Clinical trials: Metabolic Flexibility
Heart Failure With Normal Ejection Fraction, Obesity
Unsaturated Fatty Acids Enriched-diet to Improve Cardiorespiratory Fitness, Metabolic Flexibility and Glucose Tolerance in Obese Patients
The investigators hypothesize that a dietary intervention aimed at increasing unsaturated fatty acids (UFA) consumption is feasible and has the potential to improve cardiorespiratory fitness, metabolic flexibility and glucose…
- Trial name
- NCT03310099
- Testing
- Increasing daily unsaturated fatty acid consumption
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Virginia Commonwealth University
Obesity Prevention, Obesity
Molecular Landscape of Complex Lifestyle Modification
The goal of this clinical trial is to detect the impact of the 3-month complex lifestyle intervention, consisting of dietary counselling, supervised exercise training and cognitive-behavioural intervention in middle-aged…
- Conditions
- Obesity Prevention, Obesity, Metabolic Disease
- Trial name
- COPMose (NCT06954298)
- Testing
- supervised lifestyle modification
- Where
- Slovakia
- Volunteers
- 50 people
- Sponsor
- Slovak Academy of Sciences
Health Behavior
ACTyourCHANGE Study Protocol. Promoting Healthy Lifestyle With ACT for Obesity
Background: as treatment of choice in promoting psychological flexibility, Acceptance and Commitment Therapy (ACT) was found to be effective in several conditions, and among different populations, including weight management in…
- Trial name
- ACTyourCHANGE (NCT04474509)
- Testing
- FACT Module Engagement, FACT Module Openness, FACT Module Awareness
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Istituto Auxologico Italiano
Health Adult Subjects
Effects of NR Supplementation on Metabolic Flexibility in Zone 2 Training
Zone 2 training, a low-intensity endurance exercise performed at approximately 66-80% of VO₂max or near the first ventilatory threshold, has gained popularity for improving aerobic capacity, fat metabolism, and mitochondrial…
- Trial name
- NCT07344636
- Testing
- Nicotinamide Riboside (NR)
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ZHANG Jiaqi
Metabolic Syndrome (MetS), Glucose Intolerance
Metformin Withdrawal In Metabolic Syndrome
The goal of this clinical trial is to investigate how a short-term interruption of metformin treatment affects insulin sensitivity, glucose control, and metabolic flexibility in adults with metabolic syndrome who are taking…
- Trial name
- METMS (NCT07659444)
- Testing
- Temporary Metformin Withdrawal
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- University of Castilla-La Mancha
Obesity, Diabetes
Fuel Utilization, Diet Composition, and Exercise in African American Women
African American women have a high prevalence of obesity and type 2 diabetes and do not optimally burn fat and carbohydrates in response to changes in these nutrients in their diets.
- Conditions
- Obesity, Diabetes, Insulin Resistance
- Trial name
- NCT04293367
- Testing
- High Intensity Interval Training (HIIT)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Esophageal Adenocarcinoma
Chemotherapy in the Context of Esophageal and Gastroesophageal Junction Cancer Cachexia
Cachexia is a syndrome frequently associated with digestive cancers and more particularly with esophageal and gastroesophageal adenocarcinoma.
- Trial name
- CHIFMEOE (NCT05954117)
- Testing
- Adipose tissue biopsies
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Type 2 Diabetes (T2DM)
Mindfulness-informed Intervention for Improving Diabetes Outcomes in Type 2 Diabetes
The goal of this clinical trial is to learn if Acceptance and Commitment Therapy (ACT), a mindfulness-based psychological approach, can improve health and emotional well-being in adults with type 2 diabetes.
- Trial name
- NCT07130370
- Testing
- Acceptance and commitment therapy
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- National University of Modern Languages
Diabetes, Heart Diseases
An Egg Based Breakfast Maintains Flexibility in Older Adults
Aging is associated with an increased risk for metabolic diseases, such as type 2 diabetes and cardiovascular disease. There is reason to believe that the time of day when specific food groups are eaten affects this risk.
- Trial name
- NCT03164200
- Testing
- High fat breakfast, Higher carbohydrate breakfast
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Overweight (BMI > 25), Obese But Otherwise Healthy Participants
Pistachio Snacking and Metabolic Flexibility
The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults.
- Conditions
- Overweight (BMI > 25), Obese But Otherwise Healthy Participants, Overweight or Obese, Obese Patients (BMI ≥ 30 kg/m²)
- Trial name
- NCT07340125
- Testing
- Pistachio
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Fasting, Postprandial Hyperglycemia
Postprandial Metabolome and Metabolic Flexibility
Metabolic flexibility is a process in which the body can switch energy substrates in different physiological states. This flexibility plays an important role in an individual's health because losing it increases the risk of…
- Conditions
- Fasting, Postprandial Hyperglycemia, Lipid Metabolism Disorders, Glucose Metabolism Disorders
- Trial name
- NCT06878781
- Testing
- High carbohydrate challenge, High lipid challenge, High proteinchallenge
- Where
- Mexico
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Medicina Genomica
Cardiometabolic Diseases, Postmenopause
Exercise and Prolonged Fasting to Improve Brown Adipose Tissue Function in Postmenopausal Women
Type of Study: Clinical Trial Goal: The goal of this clinical trial is to investigate mitochondrial function in interscapular brown adipose tissue (iBAT) in postmenopausal women and determine whether aerobic exercise, prolonged…
- Trial name
- EMPOWER-BAT (NCT07837752)
- Testing
- Aerobic exercise, Prolonged fasting
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Metabolic Syndrome, Metabolic Syndrome Obesity
Evaluation of Clinical, Metabolic, and Physical-functional Effects of Systemic Vibratory Therapy in Metabolic Syndrome
Studies have demonstrated a strong relationship between physical inactivity and the presence of cardiovascular risk factors such as hypertension, insulin resistance, diabetes, dyslipidemia, obesity, and metabolic syndrome.
- Conditions
- Metabolic Syndrome, Metabolic Syndrome Obesity, Metabolic Syndrome X
- Trial name
- SVTandMSy (NCT06907108)
- Testing
- Systemic vibratory therapy
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- Laboratorio de Vibraçoes Mecanicas e Praticas Integrativas
Cardiorespiratory Fitness, Substrate Metabolism During Exercise
VO2max and Substrate Crossover Point
This study aims to investigate the relationship between maximal oxygen uptake (VO2max) and the substrate crossover point during incremental exercise.
- Conditions
- Cardiorespiratory Fitness, Substrate Metabolism During Exercise, Metabolic Flexibility, Maximal Oxygen Uptake
- Trial name
- VO2MAX-CROSS (NCT07799662)
- Testing
- Incremental Graded Exercise Test (Bruce Protocol)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Celil Kaçoğlu
Prediabetes
Cocoa and Metabolic Health in Prediabetes
The purpose of this study is to determine the impact of consuming cocoa on blood glucose levels, glucose metabolism, and other markers of pre-diabetes in overweight and/or obese individuals.
- Trial name
- NCT02203240
- Testing
- Cocoa
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Virginia Polytechnic Institute and State University
Type 1 Diabetes
The Influence of Glycemic Control and Obesity on Energy Balance and Metabolic Flexibility in Type 1 Diabetes
The purpose of this study is to measure the metabolic phenotype of a range of body weights in individuals with and without type 1 diabetes.
- Trial name
- ACME (NCT03379792)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Targeting Metabolic Flexibility in Amyotrophic Lateral Sclerosis (ALS)
MetFlex is an investigator led, open-label, single-arm, Phase 2a trial to determine the safety and tolerability of trimetazidine for the treatment of amyotrophic lateral sclerosis/motor neuron disease (ALS/MND).
- Trial name
- MetFlex (NCT04788745)
- Testing
- Trimetazidine Dihydrochloride
- Where
- 3 sites in Australia, Netherlands and 1 more
- Volunteers
- 21 people
- Sponsor
- The University of Queensland
Non-alcoholic Fatty Liver Disease, Obesity
Metabolic Flexibility, Gut Microbiota, Healthy Diet and Exercise in NAFLD on Genetics Base
Nonalcoholic fatty liver disease (NAFLD) is associated to obesity, metabolic syndrome and genetic predisposition: specific variants of the genes PNPLA3 and TM6SF2 are the most involved.
- Trial name
- NCT02951546
- Testing
- Mediterranean diet, Low fat diet, Aerobic exercise
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Diet, Healthy, Body Weight
Diet-Induced Changes in GEnetic Material
This is a pilot study in 10 men to test the hypothesis that perturbations in substrate flux and the circulating metabolic and pro-inflammatory milieus during a high-fat diet paradigm will modulate DNA methylation of genes in…
- Conditions
- Diet, Healthy, Body Weight, Metabolic Disturbance
- Trial name
- DIG 'EM (NCT06252922)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
PreDiabetes, Sedentary Lifestyle
Exercise Training and Metabolic Flexibility in Prediabetes
The purpose of the study is to determine if a 6-week exercise training program promotes exercise-induced metabolic flexibility, that is, the ability to switch fuel sources for energy, in older prediabetic adults.
- Trial name
- NCT04051229
- Testing
- 6-week exercise training program, Standardized isoenergetic high fat diet
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences