Clinical trials: Metabolic Control
Diabetes Mellitus
Phase 1 SAD and MAD Study of NGM282 in Healthy Adult Participants
The purpose of this study is to determine the safety and tolerability of NGM282, both single dose and multiple doses, in normal healthy adult participants.
- Trial name
- NCT01776528
- Testing
- NGM282
- Where
- Australia
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- NGM Biopharmaceuticals, Inc
Hyperlipidemia
A Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Effects of JS401
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetcs and pharmacodynamics of single-dose of JS401 in healthy volunteers with normal or mildly elevated triglycerides.
- Trial name
- NCT06041165
- Testing
- JS401
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Child Obesity
Development and Evaluation of the T.E.A.C.H. Study: A Randomized Control Trial
Using a randomized control design, this study seeks to develop and evaluate a nutrition intervention to increase Montessori teachers' nutrition knowledge, nutrition self-efficacy, nutrition teaching self-efficacy and cultural…
- Trial name
- NCT06926907
- Testing
- The Teacher Education and Classroom Habits (T.E.A.C.H.) Program
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Florida International University
Obesity, Craving
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Food Craving in Obese Individuals.
Background: Obesity is one of the most important diseases around the globe; with a continuous increase and public health concern. Current treatments present some limitations.
- Trial name
- taVNS (NCT03217929)
- Testing
- Active-taVNS
- Where
- Brazil
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Cognitive Function and Mood, Cerebral Blood Flow
The Effects of Resveratrol Supplementation on Cognition, Cerebral Blood Flow, Microbiota and Systemic Inflammation.
Previous research shows that a diet high in fat has harmful effects on gut health. This increases the chance of developing obesity-related diseases (such as type 2 diabetes) and disrupts cognition and mood.
- Conditions
- Cognitive Function and Mood, Cerebral Blood Flow, Systemic Inflammation, Gut Microbiota
- Trial name
- NCT03448094
- Testing
- Resveratrol
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Primary Hyperlipidemia and Mixed Dyslipidemia
Effects on Lipoprotein Metabolism From PCSK9 Inhibition Utilizing a Monoclonal Antibody
This is a randomized, double-blind, placebo-controlled trial to evaluate the effect of evolocumab, atorvastatin, and combination therapy on lipoprotein kinetics.
- Trial name
- FLOREY (NCT02189837)
- Testing
- Evolocumab, Atorvastatin
- Where
- 2 sites in Australia
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Amgen
Amyotrophic Lateral Sclerosis (ALS)
Circulating Biomarker for Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis (ALS) is a rare disease with a worldwide incidence of 2-3 cases per 100,000 individuals/year and it is characterized by progressive neurodegeneration of motor neurons.
- Trial name
- NCT03088839
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Type 2 Diabetes, Glycemic Control
Blood Glucose Homeostasis in Type 2 Diabetes: the Effects of Saccharose
Hyperglycemia forms a direct and independent risk factor for the development of cardiovascular co-morbidities in type 2 diabetes.
- Trial name
- NCT00821665
- Testing
- Sucrose consumption, water consumption
- Where
- Netherlands
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Osteoporosis
Comparison of Raloxifene and Lasofoxifene - A Randomized, Blinded Study of These Drugs and Placebo on Bone Loss
To compare the effects of 2 years of lasofoxifene treatment with 2 years of raloxifene 60 mg/day use and 2 years of placebo use on bone mineral density (BMD) of the lumbar spine.
- Trial name
- CORAL (NCT00163137)
- Testing
- lasofoxifene, raloxifene
- Where
- 72 sites in United States
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Ligand Pharmaceuticals
Vitamin k2 in Type 2 DM
Relation Between Plasma Vitamin K2 and Glycemic Control and Metabolic Parameters in Type 2 Diabetic Patients.
Background and Rationale: The agents inducing type 2 diabetes are yet to be clarified. Current studies show that several genetic and environmental parameters are associated with type 2 diabetes .
- Trial name
- NCT04387019
- Testing
- blood sampling
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
Optic Atrophy, Hereditary, Leber
A Randomized, Double-blind, Placebo-controlled Trial of Curcumin in Leber's Hereditary Optic Neuropathy (LHON)
Background Leber's Hereditary Optic Neuropathy (LHON) is a maternally inherited ocular disorder associated with a mutation in mtDNA .
- Trial name
- NCT00528151
- Testing
- curcumin
- Where
- Thailand
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Diabetes Mellitus, Type 2
The Effect of Alogliptin on Pulmonary Function in Obese Patients With Type 2 Diabetes Inadequately Controlled by Metformin Monotherapy
Objective: To observe the effect of alogliptin combined with metformin on pulmonary function in obese patients with type 2 diabetes inadequately controlled by metformin monotherapy (500 mg, bid po, for at least 3 months), and…
- Trial name
- NCT02798172
- Testing
- Alogliptin and Metformin
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Fourth People's Hospital of Shenyang
Diabetic Retinopathy, Neurodegeneration
Glycemic Control and Retinal Microvascular Changes
The goal of this prospective, observational study is to compare in the association of glycemic control and retinal microvascular changes in patients with type 2 diabetes mellitus (T2DM) without diabetic retinopathy (DR).
- Conditions
- Diabetic Retinopathy, Neurodegeneration, Blood Sugar; High
- Trial name
- NCT06150495
- Where
- South Korea
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Healthy Subjects
Evaluation of Safety, Tolerability, PK/PD, and Metabolism of Single-Dose Singletine(DC407) in Adults
The goal of this clinical trial is to evaluate the safety, tolerability and pharmacokinetic characteristics of Singletine in healthy adult subjects.
- Trial name
- NCT06160401
- Testing
- Singletine
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Guangzhou JOYO Pharma Co., Ltd
Insulin Resistance
The Effects of Altering Physical Activity on Cardiometabolic Health
The effects of physical inactivity on variations in blood glucose and vascular health are not fully understood. The purpose of this study is to determine if an acute transition from physical activity to inactivity alters vascular…
- Trial name
- PIA (NCT01879059)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Obesity
Safety, Toleration and Efficacy of CP-741,952 for the Treatment of Obesity
The purpose of this study is to determine whether CP-741,952 is effective in the treatment of obesity and to determine 12 week safety and toleration.
- Trial name
- NCT00367783
- Testing
- CP-741,952
- Where
- 5 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pfizer
Overweight and Obesity
The Fibre Full Study
This study will systematically investigate the effects of a diet with decreased energy density, reduced glycaemic index, and significantly increased dietary fibre, on post-prandial glycaemic response, satiety, gastrointestinal…
- Trial name
- NCT06416254
- Testing
- Fibre-enriched diet, Control diet
- Where
- Ireland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University College Cork
Type 2 Diabetes, Hepatic Steatosis
Acute Exercise and Endogenous Glucose Production in Type 2 Diabetes: Implications for Glycemic Control and Treatment of Hepatic Steatosis
The overall aim of this study is to investigate the effects of exercise on the amount of glucose that is made by the liver in people with and without Type 2 diabetes (T2D) and hepatic steatosis (fatty liver).
- Trial name
- ACELERATE-P (NCT06993454)
- Testing
- Magnetic Resonance Liver Assessment, Bike Exercise VO2max, DEXA
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Obesity and Obesity-related Medical Conditions
Study on the Weight Loss Effects and Mechanisms of Probiotic Preparation Intervention in Weight Cyclers
1. Study Background and Purpose Obesity is a complex chronic disease closely linked to comorbidities such as cardiovascular disease, hypertension, and diabetes. With lifestyle changes, obesity prevalence continues to rise.
- Trial name
- Probiotic (NCT07031596)
- Testing
- WONDERLAB SHAPE100™ Ready-to-Eat Probiotic Food (S100)., WONDERLAB SHAPE100™ Ready-to-Eat Probiotic Food (S100) + WONDERLAB Weight Management Probiotic Food.
- Where
- China
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Diabetes Mellitus, Quality of Health Care
Randomised Controlled Trial of Structured Personal Care of Type 2 Diabetes Mellitus
The aims of a concluding 14-year follow-up study are: To investigate what long-term effect the project model for structured, personalized diabetes care has on 1) the patients' mortality and development of diabetic complications…
- Conditions
- Diabetes Mellitus, Quality of Health Care, Health Services Research
- Trial name
- DCGP (NCT01074762)
- Testing
- Structured personal care
- Where
- Denmark
- Volunteers
- 1,470 people, healthy volunteers welcome
- Sponsor
- Research Unit Of General Practice, Copenhagen
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