Clinical trials: Memory Functions
Real HD-tDCS, Sham HD-tDCS
Determining the Specificity of High Definition Electrical Brain Stimulation Using Simultaneous Magnetoencephalography
Non-invasive human brain stimulation using weak transcranial direct-current stimulation (tDCS) has been thousands of times in research studies over the past fifteen years as a therapy to help improve the effectiveness of repeated…
- Conditions
- Real HD-tDCS, Sham HD-tDCS, Visual Task, Motor Task
- Trial name
- NCT02060708
- Testing
- HD-tDCS
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Aging, Alzheimer Disease
Links Between Cognitive Deficits During Normal or Pathological Aging and Slow Waves Measured in EEG
With age, memory processes (encoding, consolidation and retrieval) as well as daytime vigilance are altered. Sleep is also impaired in older adults, notably slow waves that are known to play a key role in memory consolidation.
- Trial name
- MemoAge (NCT06501495)
- Testing
- video polysomnography, Attention task
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Memory Functions, Cognition
Test-Retest Reliability of DiaMem
The goal of this observational study is to learn how reliable the DiaMem memory assessment tool is when used repeatedly over a short period.
- Trial name
- NCT07416019
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Lifestyle Risk Reduction
EMuNI Project: Multiple Nonpharmacological Interventions
By 2030, the global prevalence of Alzheimer's Disease (AD) is predicted to reach 65.7 million worldwide. Despite extensive research efforts, a cure for AD has not been identified.
- Trial name
- EMuNI (NCT03382353)
- Testing
- Nutritional supplementation, Educational training, Counselling on a brain-healthy diet
- Where
- 2 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Healthy
Effects of Sage Extracts on Cognitive Function During Aerobic Exercise
Extracts of sage have been reported to interact with central nervous system (CNS) mechanisms relevant to cognitive performance but, to date, no trial has clearly demonstrated the possible effects in healthy individuals in…
- Trial name
- NCT04804657
- Testing
- Sage extracts Cognivia
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Burgundy
Depression, Inflammation
Simvastatin and Emotional Processing (OxSTEP)
Simvastatin is being employed because it is a 'statin'. As a drug class, statins have broad anti-inflammatory properties. Low-level inflammation is thought to be a potentially important mediator of the effects of psychosocial…
- Trial name
- OxSTEP (NCT04973800)
- Testing
- Simvastatin 20mg
- Where
- United Kingdom
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Aging, Noninvasive Brain Stimulation
Memory Enhancement in Aging With Closed-Loop tACS
This project optimizes high-resolution tACS to improve memory in healthy older adults, advancing drug-free approaches for ADRD. We test stimulation schedules and develop an adaptive, brain-guided tACS system to strengthen…
- Conditions
- Aging, Noninvasive Brain Stimulation, Memory
- Trial name
- NCT07722598
- Testing
- Peak Frequency, Phase Lag, Peak Frequency + Phase Lag
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Individuality
Effects of Hydrocortisone on Social Cognition and Memory
The effects of hydrocortisone on cognition will be investigated.
- Trial name
- CORT-COG (NCT02478021)
- Testing
- Hydrocortisone
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Alzheimer Disease, Dementia
Movement Intervention for Memory Enhancement
Dancing is a complex sensorimotor rhythmic activity that integrates cognitive, physical, and social components and is applicable to seniors with various fitness levels.
- Conditions
- Alzheimer Disease, Dementia, Cognitive Decline, Cognitive Impairment
- Trial name
- MIME (NCT03475316)
- Testing
- Social Dancing, Treadmill Walking
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Major Depressive Disorder
Memory Enhancement by Gamma-hydroxybutyrate vs. Trazodone in Major Depressive Disorder.
30 healthy adults and 30 patients with major depressive disorder, will take part in three single-application pharmacological interventions (GHB vs. Trazodone vs.
- Trial name
- NCT04082806
- Testing
- GHB, Trazodone
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Erich Seifritz
Memory
BDNF Levels After Bacopa
Brain-derived neurotrophic factor (BDNF) is a well-known neurotrophic factor important for learning, memory, and synaptogenesis.
- Trial name
- NCT03974399
- Testing
- Bacopa Monnieri
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Roskamp Institute Inc.
Healthy Participants, Healthy Population
Evaluate the Safety and Feasibility of tACS With the Miamind Neurostimulator in Healthy Participants
The present study aims to assess the safety and feasibility of repeated transcranial alternating current stimulation (tACS) by the Miamind Neurostimulator in a cohort of healthy participants.
- Trial name
- MindStim (NCT05999916)
- Testing
- Personalized Miamind Neurostimulator
- Where
- Switzerland
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Bottneuro AG
Aging, Memory Loss
Couples Health Aging, Rhythms and Sleep Study
Alzheimer's disease and related dementias (ADRD), including mild cognitive impairment (MCI), are becoming among the most prevalent causes of disability, death and healthcare costs worldwide.
- Trial name
- CHARMS (NCT05952284)
- Where
- United States
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- University of Utah
Sleep Deprivation, Sleep
The Evolution of Memories Across Wake and Sleep
To further understanding of the relationship between sleep and memory the investigators will address and attempt to answer three questions, (1) how memories evolve across wake and sleep, (2) how different aspects of this memory…
- Trial name
- NCT03227406
- Testing
- Sleep deprivation, Nap
- Where
- United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
LETHE-AT: a Personalized Multidomain Lifestyle Intervention for Individuals at Increased Risk of Memory Impairment.
The goal of this clinical trial is to learn whether a hybrid multidomain lifestyle program can prevent cognitive decline and reduce dementia risk in community-dwelling adults in mid- to late life who are at increased risk of…
- Trial name
- LETHE-AT (NCT07376135)
- Testing
- A tailored hybrid multidomain lifestyle intervention group, Self-guided multimodal lifestyle advice group
- Where
- 3 sites in Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cognitive Control, Memory
Synchronization of Theta to Influence Memory
This study aims to clarify relations between brain oscillations and two cognitive functions: cognitive control and memory.
- Trial name
- STIM (NCT07468279)
- Testing
- STARSTIM Device in-phase, STARSTIM Device anti-phase
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Florida International University
Brain Health, Longevity
L-serine and Strength Training in the Elderly
This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older…
- Conditions
- Brain Health, Longevity, Cognitive Performance, Strength Training Effects
- Trial name
- AAAging (NCT07466290)
- Testing
- Strength training, L-serine supplementation, Control (cornstarch)
- Where
- Austria
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Intellectual Disability, Perceptual Disorders
Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood
The purpose of this study is to determine the relationships between sedative exposure during pediatric critical illness and long-term neurocognitive outcomes.
- Conditions
- Intellectual Disability, Perceptual Disorders, Memory Disorders
- Trial name
- RESTORE-cog (NCT02225041)
- Where
- 31 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Memory Losses, Amnesia-Memory Loss
Effect of Affective Content on Drug Induced Amnesia of Episodic Memory
The purpose of this research is to understand how some of the drugs commonly used in anesthesia impair memory. We are particularly interested in whether the emotion associated with a memory influences how well these drugs are…
- Trial name
- NCT00142493
- Testing
- Propofol, Thiopental Sodium, Dexmedetomidine Hydrochloride
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Mild Cognitive Impairment, Traumatic Brain Injury
Neuromodulation and fMRI in Neurodegenerative Diseases Study
In addition to neuronal loss, dysfunction in brain network connectivity has been identified as a correlate of cognitive deficits in neurodegenerative and post-traumatic brain injury states.
- Conditions
- Mild Cognitive Impairment, Traumatic Brain Injury, Neurodegeneration
- Trial name
- NCT06873750
- Testing
- Transcranial Alternating Current Stimulation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
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