Clinical trials: Metabolic Regulation
Polycystic Ovarian Syndrome, Obesity, Abdominal
Acupuncture in the Regulation of Dai Meridian for Polycystic Ovarian Syndrome Patients With Abdominal Obesity
The purpose of this study is to determine whether the use of electroacupuncture to dredge and regulate Dai Meridian combined with lifestyle modification are more effective than lifestyle modification only in the treatment of…
- Trial name
- NCT02785965
- Testing
- electroacupuncture, lifestyle modification
- Where
- 2 sites in China
- Volunteers
- 84 people
- Sponsor
- Dongfang Hospital Beijing University of Chinese Medicine
PreDiabetes
Personalizing Sleep Interventions to Prevent Type 2 Diabetes in Community Dwelling Adults With Pre-Diabetes
This study will use continuous glucose monitoring and actigraphy to examine whether a personalized, daily sleep extension intervention improves glucose regulation for community dwelling, sleep-restricted adults with pre-diabetes.
- Trial name
- NCT03398902
- Testing
- Sleep extension, Habitual sleep
- Where
- United States
- Volunteers
- 393 people
- Sponsor
- New York University
Hypercholesterolemia, Coronary Heart Disease
Addition of Phytosterols to a Low Phytosterol Diet
Studies have shown that phytosterols will lower LDL cholesterol. Typical diets can contain between 250 to 500 mg of naturally-occurring phytosterols.
- Trial name
- phyteaux-I (NCT00860054)
- Testing
- Different amount of phytosterols are added into diets
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Diabetes Mellitus, Type 1
Effects of Dapagliflozin on Hormonal Glucose Homeostasis in Type 1 Diabetes
Inhibitors of sodium-dependent glucose-transporter 2 (including dapagliflozin) represent intensively investigated drugs in the field of diabetes.
- Trial name
- NCT04035031
- Testing
- Forxiga 10mg
- Where
- Switzerland
- Volunteers
- 13 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Glycogen Depletion, Insulin Sensitivity
How is Glycogen Supercompensation Regulated in Human Skeletal Muscle
Nine healthy, moderately fit male volunteers participated in the study. The subjects gave written informed consent after having been informed of any possible risk and discomfort associated with the study.
- Trial name
- Supercomp (NCT03458741)
- Testing
- Glycogen Supercompensation
- Where
- Denmark
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Diabetic Nephropathy Type 2, Type 2 Diabetes Mellitus (T2DM)
Research on Gut Microbiota and Metabolomics in Diabetic Kidney Disease
Diabetic kidney disease (DKD) is characterized by high prevalence, multiple pathogenesis, and lack of effective treatment and management strategies.
- Conditions
- Diabetic Nephropathy Type 2, Type 2 Diabetes Mellitus (T2DM), Chronic Kidney Disease
- Trial name
- NCT06833541
- Where
- China
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
Prediabetes, Impaired Fasting Glucose
Mazdutide for Adults With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled Trial (DREAM-PRE)
Prediabetes affects millions of adults worldwide and carries a high risk of progression to type 2 diabetes. Mazdutide is a once-weekly injectable drug that activates both GLP-1 and glucagon receptors, lowering blood sugar and…
- Conditions
- Prediabetes, Impaired Fasting Glucose, Impaired Glucose Tolerance (Prediabetes)
- Trial name
- DREAM-PRE (NCT07654062)
- Testing
- Mazdutide, Standardized Lifestyle Intervention
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shandong Provincial Hospital
Glucose Metabolism, Appetite Regulation
Glycemic and Appetite Effects of a Pre-meal Whey-Protein Microgel
In this study, the investigators want to assess the effects of a short-term twice daily pre-meal consumption of a liquid whey-protein microgel formulation, when compared to placebo (i.e., water), on: post-prandial glucose…
- Trial name
- GAP (NCT06593769)
- Testing
- whey-protein microgel
- Where
- Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Type 1 Diabetes
Effects of Circadian Rhythm on Glycemic Regulation During Continuous Moderate Exercise and Intense Intermittent Disease in Adolescents Living With Type 1 Diabetes
Interventional research with minimal risks and constraints on the effects of circadian rhythm on glycemic regulation during intense moderate, continuous and intermittent exercise in adolescents living with type 1 diabetes
- Trial name
- CHRONODIAB1 (NCT06803446)
- Testing
- physical test
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Lille University
Anorexia of Aging, Malnutrition or Risk of Malnutrition
The SAVOR Study: Appetite and Physiological Responses
The study aims to identify key physiological factors that differentiate older adults with healthy appetites from those experiencing appetite decline.
- Trial name
- SAVOR (NCT07636369)
- Testing
- Shredded Chicken Congee
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Overweight Adolescents, Obese Adolescents
Pilot Testing a Novel Approach to Pediatric Obesity Treatment
The goal of this clinical trial is to learn if an emotion regulation and self-monitoring intervention can help treat overweight and obesity in teens.
- Trial name
- NCT06755827
- Testing
- Emotion regulation and self-monitoring to treat pediatric obesity, Psychoeducation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Texas Tech University
Obesity
Sugars-sweetened Commercial Beverages on Short-term Food Intake
The purpose of this experiment was to describe the effect of consuming 350 ml of 1% chocolate milk 60 minutes before a pizza meal on subjective appetite and short-term food intake when compared to cola, a fruit drink and a water…
- Trial name
- NCT01717703
- Testing
- Water, Fruit drink, Cola
- Where
- Canada
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Type 2 Diabetes Mellitus
The Effects of Reducing Prolonged Sitting Bouts in Individuals at High Risk of or With Type 2 Diabetes
Over 3 million in the United Kingdom are now diagnosed with type 2 diabetes, with current estimates suggesting this will rise to over 5 million by 2025.
- Trial name
- UP FOR 5 (NCT03482596)
- Testing
- Reducing/breaking prolonged sitting
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Type 2 Diabetes Mellitus, Obesity
MOLECULAR REGULATION OF MUSCLE GLUCOSE METABOLISM (AIMS 2A, 2B, 3)
The molecular nature of insulin resistance in human muscle is still incompletely defined. Our data indicate that acetylation of mitochondrial proteins in humans is regulated by muscle contraction and is dysregulated in insulin…
- Trial name
- NCT03323827
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Arizona
Insulin Secretion
Regulation of Insulin Secretion by the GLP-1 Receptor
AIM2: The purpose of Aim-2 of this study is to determine the role of basal GLP-1 action on the beta-cell response to insulin resistance.
- Trial name
- NCT02844907
- Testing
- Exendin (9-39), Dexamethasone, Hyperglycemic Clamp
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Body Awareness, Obesity
Group Skills Training for Body Awareness and Managing Emotions
The goal of this study is to evaluate the effectiveness of a skills training group informed by polyvagal theory, when delivered in an NHS setting, for those living with obesity.
- Conditions
- Body Awareness, Obesity, Emotional Regulation
- Trial name
- NCT07315763
- Testing
- Polyvagal informed skills training group
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Royal Holloway University
Mitochondrial Disorders, Li-Fraumeni Syndrome
Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome
This study will examine metabolic and biological factors in people with Li-Fraumeni syndrome, a rare hereditary disorder that greatly increases a person's susceptibility to cancer.
- Conditions
- Mitochondrial Disorders, Li-Fraumeni Syndrome, Carriers of p53 Mutation
- Trial name
- NCT00406445
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Metabolic Response to Dietary Modification
The CLOCK Study - A Human Dietary Intervention Study on Peripheral Circadian Clocks and Energy Metabolism
This human dietary intervention study with a cross-over design aims to investigate the effect of two different diurnal patterns of meal composition on peripheral circadian clocks and energy metabolism in healthy men.
- Trial name
- CLOCK (NCT02487576)
- Testing
- Carbohydrate-rich (HC), Fat-rich (HF)
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Hyperlipidemia
Sitagliptin Regulation of Intestinal and Hepatic Lipoprotein Particle and Hepatic Glucose Production in Humans
Recent studies in both animals and humans has demonstrated that the hormone GLP-1 (glucagon like peptide 1) reduces intestinal production of lipoprotein particles.
- Trial name
- NCT01600703
- Testing
- Sitagliptin
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Appetite and General Nutritional Disorders
Advanced Protein-based Program for Effective Treatment of Appetite Regulation and Obesity
INTRODUCTION: Obesity is a global epidemic, with over 2.5 billion adults being classified as overweight and 890 million of these classified as obese.
- Trial name
- APPETITE (NCT07104461)
- Testing
- Oat porridge, Whey protein isolate, Potato protein isolate
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Westminster