Clinical trials: Melioidosis
Melioidosis
Oral ARV-1801 Given in Combination With Intravenous Ceftazidime or Meropenem for Treatment of Melioidosis in Hospitalized Patients
The study investigates the effect of 14 days of twice daily doses of ARV-1801 or placebo in combination with meropenem or ceftazidime in patients hospitalized with melioidosis.
- Trial name
- NCT05105035
- Testing
- Ceftazidime or meropenem, ARV-1801
- Where
- 5 sites in Thailand
- Volunteers
- 125 people
- Sponsor
- Arrevus Inc.
Melioidosis
An Observational Study to Evaluate Clinical Characteristics of Adult Patients With Suspected or Confirmed Melioidosis
This is a prospective observational study to evaluate clinical characteristics, current practice and outcomes of adult patients (age ≥18 years) with suspected or confirmed melioidosis.
- Trial name
- NCT06089668
- Testing
- Observational Study
- Where
- 3 sites in Laos, Thailand
- Volunteers
- 200 people
- Sponsor
- AN2 Therapeutics, Inc
Visceral Leishmaniasis, Human African Trypanosomiasis
Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever)
Tropical fevers have been a diagnostic challenge from the antiquity. Nowadays, despite the availability of good diagnostic capacities, undifferentiated febrile illnesses continue to be a thorny problem for travel physicians.
- Conditions
- Visceral Leishmaniasis, Human African Trypanosomiasis, Enteric Fever, Melioidosis
- Trial name
- NCT01766830
- Testing
- rk28 ICT, IT LEISH (rK39), Immunochromatographic HAT test
- Where
- 7 sites in Cambodia, Democratic Republic of the Congo and 2 more
- Volunteers
- 1,927 people
- Sponsor
- University Hospital, Geneva
Melioidosis Pneumonia
Causes of Pneumonia in Yangon
This study will evaluate a new point of care diagnostic test for the diagnosis of melioidosis pneumonia in patients attending outpatient clinics in Yangon, Myanmar
- Trial name
- NCT03578133
- Testing
- InBios® Active Melioidosis DetectTM-Lateral Flow Assay
- Where
- Burma
- Volunteers
- 300 people
- Sponsor
- Myanmar Oxford Clinical Research Unit
Melioidosis
Environment, Pathogens, and Host Interactions in Melioidosis
This is a longitudinal, multicentre observational study conducted across three established microbiology units integrated within hospital and community health systems in Thailand, Lao PDR, and Cambodia.
- Trial name
- DeEPH (NCT07345910)
- Where
- 3 sites in Cambodia, Laos and 1 more
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Melioidosis
Co-trimoxazole as Maintenance Therapy for Melioidosis
This is a randomised, open-labelled, controlled trial to compare the efficacy and effectiveness on relapse-free rate of 12-week versus 20-week oral eradication treatment of melioidosis.
- Trial name
- NCT01420341
- Testing
- Co-trimoxazole 12, Co-trimoxazole 20
- Where
- Thailand
- Volunteers
- 667 people
- Sponsor
- Khon Kaen University
Melioidosis, Systemic Inflammatory Response Syndrome
Study to Obtain Blood and Voided Urine Samples to Improve the Diagnosis of Melioidosis
Clinical samples [blood and voided urine (only for phase A)] from patient recruited at Sihanouk Hospital Centre of HOPE (SHCH) and HOPE Community Medical Center (CMC) will be processed (decontamination) and shipped to SRI…
- Conditions
- Melioidosis, Systemic Inflammatory Response Syndrome, Suspected or Confirmed Bloodstream Infections
- Trial name
- NCT02668406
- Testing
- Venous blood sampling (2 timepoints) (Phase A and B), Venous blood sampling (1 timepoint) (Phase A and B), Voided urine sampling (first sample) (Phase A)
- Where
- 2 sites in Cambodia
- Volunteers
- 4,203 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Melioidosis
Adapting LFI for Melioidosis
Towards the goal of reducing melioidosis, this study will help clinicians in Sarawak to diagnose and understand the causes and risk factors for melioidosis.
- Trial name
- NCT03528265
- Testing
- Lateral flow immunoassay
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- Duke University
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Melioidosis
A Single-blind Stepped Wedge Cluster Randomized Controlled Behaviour Change Trial to Determine Effectiveness of Prevention Programme of Melioidosis in Diabetics in Ubon Ratchathani, Northeast Thailand
Study hypothesis: Prevention programme for melioidosis can reduce incidences of overall hospitalization due to infectious diseases and due to culture-confirmed melioidosis in diabetic population in northeast Thailand This study…
- Trial name
- PREMEL (NCT02089152)
- Testing
- An educational programme for prevention of melioidosis
- Where
- Thailand
- Volunteers
- 9,075 people
- Sponsor
- University of Oxford
Melioidosis
A Randomized Double Blinded Comparison of Ceftazidime and Meropenem in Severe Melioidosis
Melioidosis, an infection caused by the bacterium Burkholderia pseudomallei, is a major cause of community-acquired septicaemia in northeast Thailand.
- Trial name
- ATOM (NCT00579956)
- Testing
- Meropenem, Ceftazidime
- Where
- 2 sites in Thailand
- Volunteers
- 750 people
- Sponsor
- University of Oxford
Acute Febrile Illness, Melioidosis
Diagnostic Accuracy of the DPP II Assay
Burkholderia pseudomallei is responsible for melioidosis, a disease that can present a range of signs and symptoms and can be treated by a specific drug regimen.
- Conditions
- Acute Febrile Illness, Melioidosis, Diagnoses Disease
- Trial name
- NCT04299412
- Testing
- DPP Fever Panel II assay
- Where
- Australia
- Volunteers
- 104 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Melioidosis, Head and Neck Infection
Clinical Presentation of Melioidosis in Head and Neck Region
Melioidosis in head and neck was observed including clinical presentation, diagnosis with titer, and result of treatment.
- Trial name
- NCT03048513
- Testing
- Patient who presented with melioidosis in head and neck
- Where
- Thailand
- Volunteers
- 48 people
- Sponsor
- Khon Kaen University