Clinical trials: Mental and Behavioral Disorders
Substance-related Disorders
Effects of Fatty Acid Supplementation on Substance Dependent Individuals
Many substance dependent individuals continue to abuse a variety of substances during treatment for their disorder. Often, substance dependent individuals are co-diagnosed with depression and violence problems.
- Trial name
- NCT00312455
- Testing
- Pro-eicosapentaenoic acid (EPA), Pro-docosapentaenoic acid (DPA)
- Sponsor
- National Institute on Drug Abuse (NIDA)
Colorectal Cancer (Diagnosis), Anxiety
Virtual vs Physical Art Therapy for Anxiety, Psychological Well-being, and Sleep Quality in Colorectal Cancer Patients
This randomized controlled trial aims to evaluate the effects of virtual reality-based art therapy and physical art therapy on anxiety, psychological well-being, and sleep quality in patients with colorectal cancer receiving…
- Conditions
- Colorectal Cancer (Diagnosis), Anxiety, Sleep Disturbance
- Trial name
- PVART-CRC (NCT07464626)
- Testing
- Virtual Reality Art Therapy, Physical Art Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Dokuz Eylul University
Kleptomania
Memantine in the Treatment of Kleptomania
The goal of the proposed study is to evaluate the efficacy and safety of memantine in kleptomania.
- Trial name
- NCT00880685
- Testing
- Memantine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Chicago
Major Depressive Disorder, Alcohol Abuse
Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and Alcoholism
This is a study about treatment for people who suffer from both major depression and alcohol abuse or dependence. The study will examine whether the addition of acamprosate to escitalopram and behavioral interventions will…
- Conditions
- Major Depressive Disorder, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT00452543
- Testing
- acamprosate, escitalopram, Medical management
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorder, Oxytocin
Understanding Oxytocin's Neural and Behavioral Effects in Adolescents Diagnosed With Autism
The investigators explored the neural and behavioral effect of oxytocin on youth with Autism spectrum disorder using magnetoencephalography (MEG).
- Trial name
- NCT05096676
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Prof. Ilanit gordon
Anxiety, Depression Disorders
ABC School Intervention Among Ugandan Adolescents
Schools can be pivotal in addressing mental health challenges, especially in low-income settings like Uganda. This pilot cluster-randomized trial examines the impact of a culturally sensitive Act-Belong-Commit (ACT) intervention…
- Trial name
- NCT06957925
- Testing
- educational
- Where
- 2 sites in Uganda
- Volunteers
- 2,598 people
- Sponsor
- KU Leuven
Postoperative Sleep Quality, Postoperative Behaviour
Sleep Quality - Comparing the Effect of Ondansetron or Dexamethasone Given as Routine Prophylaxis Intraoperatively to Prevent Post Operative Nausea and Vomiting (SCORPION)
Nausea and vomiting are common complications after anaesthesia, and anaesthetists routinely give medications to prevent them. Dexamethasone and ondansetron are the two most commonly used agents and have a long safety record.
- Conditions
- Postoperative Sleep Quality, Postoperative Behaviour, Postoperative Recovery in Children, Postoperative Nausea and Vomiting (PONV)
- Trial name
- SCORPION (NCT07777276)
- Testing
- Dexamethasone (IV), Ondansetron iv
- Where
- 3 sites in Australia, Brazil
- Volunteers
- 500 people
- Sponsor
- Telethon Kids Institute
ADHD
Effect of Feedback and Practice on Probabilistic Decision Making in Attention Deficit and Hyperactivity Disorder
The purpose of this study is to determine how feedback and practice affect decision making in adolescents with attention deficit and hyperactivity disorder.
- Trial name
- NCT01574976
- Testing
- probabilistic choice
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Physician-Family Communication in Intensive Care Units, Surrogate Decision-making for Critically Ill Patients
Family Support Intervention in Intensive Care Units (The Four Supports Study)
The purpose of this study is to test the effectiveness of a multi-faceted communication intervention for family members of critically ill patients to reduce the family members' long-term symptoms of depression and anxiety.
- Trial name
- NCT01107704
- Testing
- Family Support Intervention
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- University of Pittsburgh
Major Depressive Disorder
Efficacy and Safety of Vortioxetine (Lu AA21004) in Treating Adults With Major Depressive Disorder
The purpose of this study is to determine the efficacy and safety of once daily vortioxetine (Lu AA21004) in adults with major depressive disorder.
- Trial name
- NCT00672958
- Testing
- Vortioxetine
- Where
- 33 sites in United States, Canada and 1 more
- Volunteers
- 600 people
- Sponsor
- Takeda
Treatment Resistant Depression
Working Mechanisms and Effectiveness of IV Ketamine-assisted Psychotherapy on Depression in TRD Clients
Ketamine-Assisted Psychotherapy (KAP) is an innovative treatment that combines intravenous ketamine with psychotherapy in a carefully monitored clinical setting.
- Trial name
- NCT07706478
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Senz
Tourette Disorder, Chronic Tic Disorder
Augmentation of Brief Habit Reversal Training With D-cycloserine or Placebo
Expert reviews and practice parameter papers recommend behavior therapy as a first-line intervention for youth with chronic tic disorders (CTDs) with mild-to-moderate tic severity.
- Trial name
- DCS+HRT (NCT02582515)
- Testing
- D-cycloserine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Nicotine Dependence, Cigarettes
Impact of Nicotine Messaging on Nicotine Beliefs and Tobacco Use Behavior
This is a 2-arm, randomized controlled, population based trial to test the impact of multiple exposures to brief nicotine corrective messages among adult tobacco cigarette smokers and non-smokers followed in waves over 12 weeks.
- Trial name
- NCT04805515
- Testing
- Nicotine Corrective Messages
- Where
- United States
- Volunteers
- 794 people
- Sponsor
- University of Vermont
Schizophrenia / Schizoaffective Disorder
Validation and Comparative Multi-Omics Benchmarking of Fluid-Derived Volatilomics Biomarkers for the Prevention and Early Detection of Schizophrenia
Schizophrenia (SZ) is one of the most severe and costly mental disorders in terms of human suffering and societal expenditure. Currently, there are no biomarkers that facilitate the early diagnosis of SZ.
- Trial name
- MZvyagintsev (NCT07876089)
- Where
- Germany
- Volunteers
- 3,692 people, healthy volunteers welcome
- Sponsor
- University Hospital, Aachen
Care Giving Burden, Dementia
E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app
The goal of this clinical trial is to test whether a web-based application called the Pain Control Enhancement App (PACE-app) can support family caregivers in managing pain for their care recipients with dementia.
- Conditions
- Care Giving Burden, Dementia, Chronic Pain, Pain Management
- Trial name
- PACE-app (NCT07032350)
- Testing
- Web-based pain management support tool, Usual Pain Management Care
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Schizophrenia Disorders, Chronic Illness
Evaluating a Collaborative Care Model for the Treatment of Schizophrenia (EQUIP)
Policy makers and consumers are increasingly concerned about the quality and efficiency of care provided to individuals with severe, chronic illnesses such as schizophrenia.
- Conditions
- Schizophrenia Disorders, Chronic Illness, Schizoaffective Disorder, Weight Gain
- Trial name
- NCT00119574
- Testing
- Collaborative Chronic Illness Model
- Where
- United States
- Volunteers
- 443 people
- Sponsor
- US Department of Veterans Affairs
Depression, Anxiety
Effect of General and Non-general Anesthesia on Perioperative Depression or Anxiety
Perioperative depression and/or anxiety play a critical role in patient presentation, satisfaction and outcomes. The aim of this study is to assess the level of perioperative depression and/or anxiety in patients with…
- Trial name
- NCT05315648
- Testing
- anesthesia approach (general anesthesia or non-general anesthesia)
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Cerebral Palsy, Autism
Rehabilitation of Children With Multiple Disabilities
The objective of the study is to compare the usual care and treatment of children and youth (0-19 years) with multiple developmental delays and disabilities and their families in Simcoe York with a co-ordinated, navigated…
- Conditions
- Cerebral Palsy, Autism, Down's Syndrome, Brain Injury
- Trial name
- NCT01379443
- Testing
- CTN model of care for children and their families
- Where
- Canada
- Volunteers
- 445 people
- Sponsor
- Children's Treatment Network
Qigong, Anxiety
Qigong Relaxation Exercise
Objective: This study was conducted to examine the effect of Qigong relaxation exercises applied in a psychiatric clinic on the anxiety and depression levels of patients diagnosed with depression.
- Conditions
- Qigong, Anxiety, Depression, Psychiatric Disorders
- Trial name
- QRE (NCT07294443)
- Testing
- Qigong relaxation exercises, Ongoing treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Saglik Bilimleri Universitesi
Alzheimer Disease
Pilot Study of the Effects of Resveratrol Supplement in Mild-to-moderate Alzheimer's Disease
Objective: To determine the effects of resveratrol extract given in a 215 mg dose in a daily supplement currently available over the counter, on cognitive and global functioning in patients with mild to moderate AD on standard…
- Trial name
- NCT00743743
- Testing
- Longevinex brand resveratrol supplement
- Sponsor
- Medical College of Wisconsin
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