Clinical trials: Mental Deterioration
Hypertension, Cognitive Decline
Implementation of Multifaceted Patient-Centered Treatment Strategies for Intensive Blood Pressure Control in Minimize Cognitive Decline
The study will test a multifaceted strategy for implementing an intensive blood pressure intervention protocol targeting systolic BP <120 mmHg on cognitive decline in racial minority and low-income hypertensive patients in…
- Trial name
- IMPACTS-MIND (NCT04797403)
- Testing
- Stepped-care protocol adapted from the SPRINT intensive-treatment algorithm
- Where
- United States
- Volunteers
- 1,306 people, healthy volunteers welcome
- Sponsor
- Tulane University
Aging, Cardiovascular Risk Factor
A Combined Multidomain Intervention to Prevent Cognitive Decline Associated With Cardiovascular Risk Factors.
The ACTIONcardioRisk trial is designed to investigate the effect of aerobic and progressive resistance training exercises combined with cognitive training, on neurocognitive functioning of sedentary older adults with and without…
- Trial name
- ACTIONcR (NCT04962061)
- Testing
- Cognitive Training, Aerobic and resistance exercises, Stretching and Toning
- Where
- Canada
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Louis Bherer
Cognition Disorders, Brain Pathology
A Precision Rehabilitation Approach to Counteract Age-Related Cognitive Declines
This study examines the behavioral, molecular, and structural biomarkers of brain health that will allow for the stratification of individuals according to their "cognitive signature" and function.
- Conditions
- Cognition Disorders, Brain Pathology, Physical Disability, Physical Activity
- Trial name
- CogEx (NCT03696082)
- Testing
- Aerobic Activity, Resistance Training, Yoga
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cognitive Decline, Executive Dysfunction
Fitness on White Matter and Cognition in Aging
Cardiorespiratory fitness (CRF) is associated with decreased risk for mild cognitive impairment (MCI) and dementia. CRF is linked with more conserved gray and white matter (WM) volume, improved WM microstructural integrity, and…
- Conditions
- Cognitive Decline, Executive Dysfunction, Cardiovascular Risk Factor
- Trial name
- NCT03775941
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- Suffolk University
Cognitive Decline Prevention in Robust Older Adults, Cognitive Decline Prevention in Pre-frail Older Adults
The StayFitLonger Study: an Innovative Computerized Home-based Training to Foster Independent Life at Home
Multimodal training, including physical and cognitive activities, has been associated with a reduction in age-related physical and cognitive decline.
- Conditions
- Cognitive Decline Prevention in Robust Older Adults, Cognitive Decline Prevention in Pre-frail Older Adults, Physical Decline Prevention in Robust Older Adults, Physical Decline Prevention in Pre-frail Older Adults
- Trial name
- SFL (NCT04237519)
- Testing
- SFL training, Active controlled training
- Where
- 4 sites in Belgium, Canada and 1 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Frailty, Cognitive Decline
Precision Stratification for Frailty and Cognitive Decline
The Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB) trial aim to test the effectiveness of an exercise, cognitive and lifestyle intervention amongst older adults over a 12-weeks…
- Trial name
- NCT07081282
- Testing
- Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB), Centre-Based Exercise Health Session
- Where
- Singapore
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Parkinson Disease
Long-term Longitudinal Imaging of Presynaptic Terminals in PD
AIM: To investigate whether SV2A loss spreads from brainstem to cerebral cortex with progression of Parkinson's disease (PD) and to determine whether longitudinal cortical SV2A loss correlates with cognitive decline in PD.
- Trial name
- NCT06875765
- Testing
- 11C-UCB-J PET-CT, 18F-PE2I PET-CT, MRI brain
- Where
- Belgium
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Artificial Intelligence Technology, Cognitive Decline
Preliminary Research Using Artificial Intelligence Technology to Identify Differences in Facial Expressions Between Healthy People, Patients With Cognitive Decline, and Patients With Dementia
Through artificial intelligence technology, we have conducted a preliminary study aimed at identifying differences in facial expressions among healthy individuals, patients with cognitive decline, and dementia patients.
- Conditions
- Artificial Intelligence Technology, Cognitive Decline, Dementia, Identify
- Trial name
- NCT06513403
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cognition Disorders
Longitudinal Evaluation of Amyloid Risk and Neurodegeneration - the LEARN Study
The LEARN study a multicenter, observational study will that will evaluate the rate of cognitive change in approximately 500 clinically normal older individuals who "screen-fail" for the A4 trial on the basis of their screening…
- Trial name
- LEARN (NCT02488720)
- Where
- 40 sites in United States
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Age-related Cognitive Decline
Study on the Chronic and Acute Effects of Nordic Berry Beverage on Cognitive Function
The aim of the current study is to investigate whether acute and 12-weeks daily intake of Nordic berries can improve cognitive abilities of adults without cognitive disease, and whether the effect can be linked to changes in…
- Trial name
- SCANBerry (NCT05693441)
- Testing
- Active berry product, Reference berry-like product
- Where
- Sweden
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Aventure AB
Age-related Cognitive Decline
Remediation of Age-related Cognitive Decline: Vortioxetine and Cognitive Training
The purpose of this research study is to examine the potential benefits of vortioxetine in combination with at-home computerized cognitive training program to improve cognition, such as memory, attention, and concentration.
- Trial name
- BBS (NCT03272711)
- Testing
- Vortioxetine 10 mg, Cognitive training program
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Cognitive Decline, Cognitive Impairment
Serum, Dietary and Supplemental Vitamin D's Association With Cognitive Decline
Serum 25(OH)D, dietary and supplemental vitamin D were shown to influence cognitive outcomes in large epidemiological studies. Sex/age-specific and race-specific associations of vitamin D status and intake were examined with…
- Trial name
- NCT03320109
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 3,720 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Subjective Cognitive Decline
Effects of Online Training Aimed at Increasing Participation in Everyday Life During a Pandemic (SCD Online).
This study evaluates the efficacy of Real-World Strategy Training (RWST) compared to a psycho-education workshop for improving everyday life performance in older adults with subjective cognitive decline (SCD).
- Trial name
- NCT04439500
- Testing
- Real World Strategy Training, Brain Education
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Baycrest
Dementia, Memory Disorders
Preventing Cognitive Decline With Alternative Therapies
Preventing dementia is an important goal for our aging population. This proposal is an initial 42 months study of the effect of standardized ginkgo biloba extract (GBE) on preventing or delaying cognitive decline in people age 85…
- Trial name
- NCT00010920
- Testing
- Ginkgo Biloba Extract
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Arterial Stiffness, White Matter Lesions
Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers
The ACE Trial, funded by the National Institute on Ageing/National Institutes of Health (NIH), is a multicenter clinical trial. The ACE Trial will determine if taking the dietary supplement Equol could slow the progression of…
- Conditions
- Arterial Stiffness, White Matter Lesions, Cognitive Decline
- Trial name
- ACE (NCT05741060)
- Testing
- S-equol
- Where
- 3 sites in United States
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Akira Sekikawa
Subjective Cognitive Decline
Impact of a Cognitive Intervention Enriched With Leisure Activities in Persons With Subjective Cognitive Decline
The team "Cognitive intervention, cognitive reserve and brain plasticity", Team 10, is part of the Canadian Consortium on Neurodegeneration in Aging (CCNA).
- Trial name
- NCT03271190
- Testing
- ENGAGE SPANISH/MUSIC, ENGAGE DISCOVERY
- Where
- 2 sites in Canada
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Ageing
Attention and Memory Training With Video Games in Old Age
Neuroplasticity-based approaches seem very promising to maintain cognitive health in older adults and postpone the onset of cognitive-decline and dementia symptoms. The aims of this project are threefold: 1.
- Trial name
- AGEGAME (NCT02796508)
- Testing
- Experimental: Non-action video game training, Active Comparator: Non-cognitive video game training
- Where
- Spain
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Educación a Distancia
Muscle Weakness, Bone Health
Healthy Older People Everyday (HOPE) - Role of Healthy Diet on Muscle and Bone Health
Certain clinical syndromes eg frailty, sarcopenia, dementia, depression, cognitive impairment, vision impairment and falls in older adults carry an increased risk for poor health outcomes and if identified early, can be…
- Conditions
- Muscle Weakness, Bone Health, Cognitive Decline
- Trial name
- HOPE-DIET (NCT03786835)
- Testing
- Protein supplementation and regular physical activity
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Community-Dwelling Older Adults, Aging
The Efficacy of a Technology-Assisted Block Training Program on Cognitive Function, Hand Dexterity, and Grip Strength in Community-Dwelling Older Adults: A Mixed-Methods Research
Block-building activities represent a promising tool for enhancing cognitive and hand function in older adults. When integrated with technological support, they offer personalized training advantages; however, their comprehensive…
- Conditions
- Community-Dwelling Older Adults, Aging, Cognitive Decline, Hand Dexterity
- Trial name
- NCT07315724
- Testing
- Technology-Assisted Block Training Program
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences