Clinical trials: Metabolic Parameters
Cardiovascular Risk Factors
Effect of Biophenol-rich Pomegranate Extract Intake on Blood Pressure, Hormones, Body Composition and Quality of Life in Healthy Volunteers.
Biophenols can act as powerful antioxidants. Pomegranate (Punica granatum) provides a rich and varied source of biophenols with the most abundant being ellagitannins, tannins, anthocyanins, ellagic and gallic acids.
- Trial name
- POM-01Expl (NCT02005939)
- Testing
- Pomegranate extract
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Healthy
The Effects of io Fibrewater Supplementation on Gut Health, Immunity and Metabolism in Overweight Adults
Despite availability of many alternative and conventional weight loss options, the prevalence of obesity increased from 15% in 1993 to 27 in 2015. In 2015, 68% of men and 58% of women in the UK were overweight or obese.
- Trial name
- IOFW (NCT05908474)
- Testing
- Enriched fibre water
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Other Endocrine/Nutritional/Metabolic Disorder
Nutritional Supplement Impact on Metabolic Parameters
This open label study seeks to study the effects of a nutritional supplement on inflammatory markers, metabolic parameters, and safety in subjects compared to baseline after taking supplement for 2 and 4 months.
- Trial name
- NCT02349555
- Testing
- Nutritional Supplement Blend
- Where
- 2 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Pharmanex
Polycystic Ovary Syndrome, Glucose Intolerance
Glucose Metabolism in Different PCOS Phenotypes
In the present study glucose metabolism and ectopic lipids in the liver, heart and muscle were investigated in women with the polycystic ovary syndrome (PCOS) and in healthy control subjects.
- Conditions
- Polycystic Ovary Syndrome, Glucose Intolerance, Liver Fat, Glucose Metabolism Disorders
- Trial name
- NCT03204461
- Testing
- Oral glucose tolerance test (OGTT), 1H-magnetic resonance spectroscopy
- Where
- Austria
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Celiac Disease, Celiac Disease in Children
Effects of A2 Dairy Consumption in Celiac Adolescents
The goal of this clinical trial is to evaluate the effect of A2 β-casein-containing milk and dairy product consumption on nutritional status, gastrointestinal symptoms, quality of life, sleep quality, and selected biochemical…
- Conditions
- Celiac Disease, Celiac Disease in Children, A2 β-casein-containing Milk and Dairy Products
- Trial name
- NCT07815821
- Testing
- A2 β-casein milk and dairy products, Standard milk and dairy products
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Halic University
Healthy, Abdominal Obesity
Intestinal Tolerance & Health Effects of Daily Consumption of Two Eggs With Fatty Acid Profile Related to Metabolic Disorders
This study has two objectives: 1) to check that the daily consumption of two eggs with a particular fatty acid pattern rich in n-3 polyunsaturated fatty acids (α-linolenic acid, docosahexaenoic acid), conjugated-linoleic acid and…
- Conditions
- Healthy, Abdominal Obesity, Sedentary Behavior
- Trial name
- Oil4Egg (NCT04583657)
- Testing
- Eggs
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Diabetes Mellitus, Type 2
Medication in Early Diabetes (MED) Study
This study compares metformin (current first-line medication) to pioglitazone (a newer diabetic medication currently approved for combination use).
- Trial name
- NCT00437970
- Testing
- Pioglitazone, Metformin
- Where
- Australia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Menzies School of Health Research
Healthy
Metabolic and Appetite Parameters Following Addition of Whey Protein to a Fat-based Breakfast
The purpose of this study is to investigate whether the addition of whey protein to a breakfast high in fat content will influence acute metabolic and appetite responses, as well as responses to a subsequent lunch meal.
- Trial name
- NCT02651051
- Testing
- Whey Protein, High Fat Breakfast Meal
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Eye Manifestations
Ocular Surface Changes in Patients With Cystic Fibrosis
Cystic fibrosis(CF) is an inherited disease affecting children, adolescents and young adults with dysfunction of secretory glands.It is caused by mutations in the protein-coding gene which function as the cystic fibrosis…
- Trial name
- NCT00345280
- Testing
- impression cytology, obtain the tear fluid
- Where
- Poland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Bialystok
Diabetes Mellitus, Type 2
First Time in Human Study Using GSK2330672
The purpose of this study is to look at the safety and tolerability of increasing single doses of GSK2330672 in healthy volunteers.
- Trial name
- NCT01416324
- Testing
- 0.1 mg GSK2330672, 0.3 mg GSK2330672, 1 mg GSK2330672
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obesity
Balanced Propofol Sedation During Upper Endoscopy in Morbidly Obese Patients
The purpose of this study is to evaluate the safety of propofol-based, gastroenterologist-administered sedation in severely obese patients (BMI≥35) undergoing upper endoscopy.
- Trial name
- NCT00782873
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Research Associates of New York, LLP
Diabetes Mellitus, Type 2, Periodontal Diseases
Evaluation of Non - Surgical Periodontal Therapy in Diabetic Patients.
Unfavorable systemic conditions condition a low resistance of the host to the virulence of the aggressive agent, causing in a periodontal disease and may lead to difficulties in the therapeutic response.
- Trial name
- NCT03764410
- Testing
- Non-surgical periodontal treatment
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidade Metropolitana de Santos
Childhood Obesity, Cardiovascular Disease
The Effects of California Strawberries on Parameters of Cardiovascular Health
The prevalence of childhood obesity has been increasing over the past couple of decades. Similar to adults, overweight and obesity in young children and adolescents is associated with an increased number of cardiovascular risk…
- Trial name
- NCT01705093
- Testing
- flavonoid-rich freeze-dried strawberry powder, macronutrient-matched control powder
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Obesity
Aquatic_Training in Obese Women
This study aims to assess the effects of 10-week water-based aerobic training (thrice a week) on anthropometrics, biochemicals, cardiovascular parameters, and explosive strength in young overweight and obese women.
- Trial name
- NCT06371105
- Testing
- 10-week water-based aerobic training
- Where
- Taiwan
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Taipei
Hypercholesterolemia
Effect of a Dietary Supplement on Lipid Pattern and Liver Parameters in Hypercholesterolemia
The joint ESC/EAS guidelines for the management of dyslipidaemias recommend, for patients at low/moderate CV risk with raised LDL-C, a set of measures collectively defined as "lifestyle interventions", with use of drugs only if…
- Trial name
- NCT04485793
- Testing
- Dietary supplement
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Dyslipidemia, Angina (Stable)
Validation of Remote Photoplethysmography (rPPG)-Derived Cardiovascular Parameters Against Standard Clinical Measurements and Risk Scores in a Community
The goal of this observational study is to evaluate whether a contactless camera-based technology, called remote photoplethysmography (rPPG), can accurately measure cardiovascular parameters and estimate cardiovascular risk in…
- Conditions
- Dyslipidemia, Angina (Stable), Coronary Artery Disease (CAD), Heart Disease
- Trial name
- NCT07502703
- Where
- Indonesia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tarumanagara University
Metabolic Syndrome
Comparison of the Effects of Green Exercise Programs on Metabolic Syndrome Parameters in Elderly Individuals
The aim of this study is to compare the effects of exercise programs that only aerobic exercise and combination aerobic exercise and resistance exercises on the metabolic syndrome parameters in the green exercise concept.
- Trial name
- NCT05251597
- Testing
- green exercise with aerobic exercise
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Healthy, Obesity
A Pharmacokinetic Study to Compare the Dosing of Valproic Acid in Subjects With Different Body Weights
The purpose of this study is to compare the blood levels of valproic acid in subjects with different body weights and to evaluate whether the pharmacokinetic parameters of this drug is altered in the obese population.
- Conditions
- Healthy, Obesity, Pharmacokinetics
- Trial name
- NCT00298857
- Testing
- Valproic acid
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Prediabetes, Obesity & Overweight
Human Pilot Study for the Investigation of the Role of Bilberry and Olive Bioactives on Oxidative Stress Parameters and Inflammatory Markers.
Numerous plant-based foods contain bioactive compounds, in particular polyphenols, which have antioxidant, anti-inflammatory, and metabolic regulatory effects.
- Conditions
- Prediabetes, Obesity & Overweight, Inflamation, Oxidative Stress
- Trial name
- BIOTRANSFORM (NCT07659028)
- Testing
- supplementation, food
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Androgen Insensitivity Syndrome, Metabolic Parameters in AIS, CAIS, PAIS and MAIS
Androgen Receptor, Implications for Health and Wellbeing: Natural History Study of Individuals With Androgen Insensitivity
Background: Androgen effects in humans are usually (but not always) mediated by the androgen receptor which is coded for by the androgen receptor gene (AR gene).
- Conditions
- Androgen Insensitivity Syndrome, Metabolic Parameters in AIS, CAIS, PAIS and MAIS, Tumor Formation in AIS, CAIS, PAIS and MAIS, Sexual Function AIS, CAIS, PAIS and MAIS
- Trial name
- NCT04708431
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)