Clinical trials: Menopause
Menopause
Effect of Menopause Relief EP-40 in Women With Menopausal Symptoms
This study compares the efficacy of a fixed combination of black cohosh (EP-40) and Rhodiola rosea (EPR-7) with low (6.5 mg) and high doses (500 mg) of a standardized black cohosh extract only in adult woman with menopausal…
- Trial name
- NCT03461380
- Testing
- Menopause Relief EP-40, Low Dose Black Cohosh, High Dose Black Cohosh
- Where
- Georgia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- EuroPharma, Inc.
Menopausal, Dementia
Development of a Personalized, Psychosocial Intervention for Menopausal Individuals With Elevated Dementia Risk
By age 45, women's lifetime risk of dementia is estimated to be 1 in 5. Two-thirds of people currently living with a dementia diagnosis are women, and-women make up the majority of carers for people with dementia.
- Trial name
- PERI-MIND (NCT06965686)
- Testing
- PERI-MIND
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Chicago
Muscle Mass and Strength, Menopause
Significance of Estrogen Status for Muscle Function, Physical Fitness, and Physiological Health Parameters - a Comparison of Age-matched Groups of Women Before and After Menopause.
As females age and transition through menopause, the decline in oestrogen level profoundly affects skeletal muscle mass and function.
- Trial name
- HER-MUSCLEX (NCT07649356)
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mette Hansen
Breast Cancer
A Study of Neoadjuvant Letrozole + Taselisib Versus Letrozole + Placebo in Post-Menopausal Women With Breast Cancer (LORELEI)
This is a two-arm, randomized, double-blind, multicenter, pre-operative study to evaluate the effect of combining letrozole and GDC-0032 (also known as taselisib) versus letrozole and placebo in postmenopausal women with estrogen…
- Trial name
- NCT02273973
- Testing
- Letrozole, Taselisib
- Where
- 117 sites in United States, Australia and 20 more
- Volunteers
- 334 people
- Sponsor
- Genentech, Inc.
Breast Cancer
Protocol for Postmenopausal Women at Increased Risk of Developing Breast Cancer
To examine nipple aspirate fluid for secretions that may be identified as a high risk indicator for development of breast cancer, and compare those to serum analysis.
- Trial name
- NCT00291083
- Where
- United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Carol Fabian, MD
Mammographic Density
Enobosarm and Anastrozole in Pre-menopausal Women With High Mammographic Breast Density
To evaluate the impact of a selective androgen receptor modulator combined with an aromatase inhibitor in reducing high mammographic breast density.
- Trial name
- NCT03264651
- Testing
- enobosarm
- Where
- Australia
- Volunteers
- 9 people
- Sponsor
- Havah Therapeutics Pty Ltd
Post Menopausal Vaginal Atrophy
Efficacy of Fractional CO2 Laser Treatment in Post-Menopausal Women With Vaginal Atrophy
Vaginal dryness, itching, burning, irritability, secretion, and various urinary problems are the symptoms of vulvovaginal atrophy.
- Trial name
- NCT06726746
- Testing
- Fractional CO2 laser
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Menopause, Opinions
Opinion of Brazilian Gynecologists on Hormone Therapy for Menopause and Prescriptive Habits
To evaluate Brazilian gynecologists, through structured online questionnaires, with questions directed to their opinions and prescriptive habits about menopause hormone therapy.
- Conditions
- Menopause, Opinions, Hormone Replacement Therapy
- Trial name
- NCT05072756
- Testing
- Applying a questionnaire
- Where
- Brazil
- Volunteers
- 1,339 people, healthy volunteers welcome
- Sponsor
- Faculdade de Medicina do ABC
Menopause
The Effect of Music Therapy on Sleep Quality and Depression in Menopausal Women
About one-third of women experience no or mild symptoms during their menopausal life, while another third experience moderate symptoms, while the remaining one-third may experience severe symptoms.
- Trial name
- NCT05545761
- Testing
- music therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Meryem Vural Şahin
Metastatic Breast Cancer
PhIb BKM120 or BEZ235+Endocrine Treatment in Post-Menopausal Patients With Hormone Receptor + Metastatic Breast Cancer
This is an open-label phase Ib multi-institution trial that evaluates the safety profile/tolerability and preliminary anti-tumor effect of BKM120 (a PI3K inhibitor) and endocrine therapy combination and BEZ235 (a PI3K/ mTOR…
- Trial name
- NCT01248494
- Testing
- BEZ235, BKM 120, Letrozole
- Where
- 6 sites in United States
- Volunteers
- 72 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Menopausal Symptoms, Menopause Symptom Management
A Randomized Controlled Trial of Menopausal Tool/App for Women
The purpose of this study is about assessing the utilization of a mobile phone application (app), designed to improve the menopause experience of midlife women experiencing related symptoms and its association with…
- Trial name
- NCT06919887
- Testing
- EMMII, Comparison Group
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Mayo Clinic
Metastatic Breast Cancer
Phase I/II Trial of Letrozole and Sorafenib in Post-Menopausal Hormone-Receptor + Breast Cancer
Letrozole is an aromatase inhibitor that is approved in the first-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer.
- Trial name
- NCT00634634
- Testing
- Sorafenib, Letrozole
- Where
- 4 sites in United States
- Volunteers
- 52 people
- Sponsor
- Rutgers, The State University of New Jersey
Postmenopausal Osteoporosis
A Study of Quarterly Intravenous Bonviva (Ibandronate) in Women With Post-Menopausal Osteoporosis.
This single arm study will assess the efficacy and safety of quarterly intravenous Bonviva in women with post-menopausal osteoporosis. All patients will receive Bonviva 3mg i.v. every 3 months.
- Trial name
- NCT00493532
- Testing
- ibandronate [Bonviva/Boniva]
- Where
- 14 sites in Taiwan
- Sponsor
- Hoffmann-La Roche
Osteoporosis
Role of Oxytocin in Post-menopausal Osteoporosis: Evaluation on the Population of the OPUS Cohort
Oxytocin is a neurohypophysial hormone involved in several central and peripheral functions including parturition, milk let-down reflex and social behaviour.
- Trial name
- NCT01192893
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Advanced Breast Cancer
Study to Assess the Safety of Alpelisib Plus Fulvestrant, in Men and Post-menopausal Women With HR-positive, HER2-negative, Advanced Breast Cancer (aBC) With PIK3CA Mutation, Whose Disease Progressed on or After Endocrine Treatment
The purpose of this study was to determine the safety of alpelisib plus fulvestrant in men and post-menopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, advanced or…
- Trial name
- ALPINIST (NCT05631795)
- Testing
- Alpelisib, Fulvestrant
- Where
- 12 sites in India
- Volunteers
- 40 people
- Sponsor
- Novartis Pharmaceuticals
Bacterial Vaginosis, Candidiasis
Vaginal Ecosystem and Network in the United States Study
The central premise of this study is that the intricate balance and diversity of the vaginal microbiome plays a pivotal role in the onset, progression, and severity of various gynecological conditions.
- Conditions
- Bacterial Vaginosis, Candidiasis, Urinary Tract Infections, Genitourinary Syndrome of Menopause
- Trial name
- VENUS (NCT06472765)
- Testing
- Vaginal Swab Collection
- Where
- 21 sites in United States, Canada
- Volunteers
- 3,250 people, healthy volunteers welcome
- Sponsor
- Vaginal Biome Science
Menopause, Obesity
Brown Adipose Tissue Activity in Pre- and Postmenopausal Women
The physiological relevance of brown adipose tissue (BAT) in humans is largely unknown. The investigators have shown that suppressing ovarian function in premenopausal women reduces resting energy expenditure (REE), and this is…
- Trial name
- NCT02927392
- Testing
- Leuprolide acetate
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cardiovascular Diseases, Heart Failure, Congestive
Estrogen, Cytokines and Heart Failure in Women
To determine the effects of estrogen therapy on postmenopausal women with congestive heart failure.
- Conditions
- Cardiovascular Diseases, Heart Failure, Congestive, Heart Diseases, Menopause
- Trial name
- NCT00041431
- Testing
- Hormone Replacement Therapy
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Menopause, Perimenopause
Effects of Hemp-Derived Cannabinoids on Menopause Symptoms
The purpose of the study is to examine the impact of hemp-derived minor cannabinoids on symptoms of menopause/perimenopause.
- Trial name
- NCT07393672
- Testing
- Hemp-derived cannabinoids
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Washington State University
Menopausal Depression
Effects of Estrogen and Hot Flashes on Mood in Postmenopausal Women
This protocol is a controlled study of estradiol therapy in early postmenopausal women with and without frequent hot flashes that will be used to determine whether hot flashes are an important intermediary in the generation of…
- Trial name
- NCT01126801
- Testing
- Estradiol
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
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