Clinical trials: Metabolic Adaptation
Overweight or Obesity
HIIT on Overweight Middle-aged Adults
36 middle-aged with overweight adults were divided into three groups: 1. L-HIIT group: the long-interval HIIT group (4 × 4 min Exercise/4 min Rest), 2.
- Trial name
- HIIT (NCT06383442)
- Testing
- L-HIIT, M-HIIT
- Where
- Taiwan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Obesity
Investigating Physiological Adaptations to Weight Loss
The purpose of this study is to examine the effect of diet-induced weight loss on the levels of circulating nutrients and hormones which are involved in feelings of hunger and satiety.
- Trial name
- NCT00870259
- Testing
- Optifast VLCD
- Where
- Australia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy, Distal Symmetric Polyneuropathy (Manifestation)
Thai PainPREDICT Validation Study
Painful diabetic neuropathy (PDN) is one of the most common and disabling complications of diabetes mellitus, substantially affecting quality of life, daily functioning, and health system burden.
- Conditions
- Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy, Distal Symmetric Polyneuropathy (Manifestation), Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- PainPREDICT-Th (NCT07195045)
- Testing
- Thai PainPREDICT Questionnaire and Mobile Application
- Where
- Thailand
- Volunteers
- 277 people
- Sponsor
- Chulalongkorn University
Multiple Myeloma and Plasma Cell Neoplasm
Melphalan and Autologous Stem Cell Transplant Followed By Bortezomib and Dexamethasone in Treating Patients With Previously Untreated Systemic Amyloidosis
The purpose of this study in patients needing treatment for AL amyloidosis is to see how well treatment with IV melphalan works and then, if some clonal plasma cells are still present about 2 to 3 months after melphalan…
- Trial name
- NCT00458822
- Testing
- bortezomib, dexamethasone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Adiposity, Insulin Sensitivity
Metabolic Adaptations to High-fat Diet
The purpose of this study is to understand how the body's response after a meal is influenced by insulin and sugar in the blood.
- Conditions
- Adiposity, Insulin Sensitivity, Impaired Glucose Tolerance, Metabolic Disturbance
- Trial name
- MetFlexHFD (NCT06537401)
- Testing
- Hypercaloric, High Fat Diet
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- George Washington University
Cardiometabolic Risk Factors
Physical Exercise on Physiological Adaptation Capacity and Chronic Pain in Individuals With Cardiovascular Risk
This research focuses on studying the effects of a 12-week exercise program on the health of individuals at risk of heart disease.
- Trial name
- NCT06201273
- Testing
- High-Intensity Interval Training, Resistance Training
- Where
- Chile
- Volunteers
- 192 people
- Sponsor
- Universidad San Sebastián
Overweight and Obesity
Validity and Reliability of Mixed Reality-Based Performance Tests in Overweight and Obese Adults
This study aims to evaluate the validity and reliability of mixed reality (MR)-based adaptations of functional mobility and performance tests developed using the Meta Quest 3 platform by comparing their outcomes with conventional…
- Trial name
- NCT07654439
- Testing
- Mixed Reality-Based Functional Mobility and Performance Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 119 people
- Sponsor
- Selcuk University
Breast Neoplasms, Exercise
Adapted Physical Activity (APA) in a Breast Cancer Population.
The aim of this study is to investigate the effect of a 6-months program of Adapted Physical Activity (APA) on lifestyle, physical activity levels, insulin resistance and adipokines, oxidative stress, microcirculatory…
- Conditions
- Breast Neoplasms, Exercise, Exercise Therapy, Insulin Resistance
- Trial name
- NCT03528473
- Testing
- Exercise
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University Of Perugia
Diabetes Mellitus, Type 2
OASIS: Peer Support for T2DM in Appalachia (Peer Participant)
The goal of this clinical trial is to compare the effects of peer coaching models in older adults with unmanaged type two diabetes.
- Trial name
- OASIS (NCT06336122)
- Testing
- Peer Coach Training - Weekly, Peer Coach Training - Biweekly
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Haematological Malignancy, Acute Leukemia
A Study to Assess a Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoietic Stem Cell Allografts
To date, allogeneic haematopoietic stem cell transplantation (aHSCT) is the only curative treatment for many paediatric and young adult haematological pathologies (acute leukaemia, myelodysplastic syndromes, haemoglobinopathies…
- Conditions
- Haematological Malignancy, Acute Leukemia, Myelodysplastic Syndromes, Hemoglobinopathy in Children
- Trial name
- EVAADE (NCT04331483)
- Testing
- Physical activity program
- Where
- France
- Sponsor
- Centre Leon Berard
Aging, Exercise
Ameliorating Effects of Aging by Physical Exercise
With increasing longevity, a significant increase in the incidence of neurodegenerative diseases is expected. According to forecasts based on data from the World Health Organization and data from epidemiological studies, up to…
- Trial name
- AMETHYST (NCT05232968)
- Testing
- Long-term exercise program, Short-term exercise program
- Where
- Slovakia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Weight Loss, Weight Gain
Role Of Metabolic Adaptation In Weight Regain
In a previous study (NCT04081337), 55 participants with obesity participated on a 18-week lifestyle intervention to reduce their body weight, targeting 10% body weight loss.
- Conditions
- Weight Loss, Weight Gain, Obesity
- Trial name
- EXPEND-FU (NCT05766358)
- Testing
- Intensive lifestyle change therapy, Tirzepatide
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Pennington Biomedical Research Center
Aging, Cardiovascular Disease
CALERIE (PBRC, Baton Rouge) - Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy
This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet improves biomarkers of aging and prevents some age-related chronic diseases such as cancer, diabetes, and…
- Conditions
- Aging, Cardiovascular Disease, Diabetes Mellitus
- Trial name
- NCT00099151
- Testing
- Caloric Restriction (CR), Exercise
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Healthy Volunteers
Metabolic and Neural Adaptations to Weight Loss, Plateau, and Regain
Background: Many people can lose weight by changing their diet or exercise. However, most people eventually regain the weight over time.
- Trial name
- NCT02199483
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes
Intestinal Sweet Taste Receptor Function and Adaptation to Dietary Sugars and Sweeteners
The purpose of this study is to collect data that will help researchers better understand the various causes of obesity and diabetes; particularly to understand how consumption of NCASs affects the way the body uses nutrients.
- Trial name
- ISTAR (NCT02835859)
- Testing
- Dietary: saccharin, Estimate glucose absorptions
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Pediatric Obesity
Adapting Diet and Action for Everyone (ADAPT+)
The purpose of this study is to refine and optimize an obesity intervention with rural underserved Latino children and their parents that combines a standard family-based behavioral approach, the "gold standard" for pediatric…
- Trial name
- ADAPT+ (NCT04800432)
- Testing
- ADAPT+, EUC
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Body Temperature Changes
Research on "Metabolic Adaptation" in Obese People
Obesity has become a global public health crisis, with 810 million adults classified as obese (BMI ≥ 30 kg/m²) worldwide in 2020. This number is projected to rise to 1.53 billion by 2035.
- Trial name
- NCT07128238
- Testing
- lifestyle intervention
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Obesity & Overweight, Older Women
Effects of Adapted Taekwondo Versus Conventional Training on Anthropometric Variables and Physical Function in Older Women With Abdominal Obesity
Therefore, this study aimed to analyze the effects of TKD on anthropometric and physical function parameters in older women with abdominal obesity, compared with conventional exercise interventions such as MCT, and WE.
- Trial name
- RCT (NCT07705750)
- Testing
- taekwondo training, multicomponent training, walking exercise
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universidad Católica del Maule
Umbilical Cord Clamping
30-Second Versus Pulsation-Based Delayed Cord Clamping in Term Newborns
This randomized controlled trial aims to compare the effects of 30-second cord clamping and pulsation-based delayed cord clamping on neonatal metabolic adaptation in term newborns delivered vaginally.
- Trial name
- NCT07833059
- Testing
- Pulsation-Based Delayed Cord Clamping, 30-Second Cord Clamping
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Tarsus University
Obesity, Metabolic Disease
Metabolic Adaptations to Weight Loss With and Without Exercise
Study Purpose: The combination of caloric restriction and exercise is the most common first-line treatment for obesity-related disorders, yet we know very little about how these two very different treatments work together.
- Conditions
- Obesity, Metabolic Disease, Metabolic Syndrome, Insulin Sensitivity
- Trial name
- WAX (NCT05806801)
- Testing
- MICT Exercise, No Exercise (Control)
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Michigan