Clinical trials: Metabolic Adaptation
Overweight (BMI > 25), Males and Females
IMPACT: Immune and Musculoskeletal Physiological Adaptations to Combined Exercise Training & Nutrition
The purpose of this study is to determine whether 12 weeks of exercise training combined with dairy consumption influences inflammation and immune responses in adults with overweight, compared to exercise training alone.
- Trial name
- NCT07513987
- Testing
- Milk, Greek Yogurt, Exercise training
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- York University
Type 1 Diabetes
Timing of Resistance Exercise in Type 1 Diabetes
The aims of the current study are 1. to compare the effects of acute morning and afternoon resistance exercise on blood glucose levels in people with type 1 diabetes. 2.
- Trial name
- T-REX (NCT05884814)
- Testing
- Morning exercise, Afternoon exercise, Habitual physical activity levels
- Where
- Kuwait
- Volunteers
- 54 people
- Sponsor
- Dasman Diabetes Institute
Sodium Excess, Hypertension
Effects of a Six-Day Whole-Diet Intervention on Taste Perception and Dietary Behaviour in Young Adults
This study aims to investigate the effects of a specific diet modification on the pleasantness, desire, and saltiness intensities of selected foods and an ad libitum breakfast buffet through a randomized controlled trial with…
- Conditions
- Sodium Excess, Hypertension, Salty Taste
- Trial name
- NCT07726394
- Testing
- Experimental: Increased Salty Food Intake, Experimental: Decrease Salty Food Intake, Active Comparator: Maintain Usual Diet
- Where
- Malaysia
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Sunway University
Pediatric Obesity
Role of Mechanical Load on Metabolic Exercise Adaptations in Response to Weight Loss in Obese Adolescents: The POWELL Study
While interdisciplinary weight loss intervention have been shown successful among adolescents with obesity, a weight regain is most of the time observed within the following weeks or months.
- Trial name
- POWELL (NCT04902001)
- Testing
- Multidisciplinary weight loss
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Heart Failure
Nutritional Ketosis in Heart Failure
Chronic, ambulatory heart failure patients will be given ketone ester dietary supplementation to determine therapeutic efficacy, metabolic adaptation, pharmacokinetics, associated cognitive changes, and safety within this patient…
- Trial name
- INNKA-HF (NCT04370600)
- Testing
- beta hydroxybutyrate (BHB) ester
- Volunteers
- 16 people
- Sponsor
- Thomas Jefferson University
Energy Expenditure
Quantifying the Persistence of Metabolic Adaptation and Weight Regain Following Extreme Weight Loss
Background: Many people regain the weight they lose through diet and exercise. This might happen because the weight loss slows their metabolism. This slowing is called metabolic adaptation.
- Trial name
- NCT02544009
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity
Impact of the Residual Gastric Volume in Laparoscopic Sleeve Gastrectomy's Failure
Obesity is a worldwide health problematic whose incidence is increasing especially in developed countries. The surgical management of this illness consists in different techniques such as Laparoscopic Sleeve Gastrectomy but this…
- Trial name
- GASTROMANCH (NCT01539967)
- Testing
- Laparoscopic Sleeve Gastrectomy
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Non-Alcoholic Fatty Liver Disease
Biological Adaptations of Strength Training.
A two-trial repeated measures design will be employed in this investigation. Both the control trial and the exercise trial will last for 3 months.
- Trial name
- NCT04098484
- Testing
- Control Trial, Exercise Trial
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Obesity
Adapted Physical Activity Study
An uncontrolled, non-randomized, open-plan, multi-centre study of treatment and therapeutic education in endocrinology-diabetes-Nutrition that seeks to assess the interest of an adapted physical activity educator for the…
- Trial name
- APA (NCT03337412)
- Testing
- Adapted physical activity
- Where
- France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Obesity, Bariatric Surgery Candidate
Tele-BARICARE to Manage COVID-19-Related Distress
Background: Over 60% of Canadians are overweight or obese and more than half have a history of a mental illness. The COVID-19 pandemic has made it difficult for people living with obesity to manage their weight even after…
- Conditions
- Obesity, Bariatric Surgery Candidate, Mental Health Disorder, Eating Disorders
- Trial name
- TELE-BARICARE (NCT05258578)
- Testing
- Tele-CBT, Self-Help Resources
- Where
- 4 sites in Canada
- Volunteers
- 140 people
- Sponsor
- University Health Network, Toronto
PCOS (Polycystic Ovary Syndrome)
Symptoms of Polycystic Ovarian Syndrome Ameliorated by Keto-Adaptation Pilot
The SPARK- Pilot study (Symptoms of PCOS Ameliorated by Responses to Keto-adaptation) is a 12-week clinical trial at The Ohio State University designed to explore how different ways of achieving ketosis may improve reproductive…
- Trial name
- (SPARK-Pilot) (NCT07227363)
- Testing
- Ketogenic diet, Exogenous Ketone Supplement
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Muscle; Atrophy, General
The Effects of the Novel Unloading Device "HEPHAISTOS" on Bone, Muscles and Vessels
11 healthy men used the HEPHAISTOS unloading orthosis in an ambulatory 8 week intervention study. It greatly reduces calf muscle forces without reducing ground reaction forces.
- Trial name
- HEP (NCT03086187)
- Testing
- Hephaistos unloading orthosis
- Where
- Germany
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- DLR German Aerospace Center
Leukemia, Lymphoblastic, Acute, Osteoporosis
A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors
Research studies have shown that children who are long-term survivors of childhood leukemia may be at greater risk for early bone loss called osteoporosis.
- Trial name
- NCT00186901
- Testing
- Calcium carbonate (Tums), vitamin D
- Where
- 3 sites in United States
- Volunteers
- 429 people
- Sponsor
- St. Jude Children's Research Hospital
Diabetes
Avoiding Diabetes After Pregnancy Trial in Moms
Mothers with previous gestational diabetes mellitus (GDM) represent a population at higher risk of future Type 2 diabetes mellitus (T2DM), which is preventable through lifestyle modification.
- Trial name
- ADAPT-M (NCT01918345)
- Testing
- Home-based Physical Activity Program with Health Coach, Home-based Low-GI Diet Program with Health Coach
- Where
- 5 sites in Canada
- Volunteers
- 345 people
- Sponsor
- Women's College Hospital
Aging, Brain Metabolic Disorder
Monitoring of Brain Metabolites Using Proton and Deuterium MR Techniques
MR pulse for whole brain optimal Deuterium (2H) Metabolic Imaging and EPSI (echo planar spectroscopic imaging) based SLOW-edited 1H-MRSI will be developed and optimized for use at an UHF scanner at 7 Tesla.
- Conditions
- Aging, Brain Metabolic Disorder, Carotid Stenosis, Alzheimer Disease
- Trial name
- SIGNATURES2023 (NCT06705010)
- Testing
- Application of new pulse sequence package SIGNATURES2023 to healthy controls, Application of new pulse sequence package SIGNATURES2023 to 4 groups of patients (pilot)
- Where
- Switzerland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Prediabetes, Overweight
Evaluation of Prevent in Underserved Populations
The goal of this study is to evaluate an online Diabetes Prevention Program adapted for patients with prediabetes in safety net health care settings.
- Conditions
- Prediabetes, Overweight, Obesity
- Trial name
- PUP (NCT02664064)
- Testing
- Prevent
- Where
- 3 sites in United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Omada Health, Inc.
Dyslipidemias
Combined Effects of Statins and Exercise on Training Sensitive Health Markers
Around the world, about 4 in 10 adults have abnormal blood fat levels-known as dyslipidaemia-which raises their chances of getting heart disease.
- Trial name
- NCT06841536
- Testing
- Atorvastatin 80mg, Exercise
- Where
- Faroe Islands
- Volunteers
- 120 people
- Sponsor
- University of the Faroe Islands
Aging
CALERIE Phase II Ancillary: Metabolic
The primary aim of this NIA sponsored ancillary study of phase 2 CALERIE is to measure whether metabolic adaptation lasts up to 2 years in response to a 25% calorie restriction in normal-weight and slightly overweight…
- Trial name
- CALERIE-II (NCT02695511)
- Testing
- Caloric restriction
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity
Can Reverse Dieting Prevent Weight Regain After Weight Loss
Introduction: It is known that weight loss results in decreased Resting Energy Expenditure (REE), due to a decrease in lean body mass (LBM), but also due to metabolic adaptation, resulting in a higher energy efficiency…
- Trial name
- NCT03434431
- Testing
- Reverse dieting
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- George Mason University
Obesity, Weight Loss
Effects of Intermittent Versus Continuous Energy Restriction on Metabolic Adaptation in Women With Obesity
One of the major challenges for treating obesity is to maintain a weight reduced state on the long term due to the high rate of weight regain.
- Trial name
- BREAK (NCT05184361)
- Testing
- Intermittent energy restriction (IER), Continuous energy restriction (CER)
- Where
- Portugal
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto