Clinical trials: Metabolic Control
PreDiabetes, Overweight and Obesity
Zein Nanoparticles for Glycemic Control
The use of zein nanoparticles as vehicles for drug delivery is under study, but of the effects observed in empty nanoparticles, in laboratory animals, the reduction of glucose levels was something worth studying.
- Conditions
- PreDiabetes, Overweight and Obesity, Adult ALL
- Trial name
- GLUCOCAPS (NCT05560412)
- Testing
- Zein nanocapsules, control
- Where
- Spain
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Obesity & Overweight, Healthcare Worker
Personalized Nutrition Coaching for a Weight Loss Program Among Overweight and Obese Nurses
Obesity among healthcare workers has become an increasing public health concern, with potential consequences for work productivity, quality of care, and long-term health outcomes.
- Conditions
- Obesity & Overweight, Healthcare Worker, Low Physical Activity Level
- Trial name
- NCT07440979
- Testing
- Personalized Nutrition Coaching
- Where
- Indonesia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universitas Padjadjaran
Overweight, Exercise
Effects of Diet Versus Diet Plus Aerobic and Resistant Exercise Program in Overweight Women
Adult women aged 18-50 years and overweight (preobese) with a BMI of 25-30 kg/m2 will be included in the study. Participants will participate in an eight-week diet and diet plus aerobic and resistance exercise program.
- Trial name
- NCT05591794
- Testing
- Aerobic and resistance exercises, Diet program, Regular walking program
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Obesity, Abdominal
Imaging on Core Muscles Function in Patients With Visceral Adiposity
The purpose of this study is to determine the effect of cavitation ultrasonic lipolysis, RUSI guided core muscle exercise and their combination (cavitation ultrasonic lipolysis and RUSI guided core muscles exercise) on…
- Trial name
- NCT05690659
- Testing
- device and exercise
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Deraya University
Obesity, Extreme Obesity
Low-level Intervention for Adolescents With Extreme Obesity
While adolescents with obesity and extreme obesity are at increased risk for health complications, especially adolescents with extreme obesity rarely seek medical care, and sustained weigh loss is hardly ever achieved.
- Trial name
- STEREO (NCT01703273)
- Testing
- manual based low key group intervention (innovation), standardized, manual based routine care
- Where
- 6 sites in Germany
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Martin Wabitsch
PreDiabetes, Overweight and Obesity
Effect of a Probiotic on the Glycemic Profile and the Fecal Microbiota of Prediabetic Subjects (PREDIABETCARE)
According to the data from the Di@bet.es study, which is part of the National Diabetes Strategy, the prevalence of type 2 diabetes among Spanish population is 13.8%.
- Trial name
- PREDIABETCAR (NCT04863313)
- Testing
- Probiotic
- Where
- Spain
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Obesity
Dose-ranging Study of SKF7™ for Obesity
This study has been designed as a randomized, double blinded, multi-centric, placebo controlled, and phase II dose-ranging study.
- Trial name
- NCT04557267
- Testing
- low-dose, Middle-dose, Higher-dose
- Where
- 3 sites in Indonesia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Diabetic Ketoacidosis, Heart Disease, Ischemic
Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient
Music intervention is a non-pharmacological and effective intervention that can alleviate anxiety and agitation in patients undergoing weaning.
- Conditions
- Diabetic Ketoacidosis, Heart Disease, Ischemic, Stroke, GastroIntestinal Bleeding
- Trial name
- NCT04977011
- Testing
- relaxing music
- Where
- Taiwan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Min-Sheng General Hospital
Diabetes
A Clinical Study to Evaluate Safety, Tolerability and Pharmacokinetics of Oral ZYGK1 in Healthy Volunteers
The purpose of this study is to determine (1) whether ZYGK1 is safe and well tolerated, (2) the pharmacokinetics (what body does to ZYGK1) and (3) pharmacodynamics (what drugs does to the body) in the healthy and diabetic subject.
- Trial name
- NCT01472809
- Testing
- ZYGK1
- Where
- India
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Zydus Lifesciences Limited
Type 1 Diabetes Mellitus
Study Assessing an Insulin Pump-controlling Algorithm to Minimize Hypo and Hyper in Type 1 During CRC Setting
Feasibility study assessing the ability of an insulin pump-controlling algorithm to minimize hypoglycemia and hyperglycemia in patients with type 1 diabetes in a clinical research setting.
- Trial name
- NCT01638299
- Testing
- Hypo-Hyper Minimizer (HHM) System
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Animas Corporation
Dental Implant, Bone Loss
Ridge Augmentation Using Allograft Particles Hydrated With or Without Recombinant Human Platelet-Derived Growth Factor
This study will compare two techniques to achieve increase in ridge dimensions as a preparation for dental implants using a resorbable barrier membrane and bone particulate allogenic graft hydrated with saline or a growth factor…
- Trial name
- NCT04954664
- Testing
- Allograft particles hydrated with rhPDGF, Allograft particles hydrated in a conventional way with saline.
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Diabetes Mellitus, Type 2
Single, Ascending Dose, First Time in Human Study for GZR18 in Healthy Subjects
Single ascending dose first time in human study for GZR18 in healthy subjects
- Trial name
- NCT05328726
- Testing
- GZR-18
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Gan and Lee Pharmaceuticals, USA
Lipid Metabolism
Investigating the Effect of Obicetrapib on Lipoprotein Metabolism
To determine the treatment effect with obicetrapib (10 mg) on the fractional catabolic rate (FCR) of apolipoprotein (apo) B100 in low-density lipoprotein (LDL).
- Trial name
- NCT05972278
- Testing
- Obicetrapib
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- NewAmsterdam Pharma
Hypercholesterolemia, Healthy Volunteers
A Study on Evaluating the Safety of HST101 in Healthy Chinese Participants
This is a single-center, randomized, double-blind, placebo-controlled, single HST101 SC dose cohort study to evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Chinese Participants with Elevated…
- Conditions
- Hypercholesterolemia, Healthy Volunteers, LDL-Cholesterol
- Trial name
- NCT06504043
- Testing
- HST101
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hasten Biopharmaceutical Co., Ltd.
Amyloidosis
A Study of NPT189 in Healthy Subjects
The purpose of the study is to evaluate the safety and tolerability of single dose of NPT189 in healthy volunteers. The study will also evaluate the pharmacokinetic characteristics of NPT189.
- Trial name
- NCT03610035
- Testing
- NPT189
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Proclara Biosciences, Inc.
Diet Modification
The Effect of Dietary Lauric Acid on the Production of the LRH-1 Ligand, Dilauroylphosphatidylcholine
A phosphatidylcholine species enriched with lauric acid at both the sn-1 and sn-2 positions, dilauroylphosphatidylcholine (DLPC), was recently identified as a ligand for the nuclear receptor, liver receptor homolog-1 (LRH-1).
- Trial name
- DLauricPC (NCT03481608)
- Testing
- Lauric acid (coconut oil), No Lauric acid (olive oil)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cornell University
Pre-diabetes, Pre-hypertension
Primary Prevention of Cardiovascular Disease (CVD) in Pre-diabetic & Pre-hypertensive Subjects
The purpose of this study is to determine whether treating pre-diabetic \& pre-hypertensive individuals using multiple drugs intervention (anti-hypertensive drugs (i.e., ACEI) plus anti-glycemic drug (i.e., metformin) plus…
- Trial name
- PPCVD (NCT01364675)
- Testing
- Metformin+Enalapril+Simvastatin
- Where
- Thailand
- Volunteers
- 8,900 people, healthy volunteers welcome
- Sponsor
- Ramathibodi Hospital
Type 2 Diabetes
The Finnish Diabetes Prevention Study
The aim of this study is to clarify whether lifestyle intervention provided to people with high type 2 diabetes risk will lower the cumulative incidence of diabetes.
- Trial name
- DPS (NCT00518167)
- Testing
- Intensive lifestyle counselling
- Where
- 4 sites in Finland
- Volunteers
- 522 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Prediabetes
Continuous Glucose Monitoring (CGM) in Prediabetes With Community Based Recruitment
The objective of this project is to develop a behavioral intervention that combines wearable continuous glucose monitoring (CGM) with smartphone feedback and educational video clips generated by artificial intelligence (AI)…
- Trial name
- G3 (NCT07477249)
- Testing
- CGM
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- David S Black, PhD
Diabetes
The Effect of Korean Red Ginseng Supplementation on Glucose Control
This study is a randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effect of Korean red ginseng supplementation on glucose control in subjects with impaired fasting glucose, impaired glucose…
- Trial name
- NCT01911663
- Testing
- KRG
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yonsei University
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