Clinical trials: Meningitis/Encephalitis
Systemic Lupus Erythematosus
Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus
The purpose of this study is to determine whether Libman-Sacks endocarditis (inflammation of the heart valves) is the cause of neuropsychiatric manifestations (stroke, transient ischemic attacks, cognitive dysfunction, seizures…
- Trial name
- NCT00858884
- Testing
- Clinical and laboratory evaluations, transesophageal echocardiography, carotid duplex, transcranial duplex, and magnetic resonance of the brain
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of New Mexico
Encephalitis
Investigating the Role of Early Intravenous Immunoglobulin Treatment for Children With Encephalitis
This is a phase III multi-centre randomised, double blind, placebo controlled trial to assess the role of intravenous immunoglobulin in the treatment of children with encephalitis.
- Trial name
- IgNiTE (NCT02308982)
- Testing
- Immunoglobulins, Intravenous (Privigen)
- Where
- 25 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Oxford
Acquired Brain Injury, Stroke/ Cerebrovascular Accident (Ischemic or Hemorrhagic)
Regulating Emotions and Behaviors After Brain Injury
After acquired brain injury (ABI), persons can experience emotional and behavioral difficulties, that can be painful both for the person and his/her family.
- Conditions
- Acquired Brain Injury, Stroke/ Cerebrovascular Accident (Ischemic or Hemorrhagic), Brain Tumor (After Recovery), Encephalitis
- Trial name
- GREMO-LCA (NCT05393492)
- Testing
- Dialectical Behavior Therapy and Radically Open dialectical behavior therapy
- Where
- France
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Ventilator Associated Bacterial Pneumonia (VABP), Hospital Acquired Bacterial Pneumonia (HABP)
Safety, Pharmacokinetics and Efficacy of BV100 Plus Low Dose Polymyxin B Plus Ceftazidime/Avibactam, or Plus Cefiderocol in Patients With Pulmonary and Extrapulmonary Infections Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex
This Phase IIb study aims to evaluate the safety and efficacy of BV100 in combination with low dose polymyxin B plus ceftazidime/avibactam or cefiderocol in patients with suspected or confirmed CRABC infections.
- Conditions
- Ventilator Associated Bacterial Pneumonia (VABP), Hospital Acquired Bacterial Pneumonia (HABP), Blood Stream Infection, Meningitis, Bacterial
- Trial name
- RIV- CARE (NCT07431307)
- Testing
- BV100 with 50 mg polymyxin B plus ceftazidime/avibactam, BV100 with 50 mg polymyxin B plus cefiderocol, Best Available Therapy (BAT)
- Volunteers
- 120 people
- Sponsor
- BioVersys AG
Traumatic Brain Injury, Intracranial Hemorrhages
Improving Diagnosis and Prediction of Outcome in Patients With Severe Disorders of Consciousness
Patients with acute severe brain injury are usually admitted to the Intensive Care Unit. A substantial proportion of these patients will have disorders of consciousness (DOC) after interruption of sedation.
- Conditions
- Traumatic Brain Injury, Intracranial Hemorrhages, Subarachnoid Hemorrhage, Meningitis
- Trial name
- IMPROVE-DOC (NCT06283901)
- Where
- 5 sites in Netherlands
- Volunteers
- 160 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
West Nile Fever
An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease
Although the serious form of West Nile Virus (WNV) disease, referred to as neuroinvasive disease, is rare, it can result in permanent disabilities and occasionally death.
- Trial name
- NCT00091845
- Testing
- AVI-4020 Injection
- Volunteers
- 50 people
- Sponsor
- Sarepta Therapeutics, Inc.
Tick Bites, Encephalitis
Evolving Diagnostic Approaches to Undocumented Lymphocytic Meningitis and Meningoencephalitis
Tick-borne encephalitis (TBE) is a viral infection transmitted by ticks. TBE is the third most common cause of encephalitis in France.
- Conditions
- Tick Bites, Encephalitis, Meningitis, Viral Encephalitis
- Trial name
- CHAN-MEE (NCT07186881)
- Testing
- Recommendation from the infectious diseases team
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Central Nervous System (CNS) Infection, Encephalitis
Establishment of Prevention and Control System of Central Nervous System Infection
Central nervous system (CNS) infection is a common nervous system acute and severe disease, mainly manifested as encephalitis, meningitis and meningoencephalitis, but also manifested as brain abscess and brain granuloma et al.
- Conditions
- Central Nervous System (CNS) Infection, Encephalitis, Meningitis
- Trial name
- NCT04722328
- Testing
- CSF metagenomic next generation sequencing (mNGS)
- Where
- China
- Volunteers
- 715 people
- Sponsor
- Xuanwu Hospital, Beijing
Cryptococcal Meningitis
Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDS
The aim of the study is to evaluate systematic pre-antiretroviral cryptococcal antigen screening and pre-emptive fluconazole therapy in antigen positive patients, as a strategy to reduce morbidity and mortality due to AIDS…
- Trial name
- PreCASA (NCT02624453)
- Testing
- Fluconazole, Antiretroviral therapy
- Where
- Cameroon
- Volunteers
- 186 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Angiostrongylosis, Hypereosinophilia
Research for Angiostrongylus Cantonensis and Costaricensis in French West Indies and French Guiana
Hospitals in the French West Indies (Fort-de-France (Martinique); Basse-Terre and Pointe-à-Pitre (Guadeloupe); and French Guiana (Cayenne, Saint-Laurent du Maroni)) have noted the emergence of eosinophilic meningitis cases in…
- Trial name
- ACCRAG (NCT03378882)
- Testing
- Parasitic serologies, Biopsy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital Center of Martinique
Neuropsychiatric Systemic Lupus Erythematosus
Magnetic Resonance Spectroscopy, Perfusion, and Diffusion Tensor Imaging in Neuropsychiatric Lupus
The purpose of this study is to determine if three functional Magnetic Resonance brain imaging techniques: Magnetic Resonance Spectroscopy(MRS),Magnetic Resonance perfusion, and Diffusion Tensor Imaging(DTI) can detect brain…
- Trial name
- NCT00730002
- Testing
- Magnetic Resonance Angiography (MRA), Magnetic resonance imaging, MRA
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Aquired Brain Injury, Stroke
Group-based Emotional Awareness and Expression Therapy to Support Recovery After Acquired Brain Injury: A Clinical Development and Evaluation Study
Difficulties in understanding and managing emotions may hinder recovery, rehabilitation, and participation in everyday life after acquired brain injury (ABI).
- Conditions
- Aquired Brain Injury, Stroke, MTBI - Mild Traumatic Brain Injury, mTBI
- Trial name
- NCT07852936
- Testing
- TAU + Group Therapy (EAET), Treatment as Usual (TAU)
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Uppsala University
Encephalitis, Meningitis
Stem Cell Transplantation In-patient With Neurological Sequelae Due to Encephalitis or Meningitis
To evaluate the safety and efficacy of autologous bone marrow-derived mononuclear cell transplantation in-patient with neurological sequelae due to encephalitis or meningitis
- Trial name
- NCT04080921
- Testing
- Stem cell transplantation
- Where
- Vietnam
- Volunteers
- 22 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Central Nervous System Infections, Bacterial Meningitis
Central Nervous System Infections in Denmark
The Danish Study Group of Infections of the Brain is a collaboration between all departments of infectious diseases in Denmark. The investigators aim to monitor epidemiological trends in central nervous system (CNS) infections by…
- Conditions
- Central Nervous System Infections, Bacterial Meningitis, Viral Meningitis, Aseptic Meningitis
- Trial name
- DASGIB (NCT03418441)
- Testing
- Community-acquired CNS infections
- Where
- 8 sites in Denmark
- Volunteers
- 1,900 people
- Sponsor
- Aalborg University Hospital
Myasthenia Gravis, Guillain-Barre Syndrome
Neurology Inpatient Clinical Education Trial
The objective of this study is to compare the effectiveness of a personalized patient education program to the current hospital education and evaluate its impact using patient satisfaction scores.
- Conditions
- Myasthenia Gravis, Guillain-Barre Syndrome, Multiple Sclerosis, Seizures
- Trial name
- NCT03826056
- Testing
- Current standard discharge educational intervention, Personalized discharge educational intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Seizure, Febrile Seizure
Nervous System Infections Among Patients With Febrile Seizure
Few studies dealing with the risk of infectious of nervous system and the utility of lumbar puncture and of emergent neuroimaging among patients with simple febrile seizure between 3 and 11 months age and with complex seizure has…
- Conditions
- Seizure, Febrile Seizure, Meningitis, Encephalitis
- Trial name
- NCT01694524
- Where
- 7 sites in France
- Volunteers
- 1,200 people
- Sponsor
- Hôpital Armand Trousseau
Acute Brain Injury
The NEUROlogically-impaired Extubation Timing Trial
This randomized controlled trial will enrol patients with acute severe brain injury who pass a spontaneous breathing trial but have decreased level of consciousness. It will directly compare (1) prompt extubation vs.
- Trial name
- NEURO-ETT (NCT02920580)
- Testing
- Extubation, Usual Care
- Where
- 13 sites in Canada
- Volunteers
- 27 people
- Sponsor
- Sunnybrook Health Sciences Centre
Meningoencephalitis, Other Syndromes Requiring Lumbar Puncture in Emergency Department
Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients
Of all emergency room patients, persons presenting with encephalitis/meningitis syndrome of a potentially infectious nature are among those of greatest concern.
- Trial name
- NCT02207647
- Testing
- no intervention
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Olive View-UCLA Education & Research Institute
Meningitis/Encephalitis
Clinical Evaluation of the FilmArray® Meningitis/Encephalitis (ME) Panel
The FilmArray Meningitis/Encephalitis (ME) Panel (hereinafter referred to as FilmArray ME Panel) is a qualitative multiplexed nucleic acid-based in vitro diagnostic test intended for use with FilmArray systems.
- Trial name
- NCT03895281
- Testing
- FilmArray Meningitis/Encephalitis (ME) Panel
- Volunteers
- 150 people
- Sponsor
- Shanghai Children's Medical Center