Clinical trials: Metabolic Regulation
Healthy Adult
SweetSpot - The Effect of Non-nutritive Sweeteners on Health
The aim of the study is to investigate the effect of non-nutritive sweeteners on glucose regulation. Secondary objectives are to investigate the effect of NNS on gut microbiome, gut hormone secretion, sweet taste sensitivity and…
- Trial name
- NCT07361406
- Testing
- Diet with non-nutritive sweeteners, Diet without non-nutritive sweeteners
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Type II Diabetes
Evaluation of Effects of Dibifree® on Regulation of Blood Sugar and HbA1c in Patients With Type II Diabetes
At present, diabetic patients mainly use drugs to control blood sugar. However, drugs have side effects and the control effect varies among individuals.
- Trial name
- NCT06224803
- Testing
- Compound plant extracts, Indigestible dextrin
- Where
- Taiwan
- Volunteers
- 56 people
- Sponsor
- Global Preventive Medicine Biotech Co., Ltd.
Obesity & Overweight, Metabolic Disorders
Diet and WB-EMS Effects in Obesity
Obesity is a major global health problem associated with metabolic dysfunction, altered adipokine signaling, and impaired appetite regulation.
- Conditions
- Obesity & Overweight, Metabolic Disorders, Electrotherapy
- Trial name
- DEMO-OB (NCT07562724)
- Testing
- Energy-Restricted Diet, Whole-Body Electromyostimulation (WB-EMS)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Firat University
Aging, Healthy, Blood Sugar; High
Circadian Health Regulation and Optimization for Rejuvenation Outcomes
In this single arm intervention trial, the investigators will assess the impact of a personalized lifestyle plan, centered on supporting biological rhythms, on blood sugar levels, physical, cognitive and immune function in older…
- Conditions
- Aging, Healthy, Blood Sugar; High, Blood Sugar (Glucose) Control, Time Restricted Eating
- Trial name
- CHRONO (NCT07203196)
- Testing
- Circadian Rhythm Optimization
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Salk Institute for Biological Studies
Diabetes Mellitus, Type 2
Incidence of Type 2 Diabetes in the di@Bet.es Study
Our aim was to determine the incidence of type 2 diabetes mellitus in a nation-wide population based cohort from Spain (di@bet.es study). The target was the Spanish population.
- Trial name
- NCT02542735
- Where
- Spain
- Volunteers
- 2,408 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Cardiovascular Diseases, Natriuretic Peptides
GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study
Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes…
- Conditions
- Cardiovascular Diseases, Natriuretic Peptides, Cardiometabolic Diseases, Energy Expenditure
- Trial name
- NCT05216042
- Testing
- Study diet, Exercise capacity VO2 max determination, Exercise Challenge
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Personality Disorders
Biological Effects of Schema Therapy
Background: The major aim of this study is to compare the effects of emotion focused (experiential) and cognitive interventions of schema therapy (ST) on emotion regulation deficits in patients with borderline personality…
- Trial name
- BE-ST (NCT06367907)
- Testing
- schema therapy
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Jena University Hospital
Overweight, Breast Cancer
Appetite and Exercise in Breast Cancer Survivors
The overall aim of this research is to investigate the acute effects of resistance exercise (REx) on the hormonal and behavioral indices of energy balance regulation in breast cancer survivors.
- Conditions
- Overweight, Breast Cancer, Obesity
- Trial name
- EARNESt (NCT04300478)
- Testing
- REx Condition First, Sedentary Control Condition First
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- University of Colorado, Denver
Bariatric Surgery Candidate, Lipid Metabolism Disorders
Lipid Metabolism in Obese Subjects Undergoing Bariatric Surgery
The aim of the study is to evaluate modifications in the metabolism of polyunsaturated fatty acids (PUFA) and biosynthesis of the lipid mediators N-acylethanolamines (NAE), both known to induce and be induced by the nuclear…
- Conditions
- Bariatric Surgery Candidate, Lipid Metabolism Disorders, Obesity
- Trial name
- NCT04984785
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- University of Cagliari
Healthy
Effect of Brazilian Fruits Peel on Metabolic Regulation and Appetite in Healthy Subjects
The purpose of the study was to investigate how Brazilian fruits peel affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective…
- Trial name
- BRASIL-MET (NCT02245906)
- Testing
- Control drink, Brazilian fruit peel flour, Negative control drink
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Lund University
Overhydration, Dry Weight Reduction
Response Options to Blood Volume Monitoring in Fluid Overloaded Hemodialysis Patients
Background: Data generated with the body composition monitor (BCM, Fresenius) show based on bioimpedance technology, that chronic fluid overload in hemodialysis patients is associated with poor survival.
- Trial name
- BVM-Reg (NCT01416753)
- Testing
- UCR, UTR
- Where
- Austria
- Volunteers
- 64 people
- Sponsor
- Marcus Saemann
Postmenopausal Osteoporosis
Study on the microRNA Expression Level in Postmenopausal Osteoporosis
The miRNA plays an important regulation role in gene expression, and also closely related to bone metabolism. Previous research found that postmenopausal osteoporosis with kidney Yin deficiency syndrome (POP) is associated with…
- Trial name
- microRNA (NCT02128009)
- Testing
- osteoporosis
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fujian Academy of Traditional Chinese Medicine
PreDiabetes, Appetitive Behavior
Prediabetes, Exercise, and Appetite Regulation
The purpose of the study is to learn about how type of exercise influences measures of appetite regulation.
- Trial name
- PEAR (NCT04910763)
- Testing
- Resistance Exercise
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Utah
Diabetes Mellitus, Type 2
Experimental Studies of the Effects of Caffeine on Glucose Regulation
This project contains experimental studies of the effects of the drug caffeine on glucose regulation in adults who have Type 2 diabetes.
- Trial name
- NCT00432887
- Testing
- caffeine administration
- Volunteers
- 150 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity
Regional Lipolysis Insulin Regulation
Adults who gain most of their excess weight in the abdominal area typically do not respond to insulin in the same way as lean adults.
- Trial name
- NCT06392854
- Testing
- Insulin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Type 1 Diabetes
FAMS-T1D Self-Regulation and Social Support for T1D
The goal of this clinical trial is to evaluate how effective the FAMS-T1D intervention is for improving self-regulation (e.g., setting and meeting goals for type 1 diabetes) and social support for meeting those goals for young…
- Trial name
- FAMS-T1D (NCT05820477)
- Testing
- FAMS-T1D, Digital resources for diabetes
- Where
- 2 sites in United States
- Volunteers
- 280 people
- Sponsor
- University of Utah
Gestational Diabetes
Assessment of Fetal Pancreatic Size and Maternal Serum Biomarkers in GDM
The investigators aimed to determine the predictive values of fetal pancreas size and maternal serum biomarkers glycated albumin (GA) and insulin-regulated aminopeptidase (IRAP) for gestational diabetes mellitus (GDM).
- Trial name
- PS-GDM-2022 (NCT05392231)
- Where
- Turkey (Türkiye)
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Appetite Regulation, Overweight and Obesity
Effectiveness of a Natural Ingredient on Appetite Regulation
Single-center, double-blind, double-crossed, randomized controlled clinical trial with two crossed branches, designed with the objective of evaluating the effect of the investigational product on satiety.
- Trial name
- SAC (NCT04345029)
- Testing
- Dietary supplement consumption
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Overweight, Obesity
Effect of Consuming Beans for One Month on Blood Lipids, Satiety, Intake Regulation and Body Weight
This project investigates the effect of regular consumption of commercially available processed white beans (5 cups per week) on food intake, body weight, blood pressure, satiety hormones and glycemic response over a 4-week…
- Conditions
- Overweight, Obesity, Metabolic Syndrome, Diabetes
- Trial name
- NCT00741923
- Testing
- navy beans added to regular diet
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Toronto
Obesity, Diet
Effect of Carbonated Soft Drinks on Appetite-Regulation
Compared to solid foods, the nutritional energy of drinks may bypass the appetite regulation leading to obesity development. Although drinks sweetened with aspartame are available the anticipated positive effect of these drinks…
- Trial name
- NCT00776971
- Testing
- Sugar-sweetened soft drink, Aspartame-sweetened soft drink, Semi-skimmed milk
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital