Clinical trials: Memory, Short-Term, open to volunteers
Traumatic Brain Injury (TBI) Patients
Transcutaneous Vagus Nerve Stimulation for Attention and Memory
This clinical trial aims to evaluate whether transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive brain stimulation method, can improve attention and memory in veterans with traumatic brain injury (TBI) and…
- Trial name
- taVNS (NCT06723743)
- Testing
- Transcutaneous vagus nerve stimulation for attention in veterans with TBI, Soterix Medical Vagus Nerve Stimulation mini-CT
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Healthy
Modulation of Working Memory by an Alternating Magnetic Field in Humans
Many studies have examined the effects of transcranial alternating current stimulation (tACS) on working memory, showing that low-intensity stimulation can enhance cognitive performance by modulating neuronal activity…
- Trial name
- MEMOCHAM (NCT07398833)
- Testing
- Electrical stimulation, Magnetic stimulation, No stimulation
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Clinique Beau Soleil
Behavior, Health
Train Your Brain 2.0 - Improving Memory and Decision Making Among Youth
The goal of this clinical trial is to deliver a computer-based working memory training program to improve delay discounting (DD) and prevent substance misuse among at-risk adolescents in a traditionally underserved area.
- Trial name
- NCT06242704
- Testing
- Working Memory Training, Working Memory
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Cognitive Impairment, Cognitive Decline
A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients
The current study is a mechanistic study to evaluate working memory gains from application of transcranial direct current stimulation (tDCS) in older adults with mild cognitive impairments (MCI) compared to cognitively healthy…
- Trial name
- AIM (NCT05998031)
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Florida
Healthy Aging, Cognition
Effects of Cannabidiol on Memory and Attention in Adults Aged 60-70: A Pilot Study
This pilot study aims to investigate the effects of a single oral dose of cannabidiol (CBD) on memory and attention in healthy adults aged 60 to 70 years.
- Trial name
- CBD-MAP (NCT07910292)
- Testing
- Cannabidiol (CBD)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Multiple Sclerosis, Electric Stimulation
Effectiveness of Personalized Alternating Current Stimulation for Treating Cognitive Impairment in CNS Demyelination Patients
Background: Central nervous system inflammatory demyelinating diseases often lead to significant cognitive impairment, presenting a critical challenge in patient management.
- Trial name
- NCT06968039
- Testing
- Neuroelectrics StarStim 32
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Xuanwu Hospital, Beijing
Older Adults (60 - 85 Years Old), Mild Cognitive Impairment (MCI)
Non-invasive Stimulation of Deep Brain Structures to Modulate Working Memory
A study investigating the effects of non-invasive electrical stimulation of deep brain structures on working memory, attention, and executive functions involved in everyday activities.
- Trial name
- DEEPBRAIN (NCT07560904)
- Testing
- Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (20 Hz), Control striatal stimulation, Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (60 Hz)
- Where
- Czechia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Down Syndrome, Intellectual Disability
Escalating Doses of Memantine in Down Syndrome (MEDS-123)
Down syndrome (DS) is typically caused by an extra chromosome 21 in the cell nucleus (trisomy 21, or T21). T21 is both the most common cause of genetically defined intellectual disability and the earliest documented cause of…
- Conditions
- Down Syndrome, Intellectual Disability, Alzheimer Dementia (AD)
- Trial name
- NCT07531940
- Testing
- Memantine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University Hospitals Cleveland Medical Center
Alcohol Use Disorder, Substance Use Disorders
Modification of Inhibitory Control and Craving Through Transcranial Direct Current Stimulation (tDCS) as an Add-On Treatment for Substance Use Disorder
The aim of this project is to investigate the potential of transcranial direct current stimulation (tDCS) to reduce cognitive deficits and substance craving in individuals with substance use disorders (SUD), with a focus on…
- Trial name
- NCT06959342
- Testing
- Transcranial direct current stimulation (tDCS), Inhibition Training
- Where
- 2 sites in Germany
- Volunteers
- 162 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Schizophrenia
Enhancing Prefrontal Oscillations and Working Memory in Early-course Schizophrenia
This study will investigate the effects of intermittent Theta Burst Stimulation (iTBS) on natural oscillatory frequency of the dorsolateral prefrontal cortex (DLPFC) and working memory in early-course schizophrenia (EC-SCZ).
- Trial name
- REDOCS (NCT05102929)
- Testing
- active intermittent Theta Burst Stimulation (iTBS)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Fabio Ferrarelli
Dementia, Alzheimer s Disease
Brain Wave Informed Non-invasive Brain Stimulation: Improving Neural Networks of Working Memory in Dementia: a Proof-of-concept Study
Working memory helps us hold information for a short time so one can think and make decisions. It keeps thoughts on track. As one gets older, working memory gets weaker.
- Trial name
- BWIBS-WM (NCT07673770)
- Testing
- EEG-triggered TMS
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Brain Tumor
Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors
The objective of this study is to estimate the feasibility and acceptability of cognitive training in the virtual reality setting with children undergoing radiotherapy for brain tumors.
- Trial name
- NCT05947045
- Testing
- Cognitive training via iPad, Cognitive training via virtual reality
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- St. Jude Children's Research Hospital
Schizophrenia, Working Memory
tACS for Working Memory in Schizophrenia
This study is a randomized, single-blind, sham-controlled crossover trial enrolling 30 schizophrenia patients, each receiving one active and one sham tACS session (7-day washout), targeting P3/P4 at individual alpha frequency…
- Trial name
- NCT07701343
- Testing
- transcranial alternating current stimulation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Central South University
Working Memory, Epilepsy
Causal Role of Top-Down Theta Oscillations in Prioritization
Purpose: The purpose of this pilot study is to investigate the dynamics between theta and alpha oscillations in the control of working memory.
- Trial name
- NCT06252532
- Testing
- Direct cortical stimulation (DCS) Alpha, Direct cortical stimulation (DCS) Theta, Direct cortical stimulation (DCS) In-Phase Theta
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of North Carolina, Chapel Hill
Executive Dysfunction
Causal Role of the Aperiodic Signal for Working Memory
Working memory (WM) is the ability to hold relevant information in mind in the absence of sensory input. The capacity for WM is a foundation for cognitive control and higher cognitive function more broadly.
- Trial name
- TRAS (NCT06126809)
- Testing
- Steep-tRAS, Flat-tRAS
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Florida State University
Neuronal Mechanisms, Laminar Circuits
Clinical Study of How Information Flows Across the Human Cortical Sheet Layers (Laminae), Aiming to Discover Key Principles of Laminar Circuits and Information Flow for Complex Behavior.
This is a basic science study of a missing dimension of human brain function, how information flows the six layers of the brain.
- Trial name
- LamCircuits (NCT07073391)
- Testing
- Recording with laminar arrays
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Christopher I. Petkov
Hypoxia, Hypoxia Brain
Study of the Effects of Acute Exposure to Moderate Altitude Hypoxia on Prospective Memory.
The goal of this study is to investigate whether prospective memory, i.e., memory for delayed intentions, is impaired at moderate altitude (4,000m).
- Conditions
- Hypoxia, Hypoxia Brain, Hypoxia Altitude Simulation Test, Hypoxia in Healthy Individuals
- Trial name
- HYPRO (NCT07585227)
- Testing
- Hypoxia exposure, Oxygen administration, Air administration
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
TBI, Cognitive Dysfunction
Strengthening Neuro-Cognitive Skills for Success in School, Work and Beyond
For many Veterans, success in achieving goals at work, school and in other aspects of life are top priorities. The abilities to regulate attention, remember key information, and stay calm and on track are fundamental to this…
- Trial name
- NCT04109027
- Testing
- BrainStrong-BSR, BrainStrong-OPT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Stroke, Cognition Disorders
Dual-site Cross-frequency Coupled Transcranial Electrical Stimulation Modulates Working Memory of Patients With Post-stroke Cognitive Impairment
This clinical trial aims to explore the effect of dual-site theta-gamma cross-frequency coupled transcranial alternating current stimulation in the frontal and parietal region on the working memory ability of patients with…
- Trial name
- NCT07573501
- Testing
- occupational therapy, real tACS
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Ke Dong, MD
Cognitive Performance, Executive Function (Cognition)
Exploring the Cognitive Benefits of a Blackcurrant-Based Supplement in Normobaric Hypoxia
This study investigates the cognitive effects of Ārepa, a blackcurrant-based drink, under simulated high-altitude conditions (4,500m normobaric hypoxia for ~180 minutes).
- Conditions
- Cognitive Performance, Executive Function (Cognition), Working Memory, Hypoxia Induced Cognitive Impairment
- Trial name
- NCT07166835
- Testing
- Nootropics (ginkgo biloba, nicergoline, piracetam, or others)
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Leeds Beckett University