Clinical trials: Metabolic Evaluation
Amyotrophic Lateral Sclerosis
Safety, Tolerability, and Exploratory Efficacy Study of Intrathecally Administered Gene Therapy AMT-162 in Adult Participants With SOD1 Amyotrophic Lateral Sclerosis (SOD1-ALS)
This is the study of AMT-162 in Participants with SOD1-ALS and is designed to evaluate the safety, tolerability, and exploratory efficacy of intrathecally administered gene therapy AMT-162.
- Trial name
- NCT06100276
- Testing
- AMT-162
- Where
- 12 sites in United States, Sweden
- Volunteers
- 20 people
- Sponsor
- UniQure Biopharma B.V.
Diabetes, Healthy
Investigation on Safety, Tolerability and Pharmacokinetics of Multiple Doses of NNC0113-0987 in an Oral Formulation in Healthy Subjects
This trial is conducted in Europe. The aim of the trial is to investigate safety, tolerability and pharmacokinetics (the exposure of the trial drug in the body) of multiple doses of NNC0113-0987 in an oral formulation in healthy…
- Trial name
- NCT01978613
- Testing
- NNC0113-0987
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Novo Nordisk A/S
Osteoporosis
TST002 Intervenous Injection in Postmenopausal Women and Men With Reduced Bone Mineral Density
This is a placebo-controlled, single-ascending dose, multicenter Phase I clinical study to evaluate the safety, tolerability, PK and PD characteristics of a single intravenous infusion of TST002 in subjects with reduced bone…
- Trial name
- NCT05391776
- Testing
- TST002 Injection
- Where
- 5 sites in China
- Volunteers
- 32 people
- Sponsor
- HJB (Hangzhou) Co., Ltd.
Diabetes Mellitus, Type 1
Evaluation of the Hypoglycaemia Notification Device Hyposafe H02
To evaluate the technical performance of the hyposafe H02 during everyday activities and during insulin-induced hypoglycaemia, in addition to safety issues associated with the implantation and use of the hyposafe H02 in subjects…
- Trial name
- NCT02925676
- Testing
- hyposafe H02
- Where
- 2 sites in Denmark
- Volunteers
- 8 people
- Sponsor
- UNEEG Medical A/S
Dyslipidaemias, Heart Failure
Effect Of GW501516X On How The Heart Obtains And Uses Energy
The purpose of this study is to determine the effect of a 4-week treatment period with GW501516X on how the heart obtains and uses energy. The energy of the heart will be measured by Magnetic Resonance Imaging (MRI).
- Trial name
- NCT00318617
- Testing
- GW510516X
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Phenylketonuria
Long-Term Extension of Previous rAvPAL-PEG Protocols in Subjects With PKU (PAL-003)
This study is an extension of previous rAvPAL-PEG studies. Administration of rAvPAL-PEG will be continued to assess whether long-term dosing of rAvPAL-PEG is safe and can maintain reduced blood Phe concentrations in PKU subjects.
- Trial name
- NCT00924703
- Testing
- rAvPAL-PEG
- Where
- 14 sites in United States
- Volunteers
- 68 people
- Sponsor
- BioMarin Pharmaceutical
Obesity
Assessment of Gastric Volume Reduction in Surgical Weight Loss Candidates
This trial will assess the feasibility of reduction gastroplasty with standard suture in bariatric patients who are candidates for surgical weight loss intervention.
- Trial name
- NCT00721227
- Testing
- Reduction Gastroplasty
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Ethicon Endo-Surgery
Healthy Male Participants
A Safety and Pharmacokinetic Study of AG-881 in Healthy Male Participants Following Administration of a Single Oral Dose of [14C] AG-881 and Concomitant Intravenous Microdose of [13C315N3] AG-881
The purpose of this Phase I, open-label study is to evaluate the absorption, distribution, metabolism, excretion, absolute bioavailability, and to characterize the metabolites of AG-881 in healthy male participants following…
- Trial name
- NCT03960502
- Testing
- AG-881, [13C315N3]AG-881
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Agios Pharmaceuticals, Inc.
Fabry Disease
This Study is Designed to Evaluate PD/PK and Safety of Replagal Manufactured by Two Different Processes.
This study is designed to evaluate safety and PK/PD in Canadian Fabry patients.
- Trial name
- NCT01304277
- Testing
- agalsidase alfa
- Where
- 5 sites in Canada
- Volunteers
- 17 people
- Sponsor
- Shire
Type 2 Diabetes
Evaluation of Basal Insulin Initialization and Titration in People With Type 2 Diabetes Wearing a Dexcom G6 Sensor
To evaluate the feasibility of the DexBasal Study System
- Trial name
- NCT07681375
- Testing
- Basal insulin, Dexcom Continuous Glucose Monitoring (CGM)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- DexCom, Inc.
Amyloidosis
Biodistribution of 89Zirconium-labelled GSK2398852 Using PET Imaging
The principal aim of this study is to investigate the cardiac uptake of 89Zr-GSK2398852 in subjects with transthyretin cardiomyopathy amyloidosis (ATTR-CM), and its biodistribution to other organs.
- Trial name
- NCT03417830
- Testing
- GSK2315698 (CPHPC), GSK2398852 (unlabeled anti-SAP mAb), 89Zr-GSK2398852 (89Zr-labeled anti-SAP mAb)
- Where
- Sweden
- Volunteers
- 2 people
- Sponsor
- GlaxoSmithKline
Type 1 Diabetes
Clinical Investigation to Assess the Feasibility of a New Diabetes Management Program
The goal of this interventional study is to assess the adherence to a personalized care plan in patients (12-15 years) with Type 1 diabetes
- Trial name
- ODIN (NCT05793645)
- Testing
- personalized care plan
- Where
- 3 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Air Liquide Santé International
Congenital Adrenal Hyperplasia, 21-OHD
A Phase 2 Study to Evaluate the Safety, Efficacy and PK of Tildacerfont in Children Aged 2-17 Years With CAH
An investigation of the safety and efficacy of tildacerfont in participants with CAH.
- Trial name
- NCT05128942
- Testing
- Tildacerfont
- Where
- 13 sites in United States
- Volunteers
- 67 people
- Sponsor
- Spruce Biosciences
Diabetes Mellitus
Evaluation of the Accuracy of an Implanted Glucose Sensor
The purpose of this clinical investigation is to evaluate the accuracy of the Senseonics Continuous Glucose Monitoring System (Senseonics CGM System) measurements when compared with reference standard measurements The…
- Trial name
- PRECISEII (NCT02647905)
- Testing
- Continuous Glucose Monitoring System
- Where
- 9 sites in United States
- Volunteers
- 90 people
- Sponsor
- Senseonics, Inc.
Primary Hyperoxaluria Type 1, Primary Hyperoxaluria Type 2
Evaluation of the Efficacy and Safety of Stiripentol in Patients 6 Years and Older With Primary Hyperoxaluria Type 1, 2 or 3
Evaluation of the efficacy and safety of stiripentol in patients 6 years and older with primary hyperoxaluria type 1, 2 or 3.
- Conditions
- Primary Hyperoxaluria Type 1, Primary Hyperoxaluria Type 2, Primary Hyperoxaluria Type 3
- Trial name
- CRYSTAL (NCT06465472)
- Testing
- Stiripentol Oral Capsule, Urine samples collect, Blood samples collect
- Volunteers
- 42 people
- Sponsor
- Biocodex
Metabolic Dysfunction-Associated Steatohepatitis(MASH)
Safety, Tolerability, PK, PD, and Immunogenicity of QL2401 in Healthy Chinese Adults
This is a first-in-human, Phase I, randomized, double-blind, placebo-controlled clinical trial to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of QL2401 following single and multiple…
- Trial name
- NCT07331545
- Testing
- QL2401
- Where
- China
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
SYNERGY PLUS: Evaluation of Next Generation Sensors (NGS) and Algorithm in Patients With Type 1 and Type 2 Diabetes
The purpose of this study is to find out how well a new continuous glucose monitor works for people with diabetes. This study will test the performance of the study sensor(s) for 7-14 days of wear in patients who are 11-80 years…
- Trial name
- NCT06719531
- Testing
- Continuous Glucose Monitoring
- Where
- 28 sites in United States
- Sponsor
- Medtronic MiniMed, Inc.
Coronary Artery Disease
Serial OCT Evaluation of Tissue Coverage in Patients Submitted to Inspiron Drug Eluting Stent Implantation
Prospective, multicentric, single-arm study to evaluate fast and effective tissue repair in patients undergone percutaneous coronary intervention with drug eluting stent Inspiron.
- Trial name
- REPAIR (NCT03269461)
- Testing
- Angiography and Optical Coherence Tomography evaluations
- Where
- 5 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- Scitech Produtos Medicos SA
Hyperuricemia, Gout
Open Label Safety/Efficacy Study of Arhalofenate in Combination With Febuxostat for Hyperuricemia in Gout Patients
The purpose of this study is to determine whether arhalofenate is safe and effective when dosed in combination with febuxostat in lowering serum uric acid in patients with gout.
- Trial name
- NCT01416402
- Testing
- Arhalofenate, Febuxostat, Colchicine
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Gilead Sciences
Postprandial Hyperglycemia
Investigation of Milk Peptides on Postprandial Blood Glucose Profile
Aim of the study is to investigate the effect of two different dosages of milk peptides on postprandial blood glucose profile in prediabetic subjects compared to placebo.
- Trial name
- NCT03932695
- Testing
- Low dose milk peptide, High Dose milk peptide
- Where
- Germany
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Ingredia S.A.
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