Clinical trials: Memory, open to volunteers
Pain, Traumatic Memory
Traumatic Long-term Memory of Pain in Humans
Few studies have focused on understanding the mechanisms underlying pain memory in humans. Thus, this project aims to investigate the link between pain memorisation and memorisation of the associated context by addressing the…
- Trial name
- TRAUMADOL (NCT04189965)
- Testing
- Validation of virtual environment and auditive stimulation with virtual reality glasses (Pilot phase), Electrical cutaneous stimulation and auditive stimulation (Principal Experimental phase), Electrical cutaneous stimulation and auditive stimulation (Secondary Experimental phase)
- Where
- France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Postpartum Psychological Stress, Mindfulness-Based Stress Reduction
Effect of Mindfulness-Based Stress Reduction on Birth Memory and Perception of Traumatic Birth
This randomized controlled trial aims to evaluate the effects of a Mindfulness-Based Stress Reduction (MBSR) program on birth memory and perception of traumatic birth among women who have undergone vaginal delivery.
- Conditions
- Postpartum Psychological Stress, Mindfulness-Based Stress Reduction, Maternal Health, Traumatic Birth
- Trial name
- MBSR-BIRTH (NCT07018765)
- Testing
- Mindfulness-Based Stress Reduction (MBSR)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kader ATABEY
Memory Impairment
Predictive Factors and Autonomy Level Change
The Alzheimer's disease or related disorders (ADRD) are among the most disabling diseases because of their main features such as cognitive impairment, loss of functional autonomy and behavioural disorders.
- Trial name
- MEMORA (NCT02302482)
- Testing
- The Lawton Instrumental Activities of Daily Living score (IADL), and the disability assessment of dementia score (DAD-6
- Where
- 2 sites in France
- Volunteers
- 10,860 people
- Sponsor
- Hospices Civils de Lyon
Posterior Cortical Atrophy
Testing Personalized High-Definition Transcranial Direct Current Stimulation (HD-tDCS) as a Treatment of Posterior Cortical Atrophy
This study is being completed to learn if high-definition transcranial direct current stimulation (HD-tDCS) has an effect on visual and thinking abilities in persons with posterior cortical atrophy (PCA).
- Trial name
- PCA (NCT07191327)
- Testing
- HD-tDCS sessions, HD-tDCS sessions - Open-label (after randomized treatment)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Child Development, Executive Functions (EF)
Sharing Tales That Teach: Shared Picturebook Reading for Early Childhood Emotional and Cognitive Development
Sharing Tales That Teach is a randomised study of a shared picturebook reading programme for 4- to 5-year-old children and their primary caregivers.
- Conditions
- Child Development, Executive Functions (EF), Emotion Regulation
- Trial name
- STTT (NCT07666802)
- Testing
- Emotion-Focused Shared Picturebook Reading, Standard Dialogic Picturebook Reading
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Greenwich
Epilepsy, Seizures
Pharmacological Modulation of Brain Oscillations in Memory Processing
The goal of this study is to learn about the effects of scopolamine (an anticholinergic drug) on areas of the brain involved in memory, and changes it may have on brain activity.
- Conditions
- Epilepsy, Seizures, Cognitive Impairment, Mild, Memory Disorders
- Trial name
- NCT05594017
- Testing
- Scopolamine (0.4mg)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Memory Replay, HippoCamera
A VIRTUAL Three-month Intervention Study of the Effects of a Smartphone Application (HippoCamera) on Memory in Teens and Young Adults With Down Syndrome
Down syndrome is a chromosomal abnormality associated with significant deficits across multiple cognitive domains, including a disproportionate deficit in hippocampally-dependent memory.
- Trial name
- NCT07008989
- Testing
- Memory replay
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston College
Kidney Transplant
Alloreactive Memory B Lymphocytes and Anti-HLA Sensitization
In transplantation, B lymphocytes are major cellular players in the alloreactive humoral response through the production of antibodies targeting allogeneic HLA molecules expressed by the transplant.
- Trial name
- ALLO-BMEM (NCT07011238)
- Testing
- Patients meeting HLA immunization criteria
- Where
- France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Rouen
Childhood Brain Tumor, Childhood Brain Tumors
The FLaME Cognitive Rehabilitation Study for Childhood Brain Tumour
Medical treatments have improved survival rates for children with brain tumours. However, most children experience long-term difficulties with 'cognition' (thinking skills such as memory and paying attention) and cognitive…
- Conditions
- Childhood Brain Tumor, Childhood Brain Tumors, Pediatric Brain Neoplasms, Pediatric Brain Tumor
- Trial name
- FLaME (NCT06770335)
- Testing
- THE FATIGUE, LEARNING, AND MEMORY ENRICHMENT (FLaME) INTERVENTION - Full intervention, THE FATIGUE, LEARNING, AND MEMORY ENRICHMENT (FLaME) INTERVENTION - Cognitive rehabilitation only
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Epilepsy, Memory Consolidation
Sleep and Rehearsal-Driven Memory in Epilepsy
Memory consolidation transforms unstable memory traces into lasting representations, a process enhanced by both sleep and rehearsal during learning.
- Trial name
- CORESOM-EPI (NCT06967935)
- Testing
- Cognitive memory task on a computer, Eye tracking, Questionnaires on task-related fatigue
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Opioid Use Disorder, Healthy
Adversity, Brain and Opioid Use Study
The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms.
- Trial name
- NCT06355778
- Testing
- Magnetic Resonance Imaging (MRI), Computer Tasks
- Where
- United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Advanced Melanoma, Metastatic Melanoma
Memory-Like Natural Killer Cells With Nivolumab and Relatlimab in Advanced or Metastatic Melanoma After Progression on Checkpoint Inhibitors
This is a Phase 1 open-label, study designed to characterize the safety, tolerability, and preliminary anti-tumor activity of memory-like natural killer cells (ML NK) in combination with nivolumab and relatlimab in subjects with…
- Trial name
- NCT05629546
- Testing
- Cytokine-induced memory-like natural killer cells, Relatilmab, Nivolumab
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Washington University School of Medicine
Lifestyle Intervention, Lifestyle Risk Reduction
Lifestyle Intervention in the Memory Clinics of General and Academic Hospitals Trial
Lifestyle Intervention in the memory clinics of General and academic Hospitals Trial (LIGHT) is a multi-center, randomized, controlled, lifestyle intervention trial among 300 older adults (≥50 years) with subjective cognitive…
- Conditions
- Lifestyle Intervention, Lifestyle Risk Reduction, Cognitive Decline, Dementia
- Trial name
- LIGHT (NCT06832761)
- Testing
- Personalized lifestyle intervention
- Where
- 2 sites in Netherlands
- Volunteers
- 300 people
- Sponsor
- Maastricht University Medical Center
Aortic Dissection
False Lumen Treatment for Prevention of Aortic Growth Using Shape Memory Polymer - First-in-Human Study
To determine the safety and feasibility of the investigational product to reduce aortic dissection false lumen perfusion.
- Trial name
- FLAGSHIP_NZL (NCT06550986)
- Testing
- False Lumen Embolization System, IMPEDE-FX RapidFill
- Where
- 2 sites in New Zealand
- Volunteers
- 30 people
- Sponsor
- Shape Memory Medical, Inc.
Alcohol Use Disorder, Substance Use Disorders
Modification of Inhibitory Control and Craving Through Transcranial Direct Current Stimulation (tDCS) as an Add-On Treatment for Substance Use Disorder
The aim of this project is to investigate the potential of transcranial direct current stimulation (tDCS) to reduce cognitive deficits and substance craving in individuals with substance use disorders (SUD), with a focus on…
- Trial name
- NCT06959342
- Testing
- Transcranial direct current stimulation (tDCS), Inhibition Training
- Where
- 2 sites in Germany
- Volunteers
- 162 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Huntington Disease, Autobiographical Memory
Autobiographical Memory, Future Thought, and Eye Movements in Huntington's Disease
Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by progressively worsening motor, cognitive, psychiatric, and behavioral deficits.
- Trial name
- MAMOC-MH (NCT07409597)
- Testing
- neuropsychological tests, Eye tracker use
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Alzheimer Disease, Caregivers of Alzheimer's Disease or Memory Problem Patients
Psychological Counseling Program for Alzheimer's Patients' Caregivers
Purpose: To investigate the effects of a psychological counseling program (PsychoCP) applied to caregivers of Alzheimer's patients on perceived stress, psychological well-being and care burden.
- Conditions
- Alzheimer Disease, Caregivers of Alzheimer's Disease or Memory Problem Patients, Perceived Stress, Well-Being (Psychological Flourishing)
- Trial name
- PsychoCP (NCT06755476)
- Testing
- Psychological Counseling Program
- Volunteers
- 80 people
- Sponsor
- Aydan Akkurt Yalçıntürk
Aging
Breaking Sitting with High-intensity Interval Training for Brain Health
This trial will examine whether interrupting 3.5 hours of sitting every 30 min with 6 min high intensity interval training (HIIT) breaks compared to light intensity interval training (LIIT) will improve brain health in…
- Trial name
- HIIT2SITLess (NCT06243016)
- Testing
- High-Intensity Interval Training (HIIT) Breaks to Sitting, Light-Intensity Interval Training (LIIT) Breaks to Sitting
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Stress Disorders, Post-Traumatic
Mismatch vs. Standard Intervention During Memory Reconsolidation Blockade With Propranolol: Effect on Psychophysiological Reactivity During Traumatic Imagery
The proposed R21 project will attempt to further develop a novel intervention for posttraumatic stress symptoms inspired by the science of memory reconsolidation.
- Trial name
- NCT05853627
- Testing
- Memory reactivation procedures, Propranolol
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Pain Control, Anxiety
Virtual Contexts for Affective Modulation
This study investigates how spatial context and perceived controllability modulate pain, affective states such as anxiety, and motivated behavior.
- Conditions
- Pain Control, Anxiety, Memory
- Trial name
- VCAM (NCT06986122)
- Testing
- Pain Threat Manipulation, Pain Controllability Manipulation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College