Clinical trials: Memory Functions
Memory Loss, Cognitive Changes
Aging and Estrogen on Cortical Function
This study will focus on how estrogen affects parts of the brain associated with memory and how the effect of estrogen is altered with aging in postmenopausal women.
- Conditions
- Memory Loss, Cognitive Changes, Postmenopausal Symptoms
- Trial name
- NCT01268046
- Testing
- Estradiol oral capsule, transderman estrogen patch
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Bilateral Hearing Loss
Pilot Study of the Feasibility and Efficacy of Working Memory Training in Children With Cochlear Implants
This study is an investigation of the effect of a computer-based working memory training program on memory and language processing in at-risk children (e.g., those with working memory weaknesses) who have received cochlear…
- Trial name
- NCT00763243
- Testing
- Cogmed Working Memory Training Program
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Indiana University
Traumatic Brain Injury
Memantine for Neuroprotection and Cognitive Enhancement Following Traumatic Brain Injury
The purpose of this study is to determine if memantine can improve cognitive and neuropsychiatric outcomes after severe traumatic brain injury.
- Trial name
- NCT02240589
- Testing
- Memantine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Indiana University
Memory Impairment, Alzheimer's Disease
Roflumilast and Donepezil to Reverse Scopolamine Induced Cognitive Deficits in Healthy Adults
The purpose of this study is to determine whether scopolamine-induced cognitive impairment is attenuated by the administration of roflumilast in combination with donepezil.
- Trial name
- NCT02051335
- Testing
- Roflumilast, Donepezil, Scopolamine
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Volunteers
Effect of Transcranial Magnetic Stimulation to the Frontoparietal Attention Network on Anxiety Potentiated Startle
Background: Researchers want to better understand brain processes related to fear and anxiety. They want to find out if transcranial magnetic stimulation (TMS), a type of brain stimulation, can reduce anxiety.
- Trial name
- NCT03027414
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- National Institute of Mental Health (NIMH)
Memory Consolidation
The Impact of Reactivation During Sleep on the Consolidation of Abstract Information in Humans
In any given cognitive domain, representations of individual elements are not independent but are organized by means of structured relations.
- Trial name
- NCT05746299
- Testing
- Congruent vs. Incongruent, Immediate vs. Awake vs. Asleep, Targeted memory reactivation (TMR)
- Where
- United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
BPG Intervention, Control
Neurodevelopmental Assessment of Children in Uganda and Malawi Using a Software Package
The investigators will use Brain Power Games as a neurocognitive "stress test" or medical "challenge" test, in order to evaluate or improve brain/behavior functional integrity in HIV-affected children.
- Trial name
- NCT03878147
- Testing
- Cognitive Games Training
- Where
- 2 sites in Malawi, Uganda
- Volunteers
- 599 people
- Sponsor
- Michigan State University
Mild Cognitive Impairment
Rhythmic Light Therapy for Alzheimer's Disease Patients
The investigator will investigate how light delivering 40 hertz (Hz) affects subjective sleep and cognition in a controlled laboratory study.
- Trial name
- NCT05015478
- Testing
- Tailored Rhythmic Lighting Intervention
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Memory, Dexmedetomidine
A Pilot Study to Assess the Amnesic Properties of Dexmedetomidine in Pediatric Patients
The goal of this study is to determine the effects of dexmedetomidine on memory and recall of children who are receiving dexmedetomidine sedation administered for magnetic resonance imaging (MRI) studies.
- Trial name
- NCT02354378
- Testing
- Dexmedetomidine, Memory Test
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Boston Children's Hospital
Aging
Enhancing Memory Consolidation in Older Adults
The purpose of this research study is to understand the neural mechanisms underlying long-term memory formation in older adults. Both sleep and memory decrease with age.
- Trial name
- NCT03657212
- Testing
- Zolpidem
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Infections, Streptococcal
Long-term Follow-up Study of Children Previously Primed With GSK Pneumococcal Vaccine (GSK1024850A) and of Unprimed Children
The objective of this study is to evaluate the immune memory through the administration of an additional dose of GSK Biologicals' pneumococcal conjugate vaccine GSK1024850A, the antibody persistence and long-term effect on…
- Trial name
- NCT00950833
- Testing
- Pneumococcal vaccine GSK1024850A
- Where
- 10 sites in Czechia
- Volunteers
- 466 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dementia, Alzheimer Disease
Care to Plan: a Tailored Resource for Family Members of Persons With Dementia
The present study will refine and conduct a preliminary efficacy evaluation of Care to Plan. Care to Plan is an online care planning tool that provides a succinct and clear overview of various types of dementia caregiver…
- Conditions
- Dementia, Alzheimer Disease, Memory Loss
- Trial name
- NCT03901456
- Testing
- Care to Plan, Usual Care
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cognitive Aging
Intervention Comparative Effectiveness for Adult Cognitive Training
The study will compare the effect of broad and directed (narrow) technology-based training on basic perceptual and cognitive abilities in older adults and on the performance of simulated tasks of daily living including driving…
- Trial name
- ICE-ACT (NCT03141281)
- Testing
- BrainHQ, Rise of Nations, IADL Training
- Where
- United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Florida State University
Schizophrenia, Schizoaffective Disorder
Remediation of Working Memory in Schizophrenia
The primary aim of the study is to test the efficacy of a novel cognitive remediation intervention that targets working memory-related functions.
- Trial name
- NCT00995553
- Testing
- Cognitive Remediation, Computer Skills
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- VA Office of Research and Development
Working Memory
Traveling-wave Transcranial Electric Stimulation
This study will assess the impact of traveling wave transcranial alternating current stimulation (tACS) on working memory performance in adults.
- Trial name
- TravelingTES (NCT05399381)
- Testing
- Transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Heart Transplantation
Multi-Drug Desensitization Protocol for Heart Transplant Candidates
Background: Patients may develop antibodies (human leukocyte antigen [HLA] alloantibodies) to other human tissues via pregnancy, transfusions or previous transplantation, which limits the ability to find an acceptable donor heart…
- Trial name
- NCT01556347
- Testing
- Bortezomib, Thymoglobulin, Rituximab, Gamimune N, (IVIG), Plasmapheresis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Providence Health & Services
Asthma, Rheumatic Disease
Acetaminophen (Tylenol) for Mood and Memory Changes Associated With Corticosteroid Therapy
Studies in humans and animals support that stress and/or elevations in corticosteroids lead to changes in hippocampal structure and functioning.
- Trial name
- NCT00377364
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Stress Disorders, Post-Traumatic
Real-time fMRI and Neurofeedback of Brain Networks Mediating Trauma Memory Recall in PTSD
The purpose of the current study is to develop a better understanding of the brain mechanisms involved in psychological treatments for posttraumatic stress disorder (PTSD).
- Trial name
- NCT02500719
- Testing
- Computational Model - Real-time Support Vector Machine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
HIV
Exercise Training to Improve Brain Health in Older HIV+ Individuals
Management and treatment of older persons living with HIV (PLWH) (≥ 40 years old) is becoming increasingly more complex as a majority is greater than 40 years old.
- Trial name
- Ex/HIV (NCT02663934)
- Testing
- Exercise, Stretching and Social Interaction
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Washington University School of Medicine
Acute Myeloid Leukemia
Cytokine Induced Memory-like NK Cell Adoptive Therapy for Relapsed AML After Allogeneic Hematopoietic Cell Transplant
Donor Lymphocyte Infusion (DLI) following salvage chemotherapy is the one of the most widely used treatment approaches in patients who relapse after allogeneic hematopoietic cell transplant (allo-HCT).
- Trial name
- NCT03068819
- Testing
- CIML NK Cell Infusion, CD3+ T Cell Product Infusion, Leukapheresis
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Washington University School of Medicine