Clinical trials: Mental Health Disorder
Kidney Transplantation, Delirium - Postoperative
A Predictive Model for Postoperative Delirium in Kidney Transplant Patients
This study aims to develop and prospectively validate a machine learning-based prediction model for postoperative delirium in kidney transplant recipients, using perioperative clinical data.
- Conditions
- Kidney Transplantation, Delirium - Postoperative, Cognitive
- Trial name
- NCT07078578
- Volunteers
- 4,800 people
- Sponsor
- Hua Zheng
ADHD
A Feasibility Study of a Support Program for Building New Parent-child Behavioral Habits
This study evaluates the feasibility and preliminary impacts of a new parent support program consisting of a series of educational videos, delivered via a popular texting platform.
- Trial name
- NCT06297135
- Testing
- Behavioral Parent Training
- Where
- 2 sites in Japan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Okinawa Institute of Science and Technology Graduate University
Obsessive-Compulsive Disorder
Trial of MR-guided Focused Ultrasound (MRgFUS) Bilateral Capsulotomy for the Treatment of Refractory Obsessive-compulsive Disorder (OCD)
The proposed study is to evaluate the safety and initial efficacy of MRgFUS for patients with treatment-refractory OCD. This study is designed as a prospective, single arm, nonrandomized study.
- Trial name
- NCT03156335
- Testing
- Focused Ultrasound
- Where
- 2 sites in Canada
- Volunteers
- 12 people
- Sponsor
- Sunnybrook Health Sciences Centre
Opioid-Related Disorders
Informational App Development for mHealth for Patient Self-Management of Opioid Use Disorder
This study will evaluate the feasibility of an app that provides drug information to people in recovery from opioid use disorder. This study is designed to test the prototype app, not to determine health outcomes.
- Trial name
- KIOS-I (NCT05859035)
- Testing
- KIOS Informational App
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Biomedical Development Corporation
Insulin Resistance, Obesity
Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With Obesity
A combination of generally regarded as safe (GRAS) compounds named GLY-LOW, which included: alpha lipoic acid, pyridoxamine, nicotinamide, piperine and thiamine, were examined in pre-clinical experiments.
- Conditions
- Insulin Resistance, Obesity, Cardiovascular Diseases, Cognitive Impairment
- Trial name
- NCT06242535
- Testing
- GLY-LOW
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Hoskinson Health and Wellness Clinic
Tobacco Dependence
Low Nicotine Cigarettes Plus Electronic Cigarettes
This study aims to determine the health effects of very low nicotine content in cigarettes, in conjunction with the availability of nicotine-containing electronic cigarettes (e-cigs) among smokers with mental health conditions…
- Trial name
- NCT04058717
- Testing
- Normal Nicotine Content research cigarettes, High Nicotine e-cigarette, Very Low Nicotine Content research cigarettes
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Pediatric Cancer
The Effect of Biofeedback-Based Virtual Reality Game on Children
The needles of port catheters, which are often used in childhood cancer treatment, must be changed every 5-7 days, which causes pain, anxiety, and fear in children every 5-7 days In recent years, the usage of virtual reality has…
- Trial name
- NCT05585840
- Testing
- Biofeedback-based virtual reality game
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Koç University
Family Conflict, Marital Conflict
Families of Youth with Developmental Disabilities: a Theory-Based Intervention
This study is designed to evaluate a preventive intervention program designed to support families (parents and typically developing adolescent siblings) that include a child with an intellectual and/or developmental disability.
- Conditions
- Family Conflict, Marital Conflict, Communication
- Trial name
- NCT03495440
- Testing
- Center Sessions, At-home
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Liver Disease Chronic, Cirrhosis
cACLD in Patients With Alcohol Use Disorder in the Hospital Detoxification Unit
The aim of this study is to conduct a quick assessment of potential liver damage caused by chronic alcohol consumption. Taking advantage of the patient's admission to a specialized detoxification unit, several tests will be…
- Conditions
- Liver Disease Chronic, Cirrhosis, Detoxification, Alcohol Abuse/Dependence
- Trial name
- HEP-UHD (NCT06838468)
- Testing
- Screening of compensated advance chronic liver disease
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Corporacion Parc Tauli
Alzheimer's Disease
EARTH 413: A Study of Aricept in Hispanic Patients With Mild to Moderate Alzheimer's Disease (AD)
12-week, open-label study to evaluate the effectiveness and safety of donepezil hydrochloride in Hispanic patients with mild to moderate Alzheimer's Disease (AD) in the U.S.
- Trial name
- NCT00230568
- Testing
- Aricept
- Where
- 35 sites in United States
- Volunteers
- 100 people
- Sponsor
- Eisai Inc.
Schizophrenia
A Bioequivalence Study of 15 mg ER OROS Paliperidone
The purpose of this study is to evaluate the bioequivalence between the Phase 3 and the to-be-marketed formulations of extended release (ER) OROS paliperidone and to evaluate the effect of food on the highest to be marketed…
- Trial name
- NCT00892489
- Testing
- ER OROS Paliperidone
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Depression, Major Depressive Disorder
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
Background: Most drugs that treat mood disorders take a long time to work. Ketamine works within hours. A dose can last for a week or more. Certain receptors in the brain might help ketamine work.
- Conditions
- Depression, Major Depressive Disorder, Major Depression
- Trial name
- NCT03973268
- Testing
- Arm 1, 2, 3 device interventions, Arm 2 Interventions, Arm 1, 2, 3 drug Interventions
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Mental Health (NIMH)
Social Anxiety
Variations of Anonymity, Transparency, and Efficacy in Digital Health Applications
Social Anxiety Disorder (SAD) is one of the most widespread mental illnesses and it has previously been shown that online therapy and online self-help tools such as the one investigated in this study can be successful in reducing…
- Trial name
- PRIVATE (NCT06465589)
- Testing
- JOURNeY anonymous, JOURNeY standard
- Where
- Switzerland
- Volunteers
- 452 people
- Sponsor
- University of Bern
Fecal Incontinence, Faecal Incontinence
FENIX™ Continence Restoration System Registry
The FENIX Registry is a multi-center, observational database designed to collect data regarding the FENIX™ Continence Restoration System in everyday clinical practice, evaluate the clinical course of patients from pre-operative…
- Trial name
- NCT04007250
- Testing
- FENIX™ Continence Restoration System
- Where
- 2 sites in France, Germany
- Volunteers
- 94 people
- Sponsor
- Torax Medical Incorporated
Breast Neoplasm, Breast Cancer
Facilitating Adaptive Coping With Fear of Recurrence Among Breast Cancer Survivors
Fear of cancer recurrence (FCR) is a highly prevalent, disruptive, and under-treated problem for breast cancer survivors. This randomized controlled trial will test the efficacy of group-based Acceptance and Commitment Therapy…
- Conditions
- Breast Neoplasm, Breast Cancer, Breast Carcinoma, Malignant Neoplasm of Breast
- Trial name
- NCT05364450
- Testing
- Enhanced Usual Care, Acceptance Commitment Therapy, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- Indiana University
Alzheimer's Disease, Late Onset
Effects of Aerobic Exercise for Treating Alzheimer's Disease
This randomized controlled trial (RCT) will investigate the effects of a 6-month, individualized, moderate-intensity cycling intervention on cognition and hippocampal volume in AD with three aims: Determine the immediate effect…
- Trial name
- FIT-AD (NCT01954550)
- Testing
- Cycling exercise, Range of motion/stretching exercise
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Minnesota
Music Therapy, Perioperative Care
Effect of Music in Intraoperative Period
Background and Aims: Music therapy has a wide range of uses in health care practice. The aim of this study was to investigate the effects of intraoperative music played during spinal anesthesia operation on the patients'…
- Conditions
- Music Therapy, Perioperative Care, Postoperative Pain, Anxiety
- Trial name
- NCT04485650
- Testing
- music therapy, sedated group, non-sedated group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Abant Izzet Baysal University
Postoperative Delirium (POD), Frailty at Older Adults
Associations of Postoperative Delirium With Perioperative Frailty Worsening and Their Combined Effect on 1-Year Mortality in Older Surgical Patients
Postoperative delirium (POD) is a frequent complication in older surgical patients and is associated with adverse outcomes, while frailty is also highly prevalent during the perioperative period.
- Conditions
- Postoperative Delirium (POD), Frailty at Older Adults, Mortality, Recovery of Function
- Trial name
- NCT07259850
- Where
- China
- Volunteers
- 6,196 people
- Sponsor
- Chinese PLA General Hospital
Post-Traumatic Stress Disorder
Healing Touch & Guided Imagery for Posttraumatic Stress Disorder Symptoms
This is a randomized controlled 2 year trial at Camp Pendleton, CA to determine whether a complementary medicine intervention (Healing Touch with Guided Imagery, HT+GI) reduces Posttraumatic Stress Disorder (PTSD) symptoms as…
- Trial name
- NCT01348750
- Testing
- Healing Touch & Guided Imagery
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Scripps Center for Integrative Medicine
Alzheimer Disease
The Effect of Repeated Transcranial Magnetic Stimulation on Off-line Resting Electroencephalographic Signal in Alzheimer's Disease
The purpose of this study is to examine whether the rTMS (repetitive Transcranial Magnetic Stimulation) could change cortical excitability measured by off-line EEG in Alzheimer's Disease (AD) patients.
- Trial name
- NCT01970150
- Testing
- rTMS real
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's