Clinical trials: Melatonin
Non-visual Photoreception
Investigating the Effects of Evening Light Exposure on Melatonin Suppression, Alertness and Nocturnal Sleep
The timing and quality of sleep is governed by environmental and physiologic factors. Environmental factors, especially ambient lighting can impact the circadian system and alter the timing and structure of sleep.
- Trial name
- NCT01586039
- Testing
- Visible light
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Mild Cognitive Impairment, Cognitive Decline
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
The study will examine whether 5mg melatonin (over the counter, OTC) over a 9-month period improves Alzheimer's disease (AD) biomarkers and cognitive function in two groups of individuals: those with mild cognitive impairment…
- Conditions
- Mild Cognitive Impairment, Cognitive Decline, Healthy Aging
- Trial name
- NCT03954899
- Testing
- melatonin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Natalie Denburg
Oxidative Stress, Inflammatory Stress
Melatonin Treatment and Inflammation, Oxidative Stress and Autonomic Function in Connection With Surgery
The purpose of this study is to determine whether treatment with melatonin can reduce cell damage and inflammation in connection with laparoscopic gall bladder surgery.
- Conditions
- Oxidative Stress, Inflammatory Stress, Myocardial Ischaemia
- Trial name
- NCT00311259
- Testing
- Melatonin (drug), Laktose
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Irritable Bowel Syndrome
Frequency of Sleep Abnormalities in Patients With Irritable Bowel Syndrome and Effect of Pharmacological Intervention
Irritable bowel syndrome (IBS), a common gastrointestinal (GI) disorder in India and in the rest of the World, is enigmatic in its pathogenesis.
- Trial name
- NCT04193501
- Testing
- Melatonin 3 mg
- Where
- 2 sites in India
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Preterm Infant, Lactation
Melatonin Degradation Rate in Human Milk
Our long term hypothesis is that giving premature infants breast milk that was pumped during the night and has high concentration of melatonin will improve outcome of several clinical conditions related to premature infants.
- Trial name
- NCT03591341
- Testing
- melatonin level in pumped breast milk
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Stress, Mental Stress
Influence of Melatonin on Cardiovascular and Thermoregulatory Responses to Stress
This study aims to evaluate the influence of acute oral melatonin supplementation on cardiovascular and skin temperature responses to mental stress.
- Trial name
- NCT07138443
- Testing
- Melatonin 3 MG Oral Tablet
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Baylor University
ICS
Melatonin Therapy for Improving ICSI Outcomes in Women With Diminished Ovarian Reserve
Diminished ovarian reserve (DOR) is a major challenge in female fertility, often leading to poor oocyte quality and low pregnancy rates during assisted reproduction.
- Trial name
- NCT07318974
- Testing
- Melatonin capsule
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Benha University
Spinal Cord Injured, Tetraplegia
The Role of Melatonin in the Regulation of Blood Coagulation
The main aim is to examine the influence of daylight and melatonin on the temporal variations of hemostatic factors with key roles in the hemostatic process and its regulation.
- Trial name
- COME (NCT01741389)
- Testing
- Melatonin ("Circadin")
- Where
- Norway
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Pregnancy Transient Hypertension
Melatonin in Pregnancy Compared to Non-pregnant
Melatonin is well known for its role in the sleep-wake cycle but it is less well known as an effective antioxidant. It has been reported to be synthesised in the placenta and may have both receptor mediated and non-receptor…
- Trial name
- MEL-P (NCT03014245)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Diabetes, Glucose Tolerance
Melatonin and Glucose Tolerance Among Individuals With a Variant of the MTNR1B Gene
The effect of 3 months of melatonin 4mg treatment on glucose tolerance in different variants of the melatonin receptor 1B gene will be evaluated.
- Trial name
- MELAG (NCT01705639)
- Testing
- Melatonin
- Where
- 2 sites in Finland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Insomnia
Study to Investigate the Effects of Melatonin, Temazepam & Zolpidem on Sleep EEG in Men and Women
This study has been designed to compare the effects of melatonin with those of drugs (temazepam and zolpidem) regularly prescribed for the treatment of insomnia, in healthy, middle-aged volunteers.
- Trial name
- NCT00940550
- Testing
- Prolonged-release melatonin, Temazepam, Zolpidem
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Sleep
Seeing the World Through Assorted Glasses
The purpose of the study is to test the use of amber glasses at night as a method to block blue light from the eye, allowing the brain to produce a dim-light melatonin onset.
- Trial name
- SWAG (NCT02483559)
- Testing
- Amber Lenses
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Pain, Postoperative, Narcotic Use
Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery
The purpose of the study is to assess if melatonin given for three nights before wisdom tooth surgery decreases post-operative pain and pain medication consumption.
- Trial name
- NCT04791943
- Testing
- Melatonin 10 MG, Lactose pill
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Gastroesophageal Reflux Disease
The Potential Therapeutic Effect of Melatonin in Gastro-Esophageal Reflux Disease
Gastro-Esophageal Reflux Disease was defined as a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications.
- Trial name
- NCT00915616
- Testing
- Melatonin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mansoura University
Healthy, Circadian Rhythm
Effects of Different Colors of Light on Human Physiology
This study will determine which color of light is most effective in stimulating a range of biological functions in humans including activation of sleep-wake regulatory system (alertness, performance, microsleeps, brain activity)…
- Trial name
- NCT00200863
- Testing
- Monochromatic visible light exposure
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Glucose, Circadian Rhythm
Interaction of Melatonin With MTNR1B Genotype on Glucose Control - Study 2
This project aims to test the impact of melatonin and MTNR1B variation on regulation glucose regulation in a highly controlled in-laboratory setting and ex vivo in pancreatic islets.
- Conditions
- Glucose, Circadian Rhythm, Melatonin, Genes
- Trial name
- NCT03464084
- Testing
- melatonin, bright light, dim light
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Disorders, Circadian Rhythm, Craniopharyngioma
Sleep Wake and Melatonin Pattern in Craniopharyngioma
The hypothalamus is a part of the brain containing a number of nuclei with a variety of functions. It is central in the regulation of hormone secretion, sleep, and circadian functions.
- Trial name
- NCT01881854
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiomyopathies
Cardioprotective Effects of Melatonin in Patients With Cardiomyopathy
The aim of current study is to: Evaluate the cardioprotective effects of melatonin in patients with cardiomyopathy.
- Trial name
- CEMC (NCT06846086)
- Testing
- Melatonin 10 MG
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Tanta University
Major Depressive Disorder
The Study of Serum Melatonin Rhythm Levels in Patients With Major Depressive Disorder
One of the main points in the biological trends is, the circadian rhythm and disturbance in this cycle, which cause mood disorders and irregularity in this bio clock, to get depression.
- Trial name
- NCT01357083
- Where
- Iran
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Science & Research Islamic Azad University Branch Khozestan
Melatonin, Pharmacokinetics
Pharmacokinetics of Intravenous, Rectal, Intravesical, Vaginal, and Transdermal Melatonin in Healthy Female Volunteers
We will investigate the safety and pharmacokinetics of melatonin, when administered rectally, intravesically, vaginally and transdermally. We will recruit 10 healthy female volunteers.
- Conditions
- Melatonin, Pharmacokinetics, Safety
- Trial name
- NCT03519750
- Testing
- Melatonin 25 mg
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Dennis Bregner Zetner