Clinical trials: Meniere Disease
Vestibular Schwannoma, Visual Impairment
Consequence of Unilateral Vestibular Loss on Visual Abilities
Unilateral vestibular lesions are frequent and disabling pathologies causing a set of oculomotor, postural and perceptual symptoms. These symptoms reduce over time according to a vestibular compensation.
- Conditions
- Vestibular Schwannoma, Visual Impairment, Vestibular Meniere Syndrome
- Trial name
- SVorthoptie (NCT03581331)
- Testing
- orthoptic balance
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Ménière
Minimally Invasive Vestibular Neurectomy Versus Tenotomy of the Stapedius and Tensor Tympani Muscles in the Management of Patients With Unilateral Meniere's Disease
The distinctive symptoms of Meniere's disease (MD) include recurrent vertigo spells, fluctuating hearing loss, aural fullness and tinnitus.
- Trial name
- NCT04847700
- Testing
- Surgical treatment
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Meniere's Disease, Ménière's Vertigo
Study of Lamotrigine to Treat Ménière's Disease
This double-blinded study evaluates the frequency of vertigo attacks and the quality of life of patients diagnosed with Ménière's disease after being randomly assigned to take a placebo or lamotrigine.
- Conditions
- Meniere's Disease, Ménière's Vertigo, Vertigo, Intermittent, Vertigo, Aural
- Trial name
- NCT02158585
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Dent Neuroscience Research Center
Meniere's Disease
Modulating Auditory Symptoms and Vertigo of Meniere's Disease by Non-invasive Mastoid Electric Stimulation
This study is a Double-blind, Randomized, Sham-controlled, Investigator-initiated trial. To explore the effectiveness of non-invasive inner ear electrical stimulation of the mastoid behind the ear in controlling auditory symptoms…
- Trial name
- NCT06001593
- Testing
- YPS-201b, betahistine
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Seoul National University Hospital
Hearing Loss, Sudden, Hearing Loss, Ototoxic
Verification of the Efficacy/safety of the Intratympanic Drug Delivery for Hearing Loss
This study is a prospective, randomized pilot study. To verify an efficacy and safety of the Intratympanic drug delivery vehicle, patients who have not responded to the existing standard treatment will be enrolled.
- Conditions
- Hearing Loss, Sudden, Hearing Loss, Ototoxic, Hearing Loss, Noise-Induced, Meniere Disease
- Trial name
- NCT04766853
- Testing
- Dexamethasone, Hyaluronic acid
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Seoul National University Hospital
Sudden Sensorineural Hearing Loss, Meniere Disease
Evaluation of the Diagnostic and Prognostic Efficacy of MRI in Acute Sensorineural Hearing Loss and Ménière's Disease
Evaluation of the diagnostic and prognostic efficacy of nuclear magnetic resonance imaging in patients with acute sensorineural hearing loss or in patients suffering from probable or definite MD.
- Conditions
- Sudden Sensorineural Hearing Loss, Meniere Disease, Ménière's Vertigo, Meniere's Disease Aggravated
- Trial name
- MRI_SSHL/MD (NCT06278129)
- Testing
- Vestibular myogenic potentials
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Ménière's Disease
Pharmacokinetic Profile of Betahistine With and Without Selegiline in Healthy Volunteers
The goal of this pharmakokinetic trial is to demonstrate that Betahistine serum concentration is higher after combination treatment with Betahistine and Selegiline compared to Betahistine alone.
- Trial name
- PK-BesT (NCT05938517)
- Testing
- Betahistine dihydrochloride, Selegiline-hydrochloride
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Vertigo, Meniere Disease
Effect of Stellate Ganglion Block on Meniere's Disease
Stellate ganglion block (SGB) has been the alternative treatment of Meniere's disease for years. However, objective evidence of the effect of SGB was still lack.
- Trial name
- NCT01574313
- Testing
- stellate ganglion block, 0.25mg, fludiazine, 25mg cephadol@ (diphenidol)
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Chi Mei Medical Hospital
Meniere Disease
Imaging of Endolymphatic Hydrops at 7T MRI
Imaging endolymphatic hydrops with 7T Sodium Imaging and 1.5 T gadolinium enhanced imaging: a comparison of diagnostic outcomes with 3T MRI Duration of study 24 months Study design Prospective cohort study Number of patients 16…
- Trial name
- NCT04370366
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- King's College Hospital NHS Trust
Meniere Disease
Phase 3 Study of OTO-104 in Subjects With Unilateral Meniere's Disease
The purpose of this study is to evaluate the effectiveness of OTO-104 for the treatment of Meniere's disease.
- Trial name
- NCT03664674
- Testing
- OTO-104
- Where
- 65 sites in United States, Belgium and 6 more
- Volunteers
- 148 people
- Sponsor
- Otonomy, Inc.
Meniere's Disease
Efficacy of Antiviral Medications in Controlling Vertigo Attacks of Patients With Meniere's Disease
Meniere's disease is a chronic illness that affects a substantial number of patients every year worldwide. The disease is characterized by intermittent episodes of vertigo lasting from minutes to hours, with fluctuating…
- Trial name
- NCT01729767
- Testing
- Acyclovir
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Tehran University of Medical Sciences
Meniere's Disease, Enlarged Vestibular Aqueduct Syndrome
Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets
Background: Disorders of hearing instability (HI) are poorly characterized and ineffectively treated. HI can cause fluctuations in hearing thresholds and speech understanding.
- Conditions
- Meniere's Disease, Enlarged Vestibular Aqueduct Syndrome, Autoimmune Inner Ear Disease
- Trial name
- NCT04806282
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Tinnitus
Caroverin and Inner Ear Diseases
This trial is a randomized, double blind, placebo controlled study on patients suffering from inner ear diseases with tinnitus as a principal symptom.
- Trial name
- NCT01174979
- Testing
- Caroverin
- Where
- Austria
- Volunteers
- 170 people
- Sponsor
- Phafag AG
Meniere Disease
Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Healthy Subjects (HYDROPS)
This prospective study aims to better characterize inner ear's perilymphatic structures with Magnetic Resonance Imaging using contrast media and delayed injection in healthy subjects MR Perfusion Imaging will be assess in both…
- Trial name
- HYDROPS (NCT02529475)
- Testing
- Gadoteric acid
- Where
- 3 sites in France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Meniere Disease, Vertigo
Safety of APSLXR in Patients Presenting Vertigo of Vestibular Origin or Meniere's Disease
The purpose of this study is to evaluate the safety of APSLXR in participants with Meniere's disease or other Verigo of vestibular origin. Pharmacokinetics will also be evaluated in a small group.
- Conditions
- Meniere Disease, Vertigo, Vertigo Vestibular
- Trial name
- NCT04674735
- Testing
- APSLXR
- Sponsor
- Apsen Farmaceutica S.A.
Meniere's Disease
Effects of Endolymphatic Sac Drainage With Steroids for Meniere's Disease
Meniere's disease is a common inner ear disease with an incidence of 15-50 per 100,000 population. Since Meniere's disease is thought to be triggered by an immune insult to inner ear, we examined intra-endolymphatic sac…
- Trial name
- EDSS (NCT00500474)
- Testing
- endolymphatic sac drainage with steroids
- Where
- Japan
- Volunteers
- 197 people
- Sponsor
- Osaka University
Meniere's Disease
OTO-104 for Meniere's Disease
The purpose of this study is to evaluate the safety of OTO-104 in subjects with unilateral Meniere's disease. The effectiveness of OTO-104 to reduce the symptoms of Meniere's disease will also be evaluated.
- Trial name
- NCT01084525
- Testing
- OTO-104 (steroid) 3 mg, OTO-104 (steroid) 12 mg
- Where
- 15 sites in United States
- Volunteers
- 44 people
- Sponsor
- Otonomy, Inc.
Unilateral Acoustic Neuroma, Meniere's Disease
Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach
The goal of this project is to determine whether subjects who have undergone labyrinthectomy or a translabyrinthine surgical approach as the treatment for vestibular schwannoma or Meniere's disease benefit from cochlear…
- Trial name
- NCT02309099
- Testing
- Cochlear Implant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of North Carolina, Chapel Hill
Meniere's Disease
Sildenafil For Meniere's Disease
Meniere's disease affects a person's sense of balance. An attack can last 20 minutes to 2 hours or longer. Symptoms include rotational vertigo, hearing loss, tinnitus and a sensation of fullness in the affected ear and may be…
- Trial name
- NCT00145483
- Testing
- Sildenafil
- Where
- 4 sites in Australia
- Volunteers
- 163 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Meniere Disease, Ménière
SPI-1005 for the Treatment of Meniere's Disease
The study is a randomized, double-blind, placebo-controlled, multi-center clinical trial (RCT) with open-label extension study (OLE), of SPI-1005 in adult subjects with definite Meniere's disease with active symptoms within three…
- Trial name
- STOPMD-3 (NCT04677972)
- Testing
- Ebselen
- Where
- 12 sites in United States
- Volunteers
- 220 people
- Sponsor
- Sound Pharmaceuticals, Incorporated