Clinical trials: Metabolic Adaptation
Metabolic Dysfunction Associated Steatotic Liver Disease, Overweight (BMI > 25)
Feasibility of the Paso Program for Patients With Metabolic Dysfunction Associated Steatotic Liver Disease
The purpose of this study is to learn whether the Paso weight loss program is feasible for Mexican and Central American patients with fatty liver disease.
- Conditions
- Metabolic Dysfunction Associated Steatotic Liver Disease, Overweight (BMI > 25), Metabolic Syndrome
- Trial name
- NCT06854185
- Testing
- Paso Program
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor College of Medicine
Type 2 Diabetes Mellitus
Concurrent Training in Type 2 Diabetes
It is recommended that individuals perform a combination of resistance exercise (RE) and endurance exercise. Lack of time is often cited as a reason for being unable to meet current exercise guidelines.
- Trial name
- CONTRADIA (NCT03278704)
- Testing
- RE only, RE + HIIT
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- University of Birmingham
Ketosis, Hypoxia
Intermittent Exogenous Ketosis (IEK) at High Altitude
Altitude-related hypoxia decreases human functional capacity, especially during exercise. Even with prolonged acclimatization, the physiological adaptations are insufficient to preserve exercise capacity, especially at higher…
- Trial name
- NCT06097754
- Testing
- Ketone ester
- Where
- 2 sites in Belgium, Slovenia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Jozef Stefan Institute
Bone Loss
A Prospective Study of Human Bone Adaptation Using a Novel in Vivo Loading Model
The purpose of this study is to understand how different types of mechanical forces can influence bone adaptation (and make bones stronger, potentially). Forces acting on bones cause mechanical strain.
- Trial name
- NCT04135196
- Testing
- voluntary forearm loading task
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Worcester Polytechnic Institute
Breast Cancer
Efficacy of Exercise Using Connected Activity Trackers and Therapeutic Education in Localized Breast Cancer
The 3-year DISCO study aims to systematically implement physical activity in breast cancer patients. The primary objective is to investigate the efficacy of a connected device (personalized non-supervised exercise program…
- Trial name
- DISCO (NCT03529383)
- Testing
- Connected device, Therapeutic education
- Where
- 3 sites in France
- Volunteers
- 436 people
- Sponsor
- Centre Leon Berard
Obesity
Effects of Diet Changes on Metabolism
This study, conducted at the NIH Clinical Research Unit at the Phoenix Indian Medical Center, will examine how the body s metabolism (energy expenditure) changes when people overeat and when they fast and how different diets…
- Trial name
- NCT00523627
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity
Weight Loss Composition and Metabolic Adaptation During Hypocaloric Dieting
Weight loss induced by hypocaloric dietary interventions is commonly accompanied by reductions in resting metabolic rate (RMR), a phenomenon often described as metabolic adaptation.
- Trial name
- NCT07627256
- Testing
- Hypocaloric Diet
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Dyslipidemia, Long-Distance Running
The Effects of Rosuvastatin on Running Training Adaptation and Safety
Statins lower low-density lipoprotein cholesterol (LDL-C) and help prevent atherosclerotic cardiovascular disease, but some users develop statin-associated muscle symptoms (SAMS) such as soreness, stiffness, weakness, or elevated…
- Conditions
- Dyslipidemia, Long-Distance Running, Endurance Training, Statin-Associated Muscle Symptoms
- Trial name
- NCT07401017
- Testing
- Rosuvastatin
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Hypoxia, Sleep Apnea
Intermittent Hypoxia 2: Cardiovascular and Metabolism
The purpose of this study is to compare cardiovascular physiological adaptation to intermittent hypoxia (IH) of nonobese healthy subjects. The exposure will be two periods of two weeks (IH versus exposure "placebo hypoxia").
- Conditions
- Hypoxia, Sleep Apnea, Obstructive Sleep Apnea
- Trial name
- IH2 (NCT02058823)
- Testing
- Valsartan, Amlodipine
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Exercise, Heat Strain
Effect of Exercise and Heat Stress on Acute Cardiometabolic Adaptations in Healthy Young Adults
Life in space is completely void of physical and environmental stress. It is well known that living things need regular physical stress (e.g. exercise) to remain strong, functional and healthy.
- Conditions
- Exercise, Heat Strain, Control Condition
- Trial name
- NCT06872762
- Testing
- Exercise, Heat strain
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Obesity
Controlled Trial Evaluating the Efficacy of Protein Supplementation in the Short Term After Bariatric Surgery
The main objective will be to evaluate the effect at 5 weeks of nutritional management associated with protein supplementation (adapted to the post-operative period) on the maintenance of lean body mass at the whole body in obese…
- Trial name
- PROTISLEEVE (NCT02712086)
- Testing
- protein supplementation
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Montpellier
Type 2 Diabetes
Metabolic Adaptation to Diabetes
Hypoglycemia or low blood sugar is a very serious complication that diabetics experience. This is of great concern because there is a lack of available information of how Non Insulin Dependent Diabetic Mellitus patients (NIDDM)…
- Trial name
- NCT00732862
- Testing
- glucose clamp
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Type 2 Diabetes Mellitus
ET-blockade and Exercise-induced Vascular Adaptations in T2DM
The purpose of this study is to establish the effect of ET blockade on vascular adaptations during an 8-week exercise program in subjects with T2DM.
- Trial name
- NCT01779609
- Testing
- Bosentan, Exercise
- Where
- Netherlands
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus Type 2 With Hyperglycemia
Pathways for Health Equity Quality Improvement Strategy
The PATHWAYS for Health Equity research program builds on the 5-year FORGE AHEAD Indigenous diabetes quality improvement research program (2013 - 2017).
- Trial name
- NCT03315728
- Testing
- Quality Improvement Strategy
- Where
- Canada
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
ICP, GDM
White Adipose Tissue in Pregnancy Study
This study aims to understand the role of metabolic tissues in the changes of the metabolism of pregnant women and whether this contributes to some women developing metabolic diseases of pregnancy such as gestational diabetes…
- Trial name
- WAT (NCT02495987)
- Where
- 2 sites in United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Diabetes (DM)
Role of Alpha-to-beta Cell Communication to Adapt Insulin Secretion to Insulin Resistance.
Glucagon secretion from α-cells has long been viewed as primarily a counterregulatory mechanism - e.g. an agent with a role to prevent blood sugar from decreasing to levels that compromise function.
- Trial name
- UPGRADE (NCT07224334)
- Testing
- Exendin-9 is a 30 amino acid peptide that is an established competitive antagonist of the GLP-1 receptor. Subjects will receive exendin-9 by intravenous infusion at a rate of 600 pmol/kg/min, Dexamethasone, Dextrose 20% solution
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- David D'Alessio, M.D.
Diabetes Mellitus, Type 2, Obesity
Culturally-Adapted Diet for Puerto Rican Adults
This pilot project will determine whether a diet culturally-adapted to Puerto Ricans can effectively decrease cardiometabolic risk for diabetes.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Hypertension, Dyslipidemias
- Trial name
- NCT03975556
- Testing
- Culturally tailored food and diet advice, Standard healthy eating advice
- Where
- Puerto Rico
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Overweight, Adolescent Behavior
Family-Based Mindful Eating Intervention for Overweight Adolescents
With currently 35% of U.S. adolescents being overweight and one in six having metabolic syndrome, adolescent obesity is one of the major global health challenges of the 21st century.
- Conditions
- Overweight, Adolescent Behavior, Family Research, Weight Loss
- Trial name
- NCT02114190
- Testing
- Adolescent Mindful Eating Group, Parent Integrated Group
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Oregon Research Institute
Childhood Obesity, Overweight and Obese Children
Development and Evaluation of a Web-based Parental Role Modeling Program for Childhood Obesity Management
The goal of this clinical trial is to learn whether an online family health education program can help Vietnamese children aged 7-9 years with overweight or obesity develop healthier habits.
- Conditions
- Childhood Obesity, Overweight and Obese Children, Pediatric Obesity, Overweight and Obesity in Schoolchildren
- Trial name
- NCT07641452
- Testing
- Web-based parental role modeling program, Standard health education materials
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Do Thi Thu Huyen
CRC (Colorectal Cancer), Liver Metastases From Colorectal Primary Cancer
SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases
This study focuses on patients with colorectal cancer undergoing surgery for the primary tumor and/or liver metastases. Tumor samples collected during surgery will be used to generate patient-derived models (primary cultures…
- Trial name
- AIRC_ IG 34634 (NCT07497789)
- Volunteers
- 156 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis