Clinical trials: Mesenchymal Stromal Cells
Mesenchymal Stromal Cell, Systemic Sclerosis
Manufacturing of Allogeneic Adipose Tissue-derived Mesenchymal Stromal Cells for Treatment of Severe Systemic Sclerosis
Mesenchymal stromal cells (MSC) are multipotent cells which carry immunomodulatory, pro-angiogenic and anti-fibrotic properties, that can target Systemic Sclerosis (SSc) pathogenesis and its clinical manifestations.
- Trial name
- Pre_MSC-AT-SSc (NCT05947682)
- Testing
- Adipose tissue harvesting
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Reconstruction, Contour Irregularities
Immunophenotyping of Fresh Stromal Vascular Fraction From Adipose Derived Stem Cells (ADSC) Enriched Fat Grafts
The purpose of this study is to investigate if there is a relationship between the take of fat grafts with and without ADSCs and the presence of specific surface markers on the cells of the stromal vascular fraction.
- Conditions
- Breast Reconstruction, Contour Irregularities, Volume Insufficiency
- Trial name
- NCT01771913
- Testing
- centrifuged fat graft, ADSCs enriched fat graft
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Xerostomia Following Radiotherapy
Treatment of Post-radiation Xerostomia With Allogeneic Mesenchymal Stromal Stem Cells
The goal of this clinical trial is to learn about toxicity of allogeneic mesenchymal stromal stem cells (MSC, derived from umbilical cord tissue) treatment in head and neck cancer patients with for post-radiation xerostomia.
- Trial name
- NCT06012604
- Testing
- allogeneic mesenchymal stromal stem cells
- Where
- 4 sites in Slovenia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institute of Oncology Ljubljana
Osteoarthritis
Mesenchymal Stromal Cells and Osteoarthritis
Osteoarthritis (OA) is one of the most frequent musculoskeletal disorders and represents the main indication for total joint arthroplasty.
- Trial name
- NCT01038596
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Osteoarthritis, Knee, Fractures, Ununited
Modern Methods of Treatment and Diagnosis of Patients With Injuries and Diseases of the Musculoskeletal System
Brief Summary This clinical study investigates the safety and effectiveness of combining advanced regenerative therapies with personalized surgical technology for patients with delayed fracture healing (non-unions), knee…
- Conditions
- Osteoarthritis, Knee, Fractures, Ununited, Arthroplasty, Replacement, Knee
- Trial name
- MTDMS (NCT07628010)
- Testing
- Autologous Mesenchymal Stromal Cells Combined with Platelet-Rich Plasma, Patient-Specific 3D-Printed Surgical Instruments
- Where
- Ukraine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zaporizhzhiya State Medical University
Myelodysplastic Syndromes, Acute Myeloid Leukemia
Constitution of a Biological Cohort Following Bone Marrow Sampling From MDS or AML Patients and Age-matched Healthy Donors
It is of clinical significance to better characterize the intrinsic defects harbored by mesenchymal stromal cells (MSC) in Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) context, as compared to physiological…
- Conditions
- Myelodysplastic Syndromes, Acute Myeloid Leukemia, Cardio-vascular Surgery
- Trial name
- COSMOS (NCT03233074)
- Testing
- Bone marrow analyses
- Where
- 2 sites in France
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Type1 Diabetes Mellitus
Wharton´s Jelly Derived Mesenchymal Stromal Cell Treatment of Adult Patients Diagnosed With Type I Diabetes
To investigate the safety and tolerance after allogeneic infusion of WJMSCs intravenously in adult patients diagnosed with type 1 diabetes.
- Trial name
- NCT03406585
- Testing
- ProTrans: Allogeneic transplantation with WJMSCs
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- NextCell Pharma Ab
Perinatal Arterial Ischemic Stroke, Neonatal Stroke
Perinatal Arterial Stroke Treated With Stromal Cells Intranasally
This study will assess safety and feasibility of bone marrow-derived allogeneic MSCs, administered by the nasal route, in neonates who suffered from PAIS.
- Trial name
- PASSIoN (NCT03356821)
- Testing
- Mesenchymal Stem Cells
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
COVID-19 Acute Respiratory Distress Syndrome, Influenza A
Treatment of Respiratory Complications Associated With COVID19,Influenza ,Metapneumovirus,RSV Infection Using ProTrans®
To investigate the safety and tolerance of a single infusion of ProTrans® in subjects with "severe" respiratory complications associated with pneumonia caused by COVID-19, Influenza A, Metapneumovirus or RSV infection.
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Influenza A, Metapneumovirus Pneumonia, Respiratory Syncytial Virus (RSV)
- Trial name
- NCT04896853
- Testing
- ProTrans®
- Where
- Sweden
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- NextCell Pharma Ab
Cardiovascular Diseases
A Study to Evaluate Mesenchymal Stem Cell Product StromaForte's Effect on Cardiovascular Events
The goal of this phase I/II clinical trial is to evaluate the safety and preventive effect of intravenous infusion of human allogeneic bone-marrow-derived mesenchymal stromal cell product StromaForte in study participants.
- Trial name
- NCT06087848
- Testing
- Human Allogeneic Bone-Marrow-Derived Mesenchymal Stromal Cell Product (StromaForte)
- Where
- The Bahamas
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cellcolabs Clinical LTD.
Chronic Periodontal Disease, Aggressive Periodontitis
Transplantation of Bone Marrow Mesenchymal Stromal Cells for Periodontal Regeneration
The goal of this study is to evaluate the capacity of allogeneic bone marrow mesenchymal stromal cells (MSC) to induce bone regeneration in patients with periodontal disease.
- Trial name
- BMMSC (NCT05975892)
- Testing
- Transplantation of allogeneic MSCs in periodontal disease
- Where
- Venezuela
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto Venezolano de Investigaciones Cientificas
Frailty
A Study of Human Allogeneic Bone-marrow-derived Mesenchymal Stromal Cell Product (StromaForte) in Patients With Aging Frailty
The goal of this phase I/II clinical trial is to evaluate the safety and tolerability of intravenous infusion of human allogeneic bone-marrow-derived mesenchymal stromal cell product StromaForte in patients with aging frailty.
- Trial name
- NCT06070532
- Testing
- Human Allogeneic Bone-Marrow-Derived Mesenchymal Stromal Cell Product (StromaForte)
- Where
- The Bahamas
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cellcolabs Clinical LTD.
Skin Irritation, Healthy Volunteers
Safety of Topical Exosome-Containing Liquid in Healthy Volunteers
This Phase 1 split-site pilot study will evaluate the safety and dermal tolerability of a topical exosome-containing liquid in 10 healthy adult volunteers.
- Trial name
- EV-SAFE-1 (NCT07703969)
- Testing
- Exosome-Containing Liquid, Vehicle Liquid
- Where
- Kazakhstan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- West Kazakhstan Marat Ospanov Medical University
Pelvic Radiation Therapy, Radiation-induced Hemorrhagic Cystitis
Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease, PRD) Refractory to Standard Therapy
Patients receiving radiation therapy are still at risk for side effects due to off-target radiation damage of normal tissues The number of cancer patients is expected to increase from 14.1 million around the world in 2012 to 19.3…
- Trial name
- PRISME (NCT02814864)
- Testing
- Mesenchymal Stromal Cell (MSC) injections
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Primary Myelofibrosis
Role of Mesenchymal Stromal Cell Derived Extracellular Vesicles of Primary Myelofibrosis Patients on CD34+ Cells
The aim of this study is to demonstrate that, in patients with myelofibrosis (PMF), a chronic neoplastic disease of the bone marrow, some of the cells that form the bone marrow microenvironment (mesenchymal stromal cells, MSCs)…
- Trial name
- NCT06896344
- Testing
- In vitro culture
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Healthy Volunteers for Bone Marrow Donation
A Study to Collect Bone Marrow for Process Development and Production of BM-MSC to Treat Severe COVID19 Pneumonitis
The COVID-19 pandemic, commonly referred to as "coronavirus", first began in the city of Wuhan, China in December 2019. This virus has since spread globally, with infections reported in nearly every country.
- Trial name
- COMET20d (NCT04397471)
- Testing
- Bone Marrow Harvest
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- CCTU- Cancer Theme
Delayed Graft Function
Can Fat Derived Stem Cells (SVF) be Used in the Treatment of Erectile Dysfunction After Prostatectomy
Prostate cancer is the most common cancer among Danish men, and the incidence is increasing. Studies have shown a high number needed to treat for each saved prostate cancer related death.
- Trial name
- NCT02240823
- Testing
- adipose derived stem cells
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Martha Haahr M.D
Osteoarthritis, Knee
Mechanisms of Treatment Effects Using Cultured, Allogeneic Mesenchymal Stromal Stem Cells (MSCs) in Knee Osteoarthritis
The goal of this clinical trial is to pharmacologically evaluate the effects of culturued allogeneic umbilical cord blood-derived mesenchymal stromal stem cell (UCB-MSCs) in the treatment of end-stage knee osteoarthritis…
- Trial name
- NCT06078059
- Testing
- Knee aspiration + UCB-MSCs, Knee aspiration
- Where
- Slovenia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Preterm Birth
The Placental Secretome as a Therapeutic Tool to Prevent Inflammation-induced Preterm Birth
Preterm birth complicates 10% of all pregnancies and is the leading cause of perinatal morbidity and mortality worldwide. Intra-amniotic inflammation (IAI) and chorioamnionitis are well-established causes of PTB; however, a…
- Trial name
- PLACENTOMICS (NCT06891508)
- Testing
- Venous blood sampling, Tissues sampling, Umbilical cord blood sampling
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Use of Stem Cells for COVID-19 Treatment
Treatment of COVID-19 Patients Using Wharton's Jelly-Mesenchymal Stem Cells
The purpose of this study is to investigate the potential use of Wharton's Jelly Mesenchymal stem cells (WJ-MSCs) for treatment of patient diagnosed with Corona Virus SARS-CoV-2 infection, and showing symptoms of COVID-19.
- Trial name
- NCT04313322
- Testing
- WJ-MSCs
- Where
- Jordan
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Stem Cells Arabia