Clinical trials: Metabolic Regulation
Food Intake Regulation, Substrate Oxidation
Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men
The purpose of this study is to investigate the effect of substrate oxidation, expressed by RER, on food intake regulation and net energy balance.
- Trial name
- NCT01888991
- Testing
- Glucose Preload and Exercise Intervention
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Physical Inactivity, Walking
Daily Goal Setting to Increase Everyday Physical Activity and Promote Cognitive Health in Midlife
The purpose of this study is to determine whether interaction with an adaptive Fitbit-based goal setting application can increase levels of everyday light intensity physical activity in middle-aged adults.
- Conditions
- Physical Inactivity, Walking, Cognitive Health, Self-regulation
- Trial name
- NCT05826379
- Testing
- Adaptive Daily Goal Setting, Interim Goal Prompt
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Healthy
Postprandial Insulin Secretion and Appetite Regulation After Moderate Alcohol Consumption
A body of epidemiologic studies show that moderate alcohol consumption is associated with a protective effect against type 2 diabetes.
- Trial name
- NCT00524550
- Testing
- moderate alcohol consumption
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TNO
Overweight, Obesity
A Controlled Study to Evaluate the Effects of a Supplement on Weight Loss, Blood Sugar, and Appetite Suppression
This is a randomized, controlled, hybrid clinical trial evaluating the effects of the Evolv GLP-1 supplement on weight loss, blood sugar regulation, and appetite suppression over 12 weeks.
- Conditions
- Overweight, Obesity, Blood Sugar Regulation, Appetite Suppression
- Trial name
- NCT07889570
- Testing
- Evolv GLP-1 Group, Control Group
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Evolv
Appetite Regulation, Overweight and Obesity
Effectiveness of a Natural Ingredient on Appetite Regulation
Single-center, double-blind, double-crossed, randomized controlled clinical trial with two crossed branches, designed with the objective of evaluating the effect of the investigational product on satiety.
- Trial name
- SAC (NCT04345029)
- Testing
- Dietary supplement consumption
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Hypercholesterolemia, Coronary Heart Disease
Addition of Phytosterols to a Low Phytosterol Diet
Studies have shown that phytosterols will lower LDL cholesterol. Typical diets can contain between 250 to 500 mg of naturally-occurring phytosterols.
- Trial name
- phyteaux-I (NCT00860054)
- Testing
- Different amount of phytosterols are added into diets
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obesity
Regulation of Muscle Protein Phenotype in Humans With Obesity
A hallmark of muscle changes in obesity is an altered muscle fiber type profile, characterized by a reduced proportion of Type I fibers - a shift associated with adverse obesity-related health outcomes.
- Trial name
- NCT04700800
- Testing
- Exercise
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Physiological Effect of TCC on Glucose Metabolism
Short-term Effects of Tai Chi Chuan Exercise on the Regulation of Lipid and Glucose Metabolisms and Endothelial Function
The short term effects of TCC exercise are the significant increase in serum insulin and insulin resistance, and the significant decrease in serum TC, HDL-C, ET-1 and insulin sensitivity in TCC practitioners.
- Trial name
- NCT03503084
- Testing
- Classical Yang's TCC exercise
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Changhua Christian Hospital
Metabolic Flexibility
Human Metabolic Flexibility: Its Role in Energy Regulation and Obesity
Obesity is commonly described as a consequence of excess calorie intake. Conventionally, the physiological variables that have been of extensive interest are food intake and energy expenditure.
- Trial name
- NCT04773132
- Testing
- Low Protein
- Where
- Singapore
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Healthy
Regulation of Metabolism and Ion Handling
This study investigates the relation between ion-handling (K+) and fatigue development during exercise. Before and after a 6-week period of high intensity interval training, performance and ion-handling is assessed in young…
- Trial name
- NCT03317704
- Testing
- Speed endurance training
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Overweight and Obesity
Effects of Oral vs Intravenous Glucose Administration on Novel Candidates of Energy Regulation
Energy regulation in humans is controlled through complicated mechanisms involving among others hormones secreted from different tissues, such as gut, muscle and adipose tissue.
- Trial name
- NCT04888325
- Testing
- Oral glucose, Intravenous glucose
- Where
- Greece
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Hyperlipidemia
Regulation of Intestinal and Hepatic Lipoprotein Production by Glucose and Fructose
Increased postprandial plasma triglycerides are associated with increased cardiovascular risk. Chronic consumption of carbohydrates is associated with increased levels of triglycerides.
- Trial name
- glucose (NCT01694446)
- Testing
- Intraduodenal glucose or fructose
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Obesity
Functional Lipids and Appetite Regulation
To evaluate the short-term effects of structured lipids on appetite regulation.
- Trial name
- NCT00259259
- Testing
- SALATRIM
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity, Healthy
IL-6 Regulation of Substrate Metabolism and Influence of Obesity
The aim of the study is to investigate the effects of blocking IL-6 signaling with tocilizumab on lipid, glucose and protein metabolism during rest and exercise in healthy and obese humans.
- Trial name
- NCT03967691
- Testing
- Tocilizumab infusion, Saline 0.9%
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Obesity
Insulin Regulation of Lipolysis and Lipolysis Proteins
These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which…
- Trial name
- NCT03866408
- Testing
- Immediate weight loss, Pioglitazone, Deferred weight loss
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Ketosis, Regulation of Muscle Protein Synthesis
Ketones and Muscle Protein Synthesis
Ketones are natural substances normally produced by the body during prolonged fasting and starvation, or in response to a "ketogenic" diet to be used as fuel by the brain and muscles.
- Trial name
- NCT04565444
- Testing
- Ketone, Ketone + Protein, Protein
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McGill University
Obesity, Appetitive Behavior
Regulation of Energy Balance and Metabolism - Mechanisms Behind and Beyond Obesity and Weight Loss
The study aims to investigate homeostatic and hedonic mechanisms regulating appetite, energy balance and metabolism in obesity and the effects of three distinct obesity treatments on these regulatory mechanisms.
- Trial name
- BALANCE (NCT03550339)
- Testing
- SURG, DIET, HAES
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Obesity
The Energy Balance Study
Very low carbohydrate diets and high-complex carbohydrate, low-fat diets are popular weight-loss methods in the United States. The purpose of the Energy Balance Study is to explore how extreme differences in diet affect eating…
- Trial name
- EBS (NCT01029483)
- Testing
- Low carbohydrate diet, High-carbohydrate ad libitum intervention, High carbohydrate diet-energy matched intervention
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Weight Gain
Oxytocin and Eating
In this protocol, the investigators propose a randomised controlled trial to explore the effects of intra-nasal oxytocin administration on appetite regulation.
- Trial name
- NCT03225456
- Testing
- Syntocinon
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale-NUS College
Type 2 Diabetes, Dyslipidemia
The Effect of Type 2 Diabetes and Dietary Regulation on VLDL1-and VLDL2-triglyceride Metabolism
In this study the investigators wish to compare Very Low-Density Lipoprotein (VLDL) kinetics in type 2 diabetic males and healthy males postabsorptive and during hyperinsulinemia.
- Trial name
- NCT01564550
- Testing
- Insulin, diet, no diet
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Aarhus