor-blinded clinical study comparing topical 30% metformin with Kligman's regimen for melasma in women aged 35-55 years at Fauji Foundation Hospital, Rawalpindi.
- Trial name
- Melasma (NCT07485777)
- Testing
- Topical 30% metformin cream, Kligman's Regimen
- Where
- Pakistan
- Volunteers
- 82 people
- Sponsor
- Foundation University Islamabad
Melasma (Facial Melasma)
Microneedling-Assisted Metformin, Tranexamic Acid, and Modified Kligman's Formula for Melasma
Melasma is a common skin condition characterized by brown or gray patches on sun-exposed areas of the face. Although several topical treatments are available, treatment outcomes are often unsatisfactory, and recurrence is common.
- Trial name
- NCT07696806
- Testing
- Metformin 30% Topical Lotion, Tranexamic Acid 0.5% Topical Solution, Modified Kligman's Formula
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Sameh Sarsik