Clinical trials: Memory Deficit
Alzheimer Dementia, Alzheimer Disease
SAD Phase I Study (First-in-human) to Investigate Contraloid Acetate
This is a single-center first-in-human single-ascending-dose clinical trial assessing the safety and tolerability of oral dosing of Contraloid acetate in healthy volunteers.
- Trial name
- NCT03944460
- Testing
- Contraloid
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Dieter Willbold
Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder
Network Control TMS fMRI
This study uses different types of functional magnetic resonance imagining (fMRI) to generate individual transcranial magnetic stimulation (TMS) targets.
- Conditions
- Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder, Working Memory
- Trial name
- NCT05736458
- Testing
- Transcranial Magnetic Stimulation (TMS), High controllability TMS target
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Aging, Memory Impairment
Neurocognitive Study for the Aging-a Longitudinal Study With a Greek Cypriot Cohort
The Neurocognitive Study for the Aging (NEUROAGE) was initially funded by the Cyprus Innovation Foundation and has received subsequent funding by the European Union Regional Development Fund.
- Conditions
- Aging, Memory Impairment, Cognitive Decline, Mild Cognitive Disorder
- Trial name
- NEUROAGE (NCT01481246)
- Testing
- Categorization training, Psychosocial and Psychoeducational Group training
- Where
- Cyprus
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Cyprus
Schizophrenia
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory
Deficits in working memory (WM) performance are the most significant cognitive impairments in schizophrenia (SCZ). It has also been shown that WM performance is contingent on the cortex synchronization, a process that relies on…
- Trial name
- NCT01494623
- Testing
- repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Memory Deficits
Neurophysiological Effects of Whole Coffee Cherry Extract in Older Adults
This study was designed to characterize the changes in the brain and body associated with whole coffee cherry extract (WCCE). WCCE is a patented extract of whole coffee fruit (coffee berries) from coffea arabica.
- Trial name
- NCT03812744
- Testing
- Whole coffee cherry extract (WCCE)
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Auburn University
Mild Cognitive Impairment, Alzheimer Disease
Trial of CORT108297 to Attenuate the Effects of Acute Stress in the Allocortex (CORT-X)
CORT-X will examine if mitigation of stress-mediated pathogenesis of Alzheimer's disease (AD) is a feasible target for intervention in individuals at risk for this disease.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Memory Impairment
- Trial name
- CORT-X (NCT04601038)
- Testing
- CORT108297
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Memory Impairment
Memory Intervention for Older Adults - (Social)
Research shows that there are a plenitude of interventions that can be used to enhance memory for older adults; however, the evidence as to whether these interventions enhance memory for daily activities is equivocal.
- Trial name
- Social (NCT02499991)
- Testing
- memory
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Mild Cognitive Impairment (MCI)
Enhancing Attention in Elderly Using a Brain-Computer-Interface
Cognitive reserve refers to the brain's ability to maintain cognitive performance despite age-related changes or neuropathology.
- Trial name
- NCT07441122
- Testing
- transcranial electrical stimulation, Mindfulness Meditation
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
LETHE-AT: a Personalized Multidomain Lifestyle Intervention for Individuals at Increased Risk of Memory Impairment.
The goal of this clinical trial is to learn whether a hybrid multidomain lifestyle program can prevent cognitive decline and reduce dementia risk in community-dwelling adults in mid- to late life who are at increased risk of…
- Trial name
- LETHE-AT (NCT07376135)
- Testing
- A tailored hybrid multidomain lifestyle intervention group, Self-guided multimodal lifestyle advice group
- Where
- 3 sites in Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Alzheimer Disease, Mild Memory Disturbance
The MObile AssessMENT of Behavioral and Psychological Symptoms of Dementia in Amnestic MCI and AD (MOMENT) Study
The purpose of this research study is to learn whether it is possible and useful for caregivers to report behavioral or psychological symptoms of people with mild memory problems or Alzheimer's disease through a smartphone mobile…
- Conditions
- Alzheimer Disease, Mild Memory Disturbance, Mild Cognitive Impairment
- Trial name
- MOMENT (NCT04482036)
- Testing
- Mobile Phone Application Assessments, Standard Assessments
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Indiana University
COVID Long-Haul, COVID-19
Neural and Cognitive Consequences of COVID-19 Survival
The novel coronavirus SARS-CoV-2 infection, COVID, continues to rage throughout the world with 115,000,000 confirmed cases and over 2,500,000 deaths (as of Mar 3, 2021).
- Conditions
- COVID Long-Haul, COVID-19, COVID-19 Pandemic, Brain Fog
- Trial name
- NCT06208943
- Testing
- cross-sectional MRI and EEG assessments (NO INTERVENTION)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- San Francisco Veterans Affairs Medical Center
Birth Outcome, Adverse, Self Efficacy
The Door to the Womb at Birth: Haptonomy
Purpose: This study aimed to examine the effect of haptonomy application on the expectant mother's birth expectations, experiences, birth self-efficacy, birth memory and reminder during labor.
- Conditions
- Birth Outcome, Adverse, Self Efficacy, Memory Impairment, Pregnancy Related
- Trial name
- NCT06508554
- Testing
- Haptonomy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Trakya University
Healthy
Assessment Of The Effects Of Single Doses Of An Investigational Drug, Given Alone Or With Donepezil, On Scopolamine-Induced Changes In Memory And Learning In Healthy Adults
This study is designed to look at the potential for an investigational drug (PF-04995274, under development by Pfizer, Inc. as a potential treatment for Alzheimer's disease) to reverse changes in memory and learning/problem…
- Trial name
- NCT01345864
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Pfizer
Amnesia, Alzheimer Disease
OCT-Angiography and Adaptive Optics in Patients With Memory Impairment
Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI : amnestic mild cognitive impairment), or to other…
- Conditions
- Amnesia, Alzheimer Disease, Lewy Body Disease, Parkinsons Disease With Dementia
- Trial name
- OCTAVO (NCT04389437)
- Testing
- Ophthalmological exam, Blood pressure measurement
- Where
- France
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Memory Problems
Brain Fitness APP for Aging With a Healthy Brain
Memory and cognitive declines are associated with normal brain aging but are also precursors to dementia, in particular the so called the pandemic of the century, Alzheimer's disease.
- Trial name
- NCT03600545
- Testing
- Brain Fitness App
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Age-associated Memory Impairment
Effect of BrainPhyt High Dose on Cognitive Function in Healthy Older Individuals
The purpose of this study is to evaluate if BrainPhyt, a microalgae based ingredient may affect cognitive function parameters in older healthy individuals with evidence of age-related cognitive decline.
- Trial name
- PHAEO-FOUR (NCT05759910)
- Testing
- Brainphyt high dose
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Microphyt
Cognitive Function, Mood
The Effects of Efalex Active 50+ on Cognitive Performance, Well-being and Cerebral Hemodynamics in Healthy Older Adults
Dietary intake of omega-3 polyunsaturated fatty acids (n-3 PUFAs) is inversely associated with cognitive decline and dementia (e.g. Kalmijn et al. 2004, Heude et al. 2003, Morris et al. 2005, Dullemeijer et al. 2009).
- Conditions
- Cognitive Function, Mood, Well-being, Cerebral Blood Flow
- Trial name
- NCT01185379
- Testing
- Efalex active 50+, DHA rich fish oil
- Where
- United Kingdom
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Exercise, Gait
Rhythmically Entrained Exercise in Community-Dwelling Older Adults
Researchers at the University of North Carolina at Greensboro conduct a single-arm intervention trial to investigate the efficacy of a music-based group exercise program for community-dwelling older adults.
- Conditions
- Exercise, Gait, Cognitive Decline, Caregiver Burden
- Trial name
- REECO (NCT05462977)
- Testing
- Group exercise program
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Greensboro
Memory Deficits, tACS
tACS Improves Memory in Elders With Subjective Memory Complaints
Subjective memory complaints (SMC), the main cognitive component of which is event memory, is a predictor of Alzheimer's disease in elderly people.
- Trial name
- NCT05569902
- Testing
- active tACS
- Where
- Iran
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Tehran
Schizophrenia
Schizophrenia Sensory Gating Deficit With Quetiapine
The purpose of this study is the use of magnetoencephalography or MEG (a machine that measures magnetic activity in your brain) and electroencephalography or EEG (a technique that measures electrical activity in your brain) to…
- Trial name
- NCT00536783
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- New Mexico VA Healthcare System