Clinical trials: Metabolic Management Center
Alzheimer's Disease
AC-1204 Long-term Efficacy Response Trial (ALERT Protocol)
The study will evaluate the safety \& efficacy of AC-1204, a ketogenic compound, administered orally on a daily basis for 6 months.
- Trial name
- ALERT (NCT01211782)
- Testing
- caprylic triglyceride, long-chain triglyceride
- Where
- United States
- Sponsor
- Cerecin
Advanced Malignancies, Solid Tumors
Pharmacokinetics of Patupilone After a Single Intravenous Administration in Patients With Advance Solid Tumor Malignancies.
The main purpose of this study is to characterize the distribution, metabolism, and elimination (ADME) of Patupilone after a single intravenous administration in patients with advanced solid tumor malignancies
- Trial name
- NCT00426140
- Testing
- Patupilone
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Ketoacidosis
Double Blinded Randomized Control Trial of Types of IVF in Children With DKA
Objectives: Intravenous (IV) fluid administration is a fundamental component of diabetic ketoacidosis (DKA) treatment. Normal saline (NS), the most common IV fluid used in DKA management, contains more chloride than human blood.
- Trial name
- NCT03066440
- Testing
- Normal saline, Lactated Ringers
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- State University of New York at Buffalo
Amyotrophic Lateral Sclerosis
Far Infrared Irradiation for Control, Management and Treatment of Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis (ALS, sometimes called Lou Gehrig's s Disease, or Maladie de Charcot) is a progressive, usually fatal, neurodegenerative disease caused by the degeneration of motor neurons, the nerve cells in the…
- Trial name
- NCT00673140
- Testing
- Far Infrared Radiation (5μm to 20μm wavelength), Far infrared radiation
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- GAAD Medical Research Institute Inc.
Type II Diabetes
A Study to Assess the Bioequivalence of Fixed Dose Combination of HR20033 Relative to Co-administration of the Individual Components in Healthy Chinese Subjects
The trial is to assess the bioequivalence between HR20033 FDC tablet and co-administration of SHR3824 tablets and metformin XR tablets.
- Trial name
- NCT05108350
- Testing
- T1: FDC 5/500 mg; R1+R: SHR3824 5 mg + Metformin 500 mg XR, T2: FDC 5/1000 mg; R2+R: SHR3824 5 mg + two Metformin 500 mg XR
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Advanced Solid Malignancies
Absorption, Distribution, Metabolism and Excretion (ADME) Study of TKI258 in Patients With Advanced Solid Malignancies
This is a phase l study to examine Absorption, Distribution, Metabolism and Excretion of TKI258. There are 2 cohorts. Cohort 1 (4 patients) will receive single radio-labeled 500mg dose of TKI258 followed after 15 days by daily…
- Trial name
- NCT00669097
- Testing
- TKI258
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- Novartis Pharmaceuticals
Healthy Volunteers
Copanlisib Mass Balance Study
The study aims to provide understanding of the relative relevance of the different excretion pathways of Copanlisib in humans, as well as to characterize its metabolite profile.
- Trial name
- NCT02119221
- Testing
- Copanlisib (BAY80-6946)
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Bayer
Obesity, Childhood, Pediatric Obesity
Treatment Efforts Addressing Child Weight Management by Unifying Patients, Parents & Providers
The US Preventive Services Task Force (USPSTF) recommends that providers screen children aged 6 years and older for obesity and offer or refer them to a comprehensive behavioral intervention (≥26 hours over a period of up to 12…
- Conditions
- Obesity, Childhood, Pediatric Obesity, Childhood Obesity, Adolescent Obesity
- Trial name
- TEAM UP (NCT03843424)
- Testing
- eSOC program, FBT program
- Where
- 7 sites in United States
- Volunteers
- 1,460 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Menkes Syndrome
Recombinant Adeno-associated Virus Administration for Patients With Menkes Syndrome
It is a single-center, open, single-arm, non-randomized investigator-initiated trial evaluating the efficacy and safety of recombinant adeno-associated virus administration for patients with Menkes syndrome.
- Trial name
- NCT05507996
- Testing
- Recombinant adeno-associated virus administration
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Kunming Hope of Health Hospital
Hepatic Cirrhosis, Hepatic Encephalopathy (HE)
MNK6106 for Liver Disease (Hepatic Cirrhosis) That in the Past Has Affected the Brain (Hepatic Encephalopathy)
The main reason for this study is to see how the study drug interacts with the body. It will compare different doses of the study drug with a drug already in use.
- Trial name
- NCT03712280
- Testing
- MNK6106, Rifaximin
- Where
- 5 sites in United States, Puerto Rico
- Volunteers
- 50 people
- Sponsor
- Mallinckrodt
Amyotrophic Lateral Sclerosis
A Safety Study of sNN0029 Administration Via Intracerebroventricular Route to Patients With ALS
This is a phase I, multicentre randomised, double-blind, placebo-controlled trial to assess the safety and tolerability of continuous i.c.v.
- Trial name
- NCT01999803
- Testing
- sNN0029
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 15 people
- Sponsor
- Newron Sweden AB
Diabetes
The Effect of Clinic Visit Audio Recordings for Self-management in Older Adults
The objective of this study is to conduct a multisite trial evaluating the impact of adding an audio recording of clinic visits (AUDIO) to usual care in older adults with multimorbidity, including diabetes, compared to After…
- Trial name
- REPLAY (NCT05824572)
- Testing
- Clinic visit audio recordings for self-management in older adults, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 336 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Diabetes Mellitus
Patient-Centered Decision Support to Improve Diabetes Management in Pre-Teens and Adolescents With Type 1 Diabetes
Investigators propose to study an intervention that will provide patient-centered, automated decision support to diabetes providers with the goals of improving adherence to medical recommendations (both patients and providers)…
- Trial name
- CHICAT1 (NCT03084900)
- Testing
- Arm 1
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Indiana University
Diabetes Mellitus, Hypertension
The Impact of Sharing Audio Recorded Clinic Visits on Self-management in Older Adults
The investigators will conduct a multi-site, two-arm, parallel-group, patient-randomized, blocked, controlled, pilot trial with a 3-month follow up in older adults (≥65 years) with diabetes and hypertension.
- Trial name
- NCT04344301
- Testing
- Audio recording
- Where
- 3 sites in United States
- Volunteers
- 91 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Hepatic Encephalopathy
Efficacy of L-Ornithine L-Aspartate in Acute Hepatic Encephalopathy.
Hepatic encephalopathy is caused by the effects on the brain of substances that under normal circumstances are efficiently metabolized in the liver.
- Trial name
- NCT01041755
- Testing
- L-ornithine-L-aspartate, Lactose
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Centro Regional para el Estudio de las Enfermedades Digestivas
Metabolic Syndrome X
Effect of Ursolic Acid Administration on Insulin Sensitivity and Metabolic Syndrome
The metabolic syndrome is characterized by the presence of overweight/obesity, insulin resistance, hyperglycemia, dyslipidaemia and hypertension and an inflammatory state, which together increase the risk of developing…
- Trial name
- NCT02337933
- Testing
- Ursolic acid
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- University of Guadalajara
Ataxia Telangiectasia
Safety and Efficacy of Mutation-targeted Precision Genetic Therapy for Ataxia-Telangiectasia (A-T)
This project aims to evaluate the safety and efficacy of precision genetic therapy for patients with Ataxia-telangiectasia (A-T), a rare neurodegenerative disease caused by mutations in the ATM gene.
- Trial name
- NCT07215416
- Testing
- Antisense oligonucleotide targeting the ATM gene
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Timothy Yu
Diabetes Mellitus
Glucose to Goal: A Model to Support Diabetes Management in Primary Care
Diabetes education is a very important part of diabetes care. Most people with diabetes receive care in primary care practices where diabetes education is not always available.
- Trial name
- NCT02715934
- Testing
- Glucose to Goal, Usual Care
- Where
- United States
- Volunteers
- 4,994 people
- Sponsor
- University of Pittsburgh
Hepatic Encephalopathy
Diet Management on Hepatic Encephalopathy of Patients With Variceal Bleeding After Intrahepatic Portosystemic Shunt Creation
Hepatic encephalopathy is a severe complication of transjugular intrahepatic portosystemic shunt (TIPS) treatment in patients with cirrhosis and variceal bleeding.
- Trial name
- DM-PTHE (NCT03372499)
- Testing
- diet management strategy for encephalopathy
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Li Yang
ALS (Amyotrophic Lateral Sclerosis)
Virtual Reality for Anxiety Management in Persons With Amyotrophic Lateral Sclerosis
Virtual Reality (VR) is gaining traction as a new and innovative leisure to augment healthcare services. Several benefits of the leisure experience, such as distraction and full sensory immersion, have demonstrated a potential to…
- Trial name
- VR ALS (NCT07473765)
- Testing
- Virtual Reality Guided Breathing Exercise
- Volunteers
- 60 people
- Sponsor
- Horizon Health Network