Clinical trials: Melatonin Bioavailability
Biological Availability
Study of the Bioavailability of a Food Supplement Rich in Melatonin Administered Sublingually and Orally (MELATONIN)
Sleep disorders represent an important public health problem that cause important personal problems, absenteeism and considerable health costs.
- Trial name
- MELATONIN (NCT03951025)
- Testing
- Melatonin oral administration, Melatonin sublingual administration
- Where
- Spain
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Healthy, Dietary Bioavailability
Effect of Fruit Elicitation With Melatonin on Human Health
The goal of this clinical trial is to learn if treating fruits with melatonin helps the body absorb and use healthy plant compounds. It will also learn how much melatonin from the fruits is taken up by the body.
- Conditions
- Healthy, Dietary Bioavailability, Plant Extracts, Phenolic Compounds
- Trial name
- NCT07192835
- Testing
- Juice from untreated control fruits, Juice from melatonin-treated fruits
- Where
- Spain
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Melatonin Bioavailability
Kinetic of Melatonin Subsequent to the Consumption of Melatonin-rich Food Supplements
This study is conducted to clinically document the melatonin bioavailability of two dietary supplements containing melatonin : one prolonged release tablet dosed at 1.9mg and one spray dosed at 1mg for 2 oral sprays.
- Trial name
- NCT04574141
- Testing
- a prolonged release tablet and a spray containing melatonin
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- PiLeJe
Pharmacokinetics of Melatonin
The Relative Bio-availability of Oral and Oromucosal Melatonin in Different Formulations in Healthy Human Volunteers.
The circadian rhythm, the sleep-wake cycle, is mainly regulated by melatonin. The synthesis of melatonin is stimulated by the absence of light, leading to peak serum levels before bedtime.
- Trial name
- Melaform (NCT02107079)
- Testing
- Melatonin
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Utrecht University
Bioavailability
Oral Bioavailability of Two Melatonin Supplements
Results from several clinical studies show that orally administered melatonin has low bioavailability and a very short half-life.
- Trial name
- MELFENIL (NCT05835258)
- Testing
- Melatonin with phenyl capsaicin, Melatonin without phenyl capsaicin
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Melatonin Bioavailability
Kinetic of Compounds of a Melatonin-based Formulation in Healthy Subjects
This study is conducted to clinically document the melatonin and zinc bioavailability of a dietary supplement containing delayed release melatonin, zinc and lemon balm
- Trial name
- NCT05419466
- Testing
- dietary supplement, 1 tablet containing delayed release melatonin, zinc and lemon balm
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Larena SAS
Emergence Delirium, Anesthesia, Child
Melatonin vs Midazolam in Children Undergoing Tonsillectomy
Used as a premedication to decrease anxiety (Caumo et al., 2007). Midazolam, though has several drawbacks (McCann and Kain, 2001). Hence, an alternative premedication to midazolam will definitely have a widespread appeal.
- Conditions
- Emergence Delirium, Anesthesia, Child, Anxiety, Midazolam Premedication
- Trial name
- NCT07336095
- Testing
- Melatonin group, Midazolam group, Control group
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Bioavailability
Bioavailability and Bioactivity of Red Wine Melatonin in Humans
Melatonin (MLT) is a bioactive compound in red wine. The investigators will investigate the serum and salivary concentrations and antioxidant power of MLT after the intake of a glass of red wine.
- Trial name
- Wine-MLT (NCT02767102)
- Testing
- Red wine with melatonin, Red wine without melatonin
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Milan