Clinical trials: Mesenchymal Stromal Cells
Mesenchymal Stem Cells；Pigmentary Disorders
Combined Therapy of Photoelectric Instruments and Human Umbilical Cord Mesenchymal Stem Cells for Pigmentary Disorders
Melasma is a common and refractory pigmentary skin disorder manifested as light to dark brown patches on the facial skin. It belongs to disfiguring dermatoses and significantly affects the physical and mental well-being of…
- Trial name
- NCT06911281
- Testing
- Mesenchymal Stem Cells；755nm picosecond laser treatment
- Volunteers
- 30 people
- Sponsor
- Shanghai East Hospital
Crohn Disease
Clinical Study of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Moderate and Severe Crohn's Disease
This is a prospective, single-arm, open-ended study to evaluate the efficacy and safety of human umbilical cord MSCs in the treatment of refractory moderate-to-severe Crohn's disease.
- Trial name
- NCT05262829
- Testing
- Human Umbilical Cord Mesenchymal Stem Cells
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai East Hospital
Pneumonia, Hematopoietic Stem Cell Transplantation
Mesenchymal Stem Cells for the Treatment of Pneumonia Post Haematopoietic Stem Cell Transplantation
The aim of this study is to determine whether mesenchymal stromal cell (MSC) treatment contribute to the good prognosis in patients with transplant-related complication, pneumonia post hematopoietic stem cell transplantation…
- Trial name
- MSCTPHSCT (NCT05131412)
- Where
- China
- Volunteers
- 107 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Graft Versus Host Disease, Acute Graft Versus Host Disease
BMT Autologous MSCs for GvHD
Subjects in this study have had an allogeneic (blood or marrow cells from another person) blood or marrow transplant to treat leukemia, lymphoma or other cancer of the blood, and have now developed Graft Versus Host Disease…
- Conditions
- Graft Versus Host Disease, Acute Graft Versus Host Disease, Chronic Graft Versus Host Disease
- Trial name
- NCT02359929
- Testing
- Autologous mesenchymal stromal cells (MSCs)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Emory University
Type1diabetes
Mesenchymal Stromal Cells to Treat Type 1 Diabetes in Children and Adolescents
This is a combined phase 1 and 2 study in 66 subjects, male or female, between 7-21 years of age that have recently (< 6 months) been diagnosed with type 1 diabetes.
- Trial name
- NCT05061030
- Testing
- the ATMP Protrans
- Where
- Sweden
- Volunteers
- 66 people
- Sponsor
- Uppsala University Hospital
Osteoarthritis
Effects of ASC Secretome on Human Osteochondral Explants
Since the need of finding effective disease-modifying anti-osteoarthritis (OA) treatments is still unmet, with this study the investigators aim to gather further evidences of the therapeutic potential of Mesenchymal Stem/stromal…
- Trial name
- ASC-OA (NCT04223622)
- Testing
- ASC secretome
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Congestive Heart Failure
Autologous Mesenchymal Stromal Cell Therapy in Heart Failure
It is a single centre, randomised controlled study of the effect of NOGA-guided direct intramyocardial injection of mesenchymal stromal cells on the development of new myocardium and blood vessels in patients with heart failure.
- Trial name
- NCT00644410
- Testing
- Mesenchymal stromal cell, Saline
- Where
- Denmark
- Volunteers
- 59 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Diabetic Peripheral Neuropathy Type 2
Treatment With Human Umbilical Cord Mesenchymal Stem Cells for Refractory Diabetic Peripheral Neuropathy
Diabetic Peripheral Neuropathy (DPN) is one of the most common chronic complications in type 2 diabetes, conventional drug therapy can only target a single pathogenesis but not treat Diabetic Peripheral Neuropathy (DPN)…
- Trial name
- NCT05507697
- Testing
- HUC-MSCs, Lipoic Acid
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Wuhan Central Hospital
Acute Ischemic Stroke, AIS
A Phase I Trial of Umbilical Cord Mesenchymal Stromal Cells for Acute Ischemic Stroke
Study Methods: The trial consists of two phases, both including a placebo control. Phase Ia (single-dose, dose-escalation): Three dose groups (low, medium, high) are set.
- Trial name
- NCT07628933
- Testing
- Human Umbilical Cord Mesenchymal Stem Cells Injection
- Where
- China
- Volunteers
- 35 people
- Sponsor
- BOE Technology Group Co., Ltd.
Partially Edentulous Maxilla, Alveolar Bone Atrophy
Effectiveness and Safety of Method of Maxilla Alveolar Process Reconstruction Using Synthetic Tricalcium Phosphate and Autologous MMSCs
Autologous MMSCs will be isolated from oral mucosa biopsy sample and expanded in vitro.Tissue engineered construction will be created using synthetic tricalcium phosphate and autologous MMSCs.
- Conditions
- Partially Edentulous Maxilla, Alveolar Bone Atrophy, Alveolar Bone Loss
- Trial name
- NCT02209311
- Testing
- Oral mucosa biopsy, Sinus lift with implantation of tissue engineered construction, Dental implant
- Where
- 2 sites in Russia
- Volunteers
- 12 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Chronic Pancreatitis, Mesenchymal Stem Cells
Autologous Mesenchymal Stromal Cells and Islet Co-transplantation in TP-IAT
This is a clinical trial for chronic pancreatitis (CP) patients undergoing total pancreatectomy with islet autotransplantation (TP-IAT).
- Trial name
- NCT05095532
- Testing
- Bone marrow-derived mesenchymal stem cells
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Medical University of South Carolina
COVID, Pulmonary Infection
Administration of Allogenic UC-MSCs as Adjuvant Therapy for Critically-Ill COVID-19 Patients
Novel Coronavirus (2019nCoV) or Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) that causes Coronavirus Disease 2019, or known as Covid-19 has recently become a global health emergency since it was first detected in…
- Conditions
- COVID, Pulmonary Infection, Sars-CoV2
- Trial name
- NCT04457609
- Testing
- Oseltamivir, Azithromycin, Umbilical Cord Mesenchymal Stem Cells
- Where
- 4 sites in Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia
Leukemia, Multiple Myeloma
MSC and Cyclophosphamide for Acute Graft-Versus-Host Disease (aGVHD) Prophylaxis
Evaluating the effectiveness of the new protocol which replace the standard immunosuppressive therapy with use of MSCs and CY in patients at high risk of relapse.
- Trial name
- MSC-CY (NCT02270307)
- Testing
- Cyclophosphamide, Mesenchymal stromal cells
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- National Research Center for Hematology, Russia
Hereditary Ataxia
Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Hereditary Ataxia
The Hereditary Ataxias are a group of genetic disorders characterized by slowly progressive incoordination of gait and often associated with poor coordination of hands, speech, and eye movements.
- Trial name
- NCT01360164
- Testing
- human umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Beike Bio-Technology Co., Ltd.
Adult Alveolar Soft Part Sarcoma, Adult Angiosarcoma
Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma
This randomized phase I/II clinical trial is studying the side effects and best dose of gamma-secretase/notch signalling pathway inhibitor RO4929097 when given together with vismodegib and to see how well they work in treating…
- Conditions
- Adult Alveolar Soft Part Sarcoma, Adult Angiosarcoma, Adult Desmoplastic Small Round Cell Tumor, Adult Epithelioid Hemangioendothelioma
- Trial name
- NCT01154452
- Testing
- Gamma-Secretase Inhibitor RO4929097, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- National Cancer Institute (NCI)
Bone Marrow Stromal Cells
Collection of Bone Marrow From Healthy Volunteers and Patients for the Production of Clinical Bone Marrow Stromal Cell (BMSC) Products
Background: Bone marrow stromal cells (BMSCs) can be grown from bone marrow provided by healthy volunteers. Volunteer bone marrow donors for BMSCs are generally required to meet the same healthy history and infectious disease…
- Trial name
- NCT01071577
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Venous Leg Ulcer
Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Therapy-resistant CVU (Phase III)
The aim of this clinical trial is to investigate the efficacy and safety of allo-APZ2-CVU, administered topically on therapy-resistant non-healing CVUs compared to placebo.
- Trial name
- NCT06489028
- Testing
- allo-APZ2-CVU
- Where
- 15 sites in United States, Austria and 10 more
- Volunteers
- 250 people
- Sponsor
- RHEACELL GmbH & Co. KG
Sickle Cell Disease, Thalassemia
Allo-HCT MUD for Non-malignant Red Blood Cell (RBC) Disorders: Sickle Cell, Thal, and DBA: Reduced Intensity Conditioning, Co-tx MSCs
The main purpose of this project is to cure patients with high risk Sickle cell disease and other red cell disorders including thalassemia and diamond-blackfan anemia by bone marrow transplantation.
- Conditions
- Sickle Cell Disease, Thalassemia, Diamond-Blackfan Anemia
- Trial name
- NCT00957931
- Testing
- Bone marrow transplantation, Mesenchymal Stromal Cells
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Stanford University
Acute Liver Failure
Hepatocyte Microbeads for Acute Liver Failure
Acute Liver Failure in children is associated with high mortality without liver transplantation. In addition, donor organ shortage makes it difficult to provide this treatment to every potential patient.
- Trial name
- HELP (NCT05491135)
- Testing
- HMB002
- Volunteers
- 17 people
- Sponsor
- King's College Hospital NHS Trust
Atrophic Nonunion of Fracture
Mesenchymal Stromal Cells for the Treatment of Non-union Fractures of Long Bones
The present study evaluates the effect of XCEL-MT-OSTEO-ALPHA in non-union fractures (pseudoarthrosis) of long bones in comparison to the standard treatment of autologous iliac crest.
- Trial name
- NCT02230514
- Testing
- XCEL-MT-OSTEO-ALPHA, autologous iliac crest, Surgery
- Where
- Spain
- Volunteers
- 19 people
- Sponsor
- Banc de Sang i Teixits