Clinical trials: Metabolic Adaptation
Friedreich Ataxia
Transitional Life Events in Patients With Friedreich's Ataxia: Implications for Genetic Counseling
The purposes of this study are to learn about significant life changes for people with Friedreich's ataxia and about patients' experiences with health care providers.
- Trial name
- NCT00056186
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Lipid Overnutrition, Constitutional Thinness
Adaptation of Lipid and Energy Metabolism During a Lipid Overnutrition in Constitutional Thinness
For a given food intake, fat and energy metabolism in adipose tissue and muscle adapt to nutrient intakes. This adaptation to nutrition may be impaired in susceptible individuals or in obese patients by promoting weight gain…
- Trial name
- Surnutrition (NCT01224561)
- Testing
- Lipid overnutrition
- Where
- 3 sites in France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Haematological Malignancy, Acute Leukemia
Feasibility Study to Assess an Adapted Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoietic Stem Cell Transplantation
Allogeneic haematopoietic stem cell transplantation (aHSCT) is the only curative treatment for many paediatric and young adult haematological pathologies (acute leukaemia, myelodysplastic syndromes haemoglobinopathies, bone…
- Conditions
- Haematological Malignancy, Acute Leukemia, Myelodysplastic Syndromes, Hemoglobinopathy in Children
- Trial name
- EVAADE (NCT05298930)
- Testing
- Physical activity program
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Centre Leon Berard
Diabetes Mellitus, Metabolic Syndrome
Effect of Bariatric Surgery "Digestive Adaptations III" on Cardiovascular Risk
Introduction- Primary prevention is the main strategy to control the global burden of cardiovascular disease. In clinical practice, food restriction represents a valuable preventive resource.
- Conditions
- Diabetes Mellitus, Metabolic Syndrome, Obesity, Atherosclerosis
- Trial name
- ADIII (NCT01581099)
- Testing
- Digestive Adaptations III surgery
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Obesity
Adapted Cognitive Behavioral Approach to Addressing Overweight and Obesity Among Qatari Youth
Levels of overweight and obesity have reached alarming proportions in Qatar and other Gulf nations. In Qatar, the need to establish national strategies for the prevention and treatment of obesity has been recognized in the new…
- Trial name
- NCT02972164
- Testing
- Weight loss program for school children
- Where
- Qatar
- Volunteers
- 799 people, healthy volunteers welcome
- Sponsor
- Qatar University
Healthy
Metabolic Adaptations to Chronic and Acute Exercise in Overweight Adults (ATX-Study)
The primary purpose of this study is to examine the effects of chronic exercise training and an acute session of exercise on key risk factors associated with Metabolic Syndrome (e.g., glucose tolerance, blood lipid profile, and…
- Trial name
- ATX (NCT02701751)
- Testing
- Exercise session
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Diabetes Mellitus, Type 2
Targeting the Endothelial Glycocalyx to Enhance Vascular Function and Exercise-Induced Vascular Adaptations in Type 2 Diabetes
The prevalence of type 2 diabetes (T2D) continues to increase in the US, with 26.8 million adults carrying a diagnosis. Importantly, T2D is widespread in the Veteran population.
- Trial name
- NCT05205005
- Testing
- Endocalyx
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- VA Office of Research and Development
Pediatric Obesity
Pedicatric Obesity - Weight - Energy - Loss - Load
Although multidisciplinary treatment of pediatric obesity has shown its effectiveness in leading to weight loss and improvement in the physical, mental and social health of children and adolescents; maintaining these benefits…
- Trial name
- POWELL-2 (NCT06085040)
- Testing
- Multidisciplinary weight loss
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Diabetes Mellitus, Colonic Diseases
Diet for Colonoscopy Preparation in Diabetic Patients
This trial will compare the efficacy of to 2 different sets of dietary recommendations to be followed before colon cleansing for colonoscopy in diabetic patients.
- Trial name
- DIMEPREP (NCT02300779)
- Testing
- Low-residue diet, Usual care
- Where
- 2 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Parc de Salut Mar
Iron Absorption
Genetic Variants and Iron Absorption
The two specific aims of this study are: 1) to assess the impact of a genetic variant on iron status; 2) to assess the impact of a genetic variant on non-heme absorption among Asian women.
- Trial name
- NCT02197624
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Cornell University
Obesity
Effectiveness of Adapted Basketball Programs in Adolescents With Obesity (ABBA)
This study aims to evaluate the effects of different basketball training programs on adolescents with obesity. The objective is to assess how these programs influence body weight, physical fitness, motivation to exercise, and…
- Trial name
- ABBA (NCT07046871)
- Testing
- 1. Intervention Name (Arm 1) Name: Adapted Basketball Program with Video Support Type: Behavioral Description: A 7-week basketball intervention for adolescents with obesity, combining pedagogically a, ADAPT Adapted Basketball Program
- Where
- Tunisia
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Sfax
Cardiovascular Diseases, Metabolic Disorders
Chinese Migrant Population Health Cohort
The Chinese Migrant Population Health Cohort is a prospective, multi-center study jointly initiated by Professor Yong Ji, President of Harbin Medical University, and Academician Guoqiang Chen, President of Hainan Medical…
- Conditions
- Cardiovascular Diseases, Metabolic Disorders, Ageing and Geriatric Health, Climate Adaptation
- Trial name
- NCT07124949
- Testing
- No intervention
- Where
- China
- Volunteers
- 26,000 people, healthy volunteers welcome
- Sponsor
- Jinwei Tian
Non Communicable Diseases, HIV
Task-shifted Adaptation of the WHO-PEN Intervention to Address Cardio-metabolic Complications in People Living With HIV in Zambia
This mixed-methods formative research study aims to adapt the WHO Package of Essential Noncommunicable Disease Interventions (WHO-PEN) approach for the Zambian public health system, and pilot test an adapted, streamlined, and…
- Trial name
- TASKPEN (NCT05005130)
- Testing
- TASKPEN
- Where
- 4 sites in Zambia
- Volunteers
- 1,129 people
- Sponsor
- University of North Carolina, Chapel Hill
Overweight and Obesity
Adapting Mindful Eating Program for French Overweight/Obese Population
The aim of this project is to validate a new mindful eating programme adapted to the overweight or obese French population. Recognising the importance of diet in the management of chronic diseases, particularly obesity, and the…
- Trial name
- MIND-EAT (NCT06157411)
- Testing
- Mindful Eating Intervention (AC group), Conventional Dietetic Intervention (DC group)
- Where
- France
- Volunteers
- 56 people
- Sponsor
- University Hospital, Montpellier
Obesity
Developmental Adaptation to an Obesogenic Environment
The purpose of this study was to evaluate whether birth weight is related to the demand for dietary protein in adult survivors of severe acute malnutrition (Kwashiorkor and Marasmus), and that leveraging of protein intake is…
- Trial name
- NCT02257593
- Testing
- Dietary protein
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Amyotrophic Lateral Sclerosis (ALS)
"New Perspectives of Adaptation to NIV in ALS"
The purpose of this study is to demonstrate that the adaptation to the Non Invasive Ventilation (NIV) at home is not worse when compared with an adaptation performed in inpatient settings.
- Trial name
- NCT02537132
- Testing
- Adaptation and training to Non Invasive Ventilation (NIV)
- Where
- 2 sites in Italy
- Volunteers
- 48 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis
Healthy Eating and Active Living for People Living With Multiple Sclerosis (HEAL MS): A Lifestyle Program for People With Multiple Sclerosis
The goal of this clinical trial is to learn whether a structured lifestyle program can improve health and wellbeing in people living with multiple sclerosis (MS).
- Trial name
- HEAL-MS (NCT07589062)
- Testing
- Multi-Domain Lifestyle Intervention
- Where
- United Arab Emirates
- Volunteers
- 30 people
- Sponsor
- New York University Abu Dhabi
Overweight and Obesity
Chronotype-adapted Diet and Weight Loss
In humans, prolonged alterations in the circadian rhythm have been linked to cognitive impairments, premature ageing, and oncological and metabolic disorders such as diabetes and obesity.
- Trial name
- CHRONODIET (NCT05941871)
- Testing
- Dietary intervention - intervention group, Dietary intervention - control group
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Amyloidosis
Risk-adapted Therapy for Primary Systemic (AL) Amyloidosis
High-dose melphalan (MEL) with autologous stem cell transplant (SCT) is an effective therapy for systemic AL amyloidosis (AL), but treatment-related mortality (TRM) has historically been high.
- Trial name
- NCT01527032
- Testing
- melphalan, thalidomide and dexamethasone
- Sponsor
- FDA Office of Orphan Products Development
Prediabetic State
Autoimmune Diabetes Accelerator Prevention Trial
The autoimmune diabetes ACCELERATOR PREVENTION TRIAL (adAPT) is based on the accelerator hypothesis. The trial is designed to establish whether metformin, an oral hypoglycaemic agent that is known to reduce insulin demand in type…
- Trial name
- adAPT (NCT02881528)
- Testing
- Metformin Hydrochloride
- Where
- 5 sites in United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Exeter