Clinical trials: Metabolic Complication
Breastfeeding, Breastfeeding Initiation
Birth & Breastfeeding Support Study
The goal of this observational study is to learn about the effects of birth practices such as cesarean section and vacuum assisted birth and diseases such as gestational diabetes and preeclampsia on exclusive breastfeeding.
- Conditions
- Breastfeeding, Breastfeeding Initiation, Breastfeeding Duration, Birth
- Trial name
- BABSS (NCT06844019)
- Where
- Denmark
- Volunteers
- 1,628 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Polycystic Ovary Syndrome, Gestational Diabetes Mellitus
Screening for GDM in Women With PCOS and Controls
Women with polycystic ovary syndrome (PCOS) are often insulin resistant. During pregnancy, insulin sensitivity decreases. The investigators examine glucose metabolism during oral glucose tolerance test and the incidense of…
- Trial name
- NCT02183558
- Testing
- OGTT by randomization, OGTT by indication
- Where
- Denmark
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Chronic Kidney Diseases, Metabolic Syndrome
Theory-based Health Behaviour Change Intervention in Patients of Metabolic Syndrome With Chronic Kidney Disease
The pilot study will adopt a 2-arm, pretest-posttest, and assessor-blind randomized controlled trial design to examine the feasibility and acceptability of a theory-based health behaviour change intervention and examine its…
- Trial name
- NCT06527768
- Testing
- Theory-based health behaviour change interventio
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Polycystic Ovary Syndrome
The Role of Autoimmunity and Obesity in Polycystic Ovary Syndrome
The goal of the study is to detect autoantibodies in the serum of the women with PCOS and evaluate the obesity markers to investigate the the role of autoimmunity and obesity in PCOS
- Trial name
- NCT05929950
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University
Hepatic Steatosis, Polycystic Ovarian Syndrome
Liver and Fat Regulation in Overweight Adolescent Girls
Women with polycystic ovarian syndrome (PCOS) have increased rates of hepatic steatosis compared to weight similar women with regular menses. It is unclear if this is related to high testosterone or insulin resistance.
- Conditions
- Hepatic Steatosis, Polycystic Ovarian Syndrome, Obesity
- Trial name
- APPLE (NCT02157974)
- Testing
- Byetta 5Mcg Pen Injection
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Polycystic Ovary Syndrome
Evaluation of Endocrine and Metabolic Parameters in the New Diagnostic Phenotypes of Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a very frequent endocrine disease of women in reproductive age, with an estimated prevalence of 5 to 10 % according to the studied population.
- Trial name
- NCT00784615
- Testing
- Blood samples, transvaginal ultrasound
- Where
- Argentina
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Córdoba
Cardiovascular Diseases, Diabetes Mellitus
Determinants of Cardiovascular Disease, Kidney Disease and Diabetes
Cardiovascular disease (CVD), chronic kidney disease (CKD), diabetes mellitus (DM) and HIV infection are long-term conditions (LTC) with major health implications for people of African ancestry.
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Chronic Kidney Diseases
- Trial name
- NCT04646408
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Pregnancy, Obesity
Nutrition and Pregnancy Intervention Study
A randomized double-blind placebo controlled intervention study with pregnant obese women (n=440) will be conducted. The intervention will involve consumption of fish oil and/or probiotic capsules from early pregnancy until 6…
- Conditions
- Pregnancy, Obesity, Gestational Diabetes Mellitus, Adiposity
- Trial name
- NCT01922791
- Where
- 2 sites in Finland
- Volunteers
- 439 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Pregnant Women, Gestational Diabetes
Education of Pregnant Women at Risk of Gestational Diabetes
There are studies in the literature showing that there is a decrease in the number of pregnant women diagnosed with gestational diabetes and improvements in parameters related to maternal and infant health, with the education to…
- Trial name
- NCT05568277
- Testing
- Education on preventive health behaviors based on Pender's Health Promotion Model
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Stroke (CVA) or TIA, Diabetes
Risk Factors, Costs, and Impacts of ED Boarding
The goal of this observational study is to learn about the risk factors, costs, and operational impacts of emergency department boarding (patients admitted to the hospital but remaining in the emergency department awaiting…
- Conditions
- Stroke (CVA) or TIA, Diabetes, Asthma (Diagnosis), COPD (Chronic Obstructive Pulmonary Disease)
- Trial name
- NCT07532564
- Where
- United States
- Volunteers
- 30,486 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Lynch Syndrome, Endometrial Cancer
Frequency of Endometrial Cancer Precursors Associated with Lynch Syndrome
Given that there is a significant prevalence of Lynch syndrome among patients with endometrial cancer (about 5% of patients with endometrial cancer), and given there is a known risk of endometrial cancer among patients with…
- Conditions
- Lynch Syndrome, Endometrial Cancer, Endometrial Hyperplasia, Mismatch Repair Deficiency
- Trial name
- NCT05257057
- Testing
- Immunohistochemical staining
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- WellSpan Health
Pre-Eclampsia, Depression
Preeclampsia Research on Vitamin D, Inflammation, & Depression
This study is designed to comprehensively investigate the anti-inflammatory role of vitamin D in reproductive aged women, and its association with preeclampsia and depression.
- Conditions
- Pre-Eclampsia, Depression, Inflammation, Vitamin D Deficiency
- Trial name
- PROVIDE (NCT03018132)
- Testing
- mental health screening, education and referral program
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Polycystic Ovary Syndrome
Resting Metabolic Rate, Fat Distribution, Endocrine and Metabolic Features in Polycystic Ovary Syndrome
In a longitudinal, prospective and observational study, patients with PCOS and controls wore the SenseWear Armband for 2 days. Resting metabolic rati (kcal/die), total energy expenditure (MET, kcal) were evaluated.
- Trial name
- NCT03132545
- Testing
- SenseWear Armband (SWA) monitoring, total body dual-energy X-ray absorptiometry
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pediatric Obesity, Obesity, Childhood
PErioperAtive CHildhood ObesitY
The incidence of childhood obesity is at epidemic levels and increasing in the UK. Obese adults are considered a high-risk group of patients for general anaesthesia with published national guidelines on the best practice…
- Conditions
- Pediatric Obesity, Obesity, Childhood, Overweight and Obesity, Perioperative/Postoperative Complications
- Trial name
- PEACHY (NCT03994419)
- Testing
- Anaesthesia for surgery
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Healthy Subjects, Pharmacokinetics of ASP8232
A Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety of ASP8232 in Subjects With Renal Impairment and in Type 2 Diabetes Mellitus Subjects With Chronic Kidney Disease
This study consists of two parts. Part 1 evaluates the effect of renal impairment on the PK and PD of a single dose of ASP8232. In addition, the safety and tolerability will be assessed.
- Conditions
- Healthy Subjects, Pharmacokinetics of ASP8232, Pharmacodynamics of ASP8232, Chronic Kidney Disease (CKD)
- Trial name
- NCT02218099
- Testing
- ASP8232
- Where
- 3 sites in Bulgaria, Moldova and 1 more
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Europe B.V.
Vitamin D Deficiency, Pre-Eclampsia
Effect of Vitamin D3 Supplementation in Pregnancy on Risk of Pre-eclampsia
Vitamin D deficient pregnant ladies were selected and randomized into 2 groups for routine daily dose of multivitamin (400IU vitamin D3) versus maximum safest treatment daily dose (4000IU vitamin D3).
- Trial name
- NCT03101150
- Testing
- 400 IU Vitamin D3, 4000 IU Vitamin D3
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- King Fahad Medical City
Gestational Diabetes
A Study Using Breath Tests to Identify Patients at Risk for Gestational Diabetes
The aim of our study is to evaluate the feasibility, and diagnostic value of oral 13C labelled glucose breath test compared to the GCT and OGTT tests.
- Trial name
- NCT07347262
- Testing
- Noninvasive Breath Test in Order to Identify Patients at Risk for Developing Gestational Diabetes
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Obesity
Effects of Two Hypocaloric Diets on Weight Loss
The investigators evaluated whether an energy-restricted protein diet with low glycaemic index carbohydrates and soluble fibers (LC-P-LGI) would be more effective than a conventional diet (LC-CONV) on weight-loss and related…
- Trial name
- NCT01312740
- Testing
- LC-P-LGI diet, LC-CONV
- Where
- France
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Ceprodi S.A. Kot
Lung Cancer, Breast Cancer
Plasma Metabolic Biomarkers for Multi-Cancer Diagnosis
The aim of this observational study is to comprehensively analyze the metabolites in plasma samples from multi-cancer patients using advanced mass spectrometry detection technology, in conjunction with metabolomics approaches.
- Conditions
- Lung Cancer, Breast Cancer, Colorectal Cancer, Thyroid Cancer
- Trial name
- NCT06363123
- Where
- 4 sites in China
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Gestational Diabetes
miRNA (microRNA) and FGF21 (Fibroblast Growth Factor-21) Profile in First Trimester and Gestational Diabetes Prediction
The goal of this observational study is to compare miRNA and FGF21 in pregnancy with and without GDM (Gestational Diabetes) The main question it aims to answer that miRNA and FGF21 are different between two groups.
- Trial name
- NCT05632055
- Testing
- blood draw
- Where
- Thailand
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chiang Mai University
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