Clinical trials: Memory Disorder
Alzheimer's Disease
Imaging of Cognition, Learning, and Memory in Aging
This investigation is designed to study how the brain functions when it is performing explicit memory tasks, and furthermore how the brain systems supporting performance on these tests change as a function of aging.
- Trial name
- NCT01297114
- Testing
- Florbetaben
- Where
- United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- Yaakov Stern
Schizophrenia, Schizoaffective Disorder
Brain Health and Exercise in Schizophrenia
To determine the effects of aerobic exercise on hippocampal volumes and severity of psychotic symptoms in a population of psychosis patients compared to healthy age/gender matched volunteers.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Poor Memory
- Trial name
- PEHP (NCT01392885)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- BC Mental Health and Addictions Research Institute
Alzheimer Disease, Dementia
A Mobile Informatics Solution to Aid in Memory
The researchers propose to develop an informatics system to assist people with memory impairment. Persons with Memory Concern (PWMC) recognize the faces they see daily, such as a spouse or caregiver, but they may confuse visiting…
- Trial name
- NCT04700540
- Testing
- Smartwatch Reminder (SR) system
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Alcohol Use Disorder, Alcohol Dependence
Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders
The purpose of this study is to examine the effects of rapamycin (sirolimus) versus a placebo, an inactive substance, on responses to alcohol cues in individuals with alcohol use disorder.
- Trial name
- NCT03732248
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Schizotypal Personality Disorder, SPD
A D1 Agonist For Working Memory
The purpose of the study is to examine the effects of the administration of a drug called DAR-0100A on attention and memory in persons with schizotypal personality disorder (SPD).
- Trial name
- NCT02507206
- Testing
- DAR 0-100A
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Antonia New
Healthy Aging, Memory Disorders in Old Age
Noninvasive Temporal Interference Stimulation: Modulating Associative Memory by Targeting Deep-brain Targets
Alzheimer's disease and its preclinical stages are characterized by progressive neurodegenerative changes in the hippocampi and default mode network resulting in dysfunctions in episodic memory and its central part the…
- Conditions
- Healthy Aging, Memory Disorders in Old Age, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- Deep-HiPs (NCT05805215)
- Testing
- Non-invasive Temporal Interference stimulation and Face-name association training task targeting the hippocampus, Non-invasive Temporal Interference stimulation and Face-name association training task targeting the Precuneus
- Where
- Czechia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Healthy, Mild Cognitive Impairment
tES Effects on Associative Memory Performance
Previous studies showed that transcranial electric stimulation (tES) applied over the prefrontal cortex improves cognitive performance in healthy elderly adults as well as in patients suffering from mild cognitive impairment or…
- Conditions
- Healthy, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT03351452
- Testing
- real anodal transcranial direct current stimulation, real transcranial alternating current stimulation
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Bern
Chronic Insomnia
Impact of Insomnia Treatment on Brain Responses During Resting-state and Cognitive Tasks
Individuals with chronic insomnia have persistent difficulty falling and staying asleep, as well as complaints of altered daytime functioning that may be associated with cognitive impairments.
- Trial name
- NCT04024787
- Testing
- Cognitive-Behavioural therapy for insomnia (CBT-I)
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Concordia University, Montreal
HIV Infections
Perspective Memory and Executive Functions in HIV+ Patients
The primary goal of this observational study is to evaluate prospective memory in HIV+ patients compared to healthy subjects. The secondary goal is to examine the relationship between prospective memory and Hot Cognition…
- Trial name
- (3514) (NCT05752578)
- Testing
- Neuropsychological testing
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Dementia
Going Down Memory Lane: A Technological Intervention
Over 90% of people living with dementia (PLWD) experience behavioural and psychological symptoms of dementia, including apathy, depression, sleep disruptions, wandering, repetitive behaviours and anxiety.
- Trial name
- NCT04131374
- Testing
- Reminiscence Therapy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Alzheimer Disease, Alzheimer Disease, Late Onset
Effectiveness of Alzheimer's Universe (Www.AlzU.Org) on Knowledge and Behavior
To evaluate the effectiveness of an online educational course on Alzheimer's disease (AD) prevention, treatment and caregiving.
- Conditions
- Alzheimer Disease, Alzheimer Disease, Late Onset, Memory Loss, Patient Education as Topic
- Trial name
- NCT03149380
- Testing
- Web-based education
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Migraine Disorders, Brain
Audition After a Lesion and in Migraine. (AuditionPostLesion)
The project studies auditory processing after brain damage (in temporal and/or frontal areas) and in migraine. The auditory processes investigated are attention, short-term memory, sound-induced emotions.
- Trial name
- NCT02791997
- Testing
- Neuropsychological tests, Neurophysiological tests
- Where
- 2 sites in France
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Schizophrenia
Schizophrenia Sensory Gating Deficit With Quetiapine
The purpose of this study is the use of magnetoencephalography or MEG (a machine that measures magnetic activity in your brain) and electroencephalography or EEG (a technique that measures electrical activity in your brain) to…
- Trial name
- NCT00536783
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- New Mexico VA Healthcare System
Memory Impairment
The Efficacy of Phosphatidylserine-Omega3 in Elderly Subjects With Memory Impairment
The primary objective of this trial is to assess the ability of Phosphatidylserine-Omega3 to improve cognitive performance in elderly subjects with memory impairment.
- Trial name
- NCT00736034
- Testing
- Phosphatidylserine-Omega3 (SharpPS™-Gold)
- Where
- Israel
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Enzymotec
Brain Damage, Chronic
The Effect of tDCS on Subcortical Brain Functioning
This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain abilities related to cognition, emotion and/or physical functioning in individuals with subcortical brain damage.
- Trial name
- NCT01602276
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Dementia
Two Interventions for Early Stage Dementia: A Comparative Efficacy Trial
Alzheimer's disease (AD) is increasing exponentially, with a projected quadrupling of cases by the mid 21st century. Individuals with AD are at increased risk for a host of medical and psychiatric conditions, and evidence is…
- Trial name
- NCT01550718
- Testing
- ESML-EX (Physical Activity Program), ESML-Social (Social Activity Program)
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Washington
Dementia, Mild Cognitive Impairment
Dual-Task Training for People With Mild Cognitive Impairment and Mild Dementia
Evidence shows that people with dementia have a higher prevalence of sleep disturbance, cognitive decline, behavioral disturbance, and experience motor dysfunction. These symptoms are interrelated.
- Conditions
- Dementia, Mild Cognitive Impairment, Older Adult
- Trial name
- DTT (NCT06348810)
- Testing
- Dual-task training, Cognitive training, Motor training
- Where
- Indonesia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Traumatic Brain Injury
Prospective Memory in Children With Traumatic Brain Injury
Prospective memory (PM) is memory to complete future tasks, such as recalling to give a note to someone when you next see them, pick up milk on the way home, or remembering to keep an appointment.
- Trial name
- NCT00061399
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
HIV Infections, Memory
Prevalence and Predictors of Neurocognitive Impairment Among HIV-infected Patients
Despite the advent of highly active antiretroviral therapy (HAART), the prevalence of neurocognitive impairment among HIV-infected patients continues to be an important issue.
- Trial name
- NCT00893815
- Where
- 3 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
COVID-19
Lymph Node Aspiration to Decipher the Immune Response of Beta-variant Recombinant Protein Booster Vaccine (VidPrevtyn Beta, Sanofi) Compared to a Bivalent mRNA Vaccine (Comirnaty Original/Omicron BA.4-5, BioNTech-Pfizer) in Adults Previously Vaccinated With at Least 3 Doses of COVID-19 mRNA Vaccine.
In order to investigate whether a germinal center response occurs following vaccine boost and to characterize it based on the type of vaccine received, we aim to analyze Spike and/or RBD-specific germinal center B cells within…
- Trial name
- LymphoBOOST (NCT05951920)
- Testing
- Lymph node aspiration / Blood sampling
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris