Clinical trials: Membranous
Membranous Ventricular Septal Defects
Closure of Perimembranous Ventricular Septal Defects With The AMPLATZER® Membranous VSD OCCLUDER
The purpose of this feasibility study is to investigate the safety of the AMPLATZER® Membranous VSD Occluder for the treatment of hemodynamically significant Perimembranous Ventricular Septal Defects.
- Trial name
- NCT00578708
- Testing
- AMPLATZER Membranous VSD Occluder
- Where
- 6 sites in United States
- Volunteers
- 35 people
- Sponsor
- Abbott Medical Devices
Death, Sudden, Cardiac, Out-Of-Hospital Cardiac Arrest
Pre-hospital ECMO in Advanced Resuscitation in Patients With Refractory Cardiac Arrest. ( SUB30 )
To establish whether a pre-hospital advanced physician/ paramedic cardiac arrest team that is ECMO capable can establish ECMO flow within 30 minutes of collapse.
- Conditions
- Death, Sudden, Cardiac, Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation, Cardiopulmonary Arrest With Successful Resuscitation
- Trial name
- SUB30 (NCT03700125)
- Testing
- ECMO resuscitation
- Where
- 2 sites in United Kingdom
- Volunteers
- 5 people
- Sponsor
- Barts & The London NHS Trust
Extracorporeal Membrane Oxygenation Complication, Coagulation Factor Deficiency
Evaluation of Coagulation Factors and Point-of-care Devices During Veno-venous ECMO Therapy
Hemorrhagic and thromboembolic complications are common in Veno-venous ECMO therapy. The aim of this study is to provide a detailed analysis of the activity of different coagulation factors and changes in functional coagulation…
- Trial name
- NCT03754868
- Testing
- Detailed coagulation monitoring
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Goettingen
Thyroid Gland Carcinoma
Gallium-68 Prostate Specific Membrane Antigen PET in Diagnosing Patients With Thyroid Cancer
This pilot clinical trial studies how well Gallium-68 prostate specific membrane antigen positron emission tomography (PET) work in diagnosing patients with thyroid cancer.
- Trial name
- NCT03463889
- Testing
- Gallium Ga 68-labeled PSMA-11, Magnetic Resonance Imaging, Positron Emission Tomography (PET)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Recurrent Pterygium, Micro-Conjunctival Autografting Combined With Amniotic Membrane Transplantation
Micro-Conjunctival Autografting Combined With Amniotic Membrane Transplantation Treating Recurrent Pterygium Trial
To observe the effect of micro-conjunctival autografting combined with amniotic membrane transplantation on the postoperative recurrence, complications and ocular surface symptoms among patients with recurrent pterygium.
- Trial name
- NCT05362253
- Testing
- Micro-Conjunctival Autograft Combined with Amniotic Membrane Transplantation, Conventional Autologous Conjunctival Transplantation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yifeng Yu
Metastatic Castration Resistant Prostate Cancer (mCRPC)
The Role of WB-MRI in the Evaluation of Prostate Cancer Patients Treated With Lutetium - Prostate Specific Membrane Antigen (Lu-PSMA)
The role of WB-MRI in the evaluation of prostate cancer patients treated with Lu-PSMA
- Trial name
- WB-LuPSMA (NCT05208229)
- Testing
- WB-MRI
- Where
- 2 sites in Italy
- Volunteers
- 2 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Peri-Implantitis
Regenerative Outcomes for Peri-implant Bony Defects Using Amnion-chorion Barrier vs. Collagen Membrane
The purpose of this study is to compare the clinical and radiographic outcomes of two different barrier membranes-amnion-chorion membranes (ACM) and conventional collagen membranes-used in guided bone regeneration (GBR)…
- Trial name
- NCT07032259
- Testing
- BioXclude Amnion Chorion Membrane, Collagen Membrane
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Extracorporeal Membrane Oxygenation, Cardiac Arrest
ON-SCENE Initiation of Extracorporeal CardioPulmonary Resuscitation During Refractory Out-of-Hospital Cardiac Arrest
Hypothesis: Implantation of on-scene ECPR by the HEMS teams in patients with sustained out-of-hospital cardiac arrest, results in the rapid return of circulation and, thus, improved survival and less neurological impairment…
- Trial name
- ON-SCENE (NCT04620070)
- Testing
- ECPR
- Where
- 4 sites in Netherlands
- Volunteers
- 221 people
- Sponsor
- Erasmus Medical Center
Acute Respiratory Failure With Hypoxia
PK of Piperacillin/Tazobactam in Adults Undergoing ECMO
This study is designed to provide preliminary data to determine if concentrations of piperacillin/tazobactam change in patients with severe respiratory failure receiving extracorporeal membrane oxygenation (ECMO).
- Trial name
- NCT03467854
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Columbia University
Chronic Kidney Disease, Chronic Renal Disease
Comparative Effects Of Dialysate Flow Rate And Membrane Packing On The Performance Of Dialyzers Used For Hemodialysis
The purposes of this study are to determine if the performance of a dialyzer depends on how tightly the hollow fiber membranes are packed in the housing of the dialyzer (the membrane packing density) and if that dependence is a…
- Trial name
- NCT00636077
- Testing
- Polyflux HD-C4 Big, HD-C4 Small, Optiflux 160NR
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vantive Health LLC
Allergic Rhinoconjunctivitis
A Safety and Immunogenicity Phase I Study of CryJ2-DNA-Lysosomal Associated Membrane Protein (CryJ2 -DNA-LAMP) Plasmid
This is a research study of a vaccine for allergy to Japanese Red Cedar. The vaccine is called CryJ2-DNA-LAMP Plasmid vaccine. This research study will determine how the vaccine is tolerated and how research participants respond…
- Trial name
- NCT01707069
- Testing
- CryJ2-DNA-LAMP plasmid vaccine by intramuscular injection
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Immunomic Therapeutics, Inc.
Horizontal Ridge Augmentation, Histological and Clinical Result
Comparison Using Pericardial Membrane Versus Titanium Mesh" in Horizontal Alveolar Ridge Augmentation
Randomized clinical trial study ,The purpose of this study To evaluate the potential application of resorbable pericardium to augment localized alveolar ridge defects in esthetic zone, from histological, radiographical and…
- Trial name
- NCT04570566
- Testing
- horizontal alveolar ridge augmentation
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Macula Hole, Retinal Detachment
Amniotic Membrane for Recurrent Macular Hole
Macular hole surgery were tried by different surgeons using many techniques with different successes but still there were many recurrences.
- Conditions
- Macula Hole, Retinal Detachment, Myopic Macular Degeneration
- Trial name
- NCT03528122
- Testing
- Recurrent opened macular hole
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Minia University
Critical Illness, Extracorporeal Membrane Oxygenation Complication
PK/PD Study of Anti-Infective Drugs in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation Treatment
Extracorporeal membrane pulmonary oxygenation (ECMO) may provide partial or complete support for organ replacement in patients with severe cardiopulmonary failure, buying time for further management of the primary disease.
- Trial name
- ECMO (NCT06319677)
- Testing
- ECMO treatment
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Periodontitis
Recombinant Human Fibroblast Growth Factor-2 (rhFGF-2) In Gingival Recession Defects
This study was a single-arm trial to obtain preliminary data on the efficacy of collagen membranes impregnated with recombinant human fibroblast growth factor (rhFGF-2) in the treatment of Miller's class I and class II gingival…
- Trial name
- NCT04361630
- Testing
- FGF 2
- Where
- India
- Volunteers
- 30 people
- Sponsor
- SVS Institute of Dental Sciences
Prostatic Neoplasms
An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With Standard of Care (SoC), Versus SoC Alone, in Adult Male Patients With Metastatic Hormone Sensitive Prostate Cancer (mHSPC)
The purpose of this study is to evaluate the efficacy and safety of 177Lu-PSMA-617 in combination with Standard of Care (SOC), versus Standard of Care alone, in adult male patients with Metastatic hormone sensitive prostate…
- Trial name
- PSMAddition (NCT04720157)
- Testing
- 177Lu-PSMA-617, 68Ga-PSMA-11, ARDT
- Where
- 167 sites in United States, Austria and 17 more
- Volunteers
- 1,140 people
- Sponsor
- Novartis Pharmaceuticals
Extracorporeal Membrane Oxygenation Complication
Use of Nafamostat Mesilate for Anticoagulation in Patients With ECMO
The purpose of this study is to evaluate the effectiveness and safety of nafamostat mesilate compared with unfractionated heparin for anticoagulation in patients with ECMO after cardiac surgery.
- Trial name
- NCT06276010
- Testing
- nafamostat mesilate, unfractionated heparin group
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xiaotong Hou
Long Term Outcome
Long Term Follow up of Patients Who Were Treated With Extracorporeal Membrane Oxygenation for Pandemic Influenza A/H1N1 Induced Severe Respiratory Failure
Patients treated with Extracorporeal Membrane Oxygenation (ecmo) for severe respiratory or circulatory failure show severe long term disability due to impaired lung -, cerebral-, cognitive function and impaired quality of life.
- Trial name
- NCT01763060
- Testing
- CT scan, Cognitive function, MRI
- Where
- Sweden
- Volunteers
- 7 people
- Sponsor
- Karolinska University Hospital
Peri-implant Soft Tissue Healing
Comparison of Freeze-Dried Amniotic and Collagen Membranes for Soft Tissue Healing After Grafted Implant Surgery
The goal of this clinical trial is to learn whether Freeze-Dried Amniotic Membrane (FD-AM) or Collagen Membrane (CM) provides better soft tissue healing after Stage I dental implant surgery with particulate bone grafting in…
- Trial name
- FDAM-CM (NCT07647120)
- Testing
- Freeze-Dried Amniotic Membrane (FD-AM), Collagen Membrane (CM)
- Where
- India
- Volunteers
- 10 people
- Sponsor
- RAJAS DENTAL COLLEGE AND HOSPITAL
Chronic Stable Angina, Vascular Dementia
The Effect of Danzhu Fuyuan Granule as Adjunctive Therapy for Chronic Stable Angina, Vascular Dementia and Idiopathic Membranous Nephropathy: A Bayesian Basket Trial
This study is designed as a bayesian basket trial , which aims to evaluate the efficacy of Danzhu Fuyuan Granule in patients with Chronic Stable Angina, Vascular Dementia and Idiopathic Membranous Nephropathy
- Conditions
- Chronic Stable Angina, Vascular Dementia, Idiopathic Membranous Nephropathy
- Trial name
- NCT04498962
- Testing
- Danzhu Fuyuan Granule
- Where
- 7 sites in China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Jingqing Hu
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