Clinical trials: Memory Complaint
Alzheimer's Disease
Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease
Recent data show that marked cell damage precedes the clinical manifestation of Alzheimer's disease (AD). Hence, targeting populations at risk with pharmacological interventions is a possible strategy to lessen the burden of the…
- Trial name
- NCT00933608
- Testing
- memantine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Subjective Cognitive Decline (SCD), Subjective Cognitive Impairment
Testing the Cog-Fun Aging Program for Older Adults With Subjective Cognitive Decline
The goal of this clinical trial is to learn if the Cog-Fun Aging program helps older adults with Subjective Cognitive Decline (SCD) manage memory challenges and improve their daily lives.
- Conditions
- Subjective Cognitive Decline (SCD), Subjective Cognitive Impairment, Subjective Memory Complaints
- Trial name
- NCT06816797
- Testing
- Cog Fun Ageing intervention, Cog-Fun Aging Crossover
- Where
- 3 sites in Israel
- Volunteers
- 27 people
- Sponsor
- Hebrew University of Jerusalem
Memory Deficits, tACS
tACS Improves Memory in Elders With Subjective Memory Complaints
Subjective memory complaints (SMC), the main cognitive component of which is event memory, is a predictor of Alzheimer's disease in elderly people.
- Trial name
- NCT05569902
- Testing
- active tACS
- Where
- Iran
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Tehran
Patient With Bipolar Disorder, Euthymic Status
Cognitive Remediation on Patients With Bipolar Disorder and Memory Complaints
Bipolar disorder is a major health concern. Intercritical periods are marked with residual symptoms, both thymic and cognitive, which affects quality of life of patients, but also the quality of observance.
- Conditions
- Patient With Bipolar Disorder, Euthymic Status, Wirh Memory Complaints
- Trial name
- COGMED (NCT02988518)
- Testing
- COGMED program
- Where
- France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Montpellier
Planned RRSO
E2 and LDX for the Treatment of Cognitive Complaints After Oophorectomy
This project seeks to address cognitive disturbance, which is a frequent adverse sequelae of riskreducing bilateral salpingo-oophorectomy (RRSO) with or without post-procedure chemotherapy and adjunctive treatments.
- Trial name
- E2LDX (NCT01986764)
- Testing
- Lisdexamfetamine, Estradiol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy Adults With Subjective Memory Complaints
Effects of HX106 on Improvement in Cognitive-Bio-Markers of Memory Function
The objectives of the current study are to evaluate the efficacy and safety of HX106 in healthy adults with subjective memory complaints for improving cognitive and neurobiolgoical markers of memory.
- Trial name
- NCT01956097
- Testing
- HX106 590mg, HX106 1180mg
- Where
- South Korea
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University
Mental Health, Cognition
Short-term Effect of Glucose and Sacharose Ingestion on Cognitive Performance and Mood in Elderly
The objective of the current study is to determine the acute effect of a glucose drink and a sacharose drink compared to a placebo on cognitive performance in elderly with light memory complaints.
- Conditions
- Mental Health, Cognition, Memory, Attention
- Trial name
- NCT01427231
- Testing
- glucose, sacharose
- Where
- Netherlands
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Cognitive Impairment, RRSO
IMProving Executive Function Study
This is a double-blind, placebo-controlled, crossover study testing whether Vyvanse (lisdexamfetamine; LDX) improves executive functioning (EF) in 100 postmenopausal women who report onset of EF difficulties after oophorectomy.
- Trial name
- IMPRES (NCT03187353)
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Acquired Brain Injury (Including Stroke)
Evaluation of the Karman Line Memory Strategy Training
Rationale: Acquired brain injury (ABI) often results in memory deficits that can have a big impact on social and vocational functioning of patients.
- Trial name
- NCT06774287
- Testing
- Karman Line memory strategy training, Treatment as usual
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Klimmendaal Revalidatiespecialisten
Mild Cognitive Impairment
Effects of rTMS on the Cognition of Elderly With Mild Memory Complaints
Memory is constituted by a set of mental abilities of information processing that will be available at a later time. Flawless performance depends on several brain systems and other cognitive domains.
- Trial name
- TMSMemOld (NCT01292382)
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- University of Sao Paulo General Hospital
Mild Cognitive Impairment, Memory Disorders
Cognitive Training and Neuroplasticity in Mild Cognitive Impairment
The purpose of this study is to evaluate if systematic cognitive training can improve cognitive performance in participants (55 and older) with memory loss.
- Conditions
- Mild Cognitive Impairment, Memory Disorders, Memory Impairment, Cognitive Impairment
- Trial name
- CogTraining (NCT03205709)
- Testing
- Computerized Cognitive Training, Crossword Puzzles
- Where
- 2 sites in United States
- Volunteers
- 107 people
- Sponsor
- New York State Psychiatric Institute
Hypertension
Walking Exercise on Memory, Subjective Cognitive Complaint, and Brain-derived Neurotrophic Factor for Hypertension
The purpose of this study is to determine the effect of 6-month aerobic walking program on memory, subjective cognitive complaints, and brain-derived neurotrophic factor for older hypertensive women.
- Trial name
- NCT04930263
- Testing
- Aerobic exercise, control group
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- National Taiwan University Hospital
Subjective Memory Complaint
Subjective Memory Complaints' Cognitive Intervention
This study will be divided into two parts: development of the mobile medical application for older adults with subjective memory decline and the intervention application.
- Trial name
- SMCCI (NCT05720585)
- Testing
- Intervention of mobile health application
- Volunteers
- 10 people
- Sponsor
- Hongli Chen
Subjective Memory Loss in Older Persons
Study of the Effects of Cerefolin NAC on Inflammation Blood Markers in Older Individuals With Memory Complaints
The purpose of this six-month research study is to determine if Cerefolin NAC reduces levels of substances in the blood that may be associated with thinking ability and the health of brain cells in subjects with memory concerns…
- Trial name
- NCT00597376
- Testing
- Cerefolin NAC (a medical food)
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Rush University Medical Center
Healthy Adults With Subjective Memory Complaints
Effects of Deer Bone Extract NS on Improvement in Cognitive-Bio-Markers of Cognitive Functions
This study aims to elucidate the effects of deer bone extract NS on cognitive function improvement and its safety in healthy adults aged 40 to 65 years who report decline in subjective cognitive functions using multimodal…
- Trial name
- NCT02379481
- Testing
- NS 550mg, NS 1100mg
- Where
- South Korea
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University
Cognitive Impairment
Vascular Alteration and Evolution of Cognitive Impairment
In the cross sectional study "Adelahyde 1" which took place between 2001 and 2005, the investigators data suggest that vascular alterations may play a role in the setting of subjective memory complaints.
- Trial name
- ADELAHYDE2 (NCT01351961)
- Testing
- blood sampling, brain MRI and TEP cerebral, Assessment of cognitive functions
- Where
- France
- Volunteers
- 131 people
- Sponsor
- Central Hospital, Nancy, France
Subjective Cognitive Decline (SCD), Subjective Cognitive Complaints (SCCs)
The Signature of Alzheimer's Disease in Subjective Cognitive Decline
This study focuses on improving early detection of Alzheimer's disease (AD) in patients with subjective cognitive decline (SCD), a preclinical stage of cognitive impairment, in the context of emerging disease-modifying therapies…
- Conditions
- Subjective Cognitive Decline (SCD), Subjective Cognitive Complaints (SCCs), Subjective Cognitive Impairment, Subjective Cognitive Concerns
- Trial name
- SIGN-AL (NCT07402161)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS Policlinico S. Donato
Active Aging Individuals Aged 65 and Over, Aging
Italian Validation of the dNA Scale and Its Correlation With Neurocognitive Variables
The goal of this experimental multicentric intervention study is to validate, in Italian, the dynamic Neurocognitive Adaptation (dNA) Scale, which has already been validated in English, among a healthy elderly population (aged 65…
- Conditions
- Active Aging Individuals Aged 65 and Over, Aging, Mild Cognitive Impairment (MCI), Dementia
- Trial name
- NCT07533084
- Where
- 8 sites in Italy
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Cerebrovascular Function, Cognition
Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity
People who report subjective memory complaints have a greater risk of developing dementia. Memory issues may be an early warning sign of dysfunctional cerebral glucose metabolism and cerebral blood flow.
- Trial name
- NCT05992571
- Testing
- β-OHB
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cognitive Impairment, Memory Complaint
Performance of AclarusDx® a Blood-Based Transcriptomic Test for AD, in French Patients Newly Referred to a Memory Center
The purpose of this study is to assess the performance of AclarusDx™, an investigational blood test detecting gene expression information, and intended to help physicians in making an Alzheimer's Disease diagnosis in patients…
- Conditions
- Cognitive Impairment, Memory Complaint, Clinical Investigation in Memory Centers
- Trial name
- DIALOG (NCT02221661)
- Volunteers
- 606 people
- Sponsor
- Diaxonhit