Clinical trials: Membranous
Primary Membranous Nephropathy
REmission in Membranous Nephropathy International Trial (REMIT)
REMIT is an investigator-initiated, international, multi-centre, prospective, randomised, open-label, parallel-group trial. A total of 224 adult participants with Primary Membranous Nephropathy (PMN) will be recruited from renal…
- Trial name
- REMIT (NCT06120673)
- Testing
- Obinutuzumab, Oral prednisolone and cyclophosphamide
- Where
- 13 sites in Australia
- Sponsor
- The University of Queensland
Plantar Fasciitis
Comparative Study of Amniotic Membrane Injectable in the Treatment of Recalcitrant Plantar Fasciitis
The purpose of this study is to determine whether the AmnioFix Injectable human amniotic membrane is effective in the treatment of recalcitrant plantar fasciitis.
- Trial name
- NCT01659827
- Testing
- Marcaine, 0.5cc AmnioFix, 1.25cc AmnioFix
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- MiMedx Group, Inc.
ECMO Outcomes, Respiratory Failure (Pediatric Patients)
ECMO Use in Pediatric Oncology and HSCT Patients: A Descriptive and Comparative Analysis
This was an observational study, with a descriptive and comparative portion. The descriptive analysis, a large single center experience, examined bleeding complications, infectious rates, and survival outcomes in patients under…
- Conditions
- ECMO Outcomes, Respiratory Failure (Pediatric Patients), Malignancies, Hematologic, Solid Tumor Malignancies
- Trial name
- NCT07712835
- Testing
- Extracorporeal membrane oxygenation (ECMO)
- Volunteers
- 22 people
- Sponsor
- Children's Mercy Hospital Kansas City
Prostate Cancer (Adenocarcinoma), Adenocarcinoma of the Prostate
RYZ711 Diagnostic Platform Study
This is a Phase 1/2 multicenter, multi-cohort imaging study to evaluate the safety, tolerability, and diagnostic performance of RYZ711 positron emission tomography/computed tomography (PET/CT) in men with histologically confirmed…
- Conditions
- Prostate Cancer (Adenocarcinoma), Adenocarcinoma of the Prostate, Metastatic Castration-resistant Prostate Cancer (mCRPC), Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
- Trial name
- NCT07862582
- Testing
- RYZ711, PSMA PET/CT
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- RayzeBio, Inc.
Hearing Loss, Sensorineural, Hearing Loss, Conductive
Wide Frequency Band Test of Hearing in Veterans
The accurate assessment of auditory status is critical for planning treatment for Veterans with hearing loss to include medical and audiological management.
- Conditions
- Hearing Loss, Sensorineural, Hearing Loss, Conductive, Hearing Loss, Mixed Conductive-Sensorineural, Otosclerosis
- Trial name
- CWTBAFV (NCT02019888)
- Where
- 2 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Epimacular Membrane
Outcomes Based on the Pre-operative Integrity of IS/OS Junction in Idiopathic Epimacular Membrane Surgery
The aim of this study is to evaluate whether the pre-operative integrity or not of the inner segment (IS) and outer segment (OS) photoreceptoral junction may influence the post-operative visual acuity, the macular morphology…
- Trial name
- NCT04158791
- Testing
- pars plana vitrectomy with epimacular membrane removal and internal limiting membrane peeling
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Bone Regeneration Following Wisdom Teeth Extraction
A Split-Blind Clinical Investigation to Compare the Performance and Safety of Inion GTR™ Biodegradable Membrane System to Resorbable Bilayer Bio-Gide®-Membrane of Geistlich Biomaterials in Enhancing Bone Regeneration After Removal of Wisdom Teeth.
The purpose of this study was to evaluate by histology and histomorphometry, thirty human osseous biopsies sampled from fifteen patients (2 biopsies per patient) following 3 months of implantation.
- Trial name
- NCT00727818
- Testing
- guided bone regeneration
- Where
- Switzerland
- Sponsor
- University of Zurich
Renal Failure, Renal Insufficiency, Acute
The Effect of Vitamin E-coated Polysulfone Membrane on Oxidative Stress, Inflammation and Monocytes in Critically Ill Patients in CRRT
The study evaluate the effect of a membrane in polysulfone covered with vitamin E (ViE15-A, ASAHI Kasey, Tokyo, Japan) versus non-vitamin E polysulfone membrane (REXEED-15A, ASAHI Kasey, Tokyo, Japan) in critically ill patients…
- Trial name
- Vitabrane E (NCT03489759)
- Testing
- ViE15-A, REXEED-15A
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- St. Bortolo Hospital
Localized Prostate Cancer
18F-DCFPyL Imaging as a Method to Assess Treatment Response to Stereotactic Body Radiation Therapy
Background: Identifying medium- and high-risk prostate cancer early may allow for treatments to work. But identification can be hard. Researchers want to see if a radiotracer used during PET scans can help.
- Trial name
- NCT05155046
- Testing
- 18F-DCFPyL
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- National Cancer Institute (NCI)
Cardiogenic Shock
The Effect of Simultaneous Renal Replacement Therapy on Extracorporeal Membrane Oxygenation Support for Cardiogenic Shock Patients
Extracorporeal membrane oxygenation (ECMO) is a temporary mechanical circulatory support device for cardiogenic shock (CS) patients.
- Trial name
- NCT02870946
- Testing
- Simultaneous RRT, Standard care
- Where
- China
- Volunteers
- 262 people
- Sponsor
- Beijing Anzhen Hospital
Alveolar Ridge Augmentation
Ridge Augmentation Without Primary Closure
This study is designed to compare the clinical and histologic results of ridge augmentation with and without primary closure over the barrier membrane.
- Trial name
- NCT01901783
- Testing
- With primary closure, Without primary closure
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Louisville
End-Stage Kidney Disease, Peritoneal Dialysis
Anti-Oxidant Effect on Peritoneal Membrane in Peritoneal Dialysis (PD) Patients
Peritoneal fibrosis is one of the major causes of technical failure in patients on peritoneal dialysis (PD) for long period of time.
- Trial name
- NCT01111422
- Testing
- N-acetylcysteine
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Ewha Womans University
Periodontal Regeneration
Amnion Chorion Membrane Combined With Allograft Bone Putty for the Management of Intrabony Defects
The ultimate goal for periodontal management is to obtain true periodontal regeneration. Periodontal regeneration implies that CAL gain is achieved through the formation of new cementum and new inserted periodontal ligaments…
- Trial name
- NCT05922527
- Testing
- Combined regenerative technique, Open flap debridement
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Epiretinal Membrane
Topical Use of Corticosteroid to Prevent Epiretinal Membrane Following Retinal Tear
In this prospective randomized controlled double blind pilot clinical study, we aim to assess whether administration of a topical corticosteroid would attenuate epiretinal membrane formation following development of retinal tears…
- Trial name
- NCT02412059
- Testing
- Prednisolone acetate
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Preterm Labor, Preterm Birth
The Efficacy of Nifedipine in the Management of Preterm Labor
Preterm labor is one of the problems of obstetrics, and is one of the leading cause of neonatal morbidity and mortality. The incidence of preterm birth is around 7 to 9 %.
- Conditions
- Preterm Labor, Preterm Birth, Preterm Labor Without Delivery, Preterm Labor With Preterm Delivery in Third Trimester
- Trial name
- BOG/TH/PTL (NCT04644354)
- Testing
- Nifedipine 10 mg
- Volunteers
- 444 people
- Sponsor
- Ethem Unal, M.D., PhD, Associate Prof of Surgery & Surgic
Respiratory Distress Neonatal, Noninvasive Ventilation
Comparison of the Silverman-Andersen Score and the Downes Score
This study aimed to compare the Silverman-Andersen score and the Downes score in predicting noninvasive ventilation (NIPPV) failure in preterm and term infants who received NIPPV support due to postnatal respiratory distress, as…
- Conditions
- Respiratory Distress Neonatal, Noninvasive Ventilation, Intubation, Scoring Systems
- Trial name
- CSASDS (NCT07183956)
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 220 people
- Sponsor
- Muğla Sıtkı Koçman University
Extracorporeal Membrane Oxygenation, Acute Respiratory Distress Syndrome
Reduction of Blood Recirculation in Veno-Venous ECMO
Blood which recirculates through the circuit of a veno-venous Extracorporeal Membrane Oxygenation (V-V ECMO) does not contribute to the systemic oxygenation of a patient on V-V ECMO and is called the recirculation fraction (Rf).
- Trial name
- NCT04754854
- Where
- Germany
- Volunteers
- 136 people
- Sponsor
- Charite University, Berlin, Germany
Advanced Age-related Macular Degeneration
Intravitreal LFG316 in Patients With Advanced Age-related Macular Degeneration
This study will assess the safety, tolerability, and serum pharmacokinetics of intravitreal LFG316 in patients with advanced age-related macular degeneration.
- Trial name
- NCT01255462
- Testing
- LFG316
- Where
- 8 sites in United States
- Volunteers
- 24 people
- Sponsor
- Novartis Pharmaceuticals
Idiopathic Epiretinal Membrane
Macular Resurfacing Using Autologous ILM Patch Transposition for Idiopathic Epiretinal Membrane
Idiopathic epiretinal membrane is a condition in which abnormal tissue grows on the surface of the retina and can cause blurred vision and distortion.
- Trial name
- NCT07767539
- Testing
- Non-Inverted Autologous Internal Limiting Membrane (ILM) Patch Transposition, Conventional Epiretinal Membrane and Internal Limiting Membrane Peeling
- Volunteers
- 90 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Breast Reconstruction Following Mastectomy
Safety and Clinical Performance of a Biological Matrix Used in Implant-based Breast Reconstruction
The general objective of the study is to confirm the medium/long-term safety and clinical performance of the CELLIS Breast membranes used in breast reconstruction and to identify emerging risks in comparison to clinical data…
- Trial name
- NCT05031962
- Testing
- CELLIS Breast (Porcine Acellular Dermal Matrix, PADM)
- Where
- 10 sites in France
- Volunteers
- 112 people
- Sponsor
- Meccellis Biotech
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