Clinical trials: Metabolic Control
Prader-Willi Syndrome
A 5 Treatment Period Pharmacokinetic Study Evaluating Dose Proportionality and Food Effects of Diazoxide Choline Controlled-Release Tablet (DCCR)
Open label, parallel-group, single site, 5 treatment-period study with 4 dose levels of DCCR, 1 of which is administered both with and without food.
- Trial name
- NCT02893618
- Testing
- Diazoxide choline controlled-release tablet
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Essentialis, Inc.
Erectile Dysfunction
Daily Oral L-arginine Plus Tadalafil in Diabetic Patients With Erectile Dysfunction
Tadalafil is an effective oral therapy in erectile dysfunction. L-arginine is a pro drug that increase the level of nitrous oxide in the smooth muscles so can increase the strength and duration of erection.
- Trial name
- NCT03834610
- Testing
- L-arginine 5 gm oral caps, Tadalafil 10 MG, serum testosterone level
- Where
- Egypt
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Physical Inactivity, Walking
Daily Goal Setting to Increase Everyday Physical Activity and Promote Cognitive Health in Midlife
The purpose of this study is to determine whether interaction with an adaptive Fitbit-based goal setting application can increase levels of everyday light intensity physical activity in middle-aged adults.
- Conditions
- Physical Inactivity, Walking, Cognitive Health, Self-regulation
- Trial name
- NCT05826379
- Testing
- Adaptive Daily Goal Setting, Interim Goal Prompt
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Healthy
Assessment of Dietary Biomarkers and Metabolic Effects After the Intake of Milk and Cheese
Dietary biomarkers are compounds in biofluids that directly reflect the intake of specific foods or food groups. Their exploration and use in the field of dietary assessments could provide an objective measure of actual intake…
- Trial name
- NCT02705560
- Testing
- Cow´s milk (3.9% fat, pasteurized), hard, yellow cheese, Soy based drink
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Gestational Diabetes Mellitus
Comparing the Effects of Water Temperature and Actives in Glucose Solution on Pregnant Women
To assess the effect of water temperature and additives on pregnant women's taste and side effect during the oral glucose tolerance test (OGTT) evaluation.
- Trial name
- NCT05508425
- Testing
- oral glucose tolerance test using water at room temperature, oral glucose tolerance test using hot water, oral glucose tolerance test using cold water
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chiayi Christian Hospital
Obesity
SoSu-liv. Mobile Media for Health Promotion
The purpose of this study is to determine whether a web- and app-based tool for health promotion for social and health care workers in Denmark has an effect on body weight (primary outcome), body fat percentage, waist…
- Trial name
- NCT02438059
- Testing
- SoSu-liv website and app
- Volunteers
- 566 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Overweight or Obesity, Diabetes
A Study of SYH2069 Injection in Healthy Participants
To evaluate the safety and tolerability of single and multiple doses of SYH2069 Injection in healthy participants.
- Trial name
- NCT07736391
- Testing
- SYH2069 Injection
- Where
- China
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- CSPC Ouyi Pharmaceutical Co., Ltd.
Healthy Adult
Nicotinamide Adenine Dinucleotide Responses to a Nutritional Supplement
The objective of this study is to evaluate nicotinamide adenine dinucleotide (NAD+) in response to a proprietary nutritional supplement in generally healthy adults, compared to placebo.
- Trial name
- NCT07428889
- Testing
- Proprietary Nutritional Supplement
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Shaklee Corporation
Glucose Intolerance
Effects of a Dietary Supplement Containing Salacia Extract, Citrus Bioflavonoids, and Trivalent Chromium on Markers of Glucose Control
This study was a double-blind, randomized, placebo-controlled, clinical trial with two parallel groups. Participants reported to a single investigational center in Ohio (i.e., The Center for Applied Health Sciences) during the 12…
- Trial name
- NCT05887050
- Testing
- Active
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- The Center for Applied Health Sciences, LLC
Diabetes Mellitus, Hypertension
Impact of Medication Therapy Management Intervention on Treatment Outcomes and Medication Adherence Among Adult Patients Comorbid With Diabetes Mellitus and Hypertension at Outpatient Clinics
The goal of this interventional study was to assess the impact of medication therapy management on treatment outcomes and medication adherence among adult patients comorbid with diabetes mellitus and hypertension at outpatient…
- Trial name
- NCT06112925
- Testing
- Medication Therapy Management
- Where
- Ethiopia
- Volunteers
- 386 people, healthy volunteers welcome
- Sponsor
- Mattu University
Diabetes
Single Ascending Oral Doses of SY-008 in Healthy Subjects
This is a phase Ⅰ，single-center, randomized, double-blinded, placebo-controlled, single ascending dose trial of SY-008 in healthy subjects.
- Trial name
- NCT03462589
- Testing
- SY-008
- Where
- China
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Suzhou Yabao Pharmaceutical R&D Co., Ltd.
Diabetes, Healthy
Comparing Semaglutide Administered Subcutaneously Once Daily to Semaglutide Administered Subcutaneously Once Weekly
This trial is conducted in Europe. The aim of this trial is to compare the steady-state exposure of semaglutide administered subcutaneously once daily to semaglutide administered subcutaneously once weekly in healthy subjects.
- Trial name
- NCT02557620
- Testing
- semaglutide
- Where
- Germany
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Obesity
The Randomized Controlled Cocoa-Appetite Trial
The purpose of this study is to determine whether high-flavonoid cocoa can decrease appetite in humans. In addition the study is designed to test epicatechin, a compound found in cocoa and procyanidins, a class of compounds found…
- Trial name
- NCT02408289
- Testing
- Lo-Flav, Hi-Flav, Epicatechin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Brooklyn College of the City University of New York
Dyslipidemia
Evaluation of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TA-8995 With Single, Escalating Doses in Healthy Subjects
The purpose of this study is to assess the safety and tolerability of single doses of TA-8995 in healthy Caucasian and Japanese volunteers.
- Trial name
- NCT01878474
- Testing
- TA-8995
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Tanabe Pharma Corporation
Non-alcoholic Fatty Liver Disease
Effect of Supplementation of Fish Oil on Non-alcoholic Fatty Liver Disease in Children
The aim of this study is to evaluate efficacy of fish oil (EPA/DHA) in children with non-alcoholic fatty liver disease.
- Trial name
- NCT01547910
- Testing
- Fish Oil
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Piotr Socha
Physical Fitness, Child Development
School-Based Physical Education Program and Its Effects on Motor Fitness in Malaysian Children
The objective of this randomized controlled trial was to compare the effects of a standard school physical education program (SPEP) and a rhythmic and gymnastic activities-based school physical education program (RGPEP) on the…
- Conditions
- Physical Fitness, Child Development, Exercise Intervention, Childhood Obesity
- Trial name
- SPEP-FIT (NCT06834620)
- Testing
- Rhythmic and Gymnastic Activities-Based School Physical Education Program
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hellenic Naval Academy
Type 2 Diabetes, Chronic Disease
PRE-STARt Intervention - Trial of an Interactive Family Based Lifestyle Programme
To investigate whether the interactive family based lifestyle programme leads to behaviour change at 6 months with the primary outcome being increased levels of moderate to vigorous physical activity (MVPA).
- Conditions
- Type 2 Diabetes, Chronic Disease, Obesity
- Trial name
- NCT02845791
- Testing
- Interactive Lifestyle programme workshop
- Where
- United Kingdom
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Adipose Tissue, Brown, Brown Adipose Tissue
Cold Induced Activation of Brown Adipose Tissue in Humans
This study investigates cold-induced brown fat activation assessed using PET/MR scans. Subjects will participate in an acute cooling intervention day and a thermoneutral intervention day with PET/MR scans on both days.
- Conditions
- Adipose Tissue, Brown, Brown Adipose Tissue, Brown Fat, Uncoupling Protein 1
- Trial name
- COLDBAT (NCT03096535)
- Testing
- Cooling, Thermoneutral
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Susanna Søberg
Diabetes Mellitus, Type 1, Bone Health
Impact of Glycemic Control on Skeletal Outcomes in Adults With Type 1 Diabetes
Background : Type 1 diabetes (T1D) is associated with an increased risk of fractures. The mechanisms accounting for this bone fragility are not yet fully understood.
- Conditions
- Diabetes Mellitus, Type 1, Bone Health, Bone Loss, Bone Diseases, Metabolic
- Trial name
- DenSiFy cohort (NCT06351176)
- Testing
- Clinical tests, Biochemical tests, DXA scan with TBS and VFA
- Where
- 2 sites in Canada
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Hypercholesterolemia
Ascending Dose Study of the Safety and Tolerability of Alirocumab (SAR236553/REGN727) in Japanese Healthy Volunteers
Primary Objective: To assess the safety and tolerability of ascending single doses of subcutaneously (SC) administered alirocumab (SAR236553/REGN727) in Japanese healthy male subjects.
- Trial name
- NCT01448317
- Testing
- Alirocumab (Solution), Alirocumab (Lyophilized formulation)
- Where
- Japan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sanofi
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