Clinical trials: Melatonin
Immediate Dental Implant
The Effect Of Hyaluronic Acid And Melatonin With Systemic Administration of Vitamin C On Implant Stability After Immediate Implant in Anterior Region
The concept of immediate implant placement at the time of tooth extraction was first introduced by Schulte et al. on animal studies.
- Trial name
- NCT03804177
- Testing
- immediate implant placement with melatonin hyaluronic acid vit C, immediate implant placement without melatonin hyaluronic acid vit C
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sleep, Burns
Circadian Rhythm of Melatonin in Burns
Evaluate markers and postulated effectors of the endogenous circadian pacemaker in children admitted to the burn intensive care unit.
- Trial name
- Sleep4 (NCT01596101)
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
Recovery From Bariatric Surgery
The Effect of Premedication With Melatonin on Postoperative Recovery From Bariatric Surgery
Melatonin has sedative, hypnotic and analgesic properties that make it a good premedication agent before anesthesia and surgery.
- Trial name
- NCT02424071
- Testing
- Melatonin
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Dental Implants, Immediate Implant Placement
Autologous Demineralized Dentin Graft With or Without Melatonin for Immediate Implant Osseointegration
This randomized clinical study aims to evaluate the effect of autologous demineralized dentin graft (ADDG) with or without melatonin gel on the osseointegration of immediately placed dental implants in the maxillary premolar…
- Conditions
- Dental Implants, Immediate Implant Placement, Osseointegration
- Trial name
- NCT07610876
- Testing
- Autologous Demineralized Dentin Graft, Melatonin gel
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Sleep
A Single-Group Study to Examine the Efficacy of a Melatonin Lotion With Magnesium to Improve Sleep Quality and Quantity
This study will evaluate the efficacy of Asutra's 'Dream the night away' nighttime lotion with melatonin and magnesium on sleep health in terms of quantity, quality, ease of falling asleep or falling back asleep after waking in…
- Trial name
- NCT06146712
- Testing
- Asutra's 'Dream the night away' nighttime lotion
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Asutra
Depressive Disorder, Major
Effects of Escitalopram on the Sleep EEG Power in Patients With Major Depressive Disorder
The main objective was to compare the differences of PSG parameters and plasma melatonin levels before and after treatment with escitalopram for 8 weeks.
- Trial name
- NCT04013464
- Testing
- Escitalopram
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Peking University Sixth Hospital
Postural Instability
Investigation of Melatonin and Zolpidem Effect on Postural Instability in Healthy Adult Subjects
This is a randomised, double-blind, 3-way crossover, single dose, placebo-controlled study investigating the effect on night time awakening body sway of melatonin and zolpidem in healthy adult subjects aged of 55 to 64 years.
- Trial name
- NCT01280734
- Testing
- Circadin (R) 2 mg, Stilnox (R) 10 mg
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Neurim Pharmaceuticals Ltd.
Electroencephalography, Melatonin
Sedation and Nursing Management in EEG Recording in Children
Electroencephalogram (EEG) has an important place in establishing the correct diagnosis, providing appropriate intervention, and predicting the prognosis in the long term in children.
- Conditions
- Electroencephalography, Melatonin, Chloral Hydrate, Hydroxyzine
- Trial name
- NCT05492812
- Testing
- Sedation and Nursing Management in EEG Recording in Children, Chloral Hydrate, Hydroxyzine
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Atopic Dermatitis
Treatment of Nighttime Pruritus in Atopic Dermatitis
This study will look at melatonin vs. first generation antihistamine vs. placebo in improving nighttime itching in children with atopic dermatitis.
- Trial name
- NCT03688464
- Testing
- Melatonin, Diphenhydramine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Melatonin Bioavailability
Kinetic of Compounds of a Melatonin-based Formulation in Healthy Subjects
This study is conducted to clinically document the melatonin and zinc bioavailability of a dietary supplement containing delayed release melatonin, zinc and lemon balm
- Trial name
- NCT05419466
- Testing
- dietary supplement, 1 tablet containing delayed release melatonin, zinc and lemon balm
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Larena SAS
Insomnia
Relationship of Nocturnal Concentrations of Melatonin, γ-aminobutyric Acid and Total Antioxidants With Insomnia
To analyze the relationship of nocturnal concentrations of melatonin, γ-aminobutyric acid and total antioxidants with insomnia after stroke.
- Trial name
- NCT03202121
- Testing
- insomnia group, non-insomnia group, normal control
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- China Rehabilitation Research Center
Healthy, Circadian Rhythm
Effects of Different Colors of Light on Human Physiology
This study will determine which color of light is most effective in stimulating a range of biological functions in humans including activation of sleep-wake regulatory system (alertness, performance, microsleeps, brain activity)…
- Trial name
- NCT00200863
- Testing
- Monochromatic visible light exposure
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Preterm Contractions
Uterine Contractions Under Blue Light
The objective in the current study is to test the hypothesis that nocturnal uterine contractions in preterm women can be suppressed by brief ocular exposure to blue light.The Olcese lab at Florida State University identified a…
- Trial name
- NCT03691740
- Testing
- Ocular light
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Delirium, Melatonin
Melatonin Use in the Intensive Care Elderly Population
The investigators are studying the use of Melatonin in non-ventilated patients over the age of 65. Primary endpoint will be assesments of delirium, with secondary endpoints to include length of stay, use of anti-psychotic…
- Trial name
- MICE (NCT03013790)
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- MICE Trial Group
Immediate Dental Implant
Evaluation of Melatonin Application of Immediate Dental Implant
The presence of periapical pathology, the absence of kera¬tinized tissue and lack of complete soft tissue closure over the extraction socket have been reported a drawbacks of immediate implant placement .
- Trial name
- NCT03689998
- Testing
- immediate implant placement, Melatonin
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy
A Study to Investigate the Pharmacokinetics of Prolonged-release Melatonin Compared to Standard, Immediate-release Melatonin in Healthy Adults
A study comparing the pharmacokinetics of prolonged-release melatonin versus standard, immediate-release melatonin. Multiple blood draws over a 10-hour period will be analysed to determine the area under the curve, time to peak…
- Trial name
- NCT04067791
- Testing
- Prolonged-Release Melatonin, Immediate-Release Melatonin
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pharmavite LLC
Postoperative Pain
The Role of Preoperative Melatonin in Reducing the Inhaled Isoflurane Requirements in Open Nephrectomy
Melatonin is a hormone that the pineal gland in the brain produces. Melatonin fulfills many functions in the body but it is mostly known for maintaining a circadian rhythm that is governed by the central circadian pacemaker…
- Trial name
- NCT04959825
- Testing
- Melatonin 5 mg, Sugar Coated Tablets
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Bipolar Disorder, Circadian Rhythm
Effects of Sex Hormones on Circadian Rhythm in Men and Women
For many years researchers have been trying to better understand the regulation of sleep and activity by studying circadian (daily) rhythms of human beings.
- Conditions
- Bipolar Disorder, Circadian Rhythm, Depressive Disorder
- Trial name
- NCT00001285
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
ICS
Melatonin Therapy for Improving ICSI Outcomes in Women With Diminished Ovarian Reserve
Diminished ovarian reserve (DOR) is a major challenge in female fertility, often leading to poor oocyte quality and low pregnancy rates during assisted reproduction.
- Trial name
- NCT07318974
- Testing
- Melatonin capsule
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Benha University
Circadian Rhythm Disruption, Healthy Volunteers
Cronobióticos Naturales
Brief Summary The goal of this clinical trial is to learn if a drink made from native berries of southern Chile can change the body's natural production of melatonin (a hormone that helps control sleep), sleep quality, and some…
- Trial name
- ChronoNaturals (NCT07848464)
- Testing
- Chronobiotic
- Where
- Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad San Sebastián