Clinical trials: Metabolic Control
Weight Loss, Cold Exposure
Cold, Appetite and Weight Loss in Individuals With Obesity
This study is an 8 week weight loss intervention with 3 randomly assigned groups: DIET, cold exposure (CE), and DIET+CE. The study will be a total of 13 weeks.
- Conditions
- Weight Loss, Cold Exposure, Appetitive Behavior
- Trial name
- NCT05076357
- Testing
- Caloric Restriction, Cold intervention
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Hyperlipidemia
A Study on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HRS-7249 Injection in Healthy Subjects
It is a randomized, double-blind, single-dose, placebo-controlled phase I clinical trial. The study plans to conduct four to six dose groups of dose 1, dose 2, dose 3, dose4, dose5 (optional), and dose 6(optional).
- Trial name
- NCT06541457
- Testing
- HRS-7249 injection
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Zinc Deficiency, Child Nutrition Disorders
Daily Zinc Supplement Effect on Prevention of Diarrhea and Acute Respiratory Infections in Children Less Than Five Years
Zinc deficiency in children is a major problem which leads to compromised immunity and accordingly repeated infections. This study aims to investigate the effect of supplementing zinc to decrease the incidence of diarrhea and…
- Trial name
- RCTZ (NCT05002101)
- Testing
- zinc
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pregnancy
Physical Exercise Program in Obese and Overweight Pregnant Women
Obesity and overweight have become an epidemic in the world and its prevalence between pregnant women is especially dangerous. Having a high Body Mass Index (BMI) is also associated with depression disorders and its serious…
- Trial name
- NCT01753622
- Testing
- Exercise group
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Technical University of Madrid
Type 2 Diabetes Mellitus, Congestive Heart Failure
Effects of Exenatide in Type 2 Diabetic Patients With Congestive Heart Failure
The purpose of this study is to determine if exenatide will improve global cardiac function in patients with type 2 diabetes mellitus and congestive heart failure, by favorable effects on cardiac metabolism leading to improvement…
- Trial name
- NCT00766857
- Testing
- exenatide, Insulin glargine
- Where
- Netherlands
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Inflammation, Malnutrition
Effects of Camelina Sativa Oil in Free-living Older Adults
The present study aims at evaluating the anti-inflammatory effects of a novel food in older adult volunteers. Briefly, this randomized, double-blind and placebo-controlled study is performed on 91 apparently healthy older adults…
- Conditions
- Inflammation, Malnutrition, Hyperglycemia, Dyslipidemias
- Trial name
- NCT04965948
- Testing
- Novel food snack
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Obesity
Randomized, Controlled, Open, Comparative Intervention Study for Obesity Prevention in Children
Randomized, controlled, open, comparative intervention study in 270 children at risk for obesity.Patients will be randomly allocated into one of two behavior intervention groups or control group in ratio of 1:1:1.The study will…
- Trial name
- 4055obesityprv (NCT00438555)
- Testing
- Parents and children group, Parent's group
- Where
- Israel
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Pharmacokinetics, Hepatic Impairment
MDMA in Subjects With Moderate Hepatic Impairment and Subjects With Normal Hepatic Function
The goal of this clinical trial to learn how MDMA is processed in people with abnormal liver function. The main questions it aims to answer are: Do people with abnormal liver function experience greater absorption of MDMA? Does…
- Trial name
- NCT03606538
- Testing
- Midomafetamine HCl
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Resilient Pharmaceuticals
Hypovitaminosis D
To Study the Nutri-Genomic Response of Vit-D Supplementation in African-Americans
Three hundred thirty (330) overweight, pre-hypertensive/controlled hypertensive, African-American participants will be enrolled in a 8 week study to assess the effect of two administrations of Vitamin D3 on Vitamin D serum…
- Trial name
- NCT02802449
- Testing
- 25 Hydroxy- Vitamin D3 [25 (OH) D3]
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Charles Drew University of Medicine and Science
Pediatric Fractures, Hypovitaminosis D
Bone Outcomes, Obesity, Sunlight, and Trauma in Children
Prospective case-control study of children (3-15 years) after low-energy trauma. We compare serum bone metabolic markers (25OHD, PTH, ALP, calcium, phosphate), BMI/percentile, and dietary calcium intake between fracture and…
- Conditions
- Pediatric Fractures, Hypovitaminosis D, Obesity and Overweight
- Trial name
- BOOST (NCT07143552)
- Where
- 2 sites in Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Paracelsus Medical University
Type 1 Diabetes
Short-term Effects of Carbohydrate-restricted Diet on Glycemic and Metabolic Control Among Children and Adolescent With Type 1 Diabetes Mellitus
The current management of type 1 diabetes mellitus (T1DM) involves the use intensive insulin therapy, frequent blood glucose monitoring and carbohydrate counting.
- Trial name
- NCT06699485
- Testing
- Low carb diet
- Where
- Egypt
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sohag University
Ornithine Transcarbamylase Deficiency
Safety, Tolerability and Pharmacokinetics of ARCT-810 in Healthy Adult Subjects
Determine the safety, tolerability and pharmacokinetics of single doses of ARCT-810 in healthy adult subjects.
- Trial name
- NCT04416126
- Testing
- ARCT-810
- Where
- New Zealand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Arcturus Therapeutics, Inc.
Diabetes Mellitus, Type 2
A 12-week Digital Physical Activity Programme, With or Without Physical Education Support for Type 2 Diabetes Patients.
Investigation into the effects of a 12-week digital physical activity programme, with or without physical education support on blood glucose control in patients with T2DM using HbA1c testing.
- Trial name
- NCT06402578
- Testing
- HbA1c testing
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Obesity, Infant
Health e-Baby: Trial to Reduce Obesity Risk Factors During the First 1,000 Days
Specific Aim: Feasibility of a Pilot Randomized Controlled Trial (RCT) in Pregnancy and Infancy to Reduce Childhood Obesity Risk Factors in Early Life.
- Trial name
- NCT05225649
- Testing
- Behavior Change Intervention
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Columbia University
Obesity, Overweight and Obesity
Investigation of the Effects of a Bifidobacterium Breve Strain on Fat Loss in Healthy Adults
Overweight has become a critical issue in North America and the market value of weight loss products is expected to rise as the population becomes more health-conscious and aware of the risks associated with excess body weight.
- Trial name
- NCT04677738
- Testing
- B. breve strain
- Where
- Canada
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Morinaga Milk Industry Co., LTD
Diabetes Mellitus, Type 2, Inflammation
Randomized Crossover Study of Magnesium Supplementation
The investigators recent epidemiologic work in several national surveys and cohorts of men and women have shown that dietary patterns high in plant-based foods and phytochemicals are associated with lower plasma levels of…
- Trial name
- NCT00737815
- Testing
- Magnesium Citrate: a total of 500 mg elemental magnesium
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Obesity
Communicating Risk Information for Obesity
This study will examine the impact of providing genetic risk information for obesity on people's attitudes and beliefs about obesity, health behaviors and weight outcomes.
- Trial name
- NCT01355224
- Testing
- Genetic, Lifestyle
- Where
- United States
- Volunteers
- 798 people, healthy volunteers welcome
- Sponsor
- Boston University
Overweight and Obesity
Water Intake and Weight Control in Older Adults
This study is a randomized controlled intervention trial in adults aged 50+ years with overweight or obesity, which will compare three groups with different diet prescriptions: 1) pre-meal water consumption (500 ml, before each…
- Trial name
- NCT05843318
- Testing
- Water intake and weight control in older adults - Premeal Water + hypocaloric diet, Water intake and weight control in older adults - Total Daily Water + hypocaloric diet, Water Intake and weight control in older adults - hypocaloric diet alone
- Where
- United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Hyperglycemia
Efficacy and Safety Between Different Dilution of Insulin
Hyperglycemia associated with insulin resistance is common in critically ill patients, even in those nondiabetic patients. Hyperglycaemia or relative insulin deficiency (or both) during critical illness may directly or indirectly…
- Trial name
- NCT06180824
- Testing
- Gelafundin
- Where
- Malaysia
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Healthy Participants
A Study to Investigate the Safety, Tolerability and Pharmacodynamics of AZD4144 in Participants With Obesity
The aim of this study is to evaluate the safety and tolerability, and pharmacodynamics (PD) of AZD4144 administered as repeated daily oral dosing.
- Trial name
- NCT06942923
- Testing
- AZD4144
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
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