Clinical trials: Metabolic Regulation
Type 1 Diabetes
Technology-delivered Physical Activity Program for Adolescents With Type 1 Diabetes
This project is comprised of a two-arm randomized control trial (RCT) testing the feasibility, acceptability, and preliminary efficacy of a nationally scalable program, Activate, a 12-week, technology-delivered diabetes…
- Trial name
- Activate (NCT05319600)
- Testing
- Diabetes behavior change skills training, Physical activity promotion program
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Vermont
Gestational Diabetes Mellitus
Study of Pregnancy Regulation of Insulin and Glucose
It is unknown whether beta cell dysfunction and insulin resistance in Gestational Diabetes Mellitus (GDM) is representative of a chronic maternal defect, unmasked by pregnancy, or whether it is the result of an imbalance of a…
- Trial name
- SPRING (NCT02763267)
- Testing
- Oral glucose tolerance test
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Massachusetts General Hospital
Obesity Prevention, Obesity
External Body Weight Effects on Body Weight in Adults With Grade II and III Obesity
Obesity is a growing problem in industrialized societies. This condition is associated with an increase in metabolic and cardiovascular diseases.
- Trial name
- NCT06619028
- Testing
- Weighted vest
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Escoles Universitaries Gimbernat
Diabete Type 2, Obesity
Effects of Plant Based Lipids on Glucose Regulation and Cognitive Variables
The overall goal is to increase the knowledge that can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people.
- Trial name
- NCT05276128
- Testing
- lipids
- Where
- 2 sites in Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Lund University
Insulin Resistance Syndrome
Diagnostic Interest of the IRAP Protein (Insulin Regulated Amino Peptidase) in Insulin Resistance
There is currently no reliable, diagnostic tests of insulin resistance other than the hyperinsulinemic euglycemic clamp which, due to its constraints and cost, is reserved for research.
- Trial name
- IRAP-IR (NCT04028895)
- Testing
- Dosage of IRAP during OGTT
- Where
- 4 sites in France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Prediabetic State
Effects of Branch Chain Amino Acids on Glucose Tolerance in Obese Pre-Diabetic Subjects
Branching chain amino acids (BCAA) have both beneficial and detrimental effects of on metabolism have been established and therefore warrants further investigation.
- Trial name
- BCAA (NCT02684565)
- Testing
- BCAA High Protein supplement, BCAA Low Protein supplement
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Los Angeles
Overweight and Obesity
Improving Emotion Regulation Skills Among Adolescents Attempting to Lose Weight
While the prevalence of overweight and obesity among children and adolescents has plateaued, national data indicate that approximately 35% of children and adolescents continue to struggle with overweight/obesity.
- Trial name
- NCT03393221
- Testing
- ER, SBWC
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Adiposity
The Role of Oxytocin-receptor Signalling in Physiological Regulation of Eating Behaviour in Individuals with Obesity
The present study evaluates appetite, glucose metabolism, gastrointestinal motility and energy expenditure in men and women with obesity (BMI 30-40 kg/m2) under oxytocin exposure compared to placebo.
- Trial name
- FOxy (NCT06189001)
- Testing
- Oxytocin
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Obesity
Metacognitive Beliefs in Obese Patients
The study aims to investigate the presence of metacognitive beliefs, emotional regulation, and emotional eating in obese patients and their possible relationships.
- Trial name
- METAOBES (NCT06800911)
- Testing
- Questionnaires
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Istituto Auxologico Italiano
Insulin Resistance
The Effect of Vasopressin on Glucose Regulation
Data from experimental animals and human epidemiological studies have suggested that hypohydration and/or low water intake is linked to poor glucose regulation and diabetes.
- Trial name
- HYPERGlu (NCT02761434)
- Testing
- Hypertonic Saline (3% NaCl), Isotonic Saline (0.9% NaCl)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Arkansas, Fayetteville
Hypovitaminosis D
Vitamin D Status in Lower Extremity Joint Replacement Surgery Patients
In the United States, ~1 million elective hip or knee replacement surgeries are performed annually. With estimated surgical site infection (SSI) rates as high as 2.5%, this represents ~25,000 patients at risk of potentially…
- Trial name
- NCT01858051
- Testing
- Cholecalciferol
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Obesity, Type II Diabetes Mellitus
Yellow Pea Fractions and Short-term Food Intake, Subjective Appetite and Glycemic Response
It is hypothesized that yellow pea protein and fiber will reduce short-term food intake, subjective appetite and glycemic response.
- Conditions
- Obesity, Type II Diabetes Mellitus, Metabolic Syndrome
- Trial name
- NCT01242059
- Testing
- yellow pea protein, yellow pea fiber, Control
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetes Mellitus, Type 2
Evaluation of the Efficacy and Safety of DBL-4pen Mobile Application in Patients With Type 2 Diabetes
This study conducted in 40 adults living with type 2 diabetes is an interventional single-arm open-label before/after multicentric national study conducted as a clinical investigation according to the law EU 2017/745 art. 62.
- Trial name
- SERENIT2 (NCT05733962)
- Testing
- Use of the device DBL-4pen
- Where
- 4 sites in France
- Volunteers
- 40 people
- Sponsor
- Diabeloop
Obesity
Acute Exercise and Energy Balance Regulation: Effect of Intensity
Physical activity is mainly considered and use for its impact on energy expenditure in the treatment of obesity, and less is known concerning its indirect effects on energy intake.
- Trial name
- NCT01036360
- Testing
- metabolic chamber
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Polycystic Ovary Syndrome
Cortisol Regulation in Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine if insulin resistance (how well the body uses insulin and clears sugar) can affect cortisol levels in normal healthy women and women with polycystic ovary syndrome of all body weights.
- Trial name
- NCT00694759
- Testing
- pioglitazone, metformin
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Childhood Obesity, Breastfeeding
Breastfeeding in Infancy and Food Intake in Preschool-Aged Children
The purpose of this study is to compare female, preschool-aged children breastfed during infancy to female, preschool-aged children bottle-fed during infancy in their ability to adjust calorie intake in response to internal…
- Trial name
- NCT00994487
- Testing
- High Energy Density Preload, Low Energy Density Preload
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Non-Alcoholic Fatty Liver Disease
Impact of Cold Exposure on Metabolic Regulation in Children With Non Alcoholic Fatty Liver Disease (NAFLD)
The aim of this project is to generate pilot data for a grant proposal to evaluate the impact of intermittent cold exposure (ICE) on brown and white adipose tissue (BAT/WAT) function in children with non-alcoholic fatty liver…
- Trial name
- ICE BAT (NCT04969744)
- Testing
- ICE
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Obesity & Overweight, Gut -Microbiota
Effects of Monday-Thursday Sunnah Fasting on Short-Chain Fatty Acids, GLP-1, Satiety, and Nutritional Status in Obese Males
This quasi-experimental study investigated the effects of 8 weeks of Monday-Thursday Sunnah fasting on fecal short-chain fatty acids (SCFA), fasting total GLP-1, appetite regulation (hunger and satiety area under the curve)…
- Trial name
- NCT07703865
- Testing
- Monday-Thursday Sunnah Dry Fasting
- Where
- Indonesia
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Muhammadiyah Jakarta
Obesity
Effects of Viscous Fibre Containing Foods on Satiety (Gel Form)
The purpose of this study is to assess whether low caloric, low energy density, konjac food products are effective in appetite regulation when administered as caloric replacements.
- Trial name
- NCT02134938
- Testing
- Konjac Glucomannan
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Obesity, Appetite Regulation
Tailoring Obesity Treatment Trial
The two main aims of this clinical study is; 1. To investigate if the results from a series of physiological tests and questionnaires prior to treatment, can be used to predict the treatment response to obesity medication 2.
- Conditions
- Obesity, Appetite Regulation, PreDiabetes
- Trial name
- TOTT (NCT06619015)
- Testing
- Pramlintide Acetate 1 MG/ML, Semaglutide Pen Injector, Sodium Chloride 0.9% Inj
- Where
- Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark